Research Topics
| Karen Dineen WagnerSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
Research Grants
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Detail Information
Publications
Out of the black box: treatment of resistant depression in adolescents and the antidepressant controversyKaren Dineen Wagner
Division of Child and Adolescent Psychiatry, The University of Texas Medical Branch, Galveston, Texas 77555, USA
J Child Adolesc Psychopharmacol 22:5-10. 2012..The purpose of this article is to describe the effects of the pediatric antidepressant controversy on the Treatment of Serotonin-Selective Reuptake Inhibitor (SSRI) Resistant Depression in Adolescents (TORDIA) trial...
Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trialsKaren Dineen Wagner
University of Texas Medical Branch, Department of Psychiatry and Behavioral Sciences, Galveston 77555 0188, USA
JAMA 290:1033-41. 2003..Comparatively few data are available on the effects of SSRIs in depressed children and adolescents...- A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorderKaren Dineen Wagner
University of Texas Medical Branch, Galveston, TX, USA
Arch Gen Psychiatry 61:1153-62. 2004..Social anxiety disorder is a debilitating, highly prevalent disorder in children and adolescents. If left untreated, it can interfere with emotional, social, and school functioning... - Pharmacotherapy for major depression in children and adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, 301 University Blvd, Galveston, TX 77555 0188, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:819-26. 2005..Treatment recommendations are discussed and the issue of suicidality and antidepressants are addressed... - A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77755, USA
Am J Psychiatry 161:1079-83. 2004..The current study investigated the efficacy and safety of citalopram compared with placebo in the treatment of pediatric patients with major depression... - Bipolar disorder and comorbid anxiety disorders in children and adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 67:16-20. 2006..Comorbid disorders may worsen the course of each individual disorder. Pharmacologic management of the comorbid anxiety disorder is complicated by potential mood destabilization in a child or adolescent with bipolar disorder... - Paroxetine treatment of mood and anxiety disorders in children and adolescentsKaren Dineen Wagner
Department of Psychiatry, University of Texas Medical Branch, TX 77555 0188, USA
Psychopharmacol Bull 37:167-75. 2003..Clinical guidelines for the use of paroxetine in children and adolescents and recommendations regarding future directions of study are discussed... - A double-blind, randomized, placebo-controlled trial of escitalopram in the treatment of pediatric depressionKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0144, USA
J Am Acad Child Adolesc Psychiatry 45:280-8. 2006..Escitalopram is a selective serotonin reuptake inhibitor antidepressant indicated for use in adults. This trial examined the efficacy and safety of escitalopram in pediatric depression... - Youths' and their parents' attitudes and experiences about participation in psychopharmacology treatment researchKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
J Child Adolesc Psychopharmacol 16:298-307. 2006..This study was designed to prospectively assess youths' and their parents' attitudes and experiences about participation in clinical treatment research... - A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77755 0188, USA
Am J Psychiatry 163:1179-86. 2006..This multicenter trial examined the efficacy and safety of oxcarbazepine in the treatment of bipolar disorder in children and adolescents... - Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
J Clin Psychiatry 67:827-30. 2006.... - An open-label trial of divalproex in children and adolescents with bipolar disorderKaren Dineen Wagner
University of Texas Medical Branch, Galveston, TX 77555 0188, USA
J Am Acad Child Adolesc Psychiatry 41:1224-30. 2002..This study evaluated the safety and effectiveness of divalproex sodium (Depakote ) in the treatment of youths with bipolar disorder... - Baby foodKaren Dineen Wagner
JAMA 300:371-2. 2008 
A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescentsKaren Dineen Wagner
University of Texas Medical Branch, USA
J Am Acad Child Adolesc Psychiatry 48:519-32. 2009....- Cognitive factors related to suicidal ideation and resolution in psychiatrically hospitalized children and adolescentsK D Wagner
Department of Psychiatry and Behavioral Sciences, Medical Branch, University of Texas, Galveston 77555 0425, USA
Am J Psychiatry 157:2017-21. 2000..This study was conducted to determine whether there are changes in the cognitive factors of attributional style, hopelessness, and self-esteem when suicidal ideation fades in psychiatrically hospitalized children and adolescents... - Diagnosis and treatment of bipolar disorder in children and adolescentsKaren Dineen Wagner
Departmetn of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0188, USA
J Clin Psychiatry 65:30-4. 2004..This article will review the epidemiology, diagnosis, course of illness, and treatment of bipolar disorder in children and adolescents... - Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: findings from the TORDIA studyJoan Rosenbaum Asarnow
University of California Los Angeles UCLA, Department of Psychiatry, Los Angeles, CA 90095 6968, USA
J Am Acad Child Adolesc Psychiatry 50:772-81. 2011..To evaluate the clinical and prognostic significance of suicide attempts (SAs) and nonsuicidal self-injury (NSSI) in adolescents with treatment-resistant depression... - Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment responseJoan Rosenbaum Asarnow
Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
J Am Acad Child Adolesc Psychiatry 48:330-9. 2009..This study examines predictors and moderators of treatment response, with the goal of informing efforts to match youths to optimal treatment strategies... - Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptomsChristopher J Kratochvil
Department of Psychiatry, Nebraska Medical Center, Omaha 68198 5581, USA
J Am Acad Child Adolesc Psychiatry 44:915-24. 2005..The authors assessed the safety and effectiveness of atomoxetine monotherapy compared with combined atomoxetine/fluoxetine therapy in a population of children and adolescents with ADHD and concurrent symptoms of depression or anxiety... - Bipolar disorder in children and adolescentsDwight V Wolf
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555-0188, USA
CNS Spectr 8:954-9. 2003..This review will provide an overview of the literature of bipolar disorder in children and adolescents, including discussion of the prevalence, diagnosis, epidemiology, course of the illness, and treatment issues... - A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescentsBarbara Geller
Department of Psychiatry, Washington University in St Louis, 660 S Euclid, St Louis, MO 63110, USA
Arch Gen Psychiatry 69:515-28. 2012..There was a paucity of comparative pharmacological research for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents... - Pharmacological management of treatment-resistant pediatric depressionChristopher J Kratochvil
Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68195-5581, USA
J Am Acad Child Adolesc Psychiatry 44:198-200. 2005 - Long-term treatment of bipolar disorder in childrenKaren Dineen Wagner
Department of Psychiatry, University of Texas Medical Branch, Galveston, USA
J Clin Psychiatry 71:e23. 2010.... - Sertraline in children and adolescents with major depressive disorderCraig L Donnelly
Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
J Am Acad Child Adolesc Psychiatry 45:1162-70. 2006.... - Treatment guidelines for children and adolescents with bipolar disorderRobert A Kowatch
Department of Psychiatry, Cincinnati Children s Hospital Medical, OH 45267 0559, USA
J Am Acad Child Adolesc Psychiatry 44:213-35. 2005..These guidelines are subject to change as our evidence base increases and practice patterns evolve... - Remission status after long-term sertraline treatment of pediatric obsessive-compulsive disorderKaren Dineen Wagner
Division of Child and Adolescent Psychiatry, University of Texas Medical Branch, Galveston, Texas 77555, USA
J Child Adolesc Psychopharmacol 13:S53-60. 2003..More research is needed to develop pharmacologic and psychotherapeutic strategies that facilitate the achievement of full remission in the remaining patients suffering from this chronic and disabling illness... - Defining the clinical course of bipolar disorder: response, remission, relapse, recurrence, and rougheningRobert Ma Hirschfeld
Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, Galveston, TX, USA
Psychopharmacol Bull 40:7-14. 2007..This manuscript presents working definitions for key clinical course indicators for bipolar disorder, including response, remission, relapse, recurrence, and roughening... - Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trialGraham J Emslie
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
J Am Acad Child Adolesc Psychiatry 41:1205-15. 2002..Fluoxetine is the only antidepressant that has demonstrated efficacy in two placebo-controlled, randomized clinical trials of pediatric depression... - Attributional style and depression in pregnant teenagersK D Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, 77555 0425, USA
Am J Psychiatry 155:1227-33. 1998..Study 2 replicated unexpected findings from study 1. Study 3 evaluated whether pregnant teenagers with a pessimistic attributional style will be more depressed after childbirth than optimistic pregnant teenagers... - Management of treatment refractory attention-deficit/hyperactivity disorder in children and adolescentsKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0188, USA
Psychopharmacol Bull 36:130-42. 2002..In this article, data on medications for treatment refractory ADHD in children and adolescents are presented and treatment strategies are discussed... - The psychopharmacologic armanmentarium in the pediatric populationKaren Dineen Wagner
Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, USA
CNS Spectr 8:252. 2003 - Teaching psychopharmacology: what works and what doesn'tSidney Zisook
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
J Clin Psychopharmacol 28:96-100. 2008.... - Childhood depression: pharmacological therapy/treatment (pharmacotherapy of childhood depression)K D Wagner
University of Texas Medical Branch, USA
J Clin Child Psychol 30:88-97. 2001..Study modifications are suggested which could improve some of the methodological limitations apparent in previous clinical drug trials... - Generalized anxiety disorder in children and adolescentsK D Wagner
Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas, USA
Psychiatr Clin North Am 24:139-53. 2001..Adequately powered, controlled, pharmacologic treatment trials are necessary. Future research should be directed toward comparing the relative efficacy of psychotherapy, pharmacotherapy, and both in the treatment of GAD in youth... - Paroxetine treatment in children and adolescents with major depressive disorder: a randomized, multicenter, double-blind, placebo-controlled trialGraham J Emslie
University of Texas Southwestern Medical Center at Dallas, 75390 8589, USA
J Am Acad Child Adolesc Psychiatry 45:709-19. 2006..To assess the efficacy and tolerability of paroxetine in pediatric major depressive disorder... - Fluoxetine treatment for prevention of relapse of depression in children and adolescents: a double-blind, placebo-controlled studyGraham J Emslie
University of Texas Southwestern Medical Center at Dallas, Texas, USA
J Am Acad Child Adolesc Psychiatry 43:1397-405. 2004..CONCLUSIONS: Fluoxetine 20 to 60 mg/day was well tolerated and can significantly delay relapse of major depressive disorder symptoms in children and adolescents... - Major depressive disorder in children and adolescents: clinical trial design and antidepressant efficacyGraham J Emslie
Child and Adolescent Psychiatry Division, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
J Clin Psychiatry 66:14-20. 2005.... - Long-term sertraline treatment of children and adolescents with major depressive disorderMoira Rynn
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Child Adolesc Psychopharmacol 16:103-16. 2006.... - Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trialDavid Brent
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
JAMA 299:901-13. 2008..There are no data to guide clinicians on subsequent treatment strategy... - Fluoxetine 40-60 mg versus fluoxetine 20 mg in the treatment of children and adolescents with a less-than-complete response to nine-week treatment with fluoxetine 10-20 mg: a pilot studyJohn H Heiligenstein
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Child Adolesc Psychopharmacol 16:207-17. 2006.... - Analysis of electrocardiographic data following use of paroxetine in pediatric depression and obsessive-compulsive disorderStan Krulewicz
GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406 2772, USA
J Am Acad Child Adolesc Psychiatry 45:422-30. 2006..Data were collected from three 8- to 10-week, randomized, placebo-controlled, double-blind trials of paroxetine in pediatric patients with major depressive disorder or obsessive-compulsive disorder... - Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials?Daniel A Geller
Obsessive Compulsive Disorder Program, Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 13:S19-29. 2003..To examine the influence of psychiatric comorbidity on response and relapse rates in children and adolescents treated with paroxetine for obsessive-compulsive disorder (OCD)... - Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trialDaniel A Geller
Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 43:1387-96. 2004..To assess the efficacy and safety of paroxetine for the treatment of pediatric obsessive-compulsive disorder... - Use of health care services among persons who screen positive for bipolar disorderMark A Frye
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, California 90095, USA
Psychiatr Serv 56:1529-33. 2005..This study examined patterns of diagnosis, consultation, and treatment of persons who screened positive for bipolar disorder... - Child and adolescent psychopharmacology in the new millennium: a workshop for academia, industry, and governmentJoseph DeVeaugh-Geiss
Duke Clinical Research Institute, Durham, NC 27715, USA
J Am Acad Child Adolesc Psychiatry 45:261-70. 2006..To give academic researchers, government officials, and industry scientists an opportunity to assess the state of pediatric psychopharmacology and identify challenges facing professionals in the field...
Research Grants
- TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTSKaren Wagner; Fiscal Year: 2006..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study ..
- Treatment of Early Age ManiaKaren Wagner; Fiscal Year: 2007..The chief study statistician, Dr. Satish lyengar is subcontracted to the coordinating site at Washington U in St. Louis and Dr. Philip Lavori is a major consultant for statistical analyses. ..