Karen Dineen Wagner

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Paroxetine treatment of mood and anxiety disorders in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry, University of Texas Medical Branch, TX 77555 0188, USA
    Psychopharmacol Bull 37:167-75. 2003
  2. pmc Out of the black box: treatment of resistant depression in adolescents and the antidepressant controversy
    Karen Dineen Wagner
    Division of Child and Adolescent Psychiatry, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Child Adolesc Psychopharmacol 22:5-10. 2012
  3. ncbi request reprint Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials
    Karen Dineen Wagner
    University of Texas Medical Branch, Department of Psychiatry and Behavioral Sciences, Galveston 77555 0188, USA
    JAMA 290:1033-41. 2003
  4. ncbi request reprint A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77755, USA
    Am J Psychiatry 161:1079-83. 2004
  5. ncbi request reprint Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 67:827-30. 2006
  6. ncbi request reprint A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77755 0188, USA
    Am J Psychiatry 163:1179-86. 2006
  7. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder
    Karen Dineen Wagner
    University of Texas Medical Branch, Galveston, TX, USA
    Arch Gen Psychiatry 61:1153-62. 2004
  8. ncbi request reprint Diagnosis and treatment of bipolar disorder in children and adolescents
    Karen Dineen Wagner
    Departmetn of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0188, USA
    J Clin Psychiatry 65:30-4. 2004
  9. ncbi request reprint Youths' and their parents' attitudes and experiences about participation in psychopharmacology treatment research
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    J Child Adolesc Psychopharmacol 16:298-307. 2006
  10. ncbi request reprint Pharmacotherapy for major depression in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, 301 University Blvd, Galveston, TX 77555 0188, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:819-26. 2005

Research Grants

  1. TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTS
    Karen Wagner; Fiscal Year: 2006
  2. Treatment of Early Age Mania
    Karen Wagner; Fiscal Year: 2007

Detail Information

Publications47

  1. ncbi request reprint Paroxetine treatment of mood and anxiety disorders in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry, University of Texas Medical Branch, TX 77555 0188, USA
    Psychopharmacol Bull 37:167-75. 2003
    ..Clinical guidelines for the use of paroxetine in children and adolescents and recommendations regarding future directions of study are discussed...
  2. pmc Out of the black box: treatment of resistant depression in adolescents and the antidepressant controversy
    Karen Dineen Wagner
    Division of Child and Adolescent Psychiatry, The University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Child Adolesc Psychopharmacol 22:5-10. 2012
    ..The purpose of this article is to describe the effects of the pediatric antidepressant controversy on the Treatment of Serotonin-Selective Reuptake Inhibitor (SSRI) Resistant Depression in Adolescents (TORDIA) trial...
  3. ncbi request reprint Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials
    Karen Dineen Wagner
    University of Texas Medical Branch, Department of Psychiatry and Behavioral Sciences, Galveston 77555 0188, USA
    JAMA 290:1033-41. 2003
    ..Comparatively few data are available on the effects of SSRIs in depressed children and adolescents...
  4. ncbi request reprint A randomized, placebo-controlled trial of citalopram for the treatment of major depression in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77755, USA
    Am J Psychiatry 161:1079-83. 2004
    ..The current study investigated the efficacy and safety of citalopram compared with placebo in the treatment of pediatric patients with major depression...
  5. ncbi request reprint Validation of the Mood Disorder Questionnaire for bipolar disorders in adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 67:827-30. 2006
    ....
  6. ncbi request reprint A double-blind, randomized, placebo-controlled trial of oxcarbazepine in the treatment of bipolar disorder in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77755 0188, USA
    Am J Psychiatry 163:1179-86. 2006
    ..This multicenter trial examined the efficacy and safety of oxcarbazepine in the treatment of bipolar disorder in children and adolescents...
  7. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder
    Karen Dineen Wagner
    University of Texas Medical Branch, Galveston, TX, USA
    Arch Gen Psychiatry 61:1153-62. 2004
    ..Social anxiety disorder is a debilitating, highly prevalent disorder in children and adolescents. If left untreated, it can interfere with emotional, social, and school functioning...
  8. ncbi request reprint Diagnosis and treatment of bipolar disorder in children and adolescents
    Karen Dineen Wagner
    Departmetn of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX 77555 0188, USA
    J Clin Psychiatry 65:30-4. 2004
    ..This article will review the epidemiology, diagnosis, course of illness, and treatment of bipolar disorder in children and adolescents...
  9. ncbi request reprint Youths' and their parents' attitudes and experiences about participation in psychopharmacology treatment research
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    J Child Adolesc Psychopharmacol 16:298-307. 2006
    ..This study was designed to prospectively assess youths' and their parents' attitudes and experiences about participation in clinical treatment research...
  10. ncbi request reprint Pharmacotherapy for major depression in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, 301 University Blvd, Galveston, TX 77555 0188, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:819-26. 2005
    ..Treatment recommendations are discussed and the issue of suicidality and antidepressants are addressed...
  11. ncbi request reprint A double-blind, randomized, placebo-controlled trial of escitalopram in the treatment of pediatric depression
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0144, USA
    J Am Acad Child Adolesc Psychiatry 45:280-8. 2006
    ..Escitalopram is a selective serotonin reuptake inhibitor antidepressant indicated for use in adults. This trial examined the efficacy and safety of escitalopram in pediatric depression...
  12. ncbi request reprint Bipolar disorder and comorbid anxiety disorders in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston 77555 0188, USA
    J Clin Psychiatry 67:16-20. 2006
    ..Comorbid disorders may worsen the course of each individual disorder. Pharmacologic management of the comorbid anxiety disorder is complicated by potential mood destabilization in a child or adolescent with bipolar disorder...
  13. ncbi request reprint An open-label trial of divalproex in children and adolescents with bipolar disorder
    Karen Dineen Wagner
    University of Texas Medical Branch, Galveston, TX 77555 0188, USA
    J Am Acad Child Adolesc Psychiatry 41:1224-30. 2002
    ..This study evaluated the safety and effectiveness of divalproex sodium (Depakote ) in the treatment of youths with bipolar disorder...
  14. doi request reprint Baby food
    Karen Dineen Wagner
    JAMA 300:371-2. 2008
  15. doi request reprint A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents
    Karen Dineen Wagner
    University of Texas Medical Branch, USA
    J Am Acad Child Adolesc Psychiatry 48:519-32. 2009
    ....
  16. ncbi request reprint Cognitive factors related to suicidal ideation and resolution in psychiatrically hospitalized children and adolescents
    K D Wagner
    Department of Psychiatry and Behavioral Sciences, Medical Branch, University of Texas, Galveston 77555 0425, USA
    Am J Psychiatry 157:2017-21. 2000
    ..This study was conducted to determine whether there are changes in the cognitive factors of attributional style, hopelessness, and self-esteem when suicidal ideation fades in psychiatrically hospitalized children and adolescents...
  17. pmc Suicide attempts and nonsuicidal self-injury in the treatment of resistant depression in adolescents: findings from the TORDIA study
    Joan Rosenbaum Asarnow
    University of California Los Angeles UCLA, Department of Psychiatry, Los Angeles, CA 90095 6968, USA
    J Am Acad Child Adolesc Psychiatry 50:772-81. 2011
    ..To evaluate the clinical and prognostic significance of suicide attempts (SAs) and nonsuicidal self-injury (NSSI) in adolescents with treatment-resistant depression...
  18. pmc Treatment of selective serotonin reuptake inhibitor-resistant depression in adolescents: predictors and moderators of treatment response
    Joan Rosenbaum Asarnow
    Department of Psychiatry, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    J Am Acad Child Adolesc Psychiatry 48:330-9. 2009
    ..This study examines predictors and moderators of treatment response, with the goal of informing efforts to match youths to optimal treatment strategies...
  19. ncbi request reprint Atomoxetine alone or combined with fluoxetine for treating ADHD with comorbid depressive or anxiety symptoms
    Christopher J Kratochvil
    Department of Psychiatry, Nebraska Medical Center, Omaha 68198 5581, USA
    J Am Acad Child Adolesc Psychiatry 44:915-24. 2005
    ..The authors assessed the safety and effectiveness of atomoxetine monotherapy compared with combined atomoxetine/fluoxetine therapy in a population of children and adolescents with ADHD and concurrent symptoms of depression or anxiety...
  20. ncbi request reprint Bipolar disorder in children and adolescents
    Dwight V Wolf
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas 77555 0188, USA
    CNS Spectr 8:954-9. 2003
    ..This review will provide an overview of the literature of bipolar disorder in children and adolescents, including discussion of the prevalence, diagnosis, epidemiology, course of the illness, and treatment issues...
  21. ncbi request reprint Bipolar disorder in adolescence
    Melissa DeFilippis
    Department of Child and Adolescent Psychiatry, The University of Texas Medical Branch, USA
    Adolesc Med State Art Rev 24:433-45, ix. 2013
    ..This article reviews the prevalence, diagnosis, course, and treatment of bipolar disorder in children and adolescents and provides physicians with information that will aid in diagnosis and treatment...
  22. pmc A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents
    Barbara Geller
    Department of Psychiatry, Washington University in St Louis, 660 S Euclid, St Louis, MO 63110, USA
    Arch Gen Psychiatry 69:515-28. 2012
    ..There was a paucity of comparative pharmacological research for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents...
  23. ncbi request reprint Pharmacological management of treatment-resistant pediatric depression
    Christopher J Kratochvil
    Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68195 5581, USA
    J Am Acad Child Adolesc Psychiatry 44:198-200. 2005
  24. ncbi request reprint Sertraline in children and adolescents with major depressive disorder
    Craig L Donnelly
    Department of Psychiatry, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Am Acad Child Adolesc Psychiatry 45:1162-70. 2006
    ....
  25. doi request reprint Long-term treatment of bipolar disorder in children
    Karen Dineen Wagner
    Department of Psychiatry, University of Texas Medical Branch, Galveston, USA
    J Clin Psychiatry 71:e23. 2010
    ....
  26. ncbi request reprint Treatment guidelines for children and adolescents with bipolar disorder
    Robert A Kowatch
    Department of Psychiatry, Cincinnati Children s Hospital Medical, OH 45267 0559, USA
    J Am Acad Child Adolesc Psychiatry 44:213-35. 2005
    ..These guidelines are subject to change as our evidence base increases and practice patterns evolve...
  27. ncbi request reprint Remission status after long-term sertraline treatment of pediatric obsessive-compulsive disorder
    Karen Dineen Wagner
    Division of Child and Adolescent Psychiatry, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Child Adolesc Psychopharmacol 13:S53-60. 2003
    ..The goal of the current analysis is to evaluate remission among children and adolescents with OCD treated with sertraline for 12 months...
  28. doi request reprint Bipolar depression in children and adolescents
    Melissa S Defilippis
    1 Department of Child and Adolescent Psychiatry, The University of Texas Medical Branch, Galveston, Texas, USA
    CNS Spectr 18:209-13. 2013
    ..This article reviews the prevalence, diagnosis, course, and treatment of bipolar depression in youth, and emphasizes the need for large, controlled treatment studies in the pediatric population. ..
  29. ncbi request reprint Defining the clinical course of bipolar disorder: response, remission, relapse, recurrence, and roughening
    Robert Ma Hirschfeld
    Psychiatry and Behavioral Sciences, The University of Texas Medical Branch, Galveston, TX, USA
    Psychopharmacol Bull 40:7-14. 2007
    ..This manuscript presents working definitions for key clinical course indicators for bipolar disorder, including response, remission, relapse, recurrence, and roughening...
  30. ncbi request reprint Fluoxetine for acute treatment of depression in children and adolescents: a placebo-controlled, randomized clinical trial
    Graham J Emslie
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, USA
    J Am Acad Child Adolesc Psychiatry 41:1205-15. 2002
    ..This report presents results from the acute treatment phase of a clinical trial designed to confirm efficacy of a fixed dose of 20 mg of fluoxetine in children and adolescents with major depressive disorder (MDD)...
  31. ncbi request reprint Attributional style and depression in pregnant teenagers
    K D Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch at Galveston, 77555 0425, USA
    Am J Psychiatry 155:1227-33. 1998
    ..Study 2 replicated unexpected findings from study 1. Study 3 evaluated whether pregnant teenagers with a pessimistic attributional style will be more depressed after childbirth than optimistic pregnant teenagers...
  32. ncbi request reprint Management of treatment refractory attention-deficit/hyperactivity disorder in children and adolescents
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0188, USA
    Psychopharmacol Bull 36:130-42. 2002
    ..In this article, data on medications for treatment refractory ADHD in children and adolescents are presented and treatment strategies are discussed...
  33. doi request reprint Teaching psychopharmacology: what works and what doesn't
    Sidney Zisook
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
    J Clin Psychopharmacol 28:96-100. 2008
    ....
  34. ncbi request reprint The psychopharmacologic armanmentarium in the pediatric population
    Karen Dineen Wagner
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, USA
    CNS Spectr 8:252. 2003
  35. ncbi request reprint Childhood depression: pharmacological therapy/treatment (pharmacotherapy of childhood depression)
    K D Wagner
    University of Texas Medical Branch, USA
    J Clin Child Psychol 30:88-97. 2001
    ..Study modifications are suggested which could improve some of the methodological limitations apparent in previous clinical drug trials...
  36. ncbi request reprint Generalized anxiety disorder in children and adolescents
    K D Wagner
    Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, Texas, USA
    Psychiatr Clin North Am 24:139-53. 2001
    ..Adequately powered, controlled, pharmacologic treatment trials are necessary. Future research should be directed toward comparing the relative efficacy of psychotherapy, pharmacotherapy, and both in the treatment of GAD in youth...
  37. ncbi request reprint Use of health care services among persons who screen positive for bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, California 90095, USA
    Psychiatr Serv 56:1529-33. 2005
    ..This study examined patterns of diagnosis, consultation, and treatment of persons who screened positive for bipolar disorder...
  38. ncbi request reprint Impact of comorbidity on treatment response to paroxetine in pediatric obsessive-compulsive disorder: is the use of exclusion criteria empirically supported in randomized clinical trials?
    Daniel A Geller
    Obsessive Compulsive Disorder Program, Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Child Adolesc Psychopharmacol 13:S19-29. 2003
    ..To examine the influence of psychiatric comorbidity on response and relapse rates in children and adolescents treated with paroxetine for obsessive-compulsive disorder (OCD)...
  39. pmc Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial
    David Brent
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    JAMA 299:901-13. 2008
    ..There are no data to guide clinicians on subsequent treatment strategy...
  40. ncbi request reprint Major depressive disorder in children and adolescents: clinical trial design and antidepressant efficacy
    Graham J Emslie
    Child and Adolescent Psychiatry Division, University of Texas Southwestern Medical Center at Dallas, Dallas, USA
    J Clin Psychiatry 66:14-20. 2005
    ....
  41. ncbi request reprint Long-term sertraline treatment of children and adolescents with major depressive disorder
    Moira Rynn
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Child Adolesc Psychopharmacol 16:103-16. 2006
    ....
  42. ncbi request reprint Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trial
    Daniel A Geller
    Harvard Medical School, Boston, MA 02114, USA
    J Am Acad Child Adolesc Psychiatry 43:1387-96. 2004
    ..To assess the efficacy and safety of paroxetine for the treatment of pediatric obsessive-compulsive disorder...
  43. ncbi request reprint Fluoxetine treatment for prevention of relapse of depression in children and adolescents: a double-blind, placebo-controlled study
    Graham J Emslie
    University of Texas Southwestern Medical Center at Dallas, Texas, USA
    J Am Acad Child Adolesc Psychiatry 43:1397-405. 2004
    ....
  44. ncbi request reprint Fluoxetine 40-60 mg versus fluoxetine 20 mg in the treatment of children and adolescents with a less-than-complete response to nine-week treatment with fluoxetine 10-20 mg: a pilot study
    John H Heiligenstein
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Child Adolesc Psychopharmacol 16:207-17. 2006
    ....
  45. ncbi request reprint Paroxetine treatment in children and adolescents with major depressive disorder: a randomized, multicenter, double-blind, placebo-controlled trial
    Graham J Emslie
    University of Texas Southwestern Medical Center at Dallas, 75390 8589, USA
    J Am Acad Child Adolesc Psychiatry 45:709-19. 2006
    ..To assess the efficacy and tolerability of paroxetine in pediatric major depressive disorder...
  46. ncbi request reprint Analysis of electrocardiographic data following use of paroxetine in pediatric depression and obsessive-compulsive disorder
    Stan Krulewicz
    GlaxoSmithKline Pharmaceuticals, King of Prussia, PA 19406 2772, USA
    J Am Acad Child Adolesc Psychiatry 45:422-30. 2006
    ..Data were collected from three 8- to 10-week, randomized, placebo-controlled, double-blind trials of paroxetine in pediatric patients with major depressive disorder or obsessive-compulsive disorder...
  47. ncbi request reprint Child and adolescent psychopharmacology in the new millennium: a workshop for academia, industry, and government
    Joseph DeVeaugh-Geiss
    Duke Clinical Research Institute, Durham, NC 27715, USA
    J Am Acad Child Adolesc Psychiatry 45:261-70. 2006
    ..To give academic researchers, government officials, and industry scientists an opportunity to assess the state of pediatric psychopharmacology and identify challenges facing professionals in the field...

Research Grants3

  1. TREATMENT OF SSRI RESISTANT DEPRESSION IN ADOLESCENTS
    Karen Wagner; Fiscal Year: 2006
    ..This site is based in Pittsburgh, which also serves as the Data Coordinating Center for the study ..
  2. Treatment of Early Age Mania
    Karen Wagner; Fiscal Year: 2007
    ..The chief study statistician, Dr. Satish lyengar is subcontracted to the coordinating site at Washington U in St. Louis and Dr. Philip Lavori is a major consultant for statistical analyses. ..