John E Wagner

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome
    Michael B Tomblyn
    Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 27:3634-41. 2009
  2. ncbi request reprint Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia
    John E Wagner
    Division of Pediatric Hematology, Oncology, and Blood Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA
    Blood 103:3226-9. 2004
  3. pmc Should double cord blood transplants be the preferred choice when a sibling donor is unavailable?
    John E Wagner
    University of Minnesota, Minneapolis, MN 55455, USA
    Best Pract Res Clin Haematol 22:551-5. 2009
  4. pmc Bone marrow transplantation for recessive dystrophic epidermolysis bullosa
    John E Wagner
    Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    N Engl J Med 363:629-39. 2010
  5. ncbi request reprint Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II-III trial
    John E Wagner
    University of Minnesota Blood and Marrow Transplantation Program, Minneapolis, MN 55455, USA
    Lancet 366:733-41. 2005
  6. doi request reprint Umbilical cord blood transplantation: the first 20 years
    John E Wagner
    Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Semin Hematol 47:3-12. 2010
  7. pmc Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia
    John E Wagner
    Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA
    Blood 109:2256-62. 2007
  8. ncbi request reprint Successful engraftment without radiation after fludarabine-based regimen in Fanconi anemia patients undergoing genotypically identical donor hematopoietic cell transplantation
    Poh Lin Tan
    Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 46:630-6. 2006
  9. doi request reprint Does the hematopoietic cell transplantation specific comorbidity index predict transplant outcomes? A validation study in a large cohort of umbilical cord blood and matched related donor transplants
    Navneet S Majhail
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:985-92. 2008
  10. doi request reprint Costs of pediatric allogeneic hematopoietic-cell transplantation
    Navneet S Majhail
    Adult Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Pediatr Blood Cancer 54:138-43. 2010

Detail Information

Publications102 found, 100 shown here

  1. pmc Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome
    Michael B Tomblyn
    Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 27:3634-41. 2009
    ..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care...
  2. ncbi request reprint Germline mutations in BRCA2: shared genetic susceptibility to breast cancer, early onset leukemia, and Fanconi anemia
    John E Wagner
    Division of Pediatric Hematology, Oncology, and Blood Marrow Transplantation, University of Minnesota Medical School, Minneapolis, MN, USA
    Blood 103:3226-9. 2004
    ..Our results suggest that BRCA2 testing should be considered in all patients with FA in whom the complementation group cannot be defined or in whom leukemia is diagnosed at or before 5 years of age...
  3. pmc Should double cord blood transplants be the preferred choice when a sibling donor is unavailable?
    John E Wagner
    University of Minnesota, Minneapolis, MN 55455, USA
    Best Pract Res Clin Haematol 22:551-5. 2009
    ....
  4. pmc Bone marrow transplantation for recessive dystrophic epidermolysis bullosa
    John E Wagner
    Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    N Engl J Med 363:629-39. 2010
    ....
  5. ncbi request reprint Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II-III trial
    John E Wagner
    University of Minnesota Blood and Marrow Transplantation Program, Minneapolis, MN 55455, USA
    Lancet 366:733-41. 2005
    ..A multi-centre, randomised trial was undertaken to determine the effects of ex-vivo T-cell depletion versus methotrexate and cyclosporine immunosuppression on 3-year disease-free survival...
  6. doi request reprint Umbilical cord blood transplantation: the first 20 years
    John E Wagner
    Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Semin Hematol 47:3-12. 2010
    ..This chapter briefly summarizes the highpoints of the history of UCBT with speculations as to what the next generation of research promises to discover...
  7. pmc Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia
    John E Wagner
    Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA
    Blood 109:2256-62. 2007
    ....
  8. ncbi request reprint Successful engraftment without radiation after fludarabine-based regimen in Fanconi anemia patients undergoing genotypically identical donor hematopoietic cell transplantation
    Poh Lin Tan
    Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 46:630-6. 2006
    ..GVHD prophylaxis consisted of cyclosporine and short course methylprednisolone...
  9. doi request reprint Does the hematopoietic cell transplantation specific comorbidity index predict transplant outcomes? A validation study in a large cohort of umbilical cord blood and matched related donor transplants
    Navneet S Majhail
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:985-92. 2008
    ..The HCT-CI, although a useful tool for capturing pretransplant comorbidity and risk-assessment, needs to be further validated prior to adopting it for routine clinical use...
  10. doi request reprint Costs of pediatric allogeneic hematopoietic-cell transplantation
    Navneet S Majhail
    Adult Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Pediatr Blood Cancer 54:138-43. 2010
    ..Allogeneic hematopoietic-cell transplantation (HCT), although curative for some high-risk diseases, is a complex and costly procedure. The costs of transplantation among children have not been described previously...
  11. pmc 4-1BB and CD28 signaling plays a synergistic role in redirecting umbilical cord blood T cells against B-cell malignancies
    Syam Tammana
    Graduate Program in Microbial Engineering, University of Minnesota, Minneapolis, MN 55455, USA
    Hum Gene Ther 21:75-86. 2010
    ..Our data suggest a synergistic role of 4-1BB and CD28 costimulation in engineering antileukemia UCB effector cells and implicate a design for redirected UCB T-cell therapy for refractory leukemia...
  12. doi request reprint Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system
    Paul D Harker-Murray
    Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 14:685-92. 2008
    ..These data support the use of allogeneic HCT in the treatment of children with poor prognosis isolated CNS relapse...
  13. pmc Umbilical cord blood transplantation after nonmyeloablative conditioning: impact on transplantation outcomes in 110 adults with hematologic disease
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis MN, USA
    Blood 110:3064-70. 2007
    ..01) and use of 2 UCB units (P = .07). These findings support the use of UCB after a nonmyeloablative conditioning as a strategy for extending the availability of transplantation therapy, particularly for older patients...
  14. pmc Unrelated cord blood transplantation in adult and pediatric acute lymphoblastic leukemia: effect of minimal residual disease on relapse and survival
    Veronika Bachanova
    Blood and Marrow Transplant Program, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:963-8. 2012
    ..05; disease-free survival, 55%; 95% CI, 43%-66%; P = .02). Our data suggest that in patients with ALL, achieving an MRD-negative state before UCBT improves outcomes...
  15. ncbi request reprint Reduced intensity compared with high dose conditioning for allotransplantation in acute myeloid leukemia and myelodysplastic syndrome: a comparative clinical analysis
    Catherine M Flynn
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Am J Hematol 82:867-72. 2007
    ..Advances in GVHD management and new approaches for relapsed or refractory disease are necessary to improve these outcomes...
  16. pmc Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors
    Margaret L Macmillan
    Blood and Marrow Transplant Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 113:2410-5. 2009
    ..This study is registered at (http://www.clinicaltrials.gov) under the identifiers NCT00305682 and NCT00309842...
  17. ncbi request reprint Chronic graft-versus-host disease (cGVHD) following unrelated donor hematopoietic stem cell transplantation (HSCT): higher response rate in recipients of unrelated donor (URD) umbilical cord blood (UCB)
    Mukta Arora
    Blood and Marrow Transplant Program, Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 13:1145-52. 2007
    ..In addition, progressive onset of cGVHD was a significant predictor of increased mortality in URD cohort. These data suggest that cGVHD following UCB transplant may be more responsive to therapy and also lead to a lower NRM...
  18. doi request reprint Promising progression-free survival for patients low and intermediate grade lymphoid malignancies after nonmyeloablative umbilical cord blood transplantation
    Claudio G Brunstein
    University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 15:214-22. 2009
    ..Based on our data, we conclude that a nonmyeloablative conditioning regimen followed by UCB transplantation is an effective treatment for patients with advanced lymphoid malignancies who lack a suitable sibling donor...
  19. pmc Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:5628-34. 2009
    ..8; 95% CI, 1.0-3.1; P = .05). Our results do not support the selection of UCB units based on KIR-L status and suggest that KIR-L mismatching should be avoided in reduced intensity UCB transplantation...
  20. ncbi request reprint Higher risk of cytomegalovirus and aspergillus infections in recipients of T cell-depleted unrelated bone marrow: analysis of infectious complications in patients treated with T cell depletion versus immunosuppressive therapy to prevent graft-versus-host
    Jo Anne H van Burik
    Department of Pediatrics and Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 13:1487-98. 2007
    ..41; 95% confidence interval = 1.03-1.91). Strategies to speed immune recovery, even in the absence of GVHD, are needed to overcome the risk of infection after unrelated donor transplantation...
  21. pmc Reduced-intensity allogeneic transplant in patients older than 55 years: unrelated umbilical cord blood is safe and effective for patients without a matched related donor
    Navneet S Majhail
    Blood and Marrow Transplant Program, Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 14:282-9. 2008
    ..A careful review of existing comorbidities is necessary when considering older patients for HCT...
  22. doi request reprint Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemia
    Theodore Honebrink
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:930-6. 2012
    ..01). This study shows that BM hematogone percentages may be useful prognostic indicators in patients with acute myeloid leukemia after umbilical cord blood transplantation and should be routinely reported in BM differential counts...
  23. doi request reprint Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donors
    Angela R Smith
    Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 15:1086-93. 2009
    ....
  24. ncbi request reprint Rapid and complete donor chimerism in adult recipients of unrelated donor umbilical cord blood transplantation after reduced-intensity conditioning
    Juliet N Barker
    Divisions of Medical and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN, USA
    Blood 102:1915-9. 2003
    ..These data demonstrate that 0-2 antigen mismatched UCB is sufficient to engraft most adults after reduced-intensity conditioning and is associated with a low incidence of severe acute GVHD...
  25. pmc Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
    Blood 117:1061-70. 2011
    ..These results set the stage for a definitive study of UCB Treg to determine its potency in preventing allogeneic aGVHD. This study is registered at http://www.clinicaltrials.gov as NCT00602693...
  26. doi request reprint Allogeneic hematopoietic stem cell transplantation in adult acute lymphocytic leukemia: impact of donor source on survival
    Priya Kumar
    Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 14:1394-400. 2008
    ..4, 95% CI, 0.2-0.6, P < .01). When compared with URD:M, OS with UCB was better (RR 0.3, 95% CI, 0.1-0.7, P = .01), supporting the use of UCB as an alternative stem cell source for adults with ALL...
  27. ncbi request reprint Response of 443 patients to steroids as primary therapy for acute graft-versus-host disease: comparison of grading systems
    Margaret L Macmillan
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Biol Blood Marrow Transplant 8:387-94. 2002
    ..More effective prophylaxis and therapy for acute GVHD is needed for mismatched unrelated donor recipients and for those with severe GVHD...
  28. doi request reprint Monitoring and preemptive rituximab therapy for Epstein-Barr virus reactivation after antithymocyte globulin containing nonmyeloablative conditioning for umbilical cord blood transplantation
    Anne H Blaes
    University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 16:287-91. 2010
    ....
  29. pmc Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood
    Claudio G Brunstein
    University of Minnesota Medical Center, Minneapolis, MN, USA
    Blood 116:4693-9. 2010
    ..For patients without an available HLA matched donor, the use of 2 partially HLA-matched UCB units is a suitable alternative...
  30. ncbi request reprint Comparable results of umbilical cord blood and HLA-matched sibling donor hematopoietic stem cell transplantation after reduced-intensity preparative regimen for advanced Hodgkin lymphoma
    Navneet S Majhail
    Blood and Marrow Transplant Program, Division of Medical and Pediatric Hematology, University of Minnesota, Minneapolis, 55455, USA
    Blood 107:3804-7. 2006
    ..67). Our results suggest comparable outcomes for reduced-intensity allo-SCT using UCB or MSD in adults at high risk with advanced Hodgkin lymphoma...
  31. pmc Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units
    Michael R Verneris
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 114:4293-9. 2009
    ..This trial was registered at http://clinicaltrials.gov as NCT00309842...
  32. pmc Allogeneic hematopoietic cell transplantation in first remission abrogates poor outcomes associated with high-risk pediatric acute myeloid leukemia
    Michael J Burke
    Division of Pediatric Hematology Oncology, University of Minnesota Amplatz Children s Hospital, Minneapolis, MN, USA
    Biol Blood Marrow Transplant 19:1021-5. 2013
    ..62), relapse (11% versus 7%, P = .71), or treatment-related mortality (17% versus 14%, P = .89). Children and young adults with HR-AML have comparable outcomes to standard-risk patients following allo-HCT in CR1...
  33. pmc Reduced-intensity conditioning transplantation in acute leukemia: the effect of source of unrelated donor stem cells on outcomes
    Claudio G Brunstein
    University of Minnesota, Minneapolis, MN 55455, USA
    Blood 119:5591-8. 2012
    ....
  34. ncbi request reprint Serious infections after unrelated donor transplantation in 136 children: impact of stem cell source
    Juliet N Barker
    Division of Medical Hematology, Oncology, and Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 11:362-70. 2005
    ..These data suggest that the risk of serious infection after pediatric UCB transplantation is comparable to that with unmanipulated BM...
  35. pmc Early lymphocyte recovery and outcomes after umbilical cord blood transplantation (UCBT) for hematologic malignancies
    Michael J Burke
    Division of Hematology Oncology and Blood and Marrow Transplantation in the Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:831-40. 2011
    ..58; 95% CI: 1.01-2.49) compared to ≤200 × 10(6)/L (n = 55). There was no significant relationship between ALC and relapse. Rapid lymphocyte recovery early after UCBT predicts better survival in patients with hematologic malignancies...
  36. pmc Human parainfluenza virus infection after hematopoietic stem cell transplantation: risk factors, management, mortality, and changes over time
    Celalettin Ustun
    Division of Hematology Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 18:1580-8. 2012
    ..HPIV incidence remains low, but may have delayed onset associated with RIC regimens and improving survival. Effective prophylaxis and treatment for HPIV are needed...
  37. doi request reprint Effect of conditioning regimen intensity on acute myeloid leukemia outcomes after umbilical cord blood transplantation
    Betul Oran
    Department of Medicine, University of Minnesota Blood and Marrow Transplantation Program, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 17:1327-34. 2011
    ..UCB with RIC extends the use of allogeneic HCT for older and frail patients without excessive TRM with greater benefit for patients in CR1 and CR2 with longer CR1...
  38. doi request reprint Induced pluripotent stem cells from individuals with recessive dystrophic epidermolysis bullosa
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Invest Dermatol 131:848-56. 2011
    ..These data identify the potential of RDEB iPS cells to generate autologous hematopoietic grafts and skin cells with the inherent capacity to treat skin and mucosal erosions that typify this genodermatosis...
  39. pmc Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation
    Jill C Beck
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 16:215-22. 2010
    ..01) and lower OS (P=.02). Thus, although recipient CMV serostatus and CMV reactivation have little demonstrable impact on UCB transplant outcomes, the development of CMV disease remains a risk, associated with inferior outcomes...
  40. pmc Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation
    Claudio G Brunstein
    Blood and Marrow Transplant Program, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Blood 108:2874-80. 2006
    ..Use of ATG in recipients of an NMA preparative regimen warrants close monitoring for evidence of EBV reactivation and potentially preemptive therapy with rituximab...
  41. pmc Survival differences between adolescents/young adults and children with B precursor acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation
    Michael J Burke
    Division of Pediatric Hematology Oncology, University of Minnesota, Amplatz Children s Hospital, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 19:138-42. 2013
    ..Further improvements in peritransplantation care are needed to limit complications in AYA patients...
  42. pmc Anti-HLA antibodies in double umbilical cord blood transplantation
    Claudio G Brunstein
    Blood and Marrow Transplantation Program, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:1704-8. 2011
    ..Further studies are needed to fully understand the value of anti-HLA antibody testing in dUCB graft selection and its impact on transplantation outcomes...
  43. ncbi request reprint Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy
    Juliet N Barker
    Blood and Marrow Transplant Program, Division of Medical and Pediatric Oncology, University of Minnesota, Box 480, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Blood 105:1343-7. 2005
    ..Therefore, transplantation of 2 partially HLA-matched UCB units is safe, and may overcome the cell-dose barrier that limits the use of UCB in many adults and adolescents...
  44. pmc Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone
    Jeffrey S Miller
    Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 110:2761-3. 2007
    ..This trial was registered at www.clinicaltrials.gov as no. NCT00303693 and www.cancer.gov/clinicaltrials as no. NCT00167180...
  45. ncbi request reprint Searching for unrelated donor hematopoietic stem cells: availability and speed of umbilical cord blood versus bone marrow
    Juliet N Barker
    Department of Medicine, University of Minnesota School of Medicine, Minneapolis, USA
    Biol Blood Marrow Transplant 8:257-60. 2002
    ..These unique features of UCB transplantation must be considered in comparisons of the outcomes of UCB versus BM transplant recipients and in the design of prospective trials comparing URD sources...
  46. pmc Activated notch supports development of cytokine producing NK cells which are hyporesponsive and fail to acquire NK cell effector functions
    Veronika Bachanova
    Division of Adult and Pediatric Hematology, Oncology, and Transplantation, University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 15:183-94. 2009
    ..However, these NK cells are immature in their cytokine production profile, are hyporesponsive, and poorly acquire NK cell receptors involved in self-tolerance and effector function...
  47. doi request reprint Haematopoeitic cell transplantation for Fanconi anaemia - when and how?
    Margaret L Macmillan
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, 55455, USA
    Br J Haematol 149:14-21. 2010
    ..This paper will review the unique challenges of HCT in FA patients, with particular emphasis on the timing and approach to HCT...
  48. pmc Early hematopoietic stem cell transplant is associated with favorable outcomes in children with MDS
    Angela R Smith
    Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 60:705-10. 2013
    ..Although hematopoietic stem cell transplantation (HSCT) is the treatment of choice for childhood myelodysplastic syndrome (MDS), there is no consensus regarding patient or disease characteristics that predict outcomes...
  49. pmc Umbilical cord blood T cells express multiple natural cytotoxicity receptors after IL-15 stimulation, but only NKp30 is functional
    Qin Tang
    Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 181:4507-15. 2008
    ..These results demonstrate differences between UCB and PB T cells regarding NCR expression and function. Such findings challenge the concept that NCRs are NK cell specific...
  50. ncbi request reprint Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptor
    Stella M Davies
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA
    Blood 100:3825-7. 2002
    ..It is possible that there will be a benefit of NK cell alloreactivity if strategies of haploidentical transplantation are used: high stem cell doses, extensive T-cell depletion, and no postgrafting immune suppression...
  51. ncbi request reprint The Minnesota Molecular and Cellular Therapeutics Facility: a state-of-the-art biotherapeutics engineering laboratory
    David H McKenna
    Division of Minnesota Molecular and Cellular Therapeutics Facility, University of Minnesota, Saint Paul, MN 55108, USA
    Transfus Med Rev 19:217-28. 2005
    ..Here we provide an overview of the Minnesota Molecular and Cellular Therapeutics (MMCT) Facility, detailing our approach to the manufacture of novel therapeutics and highlighting current and future activities...
  52. ncbi request reprint Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood?
    Satkiran S Grewal
    University of Minnesota, 420 Delaware St SE, MMC 477, Minneapolis, MN 55455, USA
    Blood 101:4233-44. 2003
  53. pmc Alternative haematopoietic stem cell sources for transplantation: place of umbilical cord blood
    Angela R Smith
    Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, MMC 484, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Br J Haematol 147:246-61. 2009
    ..This article reviews the most recent literature comparing the outcomes after umbilical cord blood transplantation with other alternative stem cell sources...
  54. pmc Mouse fetal and embryonic liver cells differentiate human umbilical cord blood progenitors into CD56-negative natural killer cell precursors in the absence of interleukin-15
    Valarie McCullar
    Division of Medical, University of Minnesota Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Exp Hematol 36:598-608. 2008
    ..Human natural killer (NK) cell maturation involves the orderly acquisition of NK cell receptors. Our aim was to understand how stromal interactions and cytokines are important in this developmental process...
  55. pmc Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome)
    Jakub Tolar
    Division of Hematology Oncology, Blood and Marrow Transplantation, Department of Pediatrics, University of MN, Minneapolis, MN, USA
    Blood 117:839-47. 2011
    ....
  56. ncbi request reprint Successful hematopoietic stem cell transplantation for Fanconi anemia from an unaffected HLA-genotype-identical sibling selected using preimplantation genetic diagnosis
    Satkiran S Grewal
    Department of Blood and Marrow Transplantation and the Center for Bioethics, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 103:1147-51. 2004
    ..The medical, legal, and ethical issues involved with this approach are discussed...
  57. ncbi request reprint Suppressor function of umbilical cord blood-derived CD4+CD25+ T-regulatory cells exposed to graft-versus-host disease drugs
    Stephen B Porter
    University of Minnesota Cancer Center and the Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 82:23-9. 2006
    ..This study examines the effects of the most commonly used graft-versus-host disease (GVHD) prophylactic drugs on inducing apoptosis and suppressor cell function of human umbilical cord blood (UCB) CD4+25+ Treg and CD4+25- cells...
  58. doi request reprint Diagnosis of myelodysplastic syndrome among a cohort of 119 patients with fanconi anemia: morphologic and cytogenetic characteristics
    Adina M Cioc
    Department of Laboratory Medicine and Pathology, University of Minnesota Masonic Cancer Center, University of Minnesota Medical School, Minneapolis 55455, USA
    Am J Clin Pathol 133:92-100. 2010
    ..The data provide a rationale for integrating cytogenetic findings with independently evaluated morphologic findings for monitoring bone marrow status in FA...
  59. ncbi request reprint Good manufacturing practices production of natural killer cells for immunotherapy: a six-year single-institution experience
    David H McKenna
    Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, University of Minnesota Medical School, Minnesota 55108, USA
    Transfusion 47:520-8. 2007
    ..Herein is a report on the experience of clinical-scale, good manufacturing practices (GMPs) production of NK cells to treat advanced cancer...
  60. pmc Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells
    Keli L Hippen
    University of Minnesota Cancer Center and Department of Pediatrics, Division of Bone, Blood and Marrow Transplantation, Minneapolis, USA
    Blood 112:2847-57. 2008
    ..These data offer a novel approach for UCB Treg expansion using aAPCs, including those coexpressing OX40L or 4-1BBL...
  61. doi request reprint Successful "in-flight" activation of natural killer cells during long-distance shipping
    Scott A Koepsell
    Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, University of Minnesota Medical School, St Paul, USA
    Transfusion 53:398-403. 2013
    ..Here we describe the qualification of in transit activation of an NK-cell therapy product in preparation for a Phase I clinical trial at a distant medical center...
  62. ncbi request reprint Using preimplantation genetic diagnosis to create a stem cell donor: issues, guidelines & limits
    Susan M Wolf
    University of Minnesota Law School, Minneapolis, Minnesota, USA
    J Law Med Ethics 31:327-39. 2003
  63. ncbi request reprint Expanding the role of umbilical cord blood transplantation
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
    Br J Haematol 137:20-35. 2007
    ..This article reviews the state of the art and future directions with umbilical cord blood as a source of haematopoietic stem cells for transplantation in both children and adults...
  64. pmc Massive ex vivo expansion of human natural regulatory T cells (T(regs)) with minimal loss of in vivo functional activity
    Keli L Hippen
    Division of Bone Marrow Transplantation, Department of Pediatrics, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Sci Transl Med 3:83ra41. 2011
    ..The capability to efficiently produce donor cell banks of functional nT(regs) could transform the treatment of GVHD and autoimmunity by providing an off-the-shelf, cost-effective, and proven cellular therapy...
  65. doi request reprint Concise review: Transplantation of human hematopoietic cells for extracellular matrix protein deficiency in epidermolysis bullosa
    Jakub Tolar
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Stem Cells 29:900-6. 2011
    ..Further modifications in the use of stem cell transplantation as a durable source of extracellular matrix proteins may make this regenerative medicine approach effective in other cutaneous and extracutaneous conditions...
  66. ncbi request reprint Hematopoietic cell transplantation for congenital bone marrow failure
    Margaret L Macmillan
    Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Curr Opin Oncol 17:106-13. 2005
    ..This review focuses on the outcome after allogeneic hematopoietic cell transplantation for the treatment of these disorders, with particular emphasis on recent discoveries and the challenges...
  67. pmc Amelioration of epidermolysis bullosa by transfer of wild-type bone marrow cells
    Jakub Tolar
    Blood and Marrow Transplantation Program, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:1167-74. 2009
    ....
  68. pmc Reduced-intensity conditioning regimens for allogeneic transplantation in children with acute lymphoblastic leukemia
    Michael R Verneris
    University of Minnesota Medical Center, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 16:1237-44. 2010
    ..These data indicate long-term DFS can be achieved using reduced-intensity conditioning regimens in children with acute lymphoblastic leukemia. Given the relatively small cohort, these findings must be validated in a larger population...
  69. ncbi request reprint Umbilical cord blood transplantation for myeloid malignancies
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    Curr Opin Hematol 14:162-9. 2007
    ..To review the available data on the outcomes of pediatric and adult patients with acute myeloid leukemia, myelodysplastic syndrome and chronic myelogenous leukemia after umbilical cord blood transplantation...
  70. ncbi request reprint Cord blood transplantation for adults
    Claudio G Brunstein
    Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA
    Vox Sang 91:195-205. 2006
    ..We review here the current state of the art on cord blood transplantation for adults, and discuss some of the newer strategies being pursued in order to improve its safety and efficacy...
  71. pmc Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation center
    Jeffrey McCullough
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 114:1684-8. 2009
    ..2%) cord blood units sent to us for transplantation were mislabeled and potentially would have been transplanted incorrectly. This error rate of 1 per 249 (0.4%) patients could have potentially devastating consequences...
  72. ncbi request reprint Umbilical cord blood transplantation and banking
    Claudio G Brunstein
    Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Annu Rev Med 57:403-17. 2006
    ..New approaches to enhance hematopoietic recovery by the use of accessory cells or direct intra-bone marrow injection are also reviewed...
  73. ncbi request reprint Umbilical cord blood transplantation: current practice and future innovations
    Juliet N Barker
    Department of Medicine, Blood and Marrow Transplant Program of the University of Minnesota School of Medicine, University of Minnesota, MMC 480 UMHC, 420 Delaware Street, SE, Minneapolis, MN 55455, USA
    Crit Rev Oncol Hematol 48:35-43. 2003
    ..This review outlines the current status of UCBT with emphasis on current and future innovations...
  74. doi request reprint Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies
    Xin Huang
    Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Mol Ther 16:580-9. 2008
    ..Taken together, these data indicate that T cells from PB and UCB can be stably modified using a non-viral DNA transfer system, and that such modified T cells may be useful in the treatment of refractory leukemia and lymphoma...
  75. ncbi request reprint Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer
    Jeffrey S Miller
    Division Medical and Pediatric Hematology Oncology, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 105:3051-7. 2005
    ..These findings suggest that haploidentical NK cells can persist and expand in vivo and may have a role in the treatment of selected malignancies used alone or as an adjunct to HCT...
  76. ncbi request reprint Fatal hemorrhage from androgen-related hepatic adenoma after hematopoietic cell transplantation
    Ashish R Kumar
    Bone Marrow Transplant Program and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    J Pediatr Hematol Oncol 26:16-8. 2004
    ..This case illustrates the need for extra vigilance in the detection and management of hepatic adenomas in patients treated with androgens, especially prior to HCT...
  77. pmc First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantation
    Christopher J Fraser
    Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 106:4377-80. 2005
    ..This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients...
  78. ncbi request reprint Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival
    John E Wagner
    Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
    Blood 100:1611-8. 2002
    ..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less...
  79. ncbi request reprint Effective treatment of alpha-mannosidosis by allogeneic hematopoietic stem cell transplantation
    Satkiran S Grewal
    Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    J Pediatr 144:569-73. 2004
    ..To study the efficacy of hematopoietic stem cell transplantation (HCT) for ameliorating the clinical manifestations of alpha-mannosidosis...
  80. ncbi request reprint Clinical-scale selection of anti-CD3/CD28-activated T cells after transduction with a retroviral vector expressing herpes simplex virus thymidine kinase and truncated nerve growth factor receptor
    Paul J Orchard
    Program in Blood and Marrow Transplantation, Department of Pediatrics, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
    Hum Gene Ther 13:979-88. 2002
    ..3% vs. 23.5%). We conclude that a strategy based on activation of human T cells with anti-CD3/CD28 beads can result in sufficient transduction, expansion, and purification based on NGFR expression for clinical trials...
  81. ncbi request reprint Novel conditioning regimens and nonmyeloablative stem cell transplants
    K Scott Baker
    Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Opin Pediatr 14:17-22. 2002
    ..The potential to use this nonmyeloablative approach in nonmalignant disorders in which regimen-related toxicity must be minimized is of particular interest in children...
  82. ncbi request reprint Umbilical cord blood transplantation: current state of the art
    Juliet N Barker
    Department of Medicine, Blood and Marrow Transplant Program, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Curr Opin Oncol 14:160-4. 2002
    ....
  83. ncbi request reprint Umbilical-cord blood transplantation for the treatment of cancer
    Juliet N Barker
    Department of Medicine, Blood and Marrow Transplant Program of the University of Minnesota School of Medicine, 420 Delaware Street, S E, Minneapolis, Minnesota 55455, USA
    Nat Rev Cancer 3:526-32. 2003
    ..These studies have identified several advantages to umbilical-cord cell transplantation, including a lower incidence of GVHD. Umbilical-cord blood is therefore a promising alternative to bone-marrow-derived stem cells...
  84. ncbi request reprint Early antithymocyte globulin therapy improves survival in patients with steroid-resistant acute graft-versus-host disease
    Margaret L Macmillan
    Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA
    Biol Blood Marrow Transplant 8:40-6. 2002
    ..These data suggest that treatment with ATG can be an active therapy, especially in patients with skin GVHD and early signs of steroid resistance...
  85. ncbi request reprint Recent developments in cell-based immune therapy for neuroblastoma
    Michael R Verneris
    Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Mayo Mail Code 366, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 2:134-9. 2007
    ....
  86. doi request reprint Neoadjuvant chemotherapy with reduced-dose carboplatin and gemcitabine for non-small cell lung cancer in a patient with Fanconi anemia
    Arkadiusz Z Dudek
    Division of Hematology, Oncology, and Transplantation, Department of Medicine, University of Minnesota Medical School, MMC 480, 420 Delaware St S E, Minneapolis, MN 55455, USA
    J Thorac Oncol 3:447-50. 2008
    ....
  87. ncbi request reprint Radiotherapy of CD19 expressing Daudi tumors in nude mice with Yttrium-90-labeled anti-CD19 antibody
    Daniel A Vallera
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Cancer Center, Minneapolis, MN, USA
    Cancer Biother Radiopharm 19:11-23. 2004
    ..Because radiolabeled anti-CD19 antibody can be used to deliver radiation selectively to lymphohematopoietic tissue, these data support the use of 90Y anti-CD19 antibodies in treating B-cell malignancies...
  88. ncbi request reprint Advances in HLA: practical implications for selecting adult donors and cord blood units
    Carolyn Katovich Hurley
    Georgetown University Medical Center, Blood and Marrow Transplant Program of the University of Minnesota, Minneapolis, 55413, USA
    Biol Blood Marrow Transplant 12:28-33. 2006
  89. ncbi request reprint Conception to obtain hematopoietic stem cells
    John A Robertson
    Hastings Cent Rep 32:34-40. 2002
    ..A couple may have a child to provide stem cells for another child. They may also use preimplantation testing--even, troubling though it is, prenatal testing and selective abortion--to ensure a close tissue match...
  90. ncbi request reprint Preimplantation testing to produce an HLA-matched donor infant
    John E Wagner
    JAMA 292:803-4; author reply 804. 2004
  91. ncbi request reprint Higher mortality after allogeneic peripheral-blood transplantation compared with bone marrow in children and adolescents: the Histocompatibility and Alternate Stem Cell Source Working Committee of the International Bone Marrow Transplant Registry
    Mary Eapen
    IBMTR ABMTR Statistical Center, International Bone Marrow Transplant Registry, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    J Clin Oncol 22:4872-80. 2004
    ..Despite lack of data on PBSC transplantation in children, there has been a change in clinical practice, with increasing numbers of children receiving PBSC allografts...
  92. pmc Peripheral blood grafts from unrelated donors are associated with increased acute and chronic graft-versus-host disease without improved survival
    Mary Eapen
    Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Biol Blood Marrow Transplant 13:1461-8. 2007
    ..The higher rate of cGVHD after PBSC transplants and, consequently, more frequent late adverse events warrant extended follow up of PBSC recipients...
  93. ncbi request reprint A scheme for defining cause of death and its application in the T cell depletion trial
    Edward Copelan
    Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Biol Blood Marrow Transplant 13:1469-76. 2007
    ..This algorithm promotes consistent assignment of primary and contributing CODs for patients with leukemia or lymphoma who expire after myeloablative allogeneic HSCT...
  94. ncbi request reprint Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study
    Mary Eapen
    Statistical Center, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI, USA
    Lancet 369:1947-54. 2007
    ....
  95. pmc Antigen-specific T-lymphocyte function after cord blood transplantation
    Geoff Cohen
    The EMMES Corporation, Rockville, Maryland, USA
    Biol Blood Marrow Transplant 12:1335-42. 2006
    ..These results indicate that naive T lymphocytes present in the HSC inoculum can contribute to the generation of antigen-specific T-lymphocyte immunity early after transplantation...
  96. ncbi request reprint Successful immune reconstitution decreases leukemic relapse and improves survival in recipients of unrelated cord blood transplantation
    Robertson Parkman
    Division of Research Immunology Bone Marrow Transplantation, Childrens Hospital Los Angeles, The Saban Research Institute, 4650 Sunset Boulevard, Mail Stop 62, Los Angeles, CA 90027, USA
    Biol Blood Marrow Transplant 12:919-27. 2006
    ..Successful antigen-specific immune reconstitution after unrelated cord blood transplantation results in decreased leukemic relapse and improved overall survival...
  97. ncbi request reprint Results of the cord blood transplantation study (COBLT): outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with lysosomal and peroxisomal storage diseases
    Paul L Martin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    Biol Blood Marrow Transplant 12:184-94. 2006
    ..Cord blood donors are readily available for rapid transplantation. Cord blood transplantation should be considered as frontline therapy for young patients with lysosomal and peroxisomal storage diseases...
  98. ncbi request reprint Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months
    Mary Eapen
    Center for Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Clin Oncol 24:145-51. 2006
    ..To describe outcomes after unrelated donor stem cell transplantation (HCT) in children (< 18 months at diagnosis) with acute leukemia and compare these with outcomes after human leukocyte antigen (HLA)-matched sibling donor HCT...
  99. ncbi request reprint Busulfan/melphalan/antithymocyte globulin followed by unrelated donor cord blood transplantation for treatment of infant leukemia and leukemia in young children: the Cord Blood Transplantation study (COBLT) experience
    Donna A Wall
    Texas Transplant Institute, Southwest Texas Methodist Hospital, San Antonio, Texas 78229, USA
    Biol Blood Marrow Transplant 11:637-46. 2005
    ....
  100. ncbi request reprint Unrelated donor bone marrow transplantation for children with juvenile myelomonocytic leukaemia
    Franklin O Smith
    Division of Hematology Oncology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Br J Haematol 116:716-24. 2002
    ..With lower relapse observed in patients with chronic GVHD, new treatment strategies that focus on enhancing the graft-versus-leukaemia effect may improve survival...
  101. ncbi request reprint Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemia
    Mary J Laughlin
    Case Comprehensive Cancer Center and University Hospitals of Cleveland Ireland Cancer Center, Cleveland, USA
    N Engl J Med 351:2265-75. 2004
    ..Data regarding the outcome of cord-blood transplantation in adults are scant, despite the fact that these grafts are increasingly used in adults...