Amy K Wagner

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Return to productive activity after traumatic brain injury: relationship with measures of disability, handicap, and community integration
    Amy K Wagner
    Charlotte Institute of Rehabilitation, Department of Physical Medicine and Rehabilitation, Charlotte, NC, USA
    Arch Phys Med Rehabil 83:107-14. 2002
  2. ncbi request reprint Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 195:475-83. 2005
  3. ncbi request reprint Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia
    Amy K Wagner
    Department of Physical Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 21:125-36. 2004
  4. ncbi request reprint Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 201 Pittsburgh, PA 15213, USA
    Brain Res 998:113-21. 2004
  5. ncbi request reprint Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, 3471 5th Avenue, Kaufmann Building, Suite 201, University of Pittsburgh, Pittsburgh, PA, USA
    Neurosci Lett 334:165-8. 2002
  6. pmc Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurochem 108:986-97. 2009
  7. pmc Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Suite 202, Pittsburgh, PA 15213, USA
    Epilepsy Res 90:259-72. 2010
  8. pmc Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
    Behav Brain Res 181:200-9. 2007
  9. pmc CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 31:1886-96. 2011
  10. pmc Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Safar Center for Resuscitation Research, Pittsburgh, PA 15227, USA
    Dev Neurosci 32:396-405. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Return to productive activity after traumatic brain injury: relationship with measures of disability, handicap, and community integration
    Amy K Wagner
    Charlotte Institute of Rehabilitation, Department of Physical Medicine and Rehabilitation, Charlotte, NC, USA
    Arch Phys Med Rehabil 83:107-14. 2002
    ....
  2. ncbi request reprint Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 195:475-83. 2005
    ..These findings may have some relevance to treatment paradigms using dopaminergic neurostimulants after TBI...
  3. ncbi request reprint Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia
    Amy K Wagner
    Department of Physical Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 21:125-36. 2004
    ..Gender and age differences in TBI pathophysiology should be considered when conducting clinical trials in TBI...
  4. ncbi request reprint Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 201 Pittsburgh, PA 15213, USA
    Brain Res 998:113-21. 2004
    ..The impact of early neuroprotection on later behavioral outcome and the anatomic structural specificity of hormonal neuroprotection require further study...
  5. ncbi request reprint Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, 3471 5th Avenue, Kaufmann Building, Suite 201, University of Pittsburgh, Pittsburgh, PA, USA
    Neurosci Lett 334:165-8. 2002
    ..EE did not impact motor performance in this setting. These findings have gender specific implications for how to approach and evaluate treatments and interventions after TBI...
  6. pmc Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurochem 108:986-97. 2009
    ..DAT expression and transcriptional changes affecting DA protein function may underlie the injury and MPH-induced alterations in neurotransmission observed...
  7. pmc Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Suite 202, Pittsburgh, PA 15213, USA
    Epilepsy Res 90:259-72. 2010
    ....
  8. pmc Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
    Behav Brain Res 181:200-9. 2007
    ..However there are gender specific drug differences in behavioral performance and sensitivity to treatment with MPH that may have implications for treatment efficacy and dosing clinically after TBI...
  9. pmc CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 31:1886-96. 2011
    ..These results show the prognostic value of Bcl-2 and CytoC profiles and suggest a dynamic apoptotic and pro-survival response to TBI...
  10. pmc Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury
    Rachel Pardes Berger
    Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Safar Center for Resuscitation Research, Pittsburgh, PA 15227, USA
    Dev Neurosci 32:396-405. 2010
    ..These data suggest that trajectory analysis of biomarker data may provide a useful approach for predicting outcome after pediatric brain injury...
  11. ncbi request reprint Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 106:538-47. 2007
    ..The purpose of this study was to determine associations between factors that affect DAT expression and cerebrospinal fluid (CSF) DA and metabolite levels after severe TBI...
  12. doi request reprint Group-based trajectory analysis applications for prognostic biomarker model development in severe TBI: a practical example
    Christian Niyonkuru
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 30:938-45. 2013
    ....
  13. pmc Genetic variability in glutamic acid decarboxylase genes: associations with post-traumatic seizures after severe TBI
    Shaun D Darrah
    University of Pittsburgh, Department of Physical Medicine and Rehabilitation, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
    Epilepsy Res 103:180-94. 2013
    ..Similarly, diplotype analysis showed those with 2 copies of the haplotype containing both risk alleles were at the highest PTS risk. These results implicate genetic variability within the GABA system in modulating the development of PTS...
  14. doi request reprint Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Inj 26:1658-69. 2012
    ..However, this association is reversed in adults with subjective memory complaints and populations vulnerable to memory deficits, a problem common in traumatic brain injury (TBI)...
  15. pmc BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury
    Nicole Zangrilli Hoh
    University of Pittsburgh School of Nursing, Department of Health Promotion and Development, Pittsburgh, Pennsylvania 15261, USA
    J Neurotrauma 27:1413-27. 2010
    ..These data support the possibility that genetic variability for pro-survival proteins, particularly genetic variation in the BCL2 gene, impacts outcomes after severe TBI...
  16. pmc Impact of aromatase genetic variation on hormone levels and global outcome after severe TBI
    Julie A Garringer
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neurotrauma 30:1415-25. 2013
    ..In contrast to clinical serum hormone studies, higher CSF E2/T ratio was associated with better outcome. Further, genetic variation in CYP19A1 influences both hormone dynamics and outcome post-TBI...
  17. pmc S100b as a prognostic biomarker in outcome prediction for patients with severe traumatic brain injury
    Akash Goyal
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 30:946-57. 2013
    ..022) and older subjects (p = 0.004). Multivariate logistic regression confirmed CSF S100b profiles in predicting GOS and DRS and showed mean and peak serum S100b as acute mortality predictors after sTBI...
  18. doi request reprint Variants of SLC6A4 in depression risk following severe TBI
    Michelle D Failla
    Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA
    Brain Inj 27:696-706. 2013
    ..Objective: To assess serotonergic function and genetic risk for PTD development over 1 year following TBI...
  19. pmc The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in rats
    Samuel S Shin
    Brain Trauma Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurotrauma 30:259-70. 2013
    ..Elucidation of these alterations in gene expression within the substantia nigra and VTA provides new insights into chronic changes in dopamine signaling post-TBI, and the potential role of EE in TBI rehabilitation...
  20. pmc Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Behav Brain Res 177:186-94. 2007
    ..One explanation for the lack of an additive effect is that EE is a very effective treatment and thus there is very little room for 8-OH-DPAT to confer additional statistically significant improvement...
  21. doi request reprint Dilantin therapy in an experimental model of traumatic brain injury: effects of limited versus daily treatment on neurological and behavioral recovery
    Shaun D Darrah
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 28:43-55. 2011
    ..These findings support clinical guidelines for limited use of Dilantin in seizure prophylaxis after TBI...
  22. ncbi request reprint Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury
    Amy K Wagner
    Safar Center for Resuscitation Research, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:407-13. 2005
    ..The purpose of this study was to evaluate associations between gender and cerebrospinal fluid glutamate and lactate/pyruvate production and the role of hypothermia with gender in attenuating these markers...
  23. pmc Controlled cortical impact injury influences methylphenidate-induced changes in striatal dopamine neurotransmission
    Amy K Wagner
    Department Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 110:801-10. 2009
    ..The findings further support the concept that daily MPH therapy restores striatal DA neurotransmission after CCI...
  24. ncbi request reprint Cerebrospinal fluid cortisol and progesterone profiles and outcomes prognostication after severe traumatic brain injury
    Martina Santarsieri
    1 University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania
    J Neurotrauma 31:699-712. 2014
    ....
  25. pmc Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis
    James W Bales
    Brain Trauma Research Center, University of Pittsburgh, PA 15260, USA
    Neurosci Biobehav Rev 33:981-1003. 2009
    ....
  26. doi request reprint Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making
    Patrick M Kochanek
    Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Crit Care 14:135-41. 2008
    ..Novel proteomic, multiplex, and lipidomic methods are also being applied...
  27. ncbi request reprint Deficits in novelty exploration after controlled cortical impact
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurotrauma 24:1308-20. 2007
    ..Future work will utilize these tasks to evaluate the neural substrates underlying exploratory deficits after TBI...
  28. ncbi request reprint Synaptosomal dopamine uptake in rat striatum following controlled cortical impact
    Margaret S Wilson
    Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA
    J Neurosci Res 80:85-91. 2005
    ..However, it is unclear whether neurons in the injured striatum can properly regulate the activity of dopamine transporters in vivo...
  29. ncbi request reprint How gender impacts career development and leadership in rehabilitation medicine: a report from the AAPM&R research committee
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Phys Med Rehabil 88:560-8. 2007
    ..To examine the role that gender plays in meeting the medical academic mission by assessing career development, leadership, and research productivity among rehabilitation researchers...
  30. pmc Concussion in sports: postconcussive activity levels, symptoms, and neurocognitive performance
    Cynthia W Majerske
    University of Pittsburgh, Pittsburgh, PA, USA
    J Athl Train 43:265-74. 2008
    ..Evidence suggests that athletes engaging in high-intensity activities after concussion have more difficulties with cognitive recovery...
  31. ncbi request reprint Physical medicine and rehabilitation consultation: relationships with acute functional outcome, length of stay, and discharge planning after traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA
    Am J Phys Med Rehabil 82:526-36. 2003
    ..The purpose of this study was to delineate relationships between physical medicine and rehabilitation consultation in this population and acute functional outcome, length of stay, and discharge planning...
  32. pmc Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitation
    Alexandra N Garcia
    Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA
    PM R 3:S18-27. 2011
    ..Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function...
  33. pmc Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 28:871-88. 2011
    ..These findings represent a paradigm shift when thinking about the role of sex steroids in neuroprotection clinically after TBI...
  34. ncbi request reprint Estrogen and stroke: a review of the current literature
    Erin Carwile
    Nurse Anesthesia Program, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA
    J Neurosci Nurs 41:18-25; quiz 26-7. 2009
    ....
  35. pmc YKL-40 expression in traumatic brain injury: an initial analysis
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 27:1215-23. 2010
    ....
  36. pmc Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury
    Rosanne Salonia
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, USA
    J Neurotrauma 27:1819-25. 2010
    ..This increase in ET-1 may mediate the hypoperfusion or cerebrovascular dysfunction accompanying severe TBI in children. Importantly, hypothermia does not affect the brain's ET-1 response as measured in the CSF...
  37. doi request reprint Mobile phone text messaging to assess symptoms after mild traumatic brain injury and provide self-care support: a pilot study
    Brian Suffoletto
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Head Trauma Rehabil 28:302-12. 2013
    ..Our secondary objective was to determine the feasibility of using text messaging to assess daily symptoms and provide support to patients with mTBI...
  38. pmc Non-spatial pre-training in the water maze as a clinically relevant model for evaluating learning and memory in experimental TBI
    Amy K Wagner
    University of Pittsburgh Department of Physical Medicine and Rehabilitation, 3471 Fifth Ave, Suite 201, Pittsburgh, PA 15213, United States University of Pittsburgh Safar Center for Resuscitation Research, 3434 Fifth Ave, Pittsburgh, PA 15260, United States Electronic address
    Neurobiol Learn Mem 106:71-86. 2013
    ..These findings also support development of non-spatial cognitive training paradigms for evaluating rehabilitation relevant combination therapies. ..
  39. ncbi request reprint Gender, sex steroids, and neuroprotection following traumatic brain injury
    Emily Rogers
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, PA 15213, USA
    J Head Trauma Rehabil 21:279-81. 2006
  40. pmc The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 207:118-27. 2007
    ....
  41. doi request reprint Neuroprotective, neuroplastic, and neurobehavioral effects of daily treatment with levetiracetam in experimental traumatic brain injury
    Huichao Zou
    1Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA
    Neurorehabil Neural Repair 27:878-88. 2013
    ..However, the potential neuroprotective and/or detrimental effects of prophylactic AED treatment on behavioral and cognitive function after TBI are not well studied...
  42. doi request reprint APOE genetic associations with seizure development after severe traumatic brain injury
    Megan A Miller
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Inj 24:1468-77. 2010
    ..The purpose of the current study is to assess the role of the APOE genotype in post-traumatic seizure (PTS) development...
  43. ncbi request reprint Measuring rehabilitation research capacity: report from the AAPM&R Research Advisory Committee
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation AKW, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Phys Med Rehabil 84:955-68. 2005
    ..Observations here provide a platform for future work in understanding the adequacy of the rehabilitation research enterprise, its appropriateness, and ability to meet societal needs for those with disabilities...
  44. ncbi request reprint Peer review: issues in physical medicine and rehabilitation
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation and Safar Center for Resucitation Research University of pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Phys Med Rehabil 82:790-802. 2003
    ..It also provides suggestions for editorial considerations and improvements in the peer-review process for physical medicine and rehabilitation research journals...