Research Topics
Genomes and Genes | Amy K WagnerSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Return to productive activity after traumatic brain injury: relationship with measures of disability, handicap, and community integrationAmy K Wagner
Charlotte Institute of Rehabilitation, Department of Physical Medicine and Rehabilitation, Charlotte, NC, USA
Arch Phys Med Rehabil 83:107-14. 2002....- Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injuryAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
Exp Neurol 195:475-83. 2005..These findings may have some relevance to treatment paradigms using dopaminergic neurostimulants after TBI... - Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermiaAmy K Wagner
Department of Physical Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Neurotrauma 21:125-36. 2004..Gender and age differences in TBI pathophysiology should be considered when conducting clinical trials in TBI... - Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injuryAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 201 Pittsburgh, PA 15213, USA
Brain Res 998:113-21. 2004..The impact of early neuroprotection on later behavioral outcome and the anatomic structural specificity of hormonal neuroprotection require further study... - Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female ratsAmy K Wagner
Department of Physical Medicine and Rehabilitation, 3471 5th Avenue, Kaufmann Building, Suite 201, University of Pittsburgh, Pittsburgh, PA, USA
Neurosci Lett 334:165-8. 2002..EE did not impact motor performance in this setting. These findings have gender specific implications for how to approach and evaluate treatments and interventions after TBI... 
Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injuryAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Neurochem 108:986-97. 2009..DAT expression and transcriptional changes affecting DA protein function may underlie the injury and MPH-induced alterations in neurotransmission observed...- Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBIAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Suite 202, Pittsburgh, PA 15213, USA
Epilepsy Res 90:259-72. 2010.... - Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injuryAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
Behav Brain Res 181:200-9. 2007..However there are gender specific drug differences in behavioral performance and sensitivity to treatment with MPH that may have implications for treatment efficacy and dosing clinically after TBI... - CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBIAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Cereb Blood Flow Metab 31:1886-96. 2011..These results show the prognostic value of Bcl-2 and CytoC profiles and suggest a dynamic apoptotic and pro-survival response to TBI... - Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injuryAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 106:538-47. 2007..The purpose of this study was to determine associations between factors that affect DAT expression and cerebrospinal fluid (CSF) DA and metabolite levels after severe TBI... - Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injuryRachel Pardes Berger
Department of Pediatrics, Children s Hospital of Pittsburgh of UPMC, Safar Center for Resuscitation Research, Pittsburgh, PA 15227, USA
Dev Neurosci 32:396-405. 2010..These data suggest that trajectory analysis of biomarker data may provide a useful approach for predicting outcome after pediatric brain injury... 
Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBIAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brain Inj 26:1658-69. 2012..However, this association is reversed in adults with subjective memory complaints and populations vulnerable to memory deficits, a problem common in traumatic brain injury (TBI)...- BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injuryNicole Zangrilli Hoh
University of Pittsburgh School of Nursing, Department of Health Promotion and Development, Pittsburgh, Pennsylvania 15261, USA
J Neurotrauma 27:1413-27. 2010..These data support the possibility that genetic variability for pro-survival proteins, particularly genetic variation in the BCL2 gene, impacts outcomes after severe TBI... - Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain traumaAnthony E Kline
Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
Behav Brain Res 177:186-94. 2007..One explanation for the lack of an additive effect is that EE is a very effective treatment and thus there is very little room for 8-OH-DPAT to confer additional statistically significant improvement... - Dilantin therapy in an experimental model of traumatic brain injury: effects of limited versus daily treatment on neurological and behavioral recoveryShaun D Darrah
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurotrauma 28:43-55. 2011..These findings support clinical guidelines for limited use of Dilantin in seizure prophylaxis after TBI... - Controlled cortical impact injury influences methylphenidate-induced changes in striatal dopamine neurotransmissionAmy K Wagner
Department Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurochem 110:801-10. 2009..The findings further support the concept that daily MPH therapy restores striatal DA neurotransmission after CCI... - Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injuryAmy K Wagner
Safar Center for Resuscitation Research, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 33:407-13. 2005..Gender- and hormone-mediated differences in central nervous system pathophysiology should be considered with clinical trials in traumatic brain injury... - Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision makingPatrick M Kochanek
Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
Curr Opin Crit Care 14:135-41. 2008..Novel proteomic, multiplex, and lipidomic methods are also being applied... - Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesisJames W Bales
Brain Trauma Research Center, University of Pittsburgh, PA 15260, USA
Neurosci Biobehav Rev 33:981-1003. 2009.... - Deficits in novelty exploration after controlled cortical impactAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Neurotrauma 24:1308-20. 2007..Future work will utilize these tasks to evaluate the neural substrates underlying exploratory deficits after TBI... - Genetic variability in glutamic acid decarboxylase genes: associations with post-traumatic seizures after severe TBIShaun D Darrah
University of Pittsburgh, Department of Physical Medicine and Rehabilitation, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
Epilepsy Res 103:180-94. 2013..Similarly, diplotype analysis showed those with 2 copies of the haplotype containing both risk alleles were at the highest PTS risk. These results implicate genetic variability within the GABA system in modulating the development of PTS... - Concussion in sports: postconcussive activity levels, symptoms, and neurocognitive performanceCynthia W Majerske
University of Pittsburgh, Pittsburgh, PA, USA
J Athl Train 43:265-74. 2008..Evidence suggests that athletes engaging in high-intensity activities after concussion have more difficulties with cognitive recovery... - Physical medicine and rehabilitation consultation: relationships with acute functional outcome, length of stay, and discharge planning after traumatic brain injuryAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA
Am J Phys Med Rehabil 82:526-36. 2003..Additional work is needed to determine how physical medicine and rehabilitation consultation impacts rehabilitation-specific medical issues, long-term functional outcome, and healthcare costs... - How gender impacts career development and leadership in rehabilitation medicine: a report from the AAPM&R research committeeAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
Arch Phys Med Rehabil 88:560-8. 2007..To examine the role that gender plays in meeting the medical academic mission by assessing career development, leadership, and research productivity among rehabilitation researchers... - Synaptosomal dopamine uptake in rat striatum following controlled cortical impactMargaret S Wilson
Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA
J Neurosci Res 80:85-91. 2005..However, it is unclear whether neurons in the injured striatum can properly regulate the activity of dopamine transporters in vivo... - Biologic and plastic effects of experimental traumatic brain injury treatment paradigms and their relevance to clinical rehabilitationAlexandra N Garcia
Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15213, USA
PM R 3:S18-27. 2011..Here we present several treatment strategies that have been evaluated by using experimental TBI models and discuss potential mechanisms of action (ie, plasticity) and how such changes affect function... - Acute serum hormone levels: characterization and prognosis after severe traumatic brain injuryAmy K Wagner
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurotrauma 28:871-88. 2011..These findings represent a paradigm shift when thinking about the role of sex steroids in neuroprotection clinically after TBI... - Estrogen and stroke: a review of the current literatureErin Carwile
Nurse Anesthesia Program, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA
J Neurosci Nurs 41:18-25; quiz 26-7. 2009.... - YKL-40 expression in traumatic brain injury: an initial analysisDafna Bonneh-Barkay
Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Neurotrauma 27:1215-23. 2010.... - Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injuryRosanne Salonia
Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, USA
J Neurotrauma 27:1819-25. 2010..This increase in ET-1 may mediate the hypoperfusion or cerebrovascular dysfunction accompanying severe TBI in children. Importantly, hypothermia does not affect the brain's ET-1 response as measured in the CSF... - The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in ratsSamuel S Shin
Brain Trauma Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurotrauma 30:259-70. 2013..Elucidation of these alterations in gene expression within the substantia nigra and VTA provides new insights into chronic changes in dopamine signaling post-TBI, and the potential role of EE in TBI rehabilitation... - Gender, sex steroids, and neuroprotection following traumatic brain injuryEmily Rogers
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, PA 15213, USA
J Head Trauma Rehabil 21:279-81. 2006 - The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imagingSriram Venneti
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Exp Neurol 207:118-27. 2007.... - APOE genetic associations with seizure development after severe traumatic brain injuryMegan A Miller
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
Brain Inj 24:1468-77. 2010..The purpose of the current study is to assess the role of the APOE genotype in post-traumatic seizure (PTS) development... - Measuring rehabilitation research capacity: report from the AAPM&R Research Advisory CommitteeAmy K Wagner
Department of Physical Medicine and Rehabilitation (AKW, University of Pittsburgh, Pittsburgh, PA, USA
Am J Phys Med Rehabil 84:955-68. 2005..Observations here provide a platform for future work in understanding the adequacy of the rehabilitation research enterprise, its appropriateness, and ability to meet societal needs for those with disabilities... - Peer review: issues in physical medicine and rehabilitationAmy K Wagner
Department of Physical Medicine and Rehabilitation and Safar Center for Resucitation Research University of pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Phys Med Rehabil 82:790-802. 2003..It also provides suggestions for editorial considerations and improvements in the peer-review process for physical medicine and rehabilitation research journals...