A K Wagner

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint A Rehabilomics focused perspective on molecular mechanisms underlying neurological injury, complications, and recovery after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, United States Safar Center for Resuscitation Research, United States Center for Neuroscience University of Pittsburgh, United States Electronic address
    Pathophysiology 20:39-48. 2013
  2. doi request reprint Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Inj 26:1658-69. 2012
  3. doi request reprint Persistent hypogonadism influences estradiol synthesis, cognition and outcome in males after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation
    Brain Inj 26:1226-42. 2012
  4. pmc Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Suite 202, Pittsburgh, PA 15213, USA
    Epilepsy Res 90:259-72. 2010
  5. ncbi request reprint Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 106:538-47. 2007
  6. ncbi request reprint How gender impacts career development and leadership in rehabilitation medicine: a report from the AAPM&R research committee
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Phys Med Rehabil 88:560-8. 2007
  7. pmc Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
    Behav Brain Res 181:200-9. 2007
  8. pmc Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 28:871-88. 2011
  9. ncbi request reprint TBI translational rehabilitation research in the 21st Century: exploring a Rehabilomics research model
    A K Wagner
    Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15237, USA
    Eur J Phys Rehabil Med 46:549-56. 2010
  10. pmc Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurochem 108:986-97. 2009

Collaborators

Detail Information

Publications36

  1. doi request reprint A Rehabilomics focused perspective on molecular mechanisms underlying neurological injury, complications, and recovery after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, United States Safar Center for Resuscitation Research, United States Center for Neuroscience University of Pittsburgh, United States Electronic address
    Pathophysiology 20:39-48. 2013
    ..In reviewing these concepts, implications for future research and theranostic principles for patient care are presented...
  2. doi request reprint Association of KIBRA rs17070145 polymorphism and episodic memory in individuals with severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Inj 26:1658-69. 2012
    ..However, this association is reversed in adults with subjective memory complaints and populations vulnerable to memory deficits, a problem common in traumatic brain injury (TBI)...
  3. doi request reprint Persistent hypogonadism influences estradiol synthesis, cognition and outcome in males after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation
    Brain Inj 26:1226-42. 2012
    ..However, AHH and persistent hypogonadotropic hypogonadism (PHH) after TBI are not well studied. The objective of this study was to characterize longitudinal hormone profiles and the impact of AHH and PHH on outcome...
  4. pmc Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Suite 202, Pittsburgh, PA 15213, USA
    Epilepsy Res 90:259-72. 2010
    ....
  5. ncbi request reprint Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pennsylvania 15213, USA
    J Neurosurg 106:538-47. 2007
    ..The purpose of this study was to determine associations between factors that affect DAT expression and cerebrospinal fluid (CSF) DA and metabolite levels after severe TBI...
  6. ncbi request reprint How gender impacts career development and leadership in rehabilitation medicine: a report from the AAPM&R research committee
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Phys Med Rehabil 88:560-8. 2007
    ..To examine the role that gender plays in meeting the medical academic mission by assessing career development, leadership, and research productivity among rehabilitation researchers...
  7. pmc Gender associations with chronic methylphenidate treatment and behavioral performance following experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 202, Pittsburgh, PA 15213, United States
    Behav Brain Res 181:200-9. 2007
    ..However there are gender specific drug differences in behavioral performance and sensitivity to treatment with MPH that may have implications for treatment efficacy and dosing clinically after TBI...
  8. pmc Acute serum hormone levels: characterization and prognosis after severe traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 28:871-88. 2011
    ..These findings represent a paradigm shift when thinking about the role of sex steroids in neuroprotection clinically after TBI...
  9. ncbi request reprint TBI translational rehabilitation research in the 21st Century: exploring a Rehabilomics research model
    A K Wagner
    Department of Physical Medicine and Rehabilitation, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15237, USA
    Eur J Phys Rehabil Med 46:549-56. 2010
    ..Specific Rehabilomics applications to TBI research, as well as relevance to the National Institutes of Health Roadmap, are discussed...
  10. pmc Chronic methylphenidate treatment enhances striatal dopamine neurotransmission after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Neurochem 108:986-97. 2009
    ..DAT expression and transcriptional changes affecting DA protein function may underlie the injury and MPH-induced alterations in neurotransmission observed...
  11. pmc Controlled cortical impact injury influences methylphenidate-induced changes in striatal dopamine neurotransmission
    Amy K Wagner
    Department Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 110:801-10. 2009
    ..The findings further support the concept that daily MPH therapy restores striatal DA neurotransmission after CCI...
  12. ncbi request reprint Deficits in novelty exploration after controlled cortical impact
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neurotrauma 24:1308-20. 2007
    ..Future work will utilize these tasks to evaluate the neural substrates underlying exploratory deficits after TBI...
  13. ncbi request reprint Controlled cortical impact injury affects dopaminergic transmission in the rat striatum
    A K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 95:457-65. 2005
    ..Collectively, these data appear to confirm that the clinical efficacy of dopamine agonists in the treatment of TBI may be related to disruptions in the activity of subcortical dopamine systems...
  14. pmc CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 31:1886-96. 2011
    ..These results show the prognostic value of Bcl-2 and CytoC profiles and suggest a dynamic apoptotic and pro-survival response to TBI...
  15. pmc BCL2 genotypes: functional and neurobehavioral outcomes after severe traumatic brain injury
    Nicole Zangrilli Hoh
    University of Pittsburgh School of Nursing, Department of Health Promotion and Development, Pittsburgh, Pennsylvania 15261, USA
    J Neurotrauma 27:1413-27. 2010
    ..These data support the possibility that genetic variability for pro-survival proteins, particularly genetic variation in the BCL2 gene, impacts outcomes after severe TBI...
  16. ncbi request reprint Gender and environmental effects on regional brain-derived neurotrophic factor expression after experimental traumatic brain injury
    X Chen
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 201, Pittsburgh, PA 15213, USA
    Neuroscience 135:11-7. 2005
    ..However, these data do not support a critical role for brain-derived neurotrophic factor in environmental enrichment mediated improvements with spatial learning...
  17. ncbi request reprint Gender associations with cerebrospinal fluid glutamate and lactate/pyruvate levels after severe traumatic brain injury
    Amy K Wagner
    Safar Center for Resuscitation Research, Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:407-13. 2005
    ..The purpose of this study was to evaluate associations between gender and cerebrospinal fluid glutamate and lactate/pyruvate production and the role of hypothermia with gender in attenuating these markers...
  18. pmc Acute treatment with the 5-HT(1A) receptor agonist 8-OH-DPAT and chronic environmental enrichment confer neurobehavioral benefit after experimental brain trauma
    Anthony E Kline
    Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, United States
    Behav Brain Res 177:186-94. 2007
    ..One explanation for the lack of an additive effect is that EE is a very effective treatment and thus there is very little room for 8-OH-DPAT to confer additional statistically significant improvement...
  19. ncbi request reprint Return to productive activity after traumatic brain injury: relationship with measures of disability, handicap, and community integration
    Amy K Wagner
    Charlotte Institute of Rehabilitation, Department of Physical Medicine and Rehabilitation, Charlotte, NC, USA
    Arch Phys Med Rehabil 83:107-14. 2002
    ....
  20. pmc Endothelin-1 is increased in cerebrospinal fluid and associated with unfavorable outcomes in children after severe traumatic brain injury
    Rosanne Salonia
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh Pennsylvania, USA
    J Neurotrauma 27:1819-25. 2010
    ..This increase in ET-1 may mediate the hypoperfusion or cerebrovascular dysfunction accompanying severe TBI in children. Importantly, hypothermia does not affect the brain's ET-1 response as measured in the CSF...
  21. ncbi request reprint Intervention with environmental enrichment after experimental brain trauma enhances cognitive recovery in male but not female rats
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, 3471 5th Avenue, Kaufmann Building, Suite 201, University of Pittsburgh, Pittsburgh, PA, USA
    Neurosci Lett 334:165-8. 2002
    ..EE did not impact motor performance in this setting. These findings have gender specific implications for how to approach and evaluate treatments and interventions after TBI...
  22. pmc YKL-40 expression in traumatic brain injury: an initial analysis
    Dafna Bonneh-Barkay
    Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurotrauma 27:1215-23. 2010
    ....
  23. ncbi request reprint Physical medicine and rehabilitation consultation: relationships with acute functional outcome, length of stay, and discharge planning after traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, School of Medicine, Pennsylvania 15213, USA
    Am J Phys Med Rehabil 82:526-36. 2003
    ..The purpose of this study was to delineate relationships between physical medicine and rehabilitation consultation in this population and acute functional outcome, length of stay, and discharge planning...
  24. ncbi request reprint Evaluation of estrous cycle stage and gender on behavioral outcome after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, 3471 Fifth Avenue, Suite 201 Pittsburgh, PA 15213, USA
    Brain Res 998:113-21. 2004
    ..The impact of early neuroprotection on later behavioral outcome and the anatomic structural specificity of hormonal neuroprotection require further study...
  25. doi request reprint Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making
    Patrick M Kochanek
    Safar Center for Resuscitation Research, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    Curr Opin Crit Care 14:135-41. 2008
    ..Novel proteomic, multiplex, and lipidomic methods are also being applied...
  26. ncbi request reprint Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia
    Amy K Wagner
    Department of Physical Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Neurotrauma 21:125-36. 2004
    ..Gender and age differences in TBI pathophysiology should be considered when conducting clinical trials in TBI...
  27. ncbi request reprint Synaptosomal dopamine uptake in rat striatum following controlled cortical impact
    Margaret S Wilson
    Safar Center for Resuscitation Research, Pittsburgh, Pennsylvania, USA
    J Neurosci Res 80:85-91. 2005
    ..However, it is unclear whether neurons in the injured striatum can properly regulate the activity of dopamine transporters in vivo...
  28. ncbi request reprint Gender and environmental enrichment impact dopamine transporter expression after experimental traumatic brain injury
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 195:475-83. 2005
    ..These findings may have some relevance to treatment paradigms using dopaminergic neurostimulants after TBI...
  29. pmc Concussion in sports: postconcussive activity levels, symptoms, and neurocognitive performance
    Cynthia W Majerske
    University of Pittsburgh, Pittsburgh, PA, USA
    J Athl Train 43:265-74. 2008
    ..Evidence suggests that athletes engaging in high-intensity activities after concussion have more difficulties with cognitive recovery...
  30. ncbi request reprint Estrogen and stroke: a review of the current literature
    Erin Carwile
    Nurse Anesthesia Program, University of Pittsburgh School of Nursing, Pittsburgh, PA, USA
    J Neurosci Nurs 41:18-25; quiz 26-7. 2009
    ....
  31. ncbi request reprint Gender, sex steroids, and neuroprotection following traumatic brain injury
    Emily Rogers
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, PA 15213, USA
    J Head Trauma Rehabil 21:279-81. 2006
  32. pmc Persistent cognitive dysfunction after traumatic brain injury: A dopamine hypothesis
    James W Bales
    Brain Trauma Research Center, University of Pittsburgh, PA 15260, USA
    Neurosci Biobehav Rev 33:981-1003. 2009
    ....
  33. ncbi request reprint An internship for college students in physical medicine and rehabilitation: effects on awareness, career choice, and disability perceptions
    A K Wagner
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pennsylvania 15237, USA
    Am J Phys Med Rehabil 80:459-65. 2001
    ....
  34. ncbi request reprint Measuring rehabilitation research capacity: report from the AAPM&R Research Advisory Committee
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation AKW, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Phys Med Rehabil 84:955-68. 2005
    ..Observations here provide a platform for future work in understanding the adequacy of the rehabilitation research enterprise, its appropriateness, and ability to meet societal needs for those with disabilities...
  35. pmc The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 207:118-27. 2007
    ....
  36. ncbi request reprint Peer review: issues in physical medicine and rehabilitation
    Amy K Wagner
    Department of Physical Medicine and Rehabilitation and Safar Center for Resucitation Research University of pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Phys Med Rehabil 82:790-802. 2003
    ..It also provides suggestions for editorial considerations and improvements in the peer-review process for physical medicine and rehabilitation research journals...

Research Grants9

  1. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  2. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
  3. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2007
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. ..
  4. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2007
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. ..