Affiliation: University of California
- Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and WhitesPathik D Wadhwa
Departments of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
PLoS ONE 7:e43931. 2012....
- The contribution of maternal stress to preterm birth: issues and considerationsPathik D Wadhwa
Departments of Psychiatry and Human Behavior, Obstetrics and Gynecology, and Epidemiology, University of California, Irvine, School of Medicine, 3177 Gillespie Neuroscience Research Facility, Irvine, CA 92697, USA
Clin Perinatol 38:351-84. 2011..Issues related to the characterization and assessment of maternal stress and candidate biologic mechanisms are addressed...
- Developmental origins of health and disease: brief history of the approach and current focus on epigenetic mechanismsPathik D Wadhwa
Department of Pediatrics, University of California, Irvine, School of Medicine, 3117 GillespieNeuroscience Research Facility, Irvine, CA 92697 4260, USA
Semin Reprod Med 27:358-68. 2009..Next, we discuss the relevance of the DOHaD approach to reproductive medicine. Finally, we consider the next steps that might be taken to apply, evaluate, and extend the DOHaD approach...
- Prenatal psychosocial factors and the neuroendocrine axis in human pregnancyP D Wadhwa
Department of Obstetrics and Gynecology, University of California, Irvine, USA
Psychosom Med 58:432-46. 1996....
- Psychoneuroendocrine processes in human pregnancy influence fetal development and healthPathik D Wadhwa
Behavioral Perinatology Research Program, Department of Psychiatry and Human Behavior, College of Medicine, University of California, Irvine, 92697 4260, USA
Psychoneuroendocrinology 30:724-43. 2005..A description of this body of work is followed by the elucidation of questions for further research and a discussion of implications for life-span development and health...
- Placental corticotropin-releasing hormone (CRH), spontaneous preterm birth, and fetal growth restriction: a prospective investigationPathik D Wadhwa
Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697 4260, USA
Am J Obstet Gynecol 191:1063-9. 2004....
- Stress, infection and preterm birth: a biobehavioural perspectiveP D Wadhwa
Department of Psychiatry and Human Behavior, University of California Irvine, 3117 Gillespie Neuroscience Building, Zot Code 4260, Irvine, CA 92697, USA
Paediatr Perinat Epidemiol 15:17-29. 2001....
- Behavioral perinatology: biobehavioral processes in human fetal developmentPathik D Wadhwa
Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697 4260, USA
Regul Pept 108:149-57. 2002..In this paper, we elaborate on the conceptual and empirical basis for this model, highlight some relevant issues and questions, and make recommendations for future research in this area...
- The neurobiology of stress in human pregnancy: implications for prematurity and development of the fetal central nervous systemP D Wadhwa
Department of Psychiatry and Human Behavior, University of California, Irvine, College of Medicine, 3117 Gillespie Neuroscience Building, Irvine, CA 92697, USA
Prog Brain Res 133:131-42. 2001..The implications of these studies for life-span development and health are discussed...
- Stress and preterm birth: neuroendocrine, immune/inflammatory, and vascular mechanismsP D Wadhwa
Department of Psychiatry and Human Behavior and Obstetrics and Gynecology, College of Medicine, Irvine, University of California, 92697, USA
Matern Child Health J 5:119-25. 2001....
- Elevated maternal cortisol early in pregnancy predicts third trimester levels of placental corticotropin releasing hormone (CRH): priming the placental clockCurt A Sandman
Women and Children s Health and Well Being Project, Department of Psychiatry, University of California, Irvine, 333 City Drive West, Suite 1200, Orange, CA 92868, USA
Peptides 27:1457-63. 2006..These findings suggested that early detection of stress signals by the placenta stimulated the subsequent release of CRH and resulted in increased risk for preterm delivery...
- Attenuation of maternal psychophysiological stress responses and the maternal cortisol awakening response over the course of human pregnancySonja Entringer
Department of Psychiatry and Human Behavior, University of California, Irvine, California, USA
Stress 13:258-68. 2010..This attenuation is unlikely to be attributable to habituation. Individual differences in the degree of attenuation of stress responses over gestation may represent a novel marker of stress susceptibility in human pregnancy...
- The maternal cortisol awakening response in human pregnancy is associated with the length of gestationClaudia Buss
Department of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, CA
Am J Obstet Gynecol 201:398.e1-8. 2009..The purpose of this study was to examine the relationship between intraindividual changes in cortisol responsiveness over pregnancy and the length of human gestation...
- Developmental origins of health and disease: environmental exposuresJames M Swanson
Department of Pediatrics, University of California, Irvine, School of Medicine, 19722 MacArthur Boulevard, Irvine, CA 92612 4480, USA
Semin Reprod Med 27:391-402. 2009....
- Pregnancy affects appraisal of negative life eventsLaura M Glynn
Department of Psychiatry and Human Behavior, University of California, Irvine, 2501 Harbor Boulevard, No 7, Costa Mesa, CA 92626, USA
J Psychosom Res 56:47-52. 2004..This study investigates whether emotional responding is diminished as well by measuring affective responses to specific life events during pregnancy...
- Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesisJames M Swanson
Department of Pediatrics, University of California, Irvine, CA 92612, USA
Neuropsychol Rev 17:39-59. 2007....
- Parity does not alter baseline or stimulated activity of the hypothalamus-pituitary-adrenal axis in womenIlona S Federenko
Department of Psychology and Social Behavior, University of California, Irvine, 3340 Social Ecology II, Irvine, CA 92697 7085, USA
Dev Psychobiol 48:703-11. 2006....
- The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependentIlona S Federenko
Department of Clinical and Theoretical Psychobiology, University of Trier, Germany
J Clin Endocrinol Metab 89:6244-50. 2004..These findings challenge previous reports on a low heritability of markers of stimulated hypothalamus pituitary adrenal axis activity and are the first to document the relevance of context for psychoendocrine heritability estimates...
- Maternal hypothalamic-pituitary-adrenal disregulation during the third trimester influences human fetal responsesCurt A Sandman
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA
Dev Neurosci 25:41-9. 2003..Results indicate that maternal stress and stress-related peptides influence fetal response patterns. It is possible that this influence persists over the life span...
- Women's mental health during pregnancy influences fetal and infant developmental and health outcomesIlona S Federenko
Department of Psychiatry and Human Behavior, College of Medicine, University of California at Irvine, 3117 Gillespie, Irvine, CA 92697-4260, USA
CNS Spectr 9:198-206. 2004..In this context, the role of race/ethnicity and genetic predisposition are discussed as two promising avenues of further investigation...
- Ecological momentary assessment of maternal cortisol profiles over a multiple-day period predicts the length of human gestationSonja Entringer
Department of Psychiatry and Human Behavior, University of California, Irvine, California 92697 4260, USA
Psychosom Med 73:469-74. 2011..In addition, associations between EMA-based measures of psychological state (negative affect) with cortisol levels during pregnancy were assessed...
- Corticotropin releasing hormone (CRH) gene variation: comprehensive resequencing for variant and molecular haplotype discovery in monosomic hybrid cell linesLawrence C Shimmin
Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA
DNA Seq 18:434-44. 2007..6), likely reflecting disruptive selection in CRH evolution. Network analysis showed that AA have retained an ancestral CRH haplotype, while the most common EA haplotype is derived from a single recombination event...
- PHYSIOLOGICAL STRESS REACTIVITY AND PREGNANCY OUTCOMESPathik Wadhwa; Fiscal Year: 2002....
- STRESS BIOLOGY, RACE/ETHNICITY & INFECTION IN PREGNANCYPathik Wadhwa; Fiscal Year: 2006..g., the ex-vivo immune challenge methodology) to identify women who are at heightened risk for infection and infection-related preterm birth, thereby improving obstetric risk assessment. ..
- OVERALL - GENE-ENVIRONMENT INTERACTIONS IN HUMAN PARTURITIONPathik Wadhwa; Fiscal Year: 2007..The four cores are A) Administrative Core (Pathik Wadhwa, Director), to serve as an administrative office for the central co-ordination of all project and core ..
- EMA Assessment of Biobehavioral Processes in Human PregnancyPathik D Wadhwa; Fiscal Year: 2010....