Research Topics
Genomes and GenesSpecies | Scott WaddellSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
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Publications
What can we teach Drosophila? What can they teach us?S Waddell
Dept of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
Trends Genet 17:719-26. 2001....
Sequential use of mushroom body neuron subsets during drosophila odor memory processingMichael J Krashes
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Neuron 53:103-15. 2007....- Dopamine reveals neural circuit mechanisms of fly memoryScott Waddell
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Trends Neurosci 33:457-64. 2010..Combinations of fly DA neurons might code negative and positive value, consistent with a motivational systems role as proposed in mammals... - Protein phosphatase 1 and memory: practice makes PP1 imperfect?Scott Waddell
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Trends Neurosci 26:117-9. 2003..Thus, PP1 apparently constrains memory formation in the mouse. Furthermore, the report proposes that PP1 promotes forgetting... - Courtship learning: scent of a womanScott Waddell
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Curr Biol 15:R88-90. 2005..Learning to predict an outcome based on previous experience is of considerable selective advantage. Getting it wrong can be costly. In a complex environment, however, using the appropriate predictor is not necessarily a trivial task... - Layered reward signalling through octopamine and dopamine in DrosophilaChristopher J Burke
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nature 492:433-7. 2012..In addition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement systems in flies are more similar to mammals than previously thought... - Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in DrosophilaMichael J Krashes
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Neurosci 28:3103-13. 2008..Last, experiments feeding and/or starving flies after training reveals a critical motivational drive that enables appetitive LTM retrieval... - A neural circuit mechanism integrating motivational state with memory expression in DrosophilaMichael J Krashes
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Cell 139:416-27. 2009..Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory... - Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidationAlex C Keene
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Curr Biol 16:1524-30. 2006..Therefore, our results suggest that the fly employs the local DPM-MB circuit to stabilize punitive- and reward-odor memories and that stable aspects of both forms of memory may reside in mushroom body alpha' and beta' lobe neurons... - Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron outputAlex C Keene
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Neuron 44:521-33. 2004..These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration... - A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom bodyJena L Pitman
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Curr Biol 21:855-61. 2011..We propose that APL neurons provide widespread inhibition to stabilize and maintain synaptic specificity of a labile memory trace in a recurrent DPM and MB α'β' neuron circuit... - Drosophila memory: dopamine signals punishment?Alex C Keene
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Biol 15:R932-4. 2005..Dopamine-containing neurons are widespread in the fly brain and have been implicated in negatively reinforced memory. Current technology allows the investigator to watch dopaminergic neurons in action in the brain of a learning fly... - There are many ways to train a flyJena L Pitman
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Fly (Austin) 3:3-9. 2009..While our bias for olfactory conditioning paradigms is obvious, our purpose here is not to pass judgment on each method. We would rather leave that to those readers who might be inspired to try each assay for themselves... - Drosophila olfactory memory: single genes to complex neural circuitsAlex C Keene
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nat Rev Neurosci 8:341-54. 2007..The studies have transformed D. melanogaster from a useful organism for gene discovery to an ideal model to understand neural circuit function in memory... - Remembering nutrient quality of sugar in DrosophilaChristopher J Burke
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Biol 21:746-50. 2011..Therefore, flies can rapidly learn to discriminate between sugars using a postingestive reward evaluation system, and they preferentially remember nutritious sugars... - Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signalingAlex C Koon
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Neurosci 14:190-9. 2011..Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range... 
Drosophila memory: will Orb(2) predict the future?Michael J Krashes
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Curr Biol 18:R74-6. 2008..Recent work in Drosophila provides promise that this analysis may soon reach the resolution of identifiable synapses...- Cryptochrome mediates light-dependent magnetosensitivity in DrosophilaRobert J Gegear
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 454:1014-8. 2008..Moreover, Cry-dependent magnetosensitivity does not require a functioning circadian clock. Our work provides, to our knowledge, the first genetic evidence for a Cry-based magnetosensitive system in any animal... - Smelling excitement in the antennal lobeBenjamin Leung
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Cell 128:431-2. 2007..Shang et al. (2007) now describe the existence of excitatory neurons within the antennal lobe that may account for some of these unexplained differences... - Sleep: what goes up must come downJena L Pitman
Department of Neurobiology, 364 Plantation Street, University of Massachusetts Medical School Worcester, MA 01605, USA
Curr Biol 19:R480-2. 2009..The function of sleep is hotly contested. Two recent studies suggest that fly sleep may be required to rescale synapses in the brain... - Learned odor discrimination in Drosophila without combinatorial odor maps in the antennal lobeShamik Dasgupta
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Curr Biol 18:1668-74. 2008..Therefore, flies can distinguish odorants without discrete spatial codes in the antennal lobe, implying an important role for odorant-evoked temporal dynamics in behavioral odorant discrimination... - Hungry flies tune to vinegarWolf Huetteroth
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Cell 145:17-8. 2011..Root et al. (2011) report that hunger modulates the sensitivity of specific olfactory sensory neurons in Drosophila and facilitates odor-search behavior... - Forgetting those painful momentsScott Waddell
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01655, USA
Neuron 35:815-7. 2002..What molecular and cellular processes underlie forgetting? In this issue of Neuron, Schwaerzel et al. indicate that extinction of an odor memory in Drosophila may involve the same neurons as those involved in forming the memory... - Four-dimensional gene expression control: memories on the flyBenjamin Leung
Department of Neurobiology, University of Massachusetts Medical School, Worcester MA 01605, USA
Trends Neurosci 27:511-3. 2004..Two recent papers describe implementation of different but related technologies that now provide this missing element in fly behavioral research... - Associative memory: without a traceEmmanuel Perisse
Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Curr Biol 21:R579-81. 2011..Some transient sensory stimuli can cause prolonged activity in the brain. Trace conditioning experiments can reveal the time over which these lasting representations can be utilized and where they reside... - The Drosophila radish gene encodes a protein required for anesthesia-resistant memoryElisabeth Folkers
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 103:17496-500. 2006..The Radish protein has recently been reported to bind to Rac1 [Formstecher et al. (2005) Genome Res. 15:376-384], a small GTPase that regulates cytoskeletal rearrangement and influences neuronal and synaptic morphology... - Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioningDinghui Yu
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 123:945-57. 2005..DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition... - The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryoJamie L Rickmyre
Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U 4200 MRBIII, 465 21st Avenue South, Nashville, TN 37232 8240, USA
J Cell Sci 120:3565-77. 2007..Finally, brains of mcph1 adult male flies have defects in mushroom body structure, suggesting an evolutionarily conserved role for MCPH1 in brain development...
Research Grants
- Motivational control of appetitive memoryScott Waddell; Fiscal Year: 2009....
- Motivational control of appetitive memoryScott Waddell; Fiscal Year: 2010....
- Mechanisms of Memory ConsolidationScott Waddell; Fiscal Year: 2010..Our work will provide a fundamental understanding of the cellular, molecular and neural circuit processes of memory providing potential avenues for mnemonic therapy in humans. ..
- How does the amnesiac gene product aid memory?Scott Waddell; Fiscal Year: 2007..Therefore molecules we identify in Drosophila learning may ultimately be useful in human mnemonic and drug rehabilitation therapy. ..