Scott Waddell

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint What can we teach Drosophila? What can they teach us?
    S Waddell
    Dept of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Genet 17:719-26. 2001
  2. pmc Sequential use of mushroom body neuron subsets during drosophila odor memory processing
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 53:103-15. 2007
  3. ncbi request reprint Protein phosphatase 1 and memory: practice makes PP1 imperfect?
    Scott Waddell
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Trends Neurosci 26:117-9. 2003
  4. pmc Dopamine reveals neural circuit mechanisms of fly memory
    Scott Waddell
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Trends Neurosci 33:457-64. 2010
  5. ncbi request reprint Courtship learning: scent of a woman
    Scott Waddell
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 15:R88-90. 2005
  6. pmc Layered reward signalling through octopamine and dopamine in Drosophila
    Christopher J Burke
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 492:433-7. 2012
  7. pmc A neural circuit mechanism integrating motivational state with memory expression in Drosophila
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 139:416-27. 2009
  8. pmc Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 28:3103-13. 2008
  9. pmc A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body
    Jena L Pitman
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 21:855-61. 2011
  10. pmc Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    Alex C Koon
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Neurosci 14:190-9. 2011

Research Grants

  1. Mechanisms of Memory Consolidation
    Scott Waddell; Fiscal Year: 2010
  2. Motivational control of appetitive memory
    Scott Waddell; Fiscal Year: 2009
  3. Motivational control of appetitive memory
    Scott Waddell; Fiscal Year: 2010
  4. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2004
  5. Mechanisms of Memory Consolidation
    Scott Waddell; Fiscal Year: 2009
  6. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2007
  7. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2006
  8. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2005

Collaborators

Detail Information

Publications30

  1. ncbi request reprint What can we teach Drosophila? What can they teach us?
    S Waddell
    Dept of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Genet 17:719-26. 2001
    ....
  2. pmc Sequential use of mushroom body neuron subsets during drosophila odor memory processing
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 53:103-15. 2007
    ....
  3. ncbi request reprint Protein phosphatase 1 and memory: practice makes PP1 imperfect?
    Scott Waddell
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Trends Neurosci 26:117-9. 2003
    ..Thus, PP1 apparently constrains memory formation in the mouse. Furthermore, the report proposes that PP1 promotes forgetting...
  4. pmc Dopamine reveals neural circuit mechanisms of fly memory
    Scott Waddell
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Trends Neurosci 33:457-64. 2010
    ..Combinations of fly DA neurons might code negative and positive value, consistent with a motivational systems role as proposed in mammals...
  5. ncbi request reprint Courtship learning: scent of a woman
    Scott Waddell
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 15:R88-90. 2005
    ..Learning to predict an outcome based on previous experience is of considerable selective advantage. Getting it wrong can be costly. In a complex environment, however, using the appropriate predictor is not necessarily a trivial task...
  6. pmc Layered reward signalling through octopamine and dopamine in Drosophila
    Christopher J Burke
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 492:433-7. 2012
    ..In addition, they reconcile previous findings with octopamine and dopamine and suggest that reinforcement systems in flies are more similar to mammals than previously thought...
  7. pmc A neural circuit mechanism integrating motivational state with memory expression in Drosophila
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 139:416-27. 2009
    ..Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory...
  8. pmc Rapid consolidation to a radish and protein synthesis-dependent long-term memory after single-session appetitive olfactory conditioning in Drosophila
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Neurosci 28:3103-13. 2008
    ..Last, experiments feeding and/or starving flies after training reveals a critical motivational drive that enables appetitive LTM retrieval...
  9. pmc A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body
    Jena L Pitman
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 21:855-61. 2011
    ..We propose that APL neurons provide widespread inhibition to stabilize and maintain synaptic specificity of a labile memory trace in a recurrent DPM and MB α'β' neuron circuit...
  10. pmc Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling
    Alex C Koon
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Neurosci 14:190-9. 2011
    ..Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range...
  11. ncbi request reprint Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation
    Alex C Keene
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 16:1524-30. 2006
    ..Therefore, our results suggest that the fly employs the local DPM-MB circuit to stabilize punitive- and reward-odor memories and that stable aspects of both forms of memory may reside in mushroom body alpha' and beta' lobe neurons...
  12. ncbi request reprint Diverse odor-conditioned memories require uniquely timed dorsal paired medial neuron output
    Alex C Keene
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 44:521-33. 2004
    ..These results suggest that DPM neurons are required to consolidate memory and are differently involved in memory of a volatile that requires multisensory integration...
  13. pmc Different kenyon cell populations drive learned approach and avoidance in Drosophila
    Emmanuel Perisse
    Centre for Neural Circuits and Behaviour, The University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Neuron 79:945-56. 2013
    ..We propose that conditioned approach requires pooling synaptic outputs from across the αβ ensemble but only from the αβs for conditioned aversion. ..
  14. ncbi request reprint Drosophila memory: dopamine signals punishment?
    Alex C Keene
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 15:R932-4. 2005
    ..Dopamine-containing neurons are widespread in the fly brain and have been implicated in negatively reinforced memory. Current technology allows the investigator to watch dopaminergic neurons in action in the brain of a learning fly...
  15. pmc There are many ways to train a fly
    Jena L Pitman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Fly (Austin) 3:3-9. 2009
    ..While our bias for olfactory conditioning paradigms is obvious, our purpose here is not to pass judgment on each method. We would rather leave that to those readers who might be inspired to try each assay for themselves...
  16. pmc Transposition-driven genomic heterogeneity in the Drosophila brain
    Paola N Perrat
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 340:91-5. 2013
    ..Paired-end deep sequencing identified more than 200 de novo transposon insertions in αβ neurons, including insertions into memory-relevant loci. Our observations indicate that genomic heterogeneity is a conserved feature of the brain...
  17. ncbi request reprint Drosophila olfactory memory: single genes to complex neural circuits
    Alex C Keene
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Rev Neurosci 8:341-54. 2007
    ..The studies have transformed D. melanogaster from a useful organism for gene discovery to an ideal model to understand neural circuit function in memory...
  18. pmc Remembering nutrient quality of sugar in Drosophila
    Christopher J Burke
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 21:746-50. 2011
    ..Therefore, flies can rapidly learn to discriminate between sugars using a postingestive reward evaluation system, and they preferentially remember nutritious sugars...
  19. doi request reprint Drosophila memory: will Orb(2) predict the future?
    Michael J Krashes
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 18:R74-6. 2008
    ..Recent work in Drosophila provides promise that this analysis may soon reach the resolution of identifiable synapses...
  20. ncbi request reprint Smelling excitement in the antennal lobe
    Benjamin Leung
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 128:431-2. 2007
    ..Shang et al. (2007) now describe the existence of excitatory neurons within the antennal lobe that may account for some of these unexplained differences...
  21. pmc Sleep: what goes up must come down
    Jena L Pitman
    Department of Neurobiology, 364 Plantation Street, University of Massachusetts Medical School Worcester, MA 01605, USA
    Curr Biol 19:R480-2. 2009
    ..The function of sleep is hotly contested. Two recent studies suggest that fly sleep may be required to rescale synapses in the brain...
  22. pmc Learned odor discrimination in Drosophila without combinatorial odor maps in the antennal lobe
    Shamik Dasgupta
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 18:1668-74. 2008
    ..Therefore, flies can distinguish odorants without discrete spatial codes in the antennal lobe, implying an important role for odorant-evoked temporal dynamics in behavioral odorant discrimination...
  23. pmc Cryptochrome mediates light-dependent magnetosensitivity in Drosophila
    Robert J Gegear
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 454:1014-8. 2008
    ..Moreover, Cry-dependent magnetosensitivity does not require a functioning circadian clock. Our work provides, to our knowledge, the first genetic evidence for a Cry-based magnetosensitive system in any animal...
  24. pmc Hungry flies tune to vinegar
    Wolf Huetteroth
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Cell 145:17-8. 2011
    ..Root et al. (2011) report that hunger modulates the sensitivity of specific olfactory sensory neurons in Drosophila and facilitates odor-search behavior...
  25. ncbi request reprint Forgetting those painful moments
    Scott Waddell
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01655, USA
    Neuron 35:815-7. 2002
    ..What molecular and cellular processes underlie forgetting? In this issue of Neuron, Schwaerzel et al. indicate that extinction of an odor memory in Drosophila may involve the same neurons as those involved in forming the memory...
  26. ncbi request reprint Associative memory: without a trace
    Emmanuel Perisse
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 21:R579-81. 2011
    ..Some transient sensory stimuli can cause prolonged activity in the brain. Trace conditioning experiments can reveal the time over which these lasting representations can be utilized and where they reside...
  27. ncbi request reprint Four-dimensional gene expression control: memories on the fly
    Benjamin Leung
    Department of Neurobiology, University of Massachusetts Medical School, Worcester MA 01605, USA
    Trends Neurosci 27:511-3. 2004
    ..Two recent papers describe implementation of different but related technologies that now provide this missing element in fly behavioral research...
  28. pmc The Drosophila radish gene encodes a protein required for anesthesia-resistant memory
    Elisabeth Folkers
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:17496-500. 2006
    ..The Radish protein has recently been reported to bind to Rac1 [Formstecher et al. (2005) Genome Res. 15:376-384], a small GTPase that regulates cytoskeletal rearrangement and influences neuronal and synaptic morphology...
  29. ncbi request reprint Drosophila DPM neurons form a delayed and branch-specific memory trace after olfactory classical conditioning
    Dinghui Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 123:945-57. 2005
    ..DPM neurons are therefore "odor generalists" and form a delayed, branch-specific, and amnesiac-dependent memory trace that may guide behavior after acquisition...
  30. ncbi request reprint The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo
    Jamie L Rickmyre
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U 4200 MRBIII, 465 21st Avenue South, Nashville, TN 37232 8240, USA
    J Cell Sci 120:3565-77. 2007
    ..Finally, brains of mcph1 adult male flies have defects in mushroom body structure, suggesting an evolutionarily conserved role for MCPH1 in brain development...

Research Grants10

  1. Mechanisms of Memory Consolidation
    Scott Waddell; Fiscal Year: 2010
    ..Our work will provide a fundamental understanding of the cellular, molecular and neural circuit processes of memory providing potential avenues for mnemonic therapy in humans. ..
  2. Motivational control of appetitive memory
    Scott Waddell; Fiscal Year: 2009
    ....
  3. Motivational control of appetitive memory
    Scott Waddell; Fiscal Year: 2010
    ....
  4. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2004
    ..Therefore molecules we identify in Drosophila learning may ultimately be useful in human mnemonic and drug rehabilitation therapy. ..
  5. Mechanisms of Memory Consolidation
    Scott Waddell; Fiscal Year: 2009
    ..Our work will provide a fundamental understanding of the cellular, molecular and neural circuit processes of memory providing potential avenues for mnemonic therapy in humans. ..
  6. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2007
    ..Therefore molecules we identify in Drosophila learning may ultimately be useful in human mnemonic and drug rehabilitation therapy. ..
  7. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2006
    ..Therefore molecules we identify in Drosophila learning may ultimately be useful in human mnemonic and drug rehabilitation therapy. ..
  8. How does the amnesiac gene product aid memory?
    Scott Waddell; Fiscal Year: 2005
    ..Therefore molecules we identify in Drosophila learning may ultimately be useful in human mnemonic and drug rehabilitation therapy. ..