Matt Wachowiak

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Functional recovery of odor representations in regenerated sensory inputs to the olfactory bulb
    Man C Cheung
    Department of Biology, Boston University Boston, MA, USA
    Front Neural Circuits 7:207. 2013
  2. pmc Optical dissection of odor information processing in vivo using GCaMPs expressed in specified cell types of the olfactory bulb
    Matt Wachowiak
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA
    J Neurosci 33:5285-300. 2013
  3. pmc All in a sniff: olfaction as a model for active sensing
    Matt Wachowiak
    Department of Physiology and Brain Institute, University of Utah, Salt Lake City, UT 84103, USA
    Neuron 71:962-73. 2011
  4. ncbi request reprint Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons
    John P McGann
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Neuron 48:1039-53. 2005
  5. pmc Cholinergic inputs from Basal forebrain add an excitatory bias to odor coding in the olfactory bulb
    Markus Rothermel
    Department of Neurobiology and Anatomy, Brain Institute, University of Utah, Salt Lake City, Utah 84103, and Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201
    J Neurosci 34:4654-64. 2014
  6. ncbi request reprint Sniffing controls an adaptive filter of sensory input to the olfactory bulb
    Justus V Verhagen
    Department of Biology, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:631-9. 2007
  7. pmc Testing the sorption hypothesis in olfaction: a limited role for sniff strength in shaping primary odor representations during behavior
    Tristan Cenier
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 33:79-92. 2013
  8. doi request reprint Low-level mechanisms for processing odor information in the behaving animal
    Matt Wachowiak
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 1170:286-92. 2009
  9. pmc Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat
    Daniel W Wesson
    Department of Biology, Boston University, Boston, MA, USA
    J Neurophysiol 101:1089-102. 2009
  10. pmc In vivo modulation of sensory input to the olfactory bulb by tonic and activity-dependent presynaptic inhibition of receptor neurons
    Nicolás Pírez
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 28:6360-71. 2008

Research Grants

Detail Information

Publications16

  1. pmc Functional recovery of odor representations in regenerated sensory inputs to the olfactory bulb
    Man C Cheung
    Department of Biology, Boston University Boston, MA, USA
    Front Neural Circuits 7:207. 2013
    ....
  2. pmc Optical dissection of odor information processing in vivo using GCaMPs expressed in specified cell types of the olfactory bulb
    Matt Wachowiak
    Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT 84132, USA
    J Neurosci 33:5285-300. 2013
    ..These results suggest multiple circuit elements with distinct roles in transforming odor representations in the OB and provide a framework for further study of early olfactory processing using optical and genetic tools...
  3. pmc All in a sniff: olfaction as a model for active sensing
    Matt Wachowiak
    Department of Physiology and Brain Institute, University of Utah, Salt Lake City, UT 84103, USA
    Neuron 71:962-73. 2011
    ....
  4. ncbi request reprint Odorant representations are modulated by intra- but not interglomerular presynaptic inhibition of olfactory sensory neurons
    John P McGann
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Neuron 48:1039-53. 2005
    ..This organization allows for control of input sensitivity while maintaining the spatial maps of glomerular activity thought to encode odorant identity...
  5. pmc Cholinergic inputs from Basal forebrain add an excitatory bias to odor coding in the olfactory bulb
    Markus Rothermel
    Department of Neurobiology and Anatomy, Brain Institute, University of Utah, Salt Lake City, Utah 84103, and Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201
    J Neurosci 34:4654-64. 2014
    ..These results are consistent with a role for the basal forebrain cholinergic system in dynamically regulating the sensitivity to or salience of odors during active sensing of the olfactory environment. ..
  6. ncbi request reprint Sniffing controls an adaptive filter of sensory input to the olfactory bulb
    Justus V Verhagen
    Department of Biology, Boston University, 24 Cummington Street, Boston, Massachusetts 02215, USA
    Nat Neurosci 10:631-9. 2007
    ..Thus, sniffing controls an adaptive filter for detecting changes in the odor landscape. These data suggest an unexpected functional role for sniffing and show that sensory codes can be transformed by sampling behavior alone...
  7. pmc Testing the sorption hypothesis in olfaction: a limited role for sniff strength in shaping primary odor representations during behavior
    Tristan Cenier
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 33:79-92. 2013
    ..These data suggest that modulating sniff strength does not shape odor representations sufficiently to be part of a strategy for active odor sensing in the behaving animal...
  8. doi request reprint Low-level mechanisms for processing odor information in the behaving animal
    Matt Wachowiak
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    Ann N Y Acad Sci 1170:286-92. 2009
    ..Thus, "high order" processing can occur even before sensory neurons transmit information to the brain...
  9. pmc Why sniff fast? The relationship between sniff frequency, odor discrimination, and receptor neuron activation in the rat
    Daniel W Wesson
    Department of Biology, Boston University, Boston, MA, USA
    J Neurophysiol 101:1089-102. 2009
    ....
  10. pmc In vivo modulation of sensory input to the olfactory bulb by tonic and activity-dependent presynaptic inhibition of receptor neurons
    Nicolás Pírez
    Department of Biology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 28:6360-71. 2008
    ..Thus, rather than adaptively shaping odor representations in an activity-dependent manner, a primary role of presynaptic inhibition in vivo may be to modulate the magnitude of sensory input to the brain as a function of behavioral state...
  11. ncbi request reprint Coding and synaptic processing of sensory information in the glomerular layer of the olfactory bulb
    Matt Wachowiak
    Department of Biology, Boston University, Boston, MA 02215, USA
    Semin Cell Dev Biol 17:411-23. 2006
    ..We speculate that odor representations and their postsynaptic processing are tuned to and shaped by the sniffing behavior of the animal...
  12. pmc Sniffing behavior of mice during performance in odor-guided tasks
    Daniel W Wesson
    Department of Biology, Boston University, Boston, MA 02215, USA
    Chem Senses 33:581-96. 2008
    ..These results show that mouse sniffing behavior is highly dynamic, varies with behavioral context, and is strongly modulated by olfactory as well as nonolfactory events...
  13. pmc Transgene expression in target-defined neuron populations mediated by retrograde infection with adeno-associated viral vectors
    Markus Rothermel
    Brain Institute and Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah 84112
    J Neurosci 33:15195-206. 2013
    ..These results establish a widely accessible tool for achieving combinatorial specificity and stable, long-term transgene expression to isolate precisely defined neuron populations in the intact animal...
  14. pmc Inhibition [corrected] of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx
    Matt Wachowiak
    Department of Biology, Boston University, MA 02215, USA
    J Neurophysiol 94:2700-12. 2005
    ..This mechanism is unique among primary sensory afferents...
  15. pmc A method for generating natural and user-defined sniffing patterns in anesthetized or reduced preparations
    Man Ching Cheung
    Department of Biology, Boston University, Boston, MA 02215, USA
    Chem Senses 34:63-76. 2009
    ..This method should prove useful in investigating how the parameters of odorant sampling shape neural responses in a variety of experimental settings...
  16. pmc Functional organization of sensory input to the olfactory bulb glomerulus analyzed by two-photon calcium imaging
    Matt Wachowiak
    Department of Biology, Boston University, 5 Cummington Street, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:9097-102. 2004
    ..Hence, sensory inputs to individual glomeruli are spatially heterogeneous but seem to be functionally indiscriminate. These results support the view of olfactory glomeruli as functional units in representing sensory information...

Research Grants3

  1. Dynamics of glomerular coding in the olfactory bulb
    DALE M WACHOWIAK; Fiscal Year: 2010
    ..Understanding this relationship could lead to new treatments for olfactory deficits or therapeutic approaches to improving odor or flavor perception in individuals with impaired nasal function. ..
  2. CRCNS: Active Sensing and Odor Processing in the Olfactory Bulb
    DALE M WACHOWIAK; Fiscal Year: 2010
    ....
  3. Dynamics of glomerular coding in the olfactory bulb
    DALE M WACHOWIAK; Fiscal Year: 2010
    ..Understanding this relationship could lead to new treatments for olfactory deficits or therapeutic approaches to improving odor or flavor perception in individuals with impaired nasal function. ..