Daniel E Voth

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates
    Daniel E Voth
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    J Bacteriol 193:1493-503. 2011
  2. pmc Bacterial Type IV secretion systems: versatile virulence machines
    Daniel E Voth
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Future Microbiol 7:241-57. 2012
  3. pmc Refining the plasmid-encoded type IV secretion system substrate repertoire of Coxiella burnetii
    Pauline Maturana
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Bacteriol 195:3269-76. 2013
  4. ncbi request reprint Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1
    Isabelle I Salles
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Microbiol 8:1272-81. 2006
  5. ncbi request reprint Variations in lethal toxin and cholesterol-dependent cytolysin production correspond to differences in cytotoxicity among strains of Clostridium sordellii
    Daniel E Voth
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    FEMS Microbiol Lett 259:295-302. 2006
  6. pmc Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
    Joseph G Graham
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA
    Cell Microbiol 15:1012-25. 2013
  7. pmc Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication
    Elaine E Hamm
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 103:14176-81. 2006
  8. pmc Coxiella burnetii alters cyclic AMP-dependent protein kinase signaling during growth in macrophages
    Laura J Macdonald
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Infect Immun 80:1980-6. 2012
  9. doi request reprint Coxiella subversion of intracellular host signaling
    S Kauser Hussain
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    Adv Exp Med Biol 984:131-40. 2012
  10. pmc Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation
    S Kauser Hussain
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences Little Rock, AR, USA
    Front Microbiol 1:137. 2010

Research Grants

Collaborators

  • Robert A Heinzen
  • S Kauser Hussain
  • Joseph G Graham
  • Laura J Macdonald
  • Uma M Sharma
  • Pauline Maturana
  • Richard C Kurten
  • Jimmy D Ballard
  • Elaine E Hamm
  • Isabelle I Salles
  • Laura J Broederdorf
  • Kenneth A Bradley
  • Kathleen M Averette
  • Rodney K Tweten
  • Sabrina C Ward

Detail Information

Publications13

  1. pmc The Coxiella burnetii cryptic plasmid is enriched in genes encoding type IV secretion system substrates
    Daniel E Voth
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    J Bacteriol 193:1493-503. 2011
    ..burnetii plasmid-encoded T4SS substrates play important roles in subversion of host cell functions, providing a plausible explanation for the absolute maintenance of plasmid genes by this pathogen...
  2. pmc Bacterial Type IV secretion systems: versatile virulence machines
    Daniel E Voth
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
    Future Microbiol 7:241-57. 2012
    ..In this review, we discuss the current state of T4SS research, with an emphasis on intracellular bacterial pathogens of humans and the diverse array of translocated effectors used to manipulate host cells...
  3. pmc Refining the plasmid-encoded type IV secretion system substrate repertoire of Coxiella burnetii
    Pauline Maturana
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Bacteriol 195:3269-76. 2013
    ..These results further support the idea of a critical role for extrachromosomal elements in C. burnetii pathogenesis. ..
  4. ncbi request reprint Cytotoxic activity of Bacillus anthracis protective antigen observed in a macrophage cell line overexpressing ANTXR1
    Isabelle I Salles
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Microbiol 8:1272-81. 2006
    ..Overall, results from the current study suggest that receptor levels dictate the extent of PA oligomer stability, and shifts in this normal process can lead to cell death via apoptosis in the absence of toxin catalytic subunits...
  5. ncbi request reprint Variations in lethal toxin and cholesterol-dependent cytolysin production correspond to differences in cytotoxicity among strains of Clostridium sordellii
    Daniel E Voth
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    FEMS Microbiol Lett 259:295-302. 2006
    ..However, supernatant from TcsL+, SDL- strains demonstrated a lower LD50 relative to TcsL-, SDL+ strains, suggesting the potential for severe C. sordellii-associated disease may be determined by the particular strain colonizing the host...
  6. pmc Virulent Coxiella burnetii pathotypes productively infect primary human alveolar macrophages
    Joseph G Graham
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA
    Cell Microbiol 15:1012-25. 2013
    ..burnetii. Collectively, the current results demonstrate the hAM model is a human disease-relevant platform for defining novel innate immune responses to C. burnetii...
  7. pmc Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication
    Elaine E Hamm
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 103:14176-81. 2006
    ....
  8. pmc Coxiella burnetii alters cyclic AMP-dependent protein kinase signaling during growth in macrophages
    Laura J Macdonald
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Infect Immun 80:1980-6. 2012
    ..Collectively, the current results suggest a versatile role for PKA in C. burnetii infection and indicate virulent organisms usurp host kinase cascades for efficient intracellular growth...
  9. doi request reprint Coxiella subversion of intracellular host signaling
    S Kauser Hussain
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    Adv Exp Med Biol 984:131-40. 2012
    ..Identification of bacterial factors that regulate signaling events will further our ability to model this intriguing infectious process...
  10. pmc Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation
    S Kauser Hussain
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences Little Rock, AR, USA
    Front Microbiol 1:137. 2010
    ..burnetii subverts numerous phosphorylation cascades. These results underscore the importance of intracellular host signaling for C. burnetii PV biogenesis...
  11. ncbi request reprint Bacillus anthracis oedema toxin as a cause of tissue necrosis and cell type-specific cytotoxicity
    Daniel E Voth
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Cell Microbiol 7:1139-49. 2005
    ..Collectively, these data suggest OT is cytotoxic in a cell-dependent manner and may contribute to disease through direct cell killing leading to tissue necrosis...
  12. ncbi request reprint Critical intermediate steps in Clostridium sordellii lethal toxin-induced apoptosis
    Daniel E Voth
    Department of Microbiology and Immunology, The University of Oklahoma Health Sciences Center, 975 N E 10th St, BRC 362A, Oklahoma City, OK 73104, USA
    Biochem Biophys Res Commun 363:959-64. 2007
    ..Collectively, these data provide insight into the cascade of signaling events that lead to apoptotic death of TcsL-intoxicated cells...
  13. pmc Clostridium difficile toxins: mechanism of action and role in disease
    Daniel E Voth
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Clin Microbiol Rev 18:247-63. 2005
    ..Collectively, the present review provides a comprehensive update on TcdA and TcdB's mechanism of action as well as the role of these toxins in disease...

Research Grants1

  1. Role of the Coxiella burnetii Cryptic Plasmid in Host Cell Parasitism
    Daniel E Voth; Fiscal Year: 2010
    ..burnetii and its host. The goals of the proposed research are to 1) characterize the interaction of C. burnetii plasmid-encoded Dot/Icm substrates with host proteins and 2) determine the role of the plasmid in pathogen virulence.) ..