Rhonda Voskuhl

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY
    Manda V Sasidhar
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Ann Rheum Dis 71:1418-22. 2012
  2. doi request reprint Sex-related factors in multiple sclerosis susceptibility and progression
    Rhonda R Voskuhl
    Department of Neurology, University of California Los Angeles, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Nat Rev Neurol 8:255-63. 2012
  3. pmc Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone
    Stefan M Gold
    Department of Neurology, Neuroscience Research Building 1, 635 Charles E, Young Drive South, University of California Los Angeles, CA 90095, USA
    J Neuroinflammation 5:32. 2008
  4. pmc Sex differences in autoimmune diseases
    Rhonda Voskuhl
    Professor, UCLA Dept, of Neurology, Jack H Skirball Chair for Multiple Sclerosis Research, Director, UCLA Multiple Sclerosis Program, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Biol Sex Differ 2:1. 2011
  5. ncbi request reprint Epitope spreading occurs in active but not passive EAE induced by myelin basic protein
    R R Voskuhl
    Laboratory of Viral and Molecular Pathogenesis, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    J Neuroimmunol 70:103-11. 1996
  6. ncbi request reprint Hormone-based therapies in MS
    R R Voskuhl
    UCLA Multiple Sclerosis Program, Department of Neurology, University of California Los Angeles, 710 Westwood Plaza, A145, Los Angeles, CA 90095, USA
    Int MS J 10:60-6. 2003
  7. ncbi request reprint Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice
    Rhonda R Voskuhl
    Reed Neurological Research Center, UCLA Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    J Neuroimmunol 139:44-50. 2003
  8. ncbi request reprint Gender issues and multiple sclerosis
    Rhonda R Voskuhl
    UCLA Department of Neurology, Reed Neurological Research Center, Room A 145, 710 Westwood Plaza, Los Angeles, CA 90024, USA
    Curr Neurol Neurosci Rep 2:277-86. 2002
  9. ncbi request reprint Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    R R Voskuhl
    Department of Neurology, University of California, Los Angeles 90095, USA
    Neuroscientist 7:258-70. 2001
  10. ncbi request reprint Myelin protein expression in lymphoid tissues: implications for peripheral tolerance
    R R Voskuhl
    Reed Neurological Research Center, UCLA Dept of Neurology 90024, USA
    Immunol Rev 164:81-92. 1998

Research Grants

  1. A Combination Trial of Copaxone Plus Estriol in RRMS
    Rhonda Voskuhl; Fiscal Year: 2009
  2. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2009
  3. Sex Chromosome Effects in Lupus
    Rhonda Voskuhl; Fiscal Year: 2007
  4. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2007
  5. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
  6. Role of sex chromosomes in gender differences in EAE
    Rhonda Voskuhl; Fiscal Year: 2004
  7. A Combination Trial of Copaxone Plus Estriol in RRMS
    Rhonda Voskuhl; Fiscal Year: 2009

Collaborators

Detail Information

Publications32

  1. doi request reprint The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY
    Manda V Sasidhar
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Ann Rheum Dis 71:1418-22. 2012
    ..This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis...
  2. doi request reprint Sex-related factors in multiple sclerosis susceptibility and progression
    Rhonda R Voskuhl
    Department of Neurology, University of California Los Angeles, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Nat Rev Neurol 8:255-63. 2012
    ....
  3. pmc Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone
    Stefan M Gold
    Department of Neurology, Neuroscience Research Building 1, 635 Charles E, Young Drive South, University of California Los Angeles, CA 90095, USA
    J Neuroinflammation 5:32. 2008
    ..Evidence from basic and clinical studies suggests that testosterone has an immunomodulatory as well as a potential neuroprotective effect that could be beneficial in MS...
  4. pmc Sex differences in autoimmune diseases
    Rhonda Voskuhl
    Professor, UCLA Dept, of Neurology, Jack H Skirball Chair for Multiple Sclerosis Research, Director, UCLA Multiple Sclerosis Program, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Biol Sex Differ 2:1. 2011
    ..First, it would lead to an insight into the major pathways of disease pathogenesis and, secondly, it would likely lead to novel treatments which would disrupt such pathways...
  5. ncbi request reprint Epitope spreading occurs in active but not passive EAE induced by myelin basic protein
    R R Voskuhl
    Laboratory of Viral and Molecular Pathogenesis, NINDS, National Institutes of Health, Bethesda, MD 20892, USA
    J Neuroimmunol 70:103-11. 1996
    ..Implications of these findings with regard to epitope spreading in MS are discussed...
  6. ncbi request reprint Hormone-based therapies in MS
    R R Voskuhl
    UCLA Multiple Sclerosis Program, Department of Neurology, University of California Los Angeles, 710 Westwood Plaza, A145, Los Angeles, CA 90095, USA
    Int MS J 10:60-6. 2003
    ..Oestrogens may be responsible, at least in part, for this protective effect. The potential use of oestrogens as therapy for MS is discussed...
  7. ncbi request reprint Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice
    Rhonda R Voskuhl
    Reed Neurological Research Center, UCLA Department of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    J Neuroimmunol 139:44-50. 2003
    ..However, there was a significant reduction in relapses in golli(+/-) mice vs. controls, suggesting a role for golli proteins in the relapses in EAE...
  8. ncbi request reprint Gender issues and multiple sclerosis
    Rhonda R Voskuhl
    UCLA Department of Neurology, Reed Neurological Research Center, Room A 145, 710 Westwood Plaza, Los Angeles, CA 90024, USA
    Curr Neurol Neurosci Rep 2:277-86. 2002
    ..Rationale for novel therapies in multiple sclerosis based on the protective roles of these sex hormones is presented...
  9. ncbi request reprint Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    R R Voskuhl
    Department of Neurology, University of California, Los Angeles 90095, USA
    Neuroscientist 7:258-70. 2001
    ..The decrease in disease severity during late pregnancy appears to be due at least in part to high levels of estriol, which characterize this time period...
  10. ncbi request reprint Myelin protein expression in lymphoid tissues: implications for peripheral tolerance
    R R Voskuhl
    Reed Neurological Research Center, UCLA Dept of Neurology 90024, USA
    Immunol Rev 164:81-92. 1998
    ....
  11. ncbi request reprint Onset of multiple sclerosis associated with anti-TNF therapy
    N L Sicotte
    Division of Brain Mapping, UCLA School of Medicine, Los Angeles, CA, USA
    Neurology 57:1885-8. 2001
    ..We report a patient with new onset MS closely associated with the initiation of anti-TNF therapy for juvenile rheumatoid arthritis. It is possible that the inhibition of TNF triggered MS in this individual...
  12. ncbi request reprint Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice
    M Ding
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 160:2560-4. 1998
    ..Thus, we have shown that the iNOS antisense ODN specifically blocked iNOS expression and ameliorated the induction of EAE...
  13. ncbi request reprint Mice resistant to experimental autoimmune encephalomyelitis have increased thymic expression of myelin basic protein and increased MBP specific T cell tolerance
    H Liu
    UCLA Dept. of Neurology, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    J Neuroimmunol 115:118-26. 2001
    ..Together, these data indicate that the list of non-MHC genes involved in susceptibility to autoimmune disease should include genes which regulate expression of autoantigens in thymi...
  14. ncbi request reprint Gender differences of inducible nitric oxide production in SJL/J mice with experimental autoimmune encephalomyelitis
    M Ding
    Department of Neurology, School of Medicine, University of California, Los Angeles 90095, USA
    J Neuroimmunol 77:99-106. 1997
    ..These data show an association between No production and EAE severity, suggesting a possible role of NO in the pathogenesis of EAE...
  15. ncbi request reprint Antisense blockade of inducible nitric oxide synthase in glial cells derived from adult SJL mice
    M Ding
    Department of Neurology, School of Medicine, University of California at Los Angeles, Reed Neurological Research Center 90095 1769, USA
    Neurosci Lett 220:89-92. 1996
    ..Sense and random S-oligo had no effect in any of these studies. These data indicate the efficacy and specificity of the antisense oligodeoxynucleotide approach in inhibiting iNOS in glial cells...
  16. pmc Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis
    J Wu
    Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Charles Young Drive South, Los Angeles, CA 90095, USA
    Neuroscience 156:586-96. 2008
    ..In addition, co-localization of MBP and the low-affinity neurotrophin receptor, p75, was demonstrated, further supporting the notion of apoptotic oligodendrocyte process degeneration in the gray matter of EAE mice...
  17. ncbi request reprint "Classic" myelin basic proteins are expressed in lymphoid tissue macrophages
    H Liu
    UCLA Department of Neurology, Reed Neurological Research Center, Los Angeles, CA 90095, USA
    J Neuroimmunol 116:83-93. 2001
    ..The expression of "classic" MBPs in lymphoid tissue macrophages raises the possibility that MBP-specific T cells may be exposed to autoantigen outside the central nervous system (CNS)...
  18. pmc Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease
    Sienmi Du
    UCLA Department of Physiological Sciences, Los Angeles, CA 90095, USA
    Eur J Immunol 41:140-50. 2011
    ..Our results demonstrate for the first time an effect of ER-β ligand treatment in vivo on DC in the target organ of a prototypic cell-mediated autoimmune disease...
  19. ncbi request reprint Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production
    S M Liva
    Department of Neurobiology, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 167:2060-7. 2001
    ..In vitro experiments demonstrated increased IL-10 production following treatment of CD4+ T lymphocytes with DHT. Thus, testosterone can act directly via androgen receptors on CD4+ T lymphocytes to increase IL-10 gene expression...
  20. ncbi request reprint Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders
    Stefan M Gold
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    Curr Opin Investig Drugs 7:625-30. 2006
    ..Further study of the therapeutic potential of testosterone is warranted in neurological and neuropsychiatric diseases...
  21. ncbi request reprint Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis
    Laurie Beth J Morales
    Multiple Sclerosis Program, Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 26:6823-33. 2006
    ..In conclusion, treatment with an ERalpha ligand is highly selective in vivo, mediating both anti-inflammatory and neuroprotective effects in EAE...
  22. ncbi request reprint Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease
    Hong Biao Liu
    Department of Neurology, Reed Neurological Research Center, University of California, Los Angeles, CA 90095, USA
    J Immunol 171:6936-40. 2003
    ..These findings are central to the design of selective ER modifiers which aim to target biologic responses in specific organ systems...
  23. ncbi request reprint Treatment of multiple sclerosis with the pregnancy hormone estriol
    Nancy L Sicotte
    Department of Neurology, Reed Neurological Research Center, University of California Los Angeles, Los Angeles, CA 90095, USA
    Ann Neurol 52:421-8. 2002
    ..This novel treatment strategy of using pregnancy doses of estriol in multiple sclerosis has relevance to other autoimmune diseases that also improve during pregnancy...
  24. ncbi request reprint Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    Karen M Palaszynski
    Department of Neurology, Reed Neurological Research Center, University of California Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90024, USA
    J Neuroimmunol 146:144-52. 2004
    ..These data provide a basis for the novel therapeutic use of supplemental testosterone for men with MS...
  25. ncbi request reprint Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    Karen M Palaszynski
    Department of Neurology, Reed Neurological Research Center, University of California School of Medicine, 750 Westwood Plaza, Los Angeles, CA 90095, USA
    J Neuroimmunol 149:84-9. 2004
    ..These data support a potential role for estriol treatment for men in addition to women with MS...
  26. pmc A role for sex chromosome complement in the female bias in autoimmune disease
    Deborah L Smith-Bouvier
    Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    J Exp Med 205:1099-108. 2008
    ..This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease...
  27. pmc Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment
    Seema Tiwari-Woodruff
    Multiple Sclerosis Program, Department of Neurology, David Geffen School of Medicine, University of California, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:14813-8. 2007
    ....
  28. ncbi request reprint Testosterone treatment in multiple sclerosis: a pilot study
    Nancy L Sicotte
    Division of Brain Mapping, Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Arch Neurol 64:683-8. 2007
    ..To study the effect of testosterone supplementation on men with multiple sclerosis (MS)...
  29. ncbi request reprint Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol
    Samantha S Soldan
    Department of Neurology, Reed Neurological Research Center, University of California School of Medicine, Los Angeles, CA 90095, USA
    J Immunol 171:6267-74. 2003
    ..Further study of oral estriol therapy is warranted in Th1-mediated autoimmune diseases with known improvement during pregnancy...
  30. ncbi request reprint Comparison of multiple sclerosis lesions at 1.5 and 3.0 Tesla
    Nancy L Sicotte
    Department of Neurology, Division of Brain Mapping, University of California Los Angeles, Los Angeles, CA, USA
    Invest Radiol 38:423-7. 2003
    ..To evaluate the relative sensitivity of MR scanning for multiple sclerosis (MS) at 1.5 Tesla (T) and 3.0 T using identical acquisition conditions, as is typical of multicenter clinical trials...
  31. ncbi request reprint A yin-yang effect between sex chromosome complement and sex hormones on the immune response
    Karen M Palaszynski
    Department of Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Endocrinology 146:3280-5. 2005
    ..This is the first experimental evidence of a compensatory yin-yang effect of sex chromosome complement and sex hormones on a biologic process...
  32. ncbi request reprint Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis
    Allan MacKenzie-Graham
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, 635 Charles Young Drive South, Los Angeles, CA 90095 1769, USA
    Neuroimage 32:1016-23. 2006
    ..The model described herein can now be used to investigate neuropathologic mechanisms that lead to the development of gray matter atrophy in this setting...

Research Grants19

  1. A Combination Trial of Copaxone Plus Estriol in RRMS
    Rhonda Voskuhl; Fiscal Year: 2009
    ..Safety measures (blood tests and gynecologic evaluations) will also be followed. The overall goal of this study will be the development of an oral treatment, estriol, for RRMS. ..
  2. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2009
    ..Together these proposed studies will greatly advance the understanding of the role of sex chromosomes on immune responses. ..
  3. Sex Chromosome Effects in Lupus
    Rhonda Voskuhl; Fiscal Year: 2007
    ..This disease was chosen in light of the 9:1 female preponderance of the human disease system lupus erythematosus. ..
  4. The Effect of Sex Chromosomes on Immune Responses
    Rhonda Voskuhl; Fiscal Year: 2007
    ..Together these proposed studies will greatly advance the understanding of the role of sex chromosomes on immune responses. ..
  5. Protective Effect of Pregnancy Doses of Estrogens in EAE
    Rhonda Voskuhl; Fiscal Year: 2005
    ..abstract_text> ..
  6. Role of sex chromosomes in gender differences in EAE
    Rhonda Voskuhl; Fiscal Year: 2004
    ..On the other hand, if immune measures differ between genotypes (XX vs. XY) within a given phenotype, we will conclude that gender differences in immune measures are due to both sex hormones and sex chromosomes. ..
  7. A Combination Trial of Copaxone Plus Estriol in RRMS
    Rhonda Voskuhl; Fiscal Year: 2009
    ..Safety measures (blood tests and gynecologic evaluations) will also be followed. The overall goal of this study will be the development of an oral treatment, estriol, for RRMS. ..