MARK E VON ZASTROW

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Role of endocytosis in signalling and regulation of G-protein-coupled receptors
    M von Zastrow
    Department of Psychiatry, University of California, San Francisco School of Medicine, Room LP A104, 401 Parnassus Avenue, San Francisco, CA 94143 90984, USA
    Biochem Soc Trans 29:500-4. 2001
  2. ncbi request reprint A cell biologist's perspective on physiological adaptation to opiate drugs
    Mark von Zastrow
    Department of Psychiatry, University of California, San Francisco, Room N212E Genentech Hall, 600 16th Street, San Francisco, CA 94143 2140, USA
    Neuropharmacology 47:286-92. 2004
  3. ncbi request reprint Opioid receptor regulation
    Mark von Zastrow
    Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143 2140, USA
    Neuromolecular Med 5:51-8. 2004
  4. ncbi request reprint Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway
    Mark von Zastrow
    Department of Psychiatry, University of California, San Francisco, Room N212E Genentech Hall, UCSF Mission Bay Campus, 600 16th Street, San Francisco, CA 94143 2140, USA
    Life Sci 74:217-24. 2003
  5. ncbi request reprint Signal transduction. A new thread in an intricate web
    M von Zastrow
    Departments of Psychiatry, University of California, San Francisco, CA 94143, USA
    Science 294:1845-7. 2001
  6. pmc Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes
    Aaron Marley
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e9325. 2010
  7. ncbi request reprint Chemical genetic engineering of G protein-coupled receptor kinase 2
    Denise M Kenski
    Chemistry and Chemical Biology Graduate Program, Department of Psychiatry, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:35051-61. 2005
  8. pmc The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis
    Elsa Noah N'Diaye
    Macrophage Biology Laboratory, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Mol Biol Cell 19:1252-60. 2008
  9. pmc Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling
    Aylin C Hanyaloglu
    University of California, San Francisco, CA 94143 2140, USA
    EMBO J 24:2265-83. 2005
  10. pmc SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane
    Benjamin E L Lauffer
    Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 190:565-74. 2010

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Role of endocytosis in signalling and regulation of G-protein-coupled receptors
    M von Zastrow
    Department of Psychiatry, University of California, San Francisco School of Medicine, Room LP A104, 401 Parnassus Avenue, San Francisco, CA 94143 90984, USA
    Biochem Soc Trans 29:500-4. 2001
    ..Progress towards understanding the mechanisms that control the specificity with which distinct GPCRs are sorted to specialized subpopulations of endocytic vesicles will be highlighted...
  2. ncbi request reprint A cell biologist's perspective on physiological adaptation to opiate drugs
    Mark von Zastrow
    Department of Psychiatry, University of California, San Francisco, Room N212E Genentech Hall, 600 16th Street, San Francisco, CA 94143 2140, USA
    Neuropharmacology 47:286-92. 2004
    ....
  3. ncbi request reprint Opioid receptor regulation
    Mark von Zastrow
    Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, CA 94143 2140, USA
    Neuromolecular Med 5:51-8. 2004
    ..They have also identified unexpected regulatory effects of opiate drugs that may be relevant to pharmacotherapy...
  4. ncbi request reprint Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway
    Mark von Zastrow
    Department of Psychiatry, University of California, San Francisco, Room N212E Genentech Hall, UCSF Mission Bay Campus, 600 16th Street, San Francisco, CA 94143 2140, USA
    Life Sci 74:217-24. 2003
    ....
  5. ncbi request reprint Signal transduction. A new thread in an intricate web
    M von Zastrow
    Departments of Psychiatry, University of California, San Francisco, CA 94143, USA
    Science 294:1845-7. 2001
    ..In a Perspective, von Zastrow and Mostov describe new work that identifies a protein called RGS-PX1 as the linchpin that connects signal transduction activated by G protein-coupled receptors with membrane trafficking events...
  6. pmc Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes
    Aaron Marley
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e9325. 2010
    ..Thus we asked if dysbindin regulates receptor number in non-neural cells, and further investigated the cellular basis of this regulation...
  7. ncbi request reprint Chemical genetic engineering of G protein-coupled receptor kinase 2
    Denise M Kenski
    Chemistry and Chemical Biology Graduate Program, Department of Psychiatry, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:35051-61. 2005
    ..These results suggest there is a difference in the GRK requirement for initial ligand-induced internalization of a G protein-coupled receptor compared with subsequent rounds of reinternalization...
  8. pmc The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis
    Elsa Noah N'Diaye
    Macrophage Biology Laboratory, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Mol Biol Cell 19:1252-60. 2008
    ..Identification of a negative regulator of GPCR clustering reveals a new function of ubiquitin-like proteins and highlights a cellular requirement for exquisite regulation of receptor dynamics...
  9. pmc Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling
    Aylin C Hanyaloglu
    University of California, San Francisco, CA 94143 2140, USA
    EMBO J 24:2265-83. 2005
    ..These studies identify a novel function of Hrs in a cargo-specific recycling mechanism, which is critical to controlling functional activity of the largest known family of signaling receptors...
  10. pmc SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane
    Benjamin E L Lauffer
    Program in Pharmaceutical Sciences and Pharmacogenomics, University of California San Francisco, San Francisco, CA 94158, USA
    J Cell Biol 190:565-74. 2010
    ..These results identify a discrete role of SNX27 in PDZ-directed recycling of a physiologically important signaling receptor, and extend the concept of cargo-specific molecular sorting in the recycling pathway...
  11. ncbi request reprint Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells
    Kyung Ah Kim
    Department of Psychiatry, University of California, San Francisco School of Medicine, San Francisco, California 94143 0984, USA
    J Neurosci 23:2075-85. 2003
    ....
  12. ncbi request reprint A novel sorting sequence in the beta2-adrenergic receptor switches recycling from default to the Hrs-dependent mechanism
    Aylin C Hanyaloglu
    Department of Psychiatry, University of California, San Francisco, California 94158, USA
    J Biol Chem 282:3095-104. 2007
    ....
  13. pmc Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion
    Y Joy Yu
    Program in Neuroscience, University of California at San Francisco, San Francisco, California 94158 2140, USA
    J Neurosci 30:11703-14. 2010
    ....
  14. ncbi request reprint Cargo regulates clathrin-coated pit dynamics
    Manojkumar A Puthenveedu
    Department of Psychiatry, University of California at San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Cell 127:113-24. 2006
    ....
  15. pmc Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions
    Robin M Shaw
    Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Cell 128:547-60. 2007
    ..These findings support an unanticipated mechanism for protein delivery to points of cell-cell contact...
  16. pmc Signaling on the endocytic pathway
    Mark von Zastrow
    Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California at San Francisco, N212E Genentech Hall, Box 2140, UCSF Mission Bay Campus, 600 16th Street, San Francisco, CA 94158, USA
    Curr Opin Cell Biol 19:436-45. 2007
    ..General principles of endosome-based signaling are beginning to emerge but, in many cases, the physiological significance of signaling on the endocytic pathway remains poorly understood...
  17. pmc DISC1 regulates primary cilia that display specific dopamine receptors
    Aaron Marley
    Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e10902. 2010
    ..We identified a role of DISC1 in the cell biology of primary cilia that display disease-relevant dopamine receptors...
  18. pmc Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway
    Guillermo A Yudowski
    Department of Psychiatry, University of California San Francisco, San Francisco, CA 94158, USA
    Mol Biol Cell 20:2774-84. 2009
    ..In contrast, net recycling measured over a longer time interval (10 to 30 min) was not detectably regulated by B2AR signaling. These results identify rapid regulation of a specific recycling pathway by a signaling receptor cargo...
  19. pmc Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes
    James N Hislop
    Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    J Biol Chem 284:19361-70. 2009
    ..We propose that ubiquitination or ubiquitination/deubiquitination cycling specifically regulates later proteolytic processing events required for destruction of the receptor's hydrophobic core...
  20. pmc Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications
    Mark von Zastrow
    Department of Psychiatry, N212E Genentech Hall, UCSF Mission Bay Campus, San Francisco, CA 94158 2140, USA
    Drug Alcohol Depend 108:166-71. 2010
    ..Two particular insights, which have emerged from pre-clinical studies, will be proposed for translational consideration...
  21. ncbi request reprint Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells
    Michelle Trester-Zedlitz
    Department of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Biochemistry 44:6133-43. 2005
    ....
  22. ncbi request reprint A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors
    Michael Tanowitz
    Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 2140, USA
    J Biol Chem 278:45978-86. 2003
    ....
  23. ncbi request reprint Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor
    Jennifer L Whistler
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California, San Francisco, Emeryville, California, USA
    Traffic 3:866-77. 2002
    ..Dissociation of two responses normally dependent on agonist binding indicates that the corresponding functions of an activated GPCR reflect different sets of changes in the receptor's conformation...
  24. ncbi request reprint Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes
    James N Hislop
    Department of Psychiatry, University of California, San Francisco, California 94143 2140, USA
    J Biol Chem 279:22522-31. 2004
    ....
  25. ncbi request reprint Identification of a novel endocytic recycling signal in the D1 dopamine receptor
    Gabriel A Vargas
    Departments of Psychiatry and Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 2140, USA
    J Biol Chem 279:37461-9. 2004
    ....
  26. ncbi request reprint Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes
    Michael Tanowitz
    Department of Psychiatry, University of California, San Francisco, California 94143 0984, USA
    J Biol Chem 277:50219-22. 2002
    ..These results demonstrate that ubiquitination of DOR is not required either for its ligand-induced endocytosis or for postendocytic trafficking to lysosomes...
  27. ncbi request reprint The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis
    Tracy T Cao
    Genentech Hall, Rm N212E, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2140, USA
    Mol Pharmacol 67:288-97. 2005
    ....
  28. ncbi request reprint Modulation of postendocytic sorting of G protein-coupled receptors
    Jennifer L Whistler
    Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, CA 94608, USA
    Science 297:615-20. 2002
    ..The GASP family of proteins may modulate lysosomal sorting and functional down-regulation of a variety of G protein-coupled receptors...
  29. ncbi request reprint Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons
    Helena Haberstock-Debic
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 2140, USA
    J Neurosci 23:4324-32. 2003
    ....
  30. ncbi request reprint Spatial regulation of Galphai protein signaling in clathrin-coated membrane microdomains containing GAIP
    Eric Elenko
    Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093 0651, USA
    Mol Pharmacol 64:11-20. 2003
    ..This constitutes a novel mechanism for regulation of Galpha signaling through spatial segregation of a GAP in clathrin-coated pits...
  31. pmc Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons
    Y Joy Yu
    Program in Neuroscience, University of California at San Francisco, San Francisco, California 94158 2140, USA
    J Neurosci 29:222-33. 2009
    ....
  32. pmc Engineered protein connectivity to actin mimics PDZ-dependent recycling of G protein-coupled receptors but not its regulation by Hrs
    Benjamin E L Lauffer
    Program in Pharmaceutical Sciences and Pharmacogenomics, Department of Psychiatry, University of California, San Francisco, California 94158 2140, USA
    J Biol Chem 284:2448-58. 2009
    ..These results suggest that actin connectivity is sufficient to mimic the core recycling activity of a GPCR-linked PDZbd but not its cellular regulation...
  33. pmc Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors
    Michael Tanowitz
    Department of Psychiatry, University of California, San Francisco, California 94158 2140, USA
    J Biol Chem 283:35614-21. 2008
    ..To our knowledge the present results are the first to establish a role of alternative RNA processing in specifying the post-endocytic sorting of G-protein-coupled receptors between divergent and functionally distinct membrane pathways...
  34. ncbi request reprint Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane
    Guillermo A Yudowski
    Department of Psychiatry, University of California San Francisco, 600 16th Street, San Francisco, California 94143, USA
    Nat Neurosci 9:622-7. 2006
    ..These results reveal a new mechanism for homeostatic regulation of postsynaptic signaling and a 'kiss-and-wait' mode of regulated membrane protein insertion in neurons...
  35. ncbi request reprint Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs
    Mark von Zastrow
    UCSF Mission Bay, 600 16th Street, San Francisco, CA 941430 2140, USA
    Curr Opin Neurobiol 13:348-53. 2003
    ..However, the functional roles that these mechanisms play in the complex physiological adaptation of the intact nervous system to opiates are only beginning to be explored...
  36. ncbi request reprint Endocytosis of neurotransmitter receptors: location matters
    Manojkumar A Puthenveedu
    Department of Psychiatry and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Cell 130:988-9. 2007
    ....
  37. ncbi request reprint Identification of protein interactions by yeast two-hybrid screening and coimmunoprecipitation
    Michael Tanowitz
    Department of Psychiatry, University of California, San Francisco, USA
    Methods Mol Biol 259:353-69. 2004
    ..Together, the yeast two-hybrid screen and coimmunoprecipitation are a useful way to identify and sort through candidate GPCR-interacting proteins prior to analysis in physiological studies...
  38. ncbi request reprint Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons
    Helena Haberstock-Debic
    Department of Psychiatry, University of California, San Francisco, California 94143, USA
    J Neurosci 25:7847-57. 2005
    ..They also suggest a cellular mechanism by which beta-arrestins may modulate the physiological effects of morphine in vivo...
  39. pmc Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors
    Guillermo A Yudowski
    Department of Psychiatry, University of California at San Francisco, San Francisco, California 94158, USA
    J Neurosci 27:11112-21. 2007
    ....
  40. pmc Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder
    Holly A Garriock
    Department of Psychiatry, University of California, San Francisco, CA 94143 0984, USA
    Am J Psychiatry 167:565-73. 2010
    ....