Research Topics
| FREDERICK VOM SAALSummaryAffiliation: University of Missouri Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Could hormone residues be involved?Frederick S vom Saal
Division of Biological Sciences, University of Missouri, 105 Lefevre Hall, Columbia, MO 65211, USA
Hum Reprod 22:1503-5. 2007- Bisphenol A eliminates brain and behavior sex dimorphisms in mice: how low can you go?Frederick S vom Saal
Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
Endocrinology 147:3679-80. 2006 - Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol AFrederick S vom Saal
Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
Environ Res 100:50-76. 2006..We discuss the importance of appropriate controls in toxicological research and that positive controls are required to determine whether conclusions from experiments that report no significant effects are valid or false... 
An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessmentFrederick S vom Saal
Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
Environ Health Perspect 113:926-33. 2005....- Commercial animal feed: variability in estrogenic activity and effects on body weight in miceFrederick S vom Saal
Division of Biological Sciences, University of Missouri--Columbia, Columbia, Missouri 65211, USA
Birth Defects Res A Clin Mol Teratol 73:474-5. 2005 - The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol AFrederick S vom Saal
Division of Biological Sciences, 105 Lefevre Hall, University of Missouri Columbia, Columbia, MO 65211, USA
Birth Defects Res A Clin Mol Teratol 73:140-5. 2005.... - The plastic world: sources, amounts, ecological impacts and effects on development, reproduction, brain and behavior in aquatic and terrestrial animals and humansFrederick S vom Saal
Division of Biological Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA
Environ Res 108:127-30. 2008 - No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female miceJulia A Taylor
Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
Reprod Toxicol 25:169-76. 2008..Therefore the large numbers of BPA studies that used non-oral administration at very low doses during the neonatal period should not be dismissed by scientists or the regulatory community based on route of administration... - Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activityWade V Welshons
Department of Veterinary Biomedical Sciences, Columbia, MO, USA
Environ Health Perspect 111:994-1006. 2003.... - Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cellsCatherine A Richter
Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Environ Health Perspect 115:902-8. 2007.... - Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposureWade V Welshons
Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
Endocrinology 147:S56-69. 2006.... - Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 miceRachel L Ruhlen
Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
Environ Health Perspect 116:322-8. 2008..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful... - Bisphenol A is released from used polycarbonate animal cages into water at room temperatureKembra L Howdeshell
Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
Environ Health Perspect 111:1180-7. 2003..Our findings suggest that laboratory animals maintained in polycarbonate and polysulfone cages are exposed to BPA via leaching, with exposure reaching the highest levels in old cages... 
A new 'crowded uterine horn' mouse model for examining the relationship between foetal growth and adult obesityBenjamin L Coe
Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
Basic Clin Pharmacol Toxicol 102:162-7. 2008....- Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposureFrederick S vom Saal
Reprod Toxicol 24:131-8. 2007 - Effects of developmental exposure to bisphenol A on brain and behavior in micePaola Palanza
Dipartimento di Biologia Evolutiva e Funzionale, University of Parma, Viale Usberti 11A, 43100 Parma, Italy
Environ Res 108:150-7. 2008..These findings, together with those from other laboratories, are evidence of long-term consequences of maternal exposure to low-dose BPA at the level of neurobehavioral development... - Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in micePaola L Palanza
Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy
Environ Health Perspect 110:415-22. 2002..The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior... - Exposure assessment for endocrine disruptors: some considerations in the design of studiesCarol Rice
Environmental and Industrial Hygiene Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
Environ Health Perspect 111:1683-90. 2003..A number of issues that must be considered in study design are summarized here... - Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethraBarry G Timms
Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 57069, USA
Proc Natl Acad Sci U S A 102:7014-9. 2005..Acceleration in the rate of proliferation of prostate epithelium during fetal life by small amounts of estrogenic chemicals could permanently disrupt cellular control systems and predispose the prostate to disease in adulthood... - Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: a response to attempts to mislead the publicFrederick S vom Saal
Toxicology 212:244-52, author reply 253-4. 2005 - Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive responseLennart Weltje
Department of Ecology and Evolution Ecotoxicology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
Hum Exp Toxicol 24:431-7. 2005.... - Meeting report: batch-to-batch variability in estrogenic activity in commercial animal diets--importance and approaches for laboratory animal researchJerrold J Heindel
Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 116:389-93. 2008..This will require laboratory animal diet manufacturers to provide investigators with information regarding the phytoestrogen content and other estrogenic compounds in commercial diets used in animal research... - Bisphenol A and risk of metabolic disordersFrederick S vom Saal
JAMA 300:1353-5. 2008 - In vivo effects of bisphenol A in laboratory rodent studiesCatherine A Richter
U S Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States
Reprod Toxicol 24:199-224. 2007..We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system... - 2,3,7,8-tetrachlorodibenzo-p-dioxin interacts with endogenous estradiol to disrupt prostate gland morphogenesis in male rat fetusesBarry G Timms
Division of Basic Biomedical Sciences, School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
Toxicol Sci 67:264-74. 2002..In addition, these TCDD effects may be mediated in part by a decrease in serum estradiol levels...
Research Grants
- Developmental toxicity of environmental chemicalsFREDERICK VOM SAAL; Fiscal Year: 2006..5a-reductase activity will be determined by radiometric assay. ..