FREDERICK VOM SAAL

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. pmc Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice
    Rachel L Ruhlen
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 116:322-8. 2008
  2. pmc Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells
    Catherine A Richter
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 115:902-8. 2007
  3. pmc Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia, MO, United States Electronic address
    Reprod Toxicol 45:105-16. 2014
  4. ncbi request reprint The plastic world: sources, amounts, ecological impacts and effects on development, reproduction, brain and behavior in aquatic and terrestrial animals and humans
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Environ Res 108:127-30. 2008
  5. ncbi request reprint Could hormone residues be involved?
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, 105 Lefevre Hall, Columbia, MO 65211, USA
    Hum Reprod 22:1503-5. 2007
  6. ncbi request reprint Bisphenol A eliminates brain and behavior sex dimorphisms in mice: how low can you go?
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Endocrinology 147:3679-80. 2006
  7. ncbi request reprint Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Environ Res 100:50-76. 2006
  8. pmc An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Environ Health Perspect 113:926-33. 2005
  9. ncbi request reprint Commercial animal feed: variability in estrogenic activity and effects on body weight in mice
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Birth Defects Res A Clin Mol Teratol 73:474-5. 2005
  10. ncbi request reprint The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, 105 Lefevre Hall, University of Missouri Columbia, Columbia, MO 65211, USA
    Birth Defects Res A Clin Mol Teratol 73:140-5. 2005

Research Grants

  1. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2002
  2. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2003
  3. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2004
  4. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2005
  5. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2006
  6. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2005

Detail Information

Publications27

  1. pmc Low phytoestrogen levels in feed increase fetal serum estradiol resulting in the "fetal estrogenization syndrome" and obesity in CD-1 mice
    Rachel L Ruhlen
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 116:322-8. 2008
    ..Although estrogenic chemicals can disrupt development of the reproductive system, there is debate about whether phytoestrogens in soy are beneficial, benign, or harmful...
  2. pmc Estradiol and Bisphenol A stimulate androgen receptor and estrogen receptor gene expression in fetal mouse prostate mesenchyme cells
    Catherine A Richter
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Environ Health Perspect 115:902-8. 2007
    ....
  3. pmc Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia, MO, United States Electronic address
    Reprod Toxicol 45:105-16. 2014
    ..We report elsewhere that there were numerous adverse effects on fetuses exposed to very low serum dBPA in these studies. ..
  4. ncbi request reprint The plastic world: sources, amounts, ecological impacts and effects on development, reproduction, brain and behavior in aquatic and terrestrial animals and humans
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Environ Res 108:127-30. 2008
  5. ncbi request reprint Could hormone residues be involved?
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, 105 Lefevre Hall, Columbia, MO 65211, USA
    Hum Reprod 22:1503-5. 2007
  6. ncbi request reprint Bisphenol A eliminates brain and behavior sex dimorphisms in mice: how low can you go?
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Endocrinology 147:3679-80. 2006
  7. ncbi request reprint Large effects from small exposures. II. The importance of positive controls in low-dose research on bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Environ Res 100:50-76. 2006
    ..We discuss the importance of appropriate controls in toxicological research and that positive controls are required to determine whether conclusions from experiments that report no significant effects are valid or false...
  8. pmc An extensive new literature concerning low-dose effects of bisphenol A shows the need for a new risk assessment
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Environ Health Perspect 113:926-33. 2005
    ....
  9. ncbi request reprint Commercial animal feed: variability in estrogenic activity and effects on body weight in mice
    Frederick S vom Saal
    Division of Biological Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Birth Defects Res A Clin Mol Teratol 73:474-5. 2005
  10. ncbi request reprint The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A
    Frederick S vom Saal
    Division of Biological Sciences, 105 Lefevre Hall, University of Missouri Columbia, Columbia, MO 65211, USA
    Birth Defects Res A Clin Mol Teratol 73:140-5. 2005
    ....
  11. ncbi request reprint Large effects from small exposures. III. Endocrine mechanisms mediating effects of bisphenol A at levels of human exposure
    Wade V Welshons
    Department of Biomedical Sciences, E102 Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211 5120, USA
    Endocrinology 147:S56-69. 2006
    ....
  12. pmc Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity
    Wade V Welshons
    Department of Veterinary Biomedical Sciences, Columbia, MO, USA
    Environ Health Perspect 111:994-1006. 2003
    ....
  13. pmc No effect of route of exposure (oral; subcutaneous injection) on plasma bisphenol A throughout 24h after administration in neonatal female mice
    Julia A Taylor
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Reprod Toxicol 25:169-76. 2008
    ..Therefore the large numbers of BPA studies that used non-oral administration at very low doses during the neonatal period should not be dismissed by scientists or the regulatory community based on route of administration...
  14. pmc Bisphenol A is released from used polycarbonate animal cages into water at room temperature
    Kembra L Howdeshell
    Division of Biological Sciences, University of Missouri, Columbia, Missouri, USA
    Environ Health Perspect 111:1180-7. 2003
    ..Our findings suggest that laboratory animals maintained in polycarbonate and polysulfone cages are exposed to BPA via leaching, with exposure reaching the highest levels in old cages...
  15. doi request reprint A new 'crowded uterine horn' mouse model for examining the relationship between foetal growth and adult obesity
    Benjamin L Coe
    Division of Biological Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
    Basic Clin Pharmacol Toxicol 102:162-7. 2008
    ....
  16. pmc Exposure to a low dose of bisphenol A during fetal life or in adulthood alters maternal behavior in mice
    Paola L Palanza
    Department of Evolutionary and Functional Biology, Parma University, Parco Area delle Scienze 11A, 43100 Parma, Italy
    Environ Health Perspect 110:415-22. 2002
    ..The changes seen in maternal behavior may be the result of a direct effect of BPA on the neuroendocrine substrates underlying the initiation of maternal behavior...
  17. ncbi request reprint Effects of developmental exposure to bisphenol A on brain and behavior in mice
    Paola Palanza
    Dipartimento di Biologia Evolutiva e Funzionale, University of Parma, Viale Usberti 11A, 43100 Parma, Italy
    Environ Res 108:150-7. 2008
    ..These findings, together with those from other laboratories, are evidence of long-term consequences of maternal exposure to low-dose BPA at the level of neurobehavioral development...
  18. ncbi request reprint Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: a response to attempts to mislead the public
    Frederick S vom Saal
    Toxicology 212:244-52, author reply 253-4. 2005
  19. pmc Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure
    Frederick S vom Saal
    Reprod Toxicol 24:131-8. 2007
  20. pmc Exposure assessment for endocrine disruptors: some considerations in the design of studies
    Carol Rice
    Environmental and Industrial Hygiene Division, University of Cincinnati, Cincinnati, Ohio 45267, USA
    Environ Health Perspect 111:1683-90. 2003
    ..A number of issues that must be considered in study design are summarized here...
  21. pmc Estrogenic chemicals in plastic and oral contraceptives disrupt development of the fetal mouse prostate and urethra
    Barry G Timms
    Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, SD 57069, USA
    Proc Natl Acad Sci U S A 102:7014-9. 2005
    ..Acceleration in the rate of proliferation of prostate epithelium during fetal life by small amounts of estrogenic chemicals could permanently disrupt cellular control systems and predispose the prostate to disease in adulthood...
  22. ncbi request reprint Reproductive stimulation by low doses of xenoestrogens contrasts with the view of hormesis as an adaptive response
    Lennart Weltje
    Department of Ecology and Evolution Ecotoxicology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Hum Exp Toxicol 24:431-7. 2005
    ....
  23. pmc In vivo effects of bisphenol A in laboratory rodent studies
    Catherine A Richter
    U S Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States
    Reprod Toxicol 24:199-224. 2007
    ..We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system...
  24. pmc Meeting report: batch-to-batch variability in estrogenic activity in commercial animal diets--importance and approaches for laboratory animal research
    Jerrold J Heindel
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Environ Health Perspect 116:389-93. 2008
    ..This will require laboratory animal diet manufacturers to provide investigators with information regarding the phytoestrogen content and other estrogenic compounds in commercial diets used in animal research...
  25. doi request reprint Bisphenol A and risk of metabolic disorders
    Frederick S vom Saal
    JAMA 300:1353-5. 2008
  26. ncbi request reprint 2,3,7,8-tetrachlorodibenzo-p-dioxin interacts with endogenous estradiol to disrupt prostate gland morphogenesis in male rat fetuses
    Barry G Timms
    Division of Basic Biomedical Sciences, School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA
    Toxicol Sci 67:264-74. 2002
    ..In addition, these TCDD effects may be mediated in part by a decrease in serum estradiol levels...

Research Grants6

  1. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2002
    ..5a-reductase activity will be determined by radiometric assay. ..
  2. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2003
    ..5a-reductase activity will be determined by radiometric assay. ..
  3. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2004
    ..5a-reductase activity will be determined by radiometric assay. ..
  4. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2005
    ..5a-reductase activity will be determined by radiometric assay. ..
  5. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2006
    ..5a-reductase activity will be determined by radiometric assay. ..
  6. Developmental toxicity of environmental chemicals
    FREDERICK VOM SAAL; Fiscal Year: 2005
    ..5a-reductase activity will be determined by radiometric assay. ..