Michael Volkert

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function
    Kenan C Murphy
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    BMC Mol Biol 13:26. 2012
  2. ncbi The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins
    Mathieu Durand
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    BMC Cell Biol 8:13. 2007
  3. ncbi The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage
    Jen Yeu Wang
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655
    Mol Cell Biol 24:6084-93. 2004
  4. ncbi Transcriptional responses to DNA damage
    M R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Microbiol 4:178-85. 2001
  5. ncbi Functional genomics reveals a family of eukaryotic oxidation protection genes
    M R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 97:14530-5. 2000
  6. ncbi The Escherichia coli methyl-directed mismatch repair system repairs base pairs containing oxidative lesions
    Jennifer Wyrzykowski
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Bacteriol 185:1701-4. 2003
  7. ncbi Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide
    Zdenka Matijasevic
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue, North Worcester, MA 01655, United States
    DNA Repair (Amst) 6:733-41. 2007
  8. ncbi A functional genomics approach to identify and characterize oxidation resistance genes
    Michael R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 477:331-42. 2008
  9. ncbi Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans
    Nathan A Elliott
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cell Biol 24:3180-7. 2004
  10. ncbi Alkylation resistance of E. coli cells expressing different isoforms of human alkyladenine DNA glycosylase (hAAG)
    Kenneth Bonanno
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    DNA Repair (Amst) 1:507-16. 2002

Research Grants

  1. FUNCTION AND REGULATION OF THE E COLI AIDB GENES
    Michael Volkert; Fiscal Year: 2002
  2. HUMAN OXIDATION RESISTANCE GENES
    Michael Volkert; Fiscal Year: 2007

Collaborators

  • Kenan C Murphy
  • P Landini
  • Zdenka Matijasevic
  • Nathan A Elliott
  • Jennifer Wyrzykowski
  • Mathieu Durand
  • Xiaozhen Liang
  • Jen Yeu Wang
  • Kenneth Bonanno
  • Myles Brown
  • Wenlin Shao
  • Timothy Farrell
  • Adrianne Kolpak
  • Heesoon Chang
  • Mary T Pickering
  • Jae U Jung
  • Timothy F Kowalik
  • Nam-Hyuk Cho
  • Nam Hyuk Cho
  • Altaf Hossain Sarker
  • Jen-Yeu Wang
  • Priscilla K Cooper
  • Wincha Chong

Detail Information

Publications11

  1. ncbi Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function
    Kenan C Murphy
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655, USA
    BMC Mol Biol 13:26. 2012
    ..Multiple spliced isoforms are expressed in a variety of human tissues, including brain...
  2. ncbi The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins
    Mathieu Durand
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    BMC Cell Biol 8:13. 2007
    ..We also examine NCOA7 expression in response to oxidative stress and its subcellular localization in human cells, comparing these properties with those of OXR1...
  3. ncbi The single-strand DNA binding activity of human PC4 prevents mutagenesis and killing by oxidative DNA damage
    Jen Yeu Wang
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655
    Mol Cell Biol 24:6084-93. 2004
    ..We discuss the possible requirement for PC4 in either global or transcription-coupled repair of oxidative DNA damage to mediate the release of XPG bound to its substrate...
  4. ncbi Transcriptional responses to DNA damage
    M R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Opin Microbiol 4:178-85. 2001
    ..Transcription of the responses to DNA damage are induced when the activated regulatory proteins stimulate transcription of the genes they control by a variety of complex and unique molecular mechanisms...
  5. ncbi Functional genomics reveals a family of eukaryotic oxidation protection genes
    M R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 97:14530-5. 2000
    ..This procedure makes use of the spontaneous mutator phenotype of E. coli oxidative repair-deficient mutants and identifies genes of interest by screening for antimutator activity resulting from cDNA expression...
  6. ncbi The Escherichia coli methyl-directed mismatch repair system repairs base pairs containing oxidative lesions
    Jennifer Wyrzykowski
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Bacteriol 185:1701-4. 2003
    ..These findings demonstrate that MMR has the ability to prevent oxidative mutagenesis either by removing 8-oxoG directly or by removing adenine misincorporated opposite 8-oxoG or both...
  7. ncbi Base excision repair sensitizes cells to sulfur mustard and chloroethyl ethyl sulfide
    Zdenka Matijasevic
    Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue, North Worcester, MA 01655, United States
    DNA Repair (Amst) 6:733-41. 2007
    ..Possible mechanisms for BER-mediated sensitization by glycosylase action on mustard lesions are discussed...
  8. ncbi A functional genomics approach to identify and characterize oxidation resistance genes
    Michael R Volkert
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    Methods Mol Biol 477:331-42. 2008
    ..Methods to determine the localization of genes in their normal host organism are also described...
  9. ncbi Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans
    Nathan A Elliott
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cell Biol 24:3180-7. 2004
    ..We also demonstrate that mitochondrial localization is required for Oxr1 protein to prevent oxidative damage...
  10. ncbi Alkylation resistance of E. coli cells expressing different isoforms of human alkyladenine DNA glycosylase (hAAG)
    Kenneth Bonanno
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    DNA Repair (Amst) 1:507-16. 2002
    ..We also demonstrate that there are no apparent differences between the two isoforms of hAAG when recovery from damage produced by all alkylating agents is tested...
  11. ncbi Deregulation of DNA damage signal transduction by herpesvirus latency-associated M2
    Xiaozhen Liang
    Department of Microbiology and Molecular Genetics, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    J Virol 80:5862-74. 2006
    ..Our results suggest that gammaHV68 M2 blocks apoptosis-mediated intracellular innate immunity, which might ultimately contribute to its role in latent infection...

Research Grants8

  1. FUNCTION AND REGULATION OF THE E COLI AIDB GENES
    Michael Volkert; Fiscal Year: 2002
    ..During the proposed funding period, I propose to characterize this factor further by genetic and biochemical means and to compare its induction mechanism with that of meAda. ..
  2. HUMAN OXIDATION RESISTANCE GENES
    Michael Volkert; Fiscal Year: 2007
    ..abstract_text> ..