David W Volk

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Early developmental disturbances of cortical inhibitory neurons: contribution to cognitive deficits in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA
    Schizophr Bull 40:952-7. 2014
  2. pmc Endocannabinoid metabolism in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Schizophr Res 147:53-7. 2013
  3. pmc Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Am J Psychiatry 169:1082-91. 2012
  4. pmc Cortical opioid markers in schizophrenia and across postnatal development
    David W Volk
    Department of Psychiatry, University of Pittsburgh, W1655 BST, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 22:1215-23. 2012
  5. ncbi request reprint Prefrontal cortical circuits in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, BST W1653, Pittsburgh, PA 15213, USA
    Curr Top Behav Neurosci 4:485-508. 2010
  6. pmc Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
  7. ncbi request reprint Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
  8. pmc Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Jaime G Maldonado-Aviles
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:450-9. 2009
  9. ncbi request reprint GABA neurons in the human prefrontal cortex
    Carol Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1764. 2004
  10. pmc Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia
    Allison A Curley
    Department of Psychiatry, W1653 Biomedical Science Tower, 200 Lothrop St University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurobiol Dis 50:179-86. 2013

Research Grants

Collaborators

Detail Information

Publications18

  1. pmc Early developmental disturbances of cortical inhibitory neurons: contribution to cognitive deficits in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA
    Schizophr Bull 40:952-7. 2014
    ....
  2. pmc Endocannabinoid metabolism in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Schizophr Res 147:53-7. 2013
    ..Higher ABHD6 mRNA levels may increase 2-AG metabolism which may influence susceptibility to cannabis in the earlier stages of schizophrenia...
  3. pmc Deficits in transcriptional regulators of cortical parvalbumin neurons in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA
    Am J Psychiatry 169:1082-91. 2012
    ..The authors investigated whether Lhx6 and/or Sox6 mRNA levels are deficient in schizophrenia, which may contribute to cell type-specific disturbances in cortical parvalbumin and somatostatin neurons...
  4. pmc Cortical opioid markers in schizophrenia and across postnatal development
    David W Volk
    Department of Psychiatry, University of Pittsburgh, W1655 BST, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Cereb Cortex 22:1215-23. 2012
    ..In schizophrenia, higher MOR mRNA levels may contribute to suppressed PFC GABA neuron activity and might be attributable to alterations in the postnatal developmental trajectory of MOR signaling...
  5. ncbi request reprint Prefrontal cortical circuits in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, BST W1653, Pittsburgh, PA 15213, USA
    Curr Top Behav Neurosci 4:485-508. 2010
    ..Increasing knowledge of the nature of the molecular alterations in these cortical circuits may lead to the development of new pathophysiologically informed treatment options for cognitive deficits in schizophrenia...
  6. pmc Alterations in metabotropic glutamate receptor 1α and regulator of G protein signaling 4 in the prefrontal cortex in schizophrenia
    David W Volk
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:1489-98. 2010
    ..The status of endocannabinoid ligands, such as 2-arachidonoylglycerol, can be inferred in part through measures of diacylglycerol lipase and monoglyceride lipase, which synthesize and degrade 2-arachidonoylglycerol, respectively...
  7. ncbi request reprint Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
    Takanori Hashimoto
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:6315-26. 2003
    ....
  8. pmc Altered markers of tonic inhibition in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Jaime G Maldonado-Aviles
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara St, W1651 BST, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:450-9. 2009
    ..The authors assessed the expression of GABA(A) receptor alpha4 and delta subunits, which coassemble to form receptors mediating tonic inhibition, in schizophrenia...
  9. ncbi request reprint GABA neurons in the human prefrontal cortex
    Carol Tamminga
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1764. 2004
  10. pmc Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia
    Allison A Curley
    Department of Psychiatry, W1653 Biomedical Science Tower, 200 Lothrop St University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurobiol Dis 50:179-86. 2013
    ..Together, these findings suggest that the correlated decrements in cortical GAD67, PV and GAT1 mRNAs in schizophrenia may be a common consequence of some other upstream factor...
  11. ncbi request reprint Selective alterations in prefrontal cortical GABA neurotransmission in schizophrenia: a novel target for the treatment of working memory dysfunction
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, W1651 BST, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 174:143-50. 2004
    ....
  12. pmc Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:57-67. 2012
    ..This compensation is thought to rebalance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control...
  13. pmc Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia
    Stephen M Eggan
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 71:114-9. 2012
    ..However, whether this correlation reflects a cause-effect relationship is unknown...
  14. ncbi request reprint Impaired prefrontal inhibition in schizophrenia: relevance for cognitive dysfunction
    David W Volk
    Department of Neuroscience, University of Pittsburgh, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:501-5. 2002
    ..Selective disruptions in inhibitory neurotransmission are likely to distort aspects of pyramidal neuron function important for working memory tasks, and thus may contribute to cognitive dysfunction in schizophrenia...
  15. ncbi request reprint Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
    ..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
  16. ncbi request reprint Effects of a mediodorsal thalamus lesion on prefrontal inhibitory circuitry: implications for schizophrenia
    David W Volk
    Department of Neuroscience, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 53:385-9. 2003
    ....
  17. pmc Elevated viral restriction factor levels in cortical blood vessels in schizophrenia
    Benjamin I Siegel
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania
    Biol Psychiatry 76:160-7. 2014
    ..However, the cell types that overexpress IFITM messenger RNA (mRNA) in schizophrenia are unknown, and it is unclear whether higher IFITM mRNA levels are associated with lower GABA-related marker levels in the same schizophrenia subjects...
  18. ncbi request reprint Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia
    David W Volk
    Department of Neuroscience, University of Pittsburgh, PA 15260, USA
    Cereb Cortex 12:1063-70. 2002
    ..Thus, disturbances in inhibition at the chandelier neuron-pyramidal neuron synapse may be a critical component of prefrontal cortical dysfunction in schizophrenia...

Research Grants1

  1. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003
    ..After a 3 month survival period, we will quantify any changes in the mRNA expression of PFC GABA markers using in situ hybridization and grain counting techniques. ..