Denys V Volgin

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6046, USA Electronic address
    Respir Physiol Neurobiol 188:301-7. 2013
  2. pmc Reduced sleep and impaired sleep initiation in adult male rats exposed to alcohol during early postnatal period
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 234:38-42. 2012
  3. pmc Dorsomedial pontine neurons with descending projections to the medullary reticular formation express orexin-1 and adrenergic alpha2A receptor mRNA
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Lett 459:115-8. 2009
  4. pmc Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol
    Denys V Volgin
    Department of Animal Biology, 209E VET, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Neurosci Lett 439:182-6. 2008
  5. pmc Regionally selective effects of GABA on hypothalamic GABAA receptor mRNA in vitro
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    Biochem Biophys Res Commun 353:726-32. 2007
  6. ncbi Postnatal development of serotonin 1B, 2 A and 2C receptors in brainstem motoneurons
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    Eur J Neurosci 17:1179-88. 2003
  7. pmc Loss of motoneurons in the ventral compartment of the rat hypoglossal nucleus following early postnatal exposure to alcohol
    Georg M Stettner
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    J Chem Neuroanat 52:87-94. 2013
  8. ncbi Single-cell RT-PCR gene expression profiling of acutely dissociated and immunocytochemically identified central neurons
    Denys V Volgin
    Department of Animal Biology 209E VET, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    J Neurosci Methods 136:229-36. 2004
  9. pmc Hypoglossal premotor neurons of the intermediate medullary reticular region express cholinergic markers
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104 6046, USA
    J Appl Physiol (1985) 105:1576-84. 2008
  10. ncbi Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
    Neuroreport 13:433-6. 2002

Detail Information

Publications16

  1. pmc Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6046, USA Electronic address
    Respir Physiol Neurobiol 188:301-7. 2013
    ..Conversely, reduced levels of 5-HT2A receptors during the rest-sleep period may exacerbate the propensity for sleep-disordered breathing in subjects with anatomically compromised upper airway...
  2. pmc Reduced sleep and impaired sleep initiation in adult male rats exposed to alcohol during early postnatal period
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 234:38-42. 2012
    ..Our data demonstrate that, in a rat model of prenatal AE, impaired sleep-wake behavior persists into the adulthood. Disordered sleep may exacerbate cognitive and behavioral disorders seen in human victims of prenatal AE...
  3. pmc Dorsomedial pontine neurons with descending projections to the medullary reticular formation express orexin-1 and adrenergic alpha2A receptor mRNA
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurosci Lett 459:115-8. 2009
    ..Our data suggest that ORX and adrenergic pathways converge on a subpopulation of cells of the pontine REM sleep-triggering region that have descending projections to the medullary region important for the motor control during REM sleep...
  4. pmc Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABA A receptors and increases behavioral sensitivity to gaboxadol
    Denys V Volgin
    Department of Animal Biology, 209E VET, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Neurosci Lett 439:182-6. 2008
    ..Thus, perinatal AE leads to GABA A receptor overexpression in the vigilance- and motor activity-promoting hypothalamic PF region, with the neurochemical and functional outcomes lasting long beyond the period of the insult...
  5. pmc Regionally selective effects of GABA on hypothalamic GABAA receptor mRNA in vitro
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    Biochem Biophys Res Commun 353:726-32. 2007
    ..We conclude that, in the PF region where GABA facilitates sleep, increased GABA release may limit GABAAR-mediated inhibition, whereas in the DM region, GABA-induced changes are mainly mediated by non-GABAA receptors...
  6. ncbi Postnatal development of serotonin 1B, 2 A and 2C receptors in brainstem motoneurons
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    Eur J Neurosci 17:1179-88. 2003
    ..The development of 5-HT receptors in XII motoneurons may be related to changes in feeding behaviour, whereas different cues regulate 5-HT receptor expression in upper spinal motoneurons...
  7. pmc Loss of motoneurons in the ventral compartment of the rat hypoglossal nucleus following early postnatal exposure to alcohol
    Georg M Stettner
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    J Chem Neuroanat 52:87-94. 2013
    ..Thus, postnatal AE causes motoneuronal loss in the XIIn-v. This may compromise upper airway control and contribute to increased risk of upper airway obstructions and sudden infant death in FASD victims...
  8. ncbi Single-cell RT-PCR gene expression profiling of acutely dissociated and immunocytochemically identified central neurons
    Denys V Volgin
    Department of Animal Biology 209E VET, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    J Neurosci Methods 136:229-36. 2004
    ..Thus, the method allows, with at least 66% confidence, immunocytochemical cell identification prior to mRNA studies of single neurons located in heterogeneous brain regions...
  9. pmc Hypoglossal premotor neurons of the intermediate medullary reticular region express cholinergic markers
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce St, Philadelphia, PA 19104 6046, USA
    J Appl Physiol (1985) 105:1576-84. 2008
    ..Thus the pre- and postsynaptic cholinergic effects previously described in XII motoneurons may originate, at least in part, in medullary IRt neurons...
  10. ncbi Developmental changes in the orexin 2 receptor mRNA in hypoglossal motoneurons
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6046, USA
    Neuroreport 13:433-6. 2002
    ..Thus, ORX may postsynaptically excite XII motoneurons, with the ORX2r mRNA production increased during the critical period for development of the rapid eye movement sleep and its disorder narcolepsy/cataplexy...
  11. ncbi Chronic intermittent hypoxia alters hypothalamic transcription of genes involved in metabolic regulation
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    Auton Neurosci 126:93-9. 2006
    ....
  12. ncbi Serotonergic receptors and effects in hypoglossal and laryngeal motoneurons semi-quantitative studies in neonatal and adult rats
    Denys V Volgin
    Department of Animal Biology, Univ of Pennsylvania, Philadelphia, PA 19104 6046, USA
    Adv Exp Med Biol 551:183-8. 2004
  13. pmc Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period
    Georg M Stettner
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Behav Brain Res 221:324-8. 2011
    ..Our findings suggest that excessive activity of ORX neurons contributes to motor hyperactivity and impaired HR acquisition following perinatal AE and that these symptoms may be alleviated by systemic antagonism of ORX-1 receptors...
  14. doi Time- and behavioral state-dependent changes in posterior hypothalamic GABAA receptors contribute to the regulation of sleep
    Denys V Volgin
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 9:e86545. 2014
    ....
  15. ncbi Activation of HIF-1alpha mRNA by hypoxia and iron chelator in isolated rat carotid body
    Arijit Roy
    Department of Physiology, School of Medicine, University of Pennsylvania, B 400 Richards Building, 3700 Hamilton Walk, Philadelphia, PA 19104 6085, USA
    Neurosci Lett 363:229-32. 2004
    ..Thus, in the CB, the main systemic O(2)-sensing organ, HIF-1alpha transcription is regulated by O(2) supply around the normoxic level; this may contribute to cellular and organismal adaptations to chronic changes in ambient O(2)...
  16. pmc Developmental profiles of neurotransmitter receptors in respiratory motor nuclei
    Leszek Kubin
    Department of Animal Biology, School of Veterinary Medicine and Center for Sleep and Respiratory Neurobiology, University of Pennsylvania, Philadelphia, PA 19104 6046, USA
    Respir Physiol Neurobiol 164:64-71. 2008
    ....