Christopher Voigt

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Genetic parts to program bacteria
    Christopher A Voigt
    Biophysics and Chemistry and Chemical Biology, Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Box 2540, 1700 4th Street, San Francisco, CA 94158, USA
    Curr Opin Biotechnol 17:548-57. 2006
  2. pmc Environmental signal integration by a modular AND gate
    J Christopher Anderson
    Department of Pharmaceutical Chemistry, QB3 California Institute for Quantitative Biological Research, The University of California San Francisco, San Francisco, CA 94158 2330, USA
    Mol Syst Biol 3:133. 2007
  3. pmc Engineering the Salmonella type III secretion system to export spider silk monomers
    Daniel M Widmaier
    Chemistry and Chemical Biology Graduate Program, University of California San Francisco, San Francisco, CA 94110, USA
    Mol Syst Biol 5:309. 2009
  4. pmc Modular control of multiple pathways using engineered orthogonal T7 polymerases
    Karsten Temme
    UCB UCSF Joint Graduate Group in Bioengineering, MC2540, Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    Nucleic Acids Res 40:8773-81. 2012
  5. ncbi request reprint Programming cellular function
    Christopher A Voigt
    Department of Pharmaceutical Chemistry and California Institute for Quantitative Biomedical Research QB3, University of California, San Francisco, San Francisco, California 94143 2540, USA
    Nat Chem Biol 1:304-7. 2005
  6. pmc The Bacillus subtilis sin operon: an evolvable network motif
    Christopher A Voigt
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genetics 169:1187-202. 2005
  7. doi request reprint Engineering bacterial signals and sensors
    Howard Salis
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
    Contrib Microbiol 16:194-225. 2009
  8. ncbi request reprint Environmentally controlled invasion of cancer cells by engineered bacteria
    J Christopher Anderson
    Howard Hughes Medical Institute, California Institute of Quantitative Biology Department of Bioengineering, University of California, 717 Potter Street, Room 257 Berkeley, CA 94720, USA
    J Mol Biol 355:619-27. 2006
  9. pmc Induction and relaxation dynamics of the regulatory network controlling the type III secretion system encoded within Salmonella pathogenicity island 1
    Karsten Temme
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA, USA
    J Mol Biol 377:47-61. 2008
  10. doi request reprint Synthesis of methyl halides from biomass using engineered microbes
    Travis S Bayer
    Department of Pharmaceutical Chemistry, University of California, San Francisco, MC 2540, Room 408C, 1700 4th Street, San Francisco, California 94158 2330, USA
    J Am Chem Soc 131:6508-15. 2009

Research Grants

Collaborators

  • Howard Salis
  • Sridhar Govindarajan
  • Wendell A Lim
  • Jay Keasling
  • Andrew Ellington
  • D V Santi
  • John M Greally
  • D M Wolf
  • Jeremy Minshull
  • Karsten Temme
  • Anselm Levskaya
  • J Christopher Anderson
  • Daniel M Widmaier
  • Rena Hill
  • Eli S Groban
  • Travis S Bayer
  • Ethan A Mirsky
  • Danielle Tullman-Ercek
  • Elizabeth J Clarke
  • Adam P Arkin
  • Christopher R Otey
  • Daniel N Bolon
  • Felix Moser
  • Thomas H Segall-Shapiro
  • Susan M Miller
  • Orion D Weiner
  • Soon Ho Hong
  • Matthew Levy
  • Zachary Booth Simpson
  • Edward M Marcotte
  • Eric A Davidson
  • Jeffrey J Tabor
  • Aaron A Chevalier
  • Laura A Lavery
  • Alexander Scouras
  • Jonathan J Silberg
  • Jeffrey B Endelman
  • Frances H Arnold
  • Geethani Bandara
  • Stephen L Mayo

Detail Information

Publications17

  1. ncbi request reprint Genetic parts to program bacteria
    Christopher A Voigt
    Biophysics and Chemistry and Chemical Biology, Department of Pharmaceutical Chemistry, University of California San Francisco, QB3 Box 2540, 1700 4th Street, San Francisco, CA 94158, USA
    Curr Opin Biotechnol 17:548-57. 2006
    ..On the basis of these developments, increasingly complex cellular machines are being constructed to build specialty chemicals, weave biomaterials, and to deliver therapeutics...
  2. pmc Environmental signal integration by a modular AND gate
    J Christopher Anderson
    Department of Pharmaceutical Chemistry, QB3 California Institute for Quantitative Biological Research, The University of California San Francisco, San Francisco, CA 94158 2330, USA
    Mol Syst Biol 3:133. 2007
    ..A mathematical model of the transfer function is derived and parameterized using experimental data...
  3. pmc Engineering the Salmonella type III secretion system to export spider silk monomers
    Daniel M Widmaier
    Chemistry and Chemical Biology Graduate Program, University of California San Francisco, San Francisco, CA 94110, USA
    Mol Syst Biol 5:309. 2009
    ..8 mg l(-1) h(-1) are demonstrated with up to 14% of expressed protein secreted. This work introduces new parts to control protein secretion in Gram-negative bacteria, which will be broadly applicable to problems in biotechnology...
  4. pmc Modular control of multiple pathways using engineered orthogonal T7 polymerases
    Karsten Temme
    UCB UCSF Joint Graduate Group in Bioengineering, MC2540, Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    Nucleic Acids Res 40:8773-81. 2012
    ....
  5. ncbi request reprint Programming cellular function
    Christopher A Voigt
    Department of Pharmaceutical Chemistry and California Institute for Quantitative Biomedical Research QB3, University of California, San Francisco, San Francisco, California 94143 2540, USA
    Nat Chem Biol 1:304-7. 2005
    ..A meeting was held in August 2005 to present progress in the field and to discuss topics in ethics, safety and security...
  6. pmc The Bacillus subtilis sin operon: an evolvable network motif
    Christopher A Voigt
    Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Genetics 169:1187-202. 2005
    ..The dynamical plasticity of the protein-antagonist operon motif suggests that it is an evolutionarily convergent design selected not only for particular immediate function but also for its evolvability...
  7. doi request reprint Engineering bacterial signals and sensors
    Howard Salis
    Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158, USA
    Contrib Microbiol 16:194-225. 2009
    ..We also provide specification sheets describing many two-component and quorum-sensing systems, focusing on the information that one needs to know in order to use them for engineering applications...
  8. ncbi request reprint Environmentally controlled invasion of cancer cells by engineered bacteria
    J Christopher Anderson
    Howard Hughes Medical Institute, California Institute of Quantitative Biology Department of Bioengineering, University of California, 717 Potter Street, Room 257 Berkeley, CA 94720, USA
    J Mol Biol 355:619-27. 2006
    ..This approach could be used to engineer bacteria to sense the microenvironment of a tumor and respond by invading cancerous cells and releasing a cytotoxic agent...
  9. pmc Induction and relaxation dynamics of the regulatory network controlling the type III secretion system encoded within Salmonella pathogenicity island 1
    Karsten Temme
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA, USA
    J Mol Biol 377:47-61. 2008
    ..This combination of theory and experiments provides a platform for predicting how genetic perturbations lead to changes in the global dynamics of a regulatory network...
  10. doi request reprint Synthesis of methyl halides from biomass using engineered microbes
    Travis S Bayer
    Department of Pharmaceutical Chemistry, University of California, San Francisco, MC 2540, Room 408C, 1700 4th Street, San Francisco, California 94158 2330, USA
    J Am Chem Soc 131:6508-15. 2009
    ..These results demonstrate the potential of producing methyl halides from non-food agricultural resources...
  11. ncbi request reprint Synthetic biology: engineering Escherichia coli to see light
    Anselm Levskaya
    Biophysics Program, University of California, San Francisco, California 94143, USA
    Nature 438:441-2. 2005
    ..This spatial control of bacterial gene expression could be used to 'print' complex biological materials, for example, and to investigate signalling pathways through precise spatial and temporal control of their phosphorylation steps...
  12. pmc Kinetic buffering of cross talk between bacterial two-component sensors
    Eli S Groban
    University of California, San Francisco, 94158, USA
    J Mol Biol 390:380-93. 2009
    ..These results support a kinetic model of buffering where both the cognate bifunctional phosphatase activity and the competition between regulator proteins for phosphate prevent cross talk in vivo...
  13. pmc Automated design of synthetic ribosome binding sites to control protein expression
    Howard M Salis
    Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA
    Nat Biotechnol 27:946-50. 2009
    ..The proposed forward engineering approach should accelerate the construction and systematic optimization of large genetic systems...
  14. pmc Spatiotemporal control of cell signalling using a light-switchable protein interaction
    Anselm Levskaya
    The Cell Propulsion Lab, UCSF UCB NIH Nanomedicine Development Center, University of California, San Francisco, California 94158 2517, USA
    Nature 461:997-1001. 2009
    ....
  15. doi request reprint Life from information
    Christopher A Voigt
    Nat Methods 5:27-8. 2008
  16. ncbi request reprint Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach
    Christopher R Otey
    Biochemistry and Molecular Biophysics Option, Mail Code 210 41, Pasadena, CA 91125, USA
    Chem Biol 11:309-18. 2004
    ..These results suggest that SCHEMA-guided recombination can be used to generate diverse p450s for exploring function evolution within the p450 structural framework...
  17. ncbi request reprint De novo design of biocatalysts
    Daniel N Bolon
    Biochemistry and Molecular Biophysics Option, California Institute of Technology, Mail Code 147 75, Pasadena, California 91125, USA
    Curr Opin Chem Biol 6:125-9. 2002
    ..Improved rational design efforts coupled with directed evolution should dramatically improve the scope of de novo enzyme design...

Research Grants4

  1. System Dynamics of the Salmonella Virulence Regulatory Network
    Christopher Voigt; Fiscal Year: 2007
    ..To determine how the topology of regulatory interactions encodes network dynamics, artificial feedback loops will be used to genetically perturb the network. This will provide insight into how complex dynamics evolve. ..
  2. System Dynamics of the Salmonella Virulence Regulatory Network
    Christopher Voigt; Fiscal Year: 2009
    ..To determine how the topology of regulatory interactions encodes network dynamics, artificial feedback loops will be used to genetically perturb the network. This will provide insight into how complex dynamics evolve. ..
  3. System Dynamics of the Salmonella Virulence Regulatory Network
    Christopher A Voigt; Fiscal Year: 2010
    ..To determine how the topology of regulatory interactions encodes network dynamics, artificial feedback loops will be used to genetically perturb the network. This will provide insight into how complex dynamics evolve. ..