Research Topics
| V G VogelSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Reducing the risk of breast cancer with tamoxifen in women at increased riskV G Vogel
Magee Women s Hospital, University of Pittsburgh Cancer Institute Breast Program, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Clin Oncol 19:87S-92S. 2001..Physicians should identify appropriate candidates with whom to discuss the possible benefits of tamoxifen for reducing the risk of breast cancer...
Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancerVictor G Vogel
NSABP, Pittsburgh, PA 15212, USA
Cancer Prev Res (Phila) 3:696-706. 2010..These results have important public health implications and clarify that both raloxifene and tamoxifen are good preventive choices for postmenopausal women with elevated risk for breast cancer...
Haploinsufficiency for BRCA1 is associated with normal levels of DNA nucleotide excision repair in breast tissue and blood lymphocytesJean J Latimer
Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
BMC Med Genet 6:26. 2005....
National surgical adjuvant breast and bowel project update: prevention trials and endocrine therapy of ductal carcinoma in situVictor G Vogel
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213 3180, USA
Clin Cancer Res 9:495S-501S. 2003..Outcomes will include both ipsilateral and contralateral new breast cancer and recurrences, as well as the occurrence of regional and distant disease. Enrollment will begin in early 2003...
Management of the high-risk patientVictor G Vogel
University of Pittsburgh, Department of Medicine, 3550 Terrace Street, Scaife 1218, Pittsburgh PA 15261, USA
Surg Clin North Am 83:733-51. 2003....
The study of tamoxifen and raloxifene: preliminary enrollment data from a randomized breast cancer risk reduction trialVictor G Vogel
The National Surgical Adjuvant Breast and Bowel Project, NSABP Foundation Inc, Pittsburgh, PA, USA
Clin Breast Cancer 3:153-9. 2002..0% of black women, and 44.5% of Hispanic women. The trial will recruit a total of 22,000 postmenopausal women and is powered to demonstrate superior efficacy of either agent or their equivalence in reducing the incidence of primary breast..
Atypia in the assessment of breast cancer risk: implications for managementVictor G Vogel
University of Pittsburgh, Cancer Institute Magee Womens Hospital, Pittsburgh, Pennsylvania 15213 3180, USA
Diagn Cytopathol 30:151-7. 2004..The procedure opens the possibility of repeatable tracking of breast cytology over time, but its role as a risk assessment tool remains to be fully defined...
Follow-up of the breast cancer prevention trial and the future of breast cancer prevention effortsV G Vogel
University of Pittsburgh Cancer Institute Magee Womens Hospital, Pennsylvania 15213 3180, USA
Clin Cancer Res 7:4413s-4418s; discussion 4411s-4412s. 2001..Ancillary studies of cognitive function will also be performed. Raloxifene should not be used for the reduction of breast cancer risk outside the context of the STAR trial...
Recent results from clinical trials using SERMs to reduce the risk of breast cancerVictor G Vogel
Department of Medicine, University of Pittsburgh Cancer Institute Magee Womens Hospital, 300 Halket Street, Room 3524, Pittsburgh, PA 15213, USA
Ann N Y Acad Sci 1089:127-42. 2006..Several ongoing and planned studies will evaluate the ability of aromatase inhibitors to reduce the risk of breast cancer in women at increased risk...
Update on breast cancer preventionPriya Rastogi
Breast Cancer Prevention Program, Magee Women s Hospital University of Pittsburgh, Department of Medicine, Section of Hematology Oncology, School of Medicine, Pittsburgh, Pennsylvania, USA
Oncology (Williston Park) 17:799-805; discussion 808-10, 813. 2003..The Study of Tamoxifen and Raloxifene is designed to compare the efficacy of tamoxifen and raloxifene in reducing breast cancer risk. Aromatase inhibitors will also be studied in the setting of chemoprevention for breast cancer...
Recognition and management of hereditary breast cancer syndromesDarcy L Thull
Magee/UPCI Breast Cancer Genetics Program, Magee-Women's Hospital, Pittsburgh, Pennsylvania 15213, USA
Oncologist 9:13-24. 2004..Application of these principles can reduce morbidity in women with genetic predispositions to breast cancer...
Endogenous sex hormones, breast cancer risk, and tamoxifen response: an ancillary study in the NSABP Breast Cancer Prevention Trial (P-1)Mary S Beattie
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA, USA
J Natl Cancer Inst 98:110-5. 2006..The purpose of this study was to determine whether sex hormone levels were associated with breast cancer risk and with response to tamoxifen in a high-risk population...
Results and implications of the Royal Marsden and other tamoxifen chemoprevention trials: an alternative viewJ P Costantino
University of Pittsburgh, Graduate School of Public Health, 130 DeSoto Street, Room 316 Parran Hall, Pittsburgh, PA 15261, USA
Clin Breast Cancer 2:41-6. 2001..The drug cannot be used indiscriminately due to the potential side effects, but benefit/risk assessment methodology can be used to identify substantial numbers of women in whom treatment would provide a net beneficial effect...
Preventing breast cancer in high-risk women, 2008Victor G Vogel
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pennsylvania, USA
Oncology (Williston Park) 22:666-73; discussion 679, 682, 684. 2008..Symptomatic side effects are comparable for the two drugs. Raloxifene is more appropriate than tamoxifen for reduction of breast cancer risk among postmenopausal women at increased risk for breast cancer...
Patient-reported symptoms and quality of life during treatment with tamoxifen or raloxifene for breast cancer prevention: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trialStephanie R Land
National Surgical Adjuvant Breast and Bowel Project NSABP Operations and Biostatistical Centers, Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
JAMA 295:2742-51. 2006..Tamoxifen has been approved for breast cancer risk reduction in high-risk women, but how raloxifene compares with tamoxifen is unknown...
Chemoprevention of breast cancer in postmenopausal womenBrian A Geller
Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Breast Dis 24:79-92. 2005..At present, tamoxifen is the only FDA-approved agent for breast cancer risk reduction. Decisions regarding its use must remain highly individualized, involving careful consideration of its risks versus benefits...
Memory impairments with adjuvant anastrozole versus tamoxifen in women with early-stage breast cancerCatherine M Bender
University of Pittsburgh School of Nursing, Pittsburgh, PA 15261, USA
Menopause 14:995-8. 2007..We hypothesized, therefore, that anastrozole would have a more profound effect on cognitive function than tamoxifen, a mixed estrogen agonist/antagonist...
Breast cancer-related lymphedema--what are the significant predictors and how they affect the severity of lymphedema?Atilla Soran
Magee Womens Hospital, Pittsburgh, Pennsylvania 15213, USA
Breast J 12:536-43. 2006..9 kg/m(2) (SD 7.5) for patients with moderate/severe LE (p < 0.05). The results of this stratified case-control study demonstrated that the risk and severity of LE was statistically related to infection, BMI, and level of hand use...
Managing the risk of invasive breast cancer in women at risk for breast cancer and osteoporosis: the role of raloxifeneVictor G Vogel
The University of Pittsburgh Cancer Institute, Magee Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213, USA
Clin Interv Aging 3:601-9. 2008..Millions of postmenopausal women could derive net benefit from raloxifene through reduced rates of fracture and invasive breast cancer...
Identifying and screening patients at risk of second cancersVictor G Vogel
Magee Womens Hospital, 300 Halket Street, Pittsburgh, PA 15213 3180, USA
Cancer Epidemiol Biomarkers Prev 15:2027-32. 2006..Some of the cancers also incur a risk for a second malignancy at another anatomic site. In addition, there are well-described clinical genetic syndromes that, as unique clinical entities, predispose to second malignant tumors...
The NSABP Study of Tamoxifen and Raloxifene (STAR) trialVictor G Vogel
University of Pittsburgh Cancer Institute, Magee Womens Hospital, Pittsburgh, PA 15213 3180, USA
Expert Rev Anticancer Ther 9:51-60. 2009..The risk of other cancers, fractures, ischemic heart disease and stroke is similar for both drugs...
Chemoprevention strategies 2006Victor G Vogel
Magee Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 3180, USA
Curr Treat Options Oncol 8:74-88. 2007....
Epidemiology, genetics, and risk evaluation of postmenopausal women at risk of breast cancerVictor G Vogel
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Menopause 15:782-9. 2008..As many as 10 million women in the United States are at increased risk, and clinicians are obligated to identify these women and manage their risk appropriately...
Raloxifene: a selective estrogen receptor modulator for reducing the risk of invasive breast cancer in postmenopausal womenVictor G Vogel
UPMC Cancer Center Magee Women s Hospital, 300 Halket Street, Room 3524, Pittsburgh, PA 15213, USA
Womens Health (Lond Engl) 3:139-53. 2007..The potential market for a compound shown to reduce the risk of breast cancer in postmenopausal women who are at increased risk for breast cancer is more than 10 million women in the USA alone...
Endocrine prevention of breast cancer using selective oestrogen receptor modulators (SORMs)Shelly S Lo
Section of Hematology/Oncology, Department of Medicine, Magee/University of Pittsburgh Cancer Institute Breast Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Best Pract Res Clin Endocrinol Metab 18:97-111. 2004..Prevention studies involving raloxifene and aromatase inhibitors are currently being conducted...
Effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the NSABP Study of Tamoxifen and Raloxifene (STAR) P-2 trialVictor G Vogel
Magee Womens Hospital, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213 3221, USA
JAMA 295:2727-41. 2006..Tamoxifen is approved for the reduction of breast cancer risk, and raloxifene has demonstrated a reduced risk of breast cancer in trials of older women with osteoporosis...
Cognitive impairment associated with adjuvant therapy in breast cancerCatherine M Bender
University of Pittsburgh School of Nursing, Victoria Building, Suite 415, Pittsburgh, PA 15261, USA
Psychooncology 15:422-30. 2006..In conclusion, adjuvant chemotherapy in women with breast cancer can be associated with deteriorations in memory and this may persist over time. The addition of tamoxifen may lead to more widespread memory deficits...
Nonsteroidal anti-inflammatory drug use and serum total estradiol in postmenopausal womenAlana G Hudson
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cancer Epidemiol Biomarkers Prev 17:680-7. 2008..These cross-sectional findings suggest that NSAID use may be associated with lower circulating estradiol levels, potentially representing one mechanism through which NSAIDs exert protective effects on breast cancer...
Assessment of cardiac dysfunction in a randomized trial comparing doxorubicin and cyclophosphamide followed by paclitaxel, with or without trastuzumab as adjuvant therapy in node-positive, human epidermal growth factor receptor 2-overexpressing breast canElizabeth Tan-Chiu
National Surgical Adjuvant Breast and Bowel Project (NSABP, University of Pittsburgh, PA, USA
J Clin Oncol 23:7811-9. 2005..CONCLUSION: Administering trastuzumab with paclitaxel after AC increases incidence of CHF and lesser CD. Potential cardiotoxicity should be carefully considered when discussing benefits and risks of this therapy...
Prognostic factors for breast cancer and their use in the clinical settingAvina Kapoor
University of Pittsburgh School of Medicine, Department of Medicine, Magee Womens Hospital, 300 Halket Street, Room 3524, Pittsburgh, PA 15213 3180, USA
Expert Rev Anticancer Ther 5:269-81. 2005..This review focuses on the clinical, pathologic, molecular and genetic prognostic tools available for use in patients with breast cancer, and their impact on clinical decisions and treatment selection...
Risedronate prevents bone loss in breast cancer survivors: a 2-year, randomized, double-blind, placebo-controlled clinical trialSusan L Greenspan
Department of Medicine, University of Pittsburgh, 3471 Fifth Ave, Kaufmann Suite 1110, Pittsburgh, PA 15213, USA
J Clin Oncol 26:2644-52. 2008..Limited data are available on the efficacy of oral bisphosphonate therapy in breast cancer survivors. Our goal was to examine prevention of breast cancer-related bone loss in this cohort...
Breast cancer risk factors and mammographic breast density in women over age 70Francesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Breast Cancer Res Treat 97:157-66. 2006..Breast density is a strong risk factor for breast cancer, but little is known about factors associated with breast density in women over 70...
Prevention of bone loss in survivors of breast cancer: A randomized, double-blind, placebo-controlled clinical trialSusan L Greenspan
Department of Medicine, University of Pittsburgh, 3471 Fifth Avenue, Suite 1110, Pittsburgh, Pennsylvania 15213 3221, USA
J Clin Endocrinol Metab 92:131-6. 2007..Few data are available on the safety and efficacy of once-weekly oral bisphosphonate therapy in breast cancer survivors...
What do perceived cognitive problems reflect?Catherine M Bender
University of Pittsburgh School of Nursing, 3500 Victoria Street, Suite 415, Pittsburgh, PA 15261, USA
J Support Oncol 6:238-42. 2008..At a minimum, our results indicated that women's complaints of cognitive problems should prompt additional assessment to clarify the bases of the problem and initiate appropriate intervention...
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancerEdward H Romond
National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, USA
N Engl J Med 353:1673-84. 2005..CONCLUSIONS: Trastuzumab combined with paclitaxel after doxorubicin and cyclophosphamide improves outcomes among women with surgically removed HER2-positive breast cancer. (ClinicalTrials.gov numbers, NCT00004067 and NCT00005970.)..
The use of tamoxifen and raloxifene for the prevention of breast cancerD Lawrence Wickerham
Operations Center, National Surgical Adjuvant Breast and Bowel Project, Allegheny Center, Pittsburgh, PA 15212, USA
Recent Results Cancer Res 181:113-9. 2009..51 vs 2.11 per 1,000; RR, 1.40; 95% CI, 0.98-2.00). There were 36 cases of uterine cancer with tamoxifen and 23 cases with raloxifene (RR, 0.63; 95% CI, 0.35-1.08)...
Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27Priya Rastogi
University of Pittsburgh Cancer Institute Magee Womens Hospital, 300 Halket St, Room 3524, Pittsburgh, PA 15213, USA
J Clin Oncol 26:778-85. 2008..Protocol B-27 was designed to determine the effect of adding docetaxel (T) to preoperative AC on tumor response rates, DFS, and OS...
Urinary estrogen metabolites in women at high risk for breast cancerAnnie Im
Magee UPCI Breast Cancer Prevention Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA
Carcinogenesis 30:1532-5. 2009....
Breast cancer preventionJennifer G Reeder
Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
Cancer Treat Res 141:149-64. 2008
American Society of Clinical Oncology technology assessment of pharmacologic interventions for breast cancer risk reduction including tamoxifen, raloxifene, and aromatase inhibitionRowan T Chlebowski
Health Services Research Department, American Society of Clinical Oncology, 1900 Duke Street, Suite 200, Alexandria, VA 22314, USA
J Clin Oncol 20:3328-43. 2002..To update an evidence-based technology assessment of chemoprevention strategies for breast cancer risk reduction. POTENTIAL INTERVENTIONS: Tamoxifen, raloxifene, aromatase inhibition, and fenretinide...
Prevention in the balanceVictor G Vogel
Magee/UPCI Breast Program, Magee-Women's Hospital University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA. vvogel.magee.edu
Oncologist 7:103-5. 2002
Have we found the ultimate risk factor for breast cancer?Victor G Vogel
J Clin Oncol 24:1791-4. 2006
Re: tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 StudyVictor G Vogel
J Natl Cancer Inst 94:1504. 2002
Impact of sentinel lymph node biopsy on lymphedema following breast cancer treatmentAtilla Soran
Breast J 11:370-1. 2005
Preventing hormone-dependent breast cancer in high-risk womenVictor G Vogel
J Natl Cancer Inst 95:91-3. 2003
American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant settingJames L Khatcheressian
Virginia Commonwealth University/Massey Cancer Center, Richmond, VA, USA
J Clin Oncol 24:5091-7. 2006..CONCLUSION: Careful history taking, physical examination, and regular mammography are recommended for appropriate detection of breast cancer recurrence...
Referral to cancer genetic counseling: are there stages of readiness?Suzanne M O'Neill
Center for Medical Genetics, Evanston Northwestern Healthcare, 1000 Central Street, Evanston, IL 60201, USA
Am J Med Genet C Semin Med Genet 142:221-31. 2006..Theoretical frameworks are needed to study adherence to referral for cancer genetic counseling. Stage-based theories may have a role to play...
Current comprehensive assessment and management of women at increased risk for breast cancerAlan B Hollingsworth
Department of Surgery, Mercy Health Center, Mercy Women s Center, 4300 McAuley Blvd, Oklahoma City, OK 73120, USA
Am J Surg 187:349-62. 2004....
Benefit from exemestane as extended adjuvant therapy after 5 years of adjuvant tamoxifen: intention-to-treat analysis of the National Surgical Adjuvant Breast And Bowel Project B-33 trialEleftherios P Mamounas
Aultman Health Foundation, 2600 6th St, SW Canton, OH 44710, USA
J Clin Oncol 26:1965-71. 2008....
Breast cancer risk managementJennifer G Reeder
Division of Hematology Oncology, University of Pittsburgh Medical Center Cancer Pavilion, PA 15232, USA
Clin Breast Cancer 7:833-40. 2007..In this article, we will review the trials that led to the emergence of both tamoxifen and raloxifene as chemopreventive agents and will then offer a management strategy for breast cancer prevention in the primary care setting...
Breast cancer risk assessment and risk reductionLisa A Newman
Breast Care Center, 1500 East Medical Center Drive, 3308 CGC, University of Michigan, Ann Arbor, MI 48109, USA
Surg Clin North Am 87:307-16, vii-viii. 2007..This article reviews available methods for assessing and reducing breast cancer risk...
Second International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: summary consensus statementSteven E Come
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Clin Cancer Res 9:443S-6S. 2003
Can statin therapy reduce the risk of breast cancer?Victor G Vogel
J Clin Oncol 23:8553-5. 2005
Why do we still use hormone replacement therapy? Why don't we use it more?Victor G Vogel
J Clin Oncol 20:616-9. 2002
Ontology, oncology, and preventive economies: developing drugs for cancer preventionVictor G Vogel
Clin Cancer Res 13:5227-8. 2007
