Research Topics
Genomes and Genes | Stefanie VogelSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infectionSaroj K Mohapatra
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
BMC Infect Dis 10:10. 2010..It has been shown previously that administration of Francisella tularensis (Ft) Live Vaccine Strain (LVS) lipopolysaccharide (LPS) protects mice against subsequent challenge with Ft LVS and blunts the pro-inflammatory cytokine response...
Mutations in TLR4 signaling that lead to increased susceptibility to infection in humans: an overviewStefanie N Vogel
Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
J Endotoxin Res 11:333-9. 2005..To date, mutations in the extracellular domain of TLR4 itself, IRAK-4, NEMO (IKK gamma), and I kappa B alpha have been identified and profoundly affect the host response to infection...- TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expressionStefanie N Vogel
Departments of Microbiology and Immunology and Medicine, University of Maryland, Baltimore, MD, USA
Mol Interv 3:466-77. 2003..Given the rapidity with which such interactions have been described, we have attempted to summarize our current understanding of the adapters that are so essential for TLR signaling and provide a working model for future studies... - Toll-like receptor 4 signalling: new perspectives on a complex signal-transduction problemS N Vogel
Department of Microbiology and Immunology, and Department of Medicine, University of Maryland, Baltimore, 655 W Baltimore Street 13 009, Baltimore, MD 21201, USA
Biochem Soc Trans 31:664-8. 2003..Collectively, our findings provide the first mechanistic basis for differential patterns of gene expression activated by TLR4 and TLR2 agonists... - TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophagesVladimir Toshchakov
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
Nat Immunol 3:392-8. 2002..Together, these findings provide the first mechanistic basis for differential patterns of gene expression activated by TLR4 and TLR2 agonists... - Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cellsAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland, Baltimore 21201, USA
J Immunol 169:5209-16. 2002..Thus, decreased TLR4-MyD88 complex formation with subsequent impairment of IRAK-1 activity may underlie the LPS-tolerant phenotype... - Differential involvement of BB loops of toll-IL-1 resistance (TIR) domain-containing adapter proteins in TLR4- versus TLR2-mediated signal transductionVladimir U Toshchakov
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
J Immunol 175:494-500. 2005..Our data suggest that the interactions required for a fully functional TLR4 signaling "platform" are disrupted by these BPs, and that the adapter BB loops may serve distinct roles in TLR4 and TLR2 signalosome assembly... - Overexpression of CD14, TLR4, and MD-2 in HEK 293T cells does not prevent induction of in vitro endotoxin toleranceAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland, Baltimore 21201, USA
J Endotoxin Res 9:60-4. 2003..Thus, altered expression and/or function of intracellular mediators downstream of the TLR4/MD-2 complex play an important role in mediating LPS tolerance... - TLR2 and TLR4 agonists stimulate unique repertoires of host resistance genes in murine macrophages: interferon-beta-dependent signaling in TLR4-mediated responsesVladimir Toshchakov
Department of Microbiology and Immunology, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA
J Endotoxin Res 9:169-75. 2003.... - Cutting edge: expression of IL-1 receptor-associated kinase-4 (IRAK-4) proteins with mutations identified in a patient with recurrent bacterial infections alters normal IRAK-4 interaction with components of the IL-1 receptor complexAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland, Baltimore, 21201, USA
J Immunol 174:6587-91. 2005..Therefore, mimetics of these truncated IRAK-4 proteins may represent a novel approach to mitigating hyperinflammatory states... - Toll receptors, CD14, and macrophage activation and deactivation by LPSMarina A Dobrovolskaia
Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
Microbes Infect 4:903-14. 2002..The most recent advances in the understanding of the function of the LPS receptor complex and its role in the development of the septic shock syndrome and endotoxin tolerance will be discussed... - Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1)Darren J Perkins
Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, School of Medicine, 660 W Baltimore Street, Suite 324, Baltimore, MD 21201, USA
Mol Microbiol 66:1003-15. 2007..pertussis infection by augmenting COX-2 expression and provides evidence against the concept that ACT functions exclusively via its inhibitory effects on phagocytic leucocytes... - Tolerance to microbial TLR ligands: molecular mechanisms and relevance to diseaseAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland, Baltimore UMB, Baltimore, Maryland 21201, USA
J Endotoxin Res 12:133-50. 2006..In this review, we present current theories of the molecular mechanisms that underlie induction and maintenance of 'microbial tolerance', and discuss the possible relevance of tolerance to several infectious and non-infectious diseases... - Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactionsVladimir Y Toshchakov
University of Maryland, Department of Microbiology and Immunology, School of Medicine, MD 21201 1559, Baltimore, USA
Expert Opin Biol Ther 7:1035-50. 2007..This review discusses cell-penetrating decoy peptides as a new tool to further understanding of the molecular interactions required for TLR signaling and evaluates the potential of this approach for the creation of therapeutic agents... - Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin toleranceAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Biol Chem 282:16042-53. 2007..Thus, our data demonstrate that TLR4 tyrosine phosphorylation is important for signaling and is impaired in endotoxin-tolerant cells, and suggest involvement of Lyn kinase in these processes... - Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophagesArnd Lentschat
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
J Immunol 174:4252-61. 2005.... - Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signalingPrasad Rallabhandi
Department of Microbiology and Immunology, University of Maryland, 660 West Redwood Street, Baltimore, MD 21201, USA
J Immunol 177:322-32. 2006..A structural model that accounts for the diminished responsiveness of mutant TLR4 polymorphisms to structurally unrelated TLR4 agonists is proposed... - Tobacco smoking inhibits expression of proinflammatory cytokines and activation of IL-1R-associated kinase, p38, and NF-kappaB in alveolar macrophages stimulated with TLR2 and TLR4 agonistsHaiyan Chen
Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
J Immunol 179:6097-106. 2007.... - Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway componentsMarina A Dobrovolskaia
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
J Immunol 170:508-19. 2003..Collectively, these data demonstrate that induction of homotolerance affects a broader spectrum of signaling components than in heterotolerance, with selective modulation of specific elements within the NF-kappaB signaling pathway... - Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativityPrasad Rallabhandi
Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
J Biol Chem 283:24314-25. 2008..Our data suggest a unique interaction between two distinct innate immune response receptors and support a novel paradigm of receptor cooperativity in inflammatory responses... - The role of the interferon regulatory factors, IRF-1 and IRF-2, in LPS-induced cyclooxygenase-2 (COX-2) expression in vivo and in vitroShuling Zhang
Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
J Endotoxin Res 8:379-88. 2002..Collectively, these data provide evidence for an important role for IRF-1 in vivo and in vitro and for IRF-2 in vitro in the regulation of COX-2 expression by LPS... - Regulation of lipopolysaccharide sensitivity by IFN regulatory factor-2Natalia Cuesta
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
J Immunol 170:5739-47. 2003..Collectively, these findings reveal a critical role for IRF-2 in endotoxicity, and point to a previously unappreciated role for IRF-2 in the regulation of apoptosis... - Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac diseaseKaren E Thomas
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, 21201, USA
J Immunol 176:2512-21. 2006.... - Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promotersZachary A Cooper
Univ of Maryland School of Medicine, Health Science Facility II, Rm S311, 20 Penn St, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 298:C171-81. 2010..These data suggest that FRT exerts its effects on cytokine gene expression in a gene-specific manner through distal effects on promoter activation rather than proximal receptor activation and signal transduction... - Cutting Edge: Differential inhibition of TLR signaling pathways by cell-permeable peptides representing BB loops of TLRsVladimir Y Toshchakov
Department of Microbiology and Immunology, University of Maryland Baltimore, 660 West Redwood Street, Baltimore, MD 21201, USA
J Immunol 178:2655-60. 2007..Our results suggest that the receptor BBPs selectively affect different TLR signaling pathways, and that the BB loops of TLR1/6 and TLR2 play distinct roles in formation of receptor heterodimers and recruitment of adaptor proteins... - TLR4/MyD88/PI3K interactions regulate TLR4 signalingMichelle H W Laird
University of Maryland, Baltimore, 660 W Redwood Street, Room 324, Baltimore, MD 21201, USA
J Leukoc Biol 85:966-77. 2009..We propose a hypothetical model in which sustained PI3K activity at the membrane limits the availability of the PI3K substrate, thereby negatively regulating signaling... - Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signalingLeah E Cole
Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
J Leukoc Biol 87:275-81. 2010..Taken together, these data suggest that prolonging or enhancing the interaction between TLR2 and its agonist overcomes the "bridging" function ascribed previously to TIRAP... - Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signalingPrasad Rallabhandi
Department of Microbiology and Immunology, Center for Vaccine Development, University of Maryland, Baltimore 21201, USA
J Immunol 180:1139-47. 2008..Thus, the combination of acylation state and host genetics may significantly impact vaccine immunogenicity and/or efficacy, whether LPS is an integral component of a whole organism vaccine or included as an adjuvant... - Immunologic consequences of Francisella tularensis live vaccine strain infection: role of the innate immune response in infection and immunityLeah E Cole
Department of Microbiology and Immunology, University of Maryland, Baltimore, School of Medicine, Baltimore, MD 21201, USA
J Immunol 176:6888-99. 2006.... - Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infectionsAndrei E Medvedev
Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 20101, USA
J Exp Med 198:521-31. 2003..Thus, IRAK-4 is pivotal in the development of a normal inflammatory response initiated by bacterial or nonbacterial insults... - Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fc gamma receptor ligation in murine macrophagesSwamy Kumar Polumuri
Department of Microbiology and Immunology, School of Medicine, University of Maryland, 660 West Redwood Street, Baltimore, MD 21201, USA
J Immunol 179:236-46. 2007..Thus, FcgammaR ligation modulates LPS-induced IL-12 via multiple PI3K-sensitive pathways that affect production, accumulation, and binding of key DNA-binding proteins required for IL-12 induction... - Vibrio cholerae flagellins induce Toll-like receptor 5-mediated interleukin-8 production through mitogen-activated protein kinase and NF-kappaB activationLisa M Harrison
Department of Microbiology and Immunology, University of Maryland Baltimore School of Medicine, Baltimore, Maryland 21201, USA
Infect Immun 76:5524-34. 2008..Collectively, these data suggest that V. cholerae flagellins are present in culture supernatants and can induce TLR5- and MAPK-dependent IL-8 secretion in host cells... - Transcriptional regulation of lipopolysaccharide (LPS)-induced Toll-like receptor (TLR) expression in murine macrophages: role of interferon regulatory factors 1 (IRF-1) and 2 (IRF-2)Quan M Nhu
Department of Microbiology and Immunology, University of Maryland Baltimore (UMB, School of Medicine, Baltimore, MD 21201, USA
J Endotoxin Res 12:285-95. 2006.... - The proteasome: a central regulator of inflammation and macrophage functionNilofer Qureshi
Department of Basic Medical Science, School of Medicine, Shock Trauma Research Center, University of Maryland Baltimore, Baltimore, MD, USA
Immunol Res 31:243-60. 2005..Taken collectively, the results suggest a potentially important role of the proteasome in inflammation and other macrophage functions... - A role for Stat1 in the regulation of lipopolysaccharide-induced interleukin-1beta expressionVishwas D Joshi
Department of Medicine, Division of Geographic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Interferon Cytokine Res 26:739-47. 2006.... 
Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathwaysTae Jin Kang
Center for Vaccine Development, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Eur J Immunol 38:1574-84. 2008..Thus different components of the same bacterium each induce IL-1beta by distinct signaling pathways. Whereas the spore-induced IL-1beta limits BA infection, LT-induced IL-1beta enables BA to escape host defenses...- Contribution of interferon-beta to the murine macrophage response to the toll-like receptor 4 agonist, lipopolysaccharideKaren E Thomas
Department of Microbiology and Immunology, University of Maryland, Baltimore, Maryland 21201, USA
J Biol Chem 281:31119-30. 2006..g. TLR4(-/-) or TRIF(-/-) mice). Collectively, these findings reveal unanticipated regulatory roles for IFN-beta in response to LPS in vitro and in vivo... - TLR4 signaling is coupled to SRC family kinase activation, tyrosine phosphorylation of zonula adherens proteins, and opening of the paracellular pathway in human lung microvascular endotheliaPing Gong
Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
J Biol Chem 283:13437-49. 2008..These data indicate that LPS recognition by TLR4 activates the SFKs, c-SRC, FYN, and YES, which, in turn, contribute to tyrosine phosphorylation of zonula adherens proteins to open the endothelial paracellular pathway... - Up-regulation of human monocyte CD163 upon activation of cell-surface Toll-like receptorsLehn K Weaver
Department of Microbiology and Immunology, Dartmouth Medical School, HB7700, Lebanon, NH 03756, USA
J Leukoc Biol 81:663-71. 2007..Thus, surface CD163 expression on mononuclear phagocytes is a carefully regulated component of the innate immune response to infection... - Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophagesNicola M Heller
Center for Vascular and Inflammatory Diseases, Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Sci Signal 1:ra17. 2008..Thus, IL-4 activates signaling pathways through type I IL-4Rs qualitatively differently from IL-13, which cooperate to induce optimal gene expression... - The anti-tumor agent, 5,6-dimethylxanthenone-4-acetic acid (DMXAA), induces IFN-beta-mediated antiviral activity in vitro and in vivoKari Ann Shirey
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Leukoc Biol 89:351-7. 2011..Collectively, this study provides data to support the use of DMXAA as a novel antiviral agent... - Role of TLR signaling in Francisella tularensis-LPS-induced, antibody-mediated protection against Francisella tularensis challengeLeah E Cole
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
J Leukoc Biol 90:787-97. 2011..e., production of Ft-LPS-specific antibody, as well as TLR-mediated macrophage activation, to fully control Francisella infection... - Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathwaysLeah E Cole
Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA
J Immunol 180:6885-91. 2008.... - Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitisTerez Shea-Donohue
Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
Innate Immun 14:117-24. 2008..This finding implies that neutrophil infiltration induced by CXCL1/KC is an essential component of the intestinal response to inflammatory stimuli as well as the ability of the intestine to restore mucosal barrier integrity... - Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanismKari Ann Shirey
Department of Microbiology and Immunology, University of Maryland, School of Medicine, Baltimore, MD 21201, USA
J Immunol 181:4159-67. 2008..Thus, redirection of macrophage differentiation by Ft LVS from a classical to an alternative activation state enables the organism to survive at the expense of the host... - Association of TLR4 polymorphisms with symptomatic respiratory syncytial virus infection in high-risk infants and young childrenAgnes A Awomoyi
Department of Microbiology and Immunology, University of Maryland Baltimore, 660 W Redwood Street, Baltimore, MD 21201, USA
J Immunol 179:3171-7. 2007.... - Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challengeLeah E Cole
Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 106:4343-8. 2009..These data support the possibility of creating effective, minimally invasive vaccines that can provide effective protection against pathogen invasion... - The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axisZachary J Roberts
Department of Microbiology and Immunology, University of Maryland Baltimore, Baltimore, MD 21201, USA
J Exp Med 204:1559-69. 2007..These findings detail a novel pathway for TBK1-mediated IRF-3 activation and provide new insights into the mechanism of this new class of chemotherapeutic drugs... - Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophagesLeah E Cole
Department of Microbiology and Immunology, University of Maryland, Baltimore, 660 West Redwood Street, Room 324, Baltimore, MD 21201, USA
Infect Immun 75:4127-37. 2007..Collectively, these data indicate that the primary macrophage response to F. tularensis LVS is overwhelmingly TLR2 dependent, requires de novo bacterial protein synthesis, and is independent of intracellular F. tularensis replication... - Annexin A2 tetramer activates human and murine macrophages through TLR4Jennifer F A Swisher
Laboratory of Molecular and Developmental Immunology, Division of Monoclonal Antibodies, Office of Biotechnology Products, Center for Drug Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA
Blood 115:549-58. 2010.... - IFN regulatory factor-2 regulates macrophage apoptosis through a STAT1/3- and caspase-1-dependent mechanismNatalia Cuesta
Department of Microbiology and Immunology, University of Maryland School of Medicine, 600 West Baltimore Street, Baltimore, MD 21201, USA
J Immunol 178:3602-11. 2007..Collectively, these data support the hypothesis that IRF-2 acts as a transcriptional repressor of Casp1, and that the absence of IRF-2 renders macrophages more sensitive to apoptotic stimuli in a caspase-1-dependent process... - Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genesAraceli E Santiago
Center for Vaccine Development, University of Maryland, Baltimore, 21201, United States
Vaccine 27:2426-36. 2009..These findings suggest the specific deletion of these target genes could generate a safe and efficacious live attenuated vaccine... - Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life spanIan Sabroe
Academic Unit of Respiratory Medicine, Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
J Immunol 170:5268-75. 2003..TLR4 signaling presents itself as a pharmacological target that may allow therapeutic modulation of neutrophil survival by direct and indirect mechanisms at sites of inflammation... - Toll-like receptors 2 and 4 activate STAT1 serine phosphorylation by distinct mechanisms in macrophagesSang Hoon Rhee
The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 278:22506-12. 2003..Furthermore, p38 mitogen-activated protein kinase, protein kinase C-delta, and a novel TLR2-specific signaling pathway appear to be necessary to induce Ser-727 STAT1 phosphorylation... - Proteasome-mediated regulation of CpG DNA- and peptidoglycan-induced cytokines, inflammatory genes, and mitogen-activated protein kinase activationJing Shen
Department of Basic Medical Science, School of Medicine, and Shock/Trauma Research Center, University of Missouri-Kansas City, Kansas City, MO 64108, USA
Shock 25:594-9. 2006..Collectively, these data strongly support the conclusion that the proteasome is a key regulator of the CpG DNA- and PG-induced signaling pathways... - Induction of early inflammatory gene expression in a murine model of nonresuscitated, fixed-volume hemorrhageMichael Rajnik
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4799, USA
Shock 17:322-8. 2002.... - Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharideJian Jun Gao
Department of Basic Medical Sciences, University of Missouri Kansas City, 64108, USA
J Leukoc Biol 72:1234-45. 2002..We conclude that CpG-DNA signaling through TLR9 activates a subset of genes induced by LPS-TLR4 signaling... - Host immune response to Salmonella enterica serovar Typhimurium infection in mice derived from wild strainsGiovanna Sebastiani
Department of Biochemistry, McGill University, , , Canada H3G 1A4
Infect Immun 70:1997-2009. 2002..The high levels of IL-1 expression in the spleens and livers of MOLF/Ei mice may have important implications for the activation of peripheral and central innate immune mechanisms... - Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophagesDagmar Schilling
Pulmonary Center, School of Medicine, Boston University, Boston, MA 02118, USA
J Immunol 169:5874-80. 2002..Together, these studies demonstrate that IL-6, like iNOS and IP-10, is differentially expressed in macrophages stimulated via TLR2 vs TLR4, although these differences appear to arise from distinct signaling mechanisms... - The proteasome as a lipopolysaccharide-binding protein in macrophages: differential effects of proteasome inhibition on lipopolysaccharide-induced signaling eventsNilofer Qureshi
Department of Basic Medical Science, School of Medicine and Shock Trauma Research Center, University of Missouri, Kansas City, MO 64108, USA
J Immunol 171:1515-25. 2003..These data strongly suggest that the proteasome complex regulates the LPS-induced signal transduction and that it may be an important therapeutic target in Gram-negative sepsis... - Bacterial LPS and CpG DNA differentially induce gene expression profiles in mouse macrophagesJian Jun Gao
Department of Basic Medical Sciences, University of Missouri Kansas City, Kansas City, MO 64108, USA
J Endotoxin Res 9:237-43. 2003..These data indicate that the CpG DNA signaling pathway through TLR9 activates only a subset of genes induced by the LPS TLR4 signaling pathway... - Toll-like receptor (TLR)2 and TLR4 agonists regulate CCR expression in human monocytic cellsLisa C Parker
Section of Functional Genomics, Division of Genomic Medicine, University of Sheffield, Sheffield, United Kingdom
J Immunol 172:4977-86. 2004..This work provides further insights into the mechanisms that regulate leukocyte recruitment and trafficking during TLR-induced inflammatory responses... - A novel cell-based system for the rapid quantitative evaluation of (anti)-inflammatory potential of test substancesSerguei V Kozlov
Cancer and Developmental Biology Laboratory, National Cancer Institute, P O Box B, Building 539, Frederick, MD 21702, USA
J Immunol Methods 281:51-63. 2003..In addition, the dual selection capability of the model provides a powerful tool to discover novel molecular components of the NF-kappaB signal transduction pathway... - The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signalsKristi L Williams
Lineberger Comprehensive Cancer Center, Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina 27599, USA
J Biol Chem 280:39914-24. 2005..Mutants containing the NBD-LRR or PyD-NBD also blocked IRAK-1 activation. This is the first example of a CLR protein that antagonizes inflammatory responses initiated by TLR agonists via interference with IRAK-1 activation... - Toll-like receptors in health and disease: complex questions remainIan Sabroe
Division of Genomic Medicine, University of Sheffield, Royal Hallamshire Hospital, Sheffield, United Kingdom
J Immunol 171:1630-5. 2003 - Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105Senad Divanovic
Division of Molecular Immunology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
Nat Immunol 6:571-8. 2005..Finally, RP105 regulated TLR4 signaling in dendritic cells as well as endotoxin responses in vivo. Thus, our results identify RP105 as a physiological negative regulator of TLR4 responses... - TLR2 and TLR4 serve distinct roles in the host immune response against Mycobacterium bovis BCGKurt A Heldwein
The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Massachusetts, USA
J Leukoc Biol 74:277-86. 2003..Thus, TLR2 and TLR4 appear to regulate distinct aspects of the host immune response against BCG... - An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptorsGrace Pinhal-Enfield
Department of Cell Biology and Molecular Medicine, New Jersey Medical School, UMDNJ, Newark, New Jersey 07013, USA
Am J Pathol 163:711-21. 2003..This angiogenic switch may play an important role in ischemia when TLR agonists are present, providing an interface between innate immunity and wound healing... - Key inflammatory signaling pathways are regulated by the proteasomeJing Shen
Department of Basic Medical Science, School of Medicine, and Shock/Trauma Research Center, University of Missouri, Kansas City, MO 64108, USA
Shock 25:472-84. 2006..This represents a novel approach to the identification of signaling pathways that are both toll-like receptor 4- and proteasome-dependent and may lead to the development of new drug targets in Gram-negative sepsis and septic shock... - Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharideMichael Martin
Department of Microbiology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 171:717-25. 2003..gingivalis LPS affects the induction of key immunoregulatory cytokines that control both qualitative and quantitative aspects of innate and adaptive immunity... - Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVSJannet Katz
Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Infect Immun 74:2809-16. 2006..Taken together, our results demonstrate the role of TLR2/TLR6 in the host's inflammatory response to F. tularensis LVS in vitro and the regulatory function of NF-kappaB in modulating the inflammatory response... - Inhibition of TLR-4/MD-2 signaling by RP105/MD-1Senad Divanovic
Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
J Endotoxin Res 11:363-8. 2005.... - CpG DNA induced IL-12 p40 gene activation is independent of STAT1 activation or production of interferon consensus sequence binding proteinMary Bradford
Department of Veterans Affairs Medical Center, University of Iowa, College of Medicine, Iowa City, Iowa 52246, USA
J Biomed Sci 9:688-96. 2002..Thus, CpG DNA-induced IL-12 p40 secretion is mediated by one or more signaling elements distinct from those induced by either LPS or IFN-gamma... - Measurement of Fc gamma receptor-mediated binding and phagocytosisAlexander D Politis
National Institute of Health, Bethesda, Maryland, USA
Curr Protoc Immunol . 2005..A choice of opsonin in both methods allows for some discrimination between subclasses of FcgammaRs that are responsible for the observed results... - Flagellin of enteropathogenic Escherichia coli stimulates interleukin-8 production in T84 cellsXin Zhou
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Infect Immun 71:2120-9. 2003..Our data clearly indicate that FliC of EPEC is sufficient to induce IL-8 release in T84 cells and that activation of the Erk and p38 pathways is required for IL-8 induction... - The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemiaAndre Bafica
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 179:5514-22. 2007..Thus, our findings reveal a new host-protective function for this GTPase in the response to pathogenic encounter... - Pivotal advance: activation of cell surface Toll-like receptors causes shedding of the hemoglobin scavenger receptor CD163Lehn K Weaver
Department of Physiology, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA
J Leukoc Biol 80:26-35. 2006..These data demonstrate that the soluble HbSR is released from monocytic cells in response to TLR signaling as an acute innate immune response to extracellular pathogen infections...
Research Grants
- DIFFERENTIATIVE SIGNALS FOR MACROPHAGE ACTIVATIONStefanie N Vogel; Fiscal Year: 2010..Our findings will lead to development of new drugs that will increase the capacity of macrophages to kill bacteria and viruses more effectively or to prevent or repair damage to tissues caused by bacterial or viral infection. ..
- DIFFERENTIATIVE SIGNALS FOR MACROPHAGE ACTIVATIONStefanie Vogel; Fiscal Year: 2007..abstract_text> ..
- Mechanisms and Consequences of Toll Like Receptor Signal TransductionStefanie Vogel; Fiscal Year: 2007..3) Assess the mechanism of TLR tyrosine phosphorylation and its functional consequences. ..
- ROLES OF TOLL LIKE RECEPTORS IN INNATE IMMUNITYStefanie Vogel; Fiscal Year: 2005....
- EARLY ENDOTOXIN TOLERANCE: CELLULAR/MOLECULAR MECHANISMSStefanie Vogel; Fiscal Year: 2004..It is expected that, at the conclusion of this research, the mechanism of endotoxin tolerance and its potential impact on disease outcome in both sepsis and other diseases will be better understood. ..
- DIFFERENTIATIVE SIGNALS FOR MACROPHAGE ACTIVATIONStefanie N Vogel; Fiscal Year: 2010..Our findings will lead to development of new drugs that will increase the capacity of macrophages to kill bacteria and viruses more effectively or to prevent or repair damage to tissues caused by bacterial or viral infection. ..