NORBERT E VOELKEL

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Vascular endothelial growth factor in the lung
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
  2. ncbi request reprint Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure
    Norbert F Voelkel
    Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, 4200 E Ninth Ave, MC C272, Denver, CO 80262, USA
    Circulation 114:1883-91. 2006
  3. ncbi request reprint Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Crit Care Med 30:S251-6. 2002
  4. ncbi request reprint A conference report. The second Siena International Conference on animal models of chronic obstructive pulmonary disease
    Norbert F Voelkel
    COPD Center, Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Centre, Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Pulm Pharmacol Ther 17:61-3. 2004
  5. ncbi request reprint Emphysema: an autoimmune vascular disease?
    Norbert Voelkel
    COPD Center, Pulmonary and Critical Care Medicine Division, 4200 East Ninth Avenue, C272, Denver, CO 80262, USA
    Proc Am Thorac Soc 2:23-5. 2005
  6. ncbi request reprint cGMP and cAMP cause pulmonary vasoconstriction in the presence of hemolysate
    N F Voelkel
    Pulmonary Hypertension Center, University of Colorado Medical School, Denver, Colorado 20262, USA
    J Appl Physiol 86:1715-20. 1999
  7. ncbi request reprint COPD at the 2004 9th European Pulmonary Summit
    N F Voelkel
    Pulmonary and Critical Care Medicine Division, University of Colorado Health Sciences Center, PO Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Pulm Pharmacol Ther 17:249-51. 2004
  8. ncbi request reprint Pathology of pulmonary hypertension
    Norbert F Voelkel
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Pathology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cardiol Clin 22:343-51, v. 2004
  9. ncbi request reprint Pulmonary vascular involvement in chronic obstructive pulmonary disease
    N F Voelkel
    Pulmonary Hypertension Center, Dept of Pathology, University of Colorado, Health Sciences Center, Denver, Colorado, USA
    Eur Respir J Suppl 46:28s-32s. 2003
  10. pmc Hypoxia and the lung: beyond hypoxic vasoconstriction
    Mark R Nicolls
    Pulmonary Hypertension Center and Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Antioxid Redox Signal 9:741-3. 2007

Detail Information

Publications74

  1. ncbi request reprint Vascular endothelial growth factor in the lung
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Pulmonary and Critical Care Division, 4200 E Ninth Ave, C272, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 290:L209-21. 2006
    ..Here we provide a comprehensive overview of the rapidly expanding literature...
  2. ncbi request reprint Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure
    Norbert F Voelkel
    Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, 4200 E Ninth Ave, MC C272, Denver, CO 80262, USA
    Circulation 114:1883-91. 2006
  3. ncbi request reprint Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Crit Care Med 30:S251-6. 2002
    ..Chemotherapy strategies can now be employed in the animal model in an attempt to treat established vascular-obliterative lung disease...
  4. ncbi request reprint A conference report. The second Siena International Conference on animal models of chronic obstructive pulmonary disease
    Norbert F Voelkel
    COPD Center, Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Centre, Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Pulm Pharmacol Ther 17:61-3. 2004
  5. ncbi request reprint Emphysema: an autoimmune vascular disease?
    Norbert Voelkel
    COPD Center, Pulmonary and Critical Care Medicine Division, 4200 East Ninth Avenue, C272, Denver, CO 80262, USA
    Proc Am Thorac Soc 2:23-5. 2005
    ..Interestingly, the methylprednisolone model illustrates that inflammation is not necessary for the development of emphysema...
  6. ncbi request reprint cGMP and cAMP cause pulmonary vasoconstriction in the presence of hemolysate
    N F Voelkel
    Pulmonary Hypertension Center, University of Colorado Medical School, Denver, Colorado 20262, USA
    J Appl Physiol 86:1715-20. 1999
    ..The importance of our finding is the paradoxical nature of the response to (analogs of) cyclic nucleotides because, to our knowledge, cyclic nucleotide-induced vasoconstriction has not been previously reported...
  7. ncbi request reprint COPD at the 2004 9th European Pulmonary Summit
    N F Voelkel
    Pulmonary and Critical Care Medicine Division, University of Colorado Health Sciences Center, PO Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Pulm Pharmacol Ther 17:249-51. 2004
  8. ncbi request reprint Pathology of pulmonary hypertension
    Norbert F Voelkel
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Pathology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Cardiol Clin 22:343-51, v. 2004
    ..This article briefly discusses the traditional concepts of severe pulmonary hypertension and then details how the concept of severe pulmonary hypertension has moved from a vasoconstrictive to an angioproliferative disorder...
  9. ncbi request reprint Pulmonary vascular involvement in chronic obstructive pulmonary disease
    N F Voelkel
    Pulmonary Hypertension Center, Dept of Pathology, University of Colorado, Health Sciences Center, Denver, Colorado, USA
    Eur Respir J Suppl 46:28s-32s. 2003
    ..They also underscore the importance of the vasculature in what is traditionally thought of as an airways disease. Future treatment strategies need to address the vascular components of chronic obstructive lung disease...
  10. pmc Hypoxia and the lung: beyond hypoxic vasoconstriction
    Mark R Nicolls
    Pulmonary Hypertension Center and Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Antioxid Redox Signal 9:741-3. 2007
    ..How hypoxia shapes immune responses through VEGF and its receptors on mast cells, eosinophils, and dendritic cells and through lung endothelial cell/lymphocyte interactions will be a productive area for future research...
  11. ncbi request reprint Raising awareness of COPD in primary care
    N F Voelkel
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 117:372S-5S. 2000
    ..Simple questionnaires can promote patient awareness and provide feedback to physicians. COPD needs to be identified as not just a disease of smokers...
  12. ncbi request reprint COPD: exacerbation
    N F Voelkel
    Division of Pulmonary Sciences and Critical Care Medicine and Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 117:376S-9S. 2000
    ..The following assessment will raise more questions than answers and will review some of the past and current concepts and contexts...
  13. ncbi request reprint Angiogenesis in chronic lung disease
    Norbert F Voelkel
    University of Colorado at Denver Health Sciences Center, COPD Center, Division of Pulmonary Sciences and Critical Care Medicine, 4200 E Ninth Ave, Box C272, Denver, CO 80220, USA
    Chest 131:874-9. 2007
    ..This review will therefore discuss angiogenesis in several chronic lung diseases and will speculate on how altered vascular homeostasis may contribute to lung disease development...
  14. ncbi request reprint Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade
    Rubin M Tuder
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 29:88-97. 2003
    ..Oxidative stress and apoptosis, which cause lung cellular destruction in emphysema induced by VEGF receptor blockade, may be important mediators common to human and experimental emphysema...
  15. ncbi request reprint Oxygen-dependent regulation of pulmonary circulation
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Department of Pathology, The Johns Hopkinds University School of Medicine, Baltimore, Maryland 21205, USA
    Methods Enzymol 381:87-106. 2004
  16. ncbi request reprint Gene expression profiling in pulmonary hypertension
    Todd M Bull
    Pulmonary and Critical Care Medicine Division, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80262, USA
    Proc Am Thorac Soc 4:117-20. 2007
    ..As will be discussed in this article, the investigation of pulmonary hypertension has already benefited greatly from the application of this technology...
  17. ncbi request reprint Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth
    Shingo Ameshima
    Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colo, USA
    Circ Res 92:1162-9. 2003
    ..We conclude that fluid shear stress decreases the expression of PPARgamma in endothelial cells and that loss of PPARgamma expression characterizes an abnormal, proliferating, apoptosis-resistant endothelial cell phenotype...
  18. ncbi request reprint VEGF receptor inhibition blocks liver cyst growth in pkd2(WS25/-) mice
    Claudia R Amura
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Am J Physiol Cell Physiol 293:C419-28. 2007
    ....
  19. ncbi request reprint Simvastatin causes endothelial cell apoptosis and attenuates severe pulmonary hypertension
    Laimute Taraseviciene-Stewart
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L668-76. 2006
    ..We conclude that simvastatin is effective in inducing apoptosis in hyperproliferative pulmonary vascular lesions and could be considered as a potential drug for treatment of human SPH...
  20. pmc Beta-catenin in the fibroproliferative response to acute lung injury
    Ivor S Douglas
    Department of Medicine, Pulmonary Sciences and Critical Care Medicine, Univ of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 34:274-85. 2006
    ..The noncanonical cadherin-beta-catenin axis is associated with fibroproliferative repair after BHT/hyperoxia exposure and may regulate epithelial proliferation and lung matrix remodeling and repair in response to lung injury...
  21. ncbi request reprint Initial apoptosis is followed by increased proliferation of apoptosis-resistant endothelial cells
    Seiichiro Sakao
    The Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    FASEB J 19:1178-80. 2005
    ..In conclusion, endothelial cell death resulted in the selection of an apoptosis-resistant, proliferating phenotypically altered endothelial cell phenotype...
  22. ncbi request reprint N-acetylcysteine treatment protects against VEGF-receptor blockade-related emphysema
    Yoshiki Demura
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, C272, Denver, Colorado 80262, USA
    COPD 1:25-32. 2004
    ....
  23. ncbi request reprint An animal model of autoimmune emphysema
    Laimute Taraseviciene-Stewart
    Department of Medicine, Division of Pulmonary Sciences, UCHSC, 4200 East Ninth Ave, C272, Denver, CO 80262, USA
    Am J Respir Crit Care Med 171:734-42. 2005
    ..This study shows for the first time that humoral- and CD4+ cell-dependent mechanisms are sufficient to trigger the development of emphysema, suggesting that alveolar septal cell destruction might result from immune mechanisms...
  24. pmc Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling
    Laimute Taraseviciene-Stewart
    Division of Pulmonary Sciences, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Respir Crit Care Med 175:1280-9. 2007
    ..Severe pulmonary arterial hypertension (SPH) is a frequently lethal condition characterized by pulmonary vascular remodeling and right heart strain or failure. SPH is also often associated with autoimmune and collagen vascular disorders...
  25. ncbi request reprint The expression of prostacyclin synthase is decreased in the small pulmonary arteries from patients with emphysema
    Jong Deog Lee
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:575S. 2005
  26. ncbi request reprint Microarray analysis of peripheral blood cells in pulmonary arterial hypertension, surrogate to biopsy
    Todd M Bull
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:584S. 2005
  27. ncbi request reprint Vascular endothelial growth factor receptor blockade by SU5416 combined with pulsatile shear stress causes apoptosis and subsequent proliferation of apoptosis-resistant endothelial cells
    Seiichiro Sakao
    Pulmonary Hypertension Center, Denver, CO, USA
    Chest 128:610S-611S. 2005
  28. ncbi request reprint Metastatic cancer while receiving continuous prostacyclin therapy
    Karen A Fagan
    Department of Medicine, Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, Denver, CO, USA
    Chest 128:619S-620S. 2005
  29. pmc Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis
    Ashok N Babu
    Department of Surgery, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 117:3774-85. 2007
    ..One implication of this study is that bronchial artery revascularization at the time of lung transplantation may decrease the risk of subsequent airway fibrosis...
  30. ncbi request reprint Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats
    Masahiko Oka
    Cardiovascular Pulmonary Research Laboratory and Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Circ Res 100:923-9. 2007
    ....
  31. ncbi request reprint Morphologic changes in explanted lungs after prostacyclin therapy for pulmonary hypertension
    Rosane O D Achcar
    Department of Pathology, University of Colorado Health Sciences Center, Denver, USA
    Eur J Med Res 11:203-7. 2006
    ..In conclusion, PGI2-treated cases revealed more pronounced pulmonary alveolar edema and inflammation, but no morphological evidence of altered vascular remodeling or PGIR expression after PGI2 therapy...
  32. pmc HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques
    John C Marecki
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Box C272, Denver, CO 80262, USA
    Am J Respir Crit Care Med 174:437-45. 2006
    ....
  33. pmc Mechanisms of autoimmune emphysema
    Laimute Taraseviciene-Stewart
    Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, USA
    Proc Am Thorac Soc 3:486-7. 2006
  34. ncbi request reprint Prostacyclin synthase in smoking-related lung disease
    S Patrick Nana-Sinkam
    Division of Pulmonary Sciences and Critical Care Medicine and COPD Center, University of Colorado Health Science Center, 4200 East Ninth Avenue, Belle Bonfils 3B10, Denver, 80262, USA
    Proc Am Thorac Soc 3:517. 2006
  35. ncbi request reprint Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease?
    Laima Taraseviciene-Stewart
    University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Am Thorac Soc 3:687-90. 2006
    ..Presently, we are in the process of investigating whether cigarette smoke extract causes emphysema. We recently identified anti-endothelial cell antibodies in the serum of patients with end-stage emphysema...
  36. ncbi request reprint Importance of right ventricular end-systolic regional wall stress in idiopathic pulmonary arterial hypertension: a new method for estimation of right ventricular wall stress
    Robert A Quaife
    Cardiac Imaging, Division of Cardiology, University of Colorado Health Sciences Center, B 120, 4200 East Ninth Avenue, Denver, Colorado 80262, USA
    Eur J Med Res 11:214-20. 2006
    ..0001). Right ventricular RWS is significantly elevated in IPAH and may provide a useful quantitative monitoring tool in patients with IPAH to assess the benefit of different therapeutic interventions and provide prognostic information...
  37. ncbi request reprint Circulating endothelial cells in pulmonary hypertension
    Todd M Bull
    Division of Pulmonary Sciences and Critical Care Medicine, Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver, CO 80262, USA
    Thromb Haemost 90:698-703. 2003
    ..CECs may provide a non-invasive mean of accessing cells important to the pathobiology of severe pulmonary hypertension...
  38. ncbi request reprint Hypoxia induces different genes in the lungs of rats compared with mice
    Yasushi Hoshikawa
    Pulmonary Hypertension Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Physiol Genomics 12:209-19. 2003
    ....
  39. ncbi request reprint Microsatellite mutational analysis of endothelial cells within plexiform lesions from patients with familial, pediatric, and sporadic pulmonary hypertension
    Michael E Yeager
    Pulmonary Hypertension Center, Division of Pulmonary Sciences, Department of Medicine, University of Colorado Health Sciences Center, Denver CO 80262, USA
    Chest 121:61S. 2002
  40. ncbi request reprint Pulmonary hypertension: cellular and molecular mechanisms
    Carlyne D Cool
    Department of Pathology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 128:565S-571S. 2005
  41. ncbi request reprint A bradykinin antagonist and a caspase inhibitor prevent severe pulmonary hypertension in a rat model
    Laimute Taraseviciene-Stewart
    Pulmonary Hypertension Center, University of Colorado School of Medicine, Denver 80262, USA
    Can J Physiol Pharmacol 80:269-74. 2002
    ..We conclude that EC death induced by VEGFR-2 blockade with SU5416 may trigger an EC selection process that allows for the expansion of apoptosis-resistant EC, possibly driven by mechanisms independent of VEGF and VEGFR-2...
  42. ncbi request reprint Gene microarray analysis of peripheral blood cells in pulmonary arterial hypertension
    Todd M Bull
    Division of Pulmonary Sciences and Critical Care Medicine, 4200 East 9th Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 170:911-9. 2004
    ..Microarray expression profiling of peripheral blood cells can discriminate between patients with PAH and normal volunteers. These findings may have important implications toward diagnosis, screening, and pathogenesis of this disease...
  43. ncbi request reprint Plasma and lipids from stored platelets cause acute lung injury in an animal model
    Christopher C Silliman
    Bonfils Blood Center, 717 Yosemite Circle, Denver, CO 80123, USA
    Transfusion 43:633-40. 2003
    ..We hypothesize that lipids generated during storage of PLTs cause TRALI in a two-event animal model...
  44. ncbi request reprint Angiogenesis and pulmonary hypertension: a unique process in a unique disease
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Antioxid Redox Signal 4:833-43. 2002
    ..The unraveling of the pathobiology of severe pulmonary hypertension may lead us to novel therapies and approaches to better diagnose the disease...
  45. ncbi request reprint Apoptosis of pulmonary microvascular endothelial cells stimulates vascular smooth muscle cell growth
    Seiichiro Sakao
    Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, 80262, USA
    Am J Physiol Lung Cell Mol Physiol 291:L362-8. 2006
    ..In conclusion, EC death induced by high shear stress and VEGFR blockade leads to the production of factors, in particular TGF-beta1, that activate VSMC proliferation...
  46. ncbi request reprint Gene expression profiles in pulmonary hypertension
    Mark W Geraci
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Chest 121:104S-105S. 2002
  47. pmc The cancer paradigm of severe pulmonary arterial hypertension
    Pradeep R Rai
    Department of Pathology, University of Colorado at Denver and Health Sciences Center, Denver, Colorado, USA
    Am J Respir Crit Care Med 178:558-64. 2008
    ..The concept of the endothelial cell as a "quasi-malignant" cell provides a new framework for antiproliferative, antiangiogenic therapy in severe PAH...
  48. ncbi request reprint Emphysema lung tissue gene expression profiling
    Heiko A Golpon
    Division of Pulmonary Sciences and Critical Care Medicine, 4200 East Ninth Avenue, C272, Denver, CO 80262, USA
    Am J Respir Cell Mol Biol 31:595-600. 2004
    ....
  49. ncbi request reprint The protective role of T-lymphocytes in pulmonary vascular remodeling
    L Taraseviciene-Stewart
    Pulmonary Hypertension Center, Denver, CO, USA
    Chest 128:571S-572S. 2005
  50. ncbi request reprint Treatment of severe pulmonary hypertension: a bradykinin receptor 2 agonist B9972 causes reduction of pulmonary artery pressure and right ventricular hypertrophy
    Laimute Taraseviciene-Stewart
    Pulmonary Hypertension Center, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C272, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Peptides 26:1292-300. 2005
    ....
  51. ncbi request reprint Angiotensin-converting enzyme DD genotype in patients with primary pulmonary hypertension: increased frequency and association with preserved haemodynamics
    William T Abraham
    Department of Medicine, University of Colorado, School of Medicine, Denver, USA
    J Renin Angiotensin Aldosterone Syst 4:27-30. 2003
    ....
  52. ncbi request reprint Lipid A fraction of LPS induces a discrete MAPK activation in acute lung injury
    Wen Feng Fang
    Divisio of Pulmonary Sciences and Critical Care Medicine, University of Colorado at Denver, Health Sciences Center, Denver, CO 80204, USA
    Am J Physiol Lung Cell Mol Physiol 293:L336-44. 2007
    ..Compared with whole LPS, the lipid A fraction is associated with amplified whole lung MPO and ERK activation 6 h after intratracheal instillation in mice...
  53. ncbi request reprint VEGF-R blockade causes endothelial cell apoptosis, expansion of surviving CD34+ precursor cells and transdifferentiation to smooth muscle-like and neuronal-like cells
    Seiichiro Sakao
    Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver, Colorado, USA
    FASEB J 21:3640-52. 2007
    ..In conclusion, our data show that SU5416 generated a selection pressure that killed some EC and expanded progenitor-like cells to transdifferentiate to SM-like and neuronal-like cells...
  54. pmc Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema
    Andrew K Sullivan
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Respir Crit Care Med 172:590-6. 2005
    ..Foci of T lymphocytes in the small airways of patients with emphysema have been associated with disease severity. Whether these T cells play an important role in this continued inflammatory response is unknown...
  55. pmc Activated oligoclonal CD4+ T cells in the lungs of patients with severe emphysema
    Andrew K Sullivan
    Univerisity of Colorado Health Sciences Center, Denver, USA
    Proc Am Thorac Soc 3:486. 2006
  56. ncbi request reprint Expression of human herpesvirus 8 in primary pulmonary hypertension
    Carlyne D Cool
    Pulmonary Hypertension Center, University of Colorado Health Sciences Center, Denver 80262, USA
    N Engl J Med 349:1113-22. 2003
    ..The only viral infection associated with severe pulmonary hypertension has been that due to human immunodeficiency virus type 1, but neither the viral genome nor viral antigens have been demonstrated in pathologic lesions...
  57. ncbi request reprint Life after corpse engulfment: phagocytosis of apoptotic cells leads to VEGF secretion and cell growth
    Heiko A Golpon
    Pulmonary Hypertension Center, University of Colorado, Health Sciences Center, Denver, Colorado, USA
    FASEB J 18:1716-8. 2004
    ..We conclude that phagocytosis of apoptotic cells leads to secretion of growth and survival factors by phagocytes that represents a new form of life-promoting cell-cell interaction...
  58. ncbi request reprint Oxidative stress in severe pulmonary hypertension
    Rebecca Bowers
    Pulmonary Hypertension Center, University of Colorado Health Sciences Center, National Jewish Medical and Research Center, Denver 80262, USA
    Am J Respir Crit Care Med 169:764-9. 2004
    ..We conclude that indeed the lungs from patients with severe PH are under oxidative stress and that chronic prostacyclin infusion has an antiinflammatory effect on the lung tissue...
  59. doi request reprint Symposium: Thomas L. Petty Aspen Lung Conference: lung injury and repair. Conference summary
    Norbert F Voelkel
    Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    Proc Am Thorac Soc 5:354-7. 2008
  60. pmc Molecular pathogenesis of emphysema
    Laimute Taraseviciene-Stewart
    Pulmonary and Critical Care Medicine Division, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Clin Invest 118:394-402. 2008
    ....
  61. ncbi request reprint Impaired transforming growth factor-beta signaling in idiopathic pulmonary arterial hypertension
    Amy Richter
    Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Crit Care Med 170:1340-8. 2004
    ....
  62. ncbi request reprint Loss of caveolin and heme oxygenase expression in severe pulmonary hypertension
    Rosane O D Achcar
    Pulmonary Hypertension Center, and Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, C272, Denver, CO 80262, USA
    Chest 129:696-705. 2006
    ..We propose that loss of caveolin expression in the cells of the complex vascular lesions in severe PH reflects the proliferating and apoptosis-resistant nature of these cells...
  63. ncbi request reprint Apoptosis and emphysema: the missing link
    Rubin M Tuder
    Division of Cardiopulmonary Pathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Am J Respir Cell Mol Biol 28:551-4. 2003
  64. ncbi request reprint Methylprednisolone causes matrix metalloproteinase-dependent emphysema in adult rats
    Kang Hyeon Choe
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Box C 272, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Am J Respir Crit Care Med 167:1516-21. 2003
    ..We conclude that systemic treatment of adult rats with the antiinflammatory steroid methylprednisolone increases the activity of matrix metalloproteinases in the lung and causes emphysema...
  65. ncbi request reprint Severe pulmonary hypertension in postmenopausal obese women
    Agne Taraseviciute
    Pulmonary Hypertension Center, University of Colorado Health Science Center, Box C272, 4200 E 9th Ave, Denver, Colorado 80262, USA
    Eur J Med Res 11:198-202. 2006
    ..However, we noticed recently in the UCHSC Pulmonary Hypertension Center that women with severe PH are frequently postmenopausal and overweight or obese...
  66. ncbi request reprint Sarcoidois and pulmonary hypertension--a case report
    Shalini Tayal
    Box 216, Department of Pathology, University of Colorado Health Science Center, 4200, E Ninth Avenue, Denver, Colorado 80262, USA
    Eur J Med Res 11:194-7. 2006
    ..Plexiform lesions indicating severe pulmonary hypertension were identified in pulmonary arteries, which were not involved by granulomas...
  67. ncbi request reprint High-altitude pulmonary edema
    Norbert F Voelkel
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    N Engl J Med 346:1606-7. 2002
  68. pmc Pulmonary arterial remodeling induced by a Th2 immune response
    Eleen Daley
    St Luke s Roosevelt Hospital, New York, NY 10019, USA
    J Exp Med 205:361-72. 2008
    ....
  69. ncbi request reprint Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop
    John H Newman
    Departments of Medicine, Nashville VA Medical Center GRECC, and Vanderbilt University, Nashville, Tenn, USA
    Circulation 109:2947-52. 2004
  70. pmc A novel antiapoptotic role for alpha1-antitrypsin in the prevention of pulmonary emphysema
    Irina Petrache
    Division of Pulmonary and Critical Care, Department of Medicine, John Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 173:1222-8. 2006
    ..The association of alpha1-antitrypsin deficiency with the development of emphysema has supported the concept that protease/antiprotease imbalance mediates cigarette smoke-induced emphysema...
  71. pmc Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke
    S Patrick Nana-Sinkam
    The Ohio State University, Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, 201 Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210, USA
    Am J Respir Crit Care Med 175:676-85. 2007
    ..Prostacyclin (PGI(2)) is a major product of the cyclooxygenase pathway with potent vasodilatory and antimitogenic properties and may be relevant to endothelial dysfunction in COPD...
  72. ncbi request reprint Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure
    Timothy D Le Cras
    Departments of Pediatrics, University of Colorado School of Medicine, Denver 80262, USA
    Am J Physiol Lung Cell Mol Physiol 283:L555-62. 2002
    ....
  73. ncbi request reprint Pulmonary flow reserve in children with idiopathic pulmonary arterial hypertension: implications for diagnosis and therapy
    R Zimmermann
    Paediatric Heart Center, Justus Liebig University, Feulgenstrasse 12, D 35385 Giessen, Germany
    Eur J Med Res 11:208-13. 2006
    ..We hypothesize that there are different patterns of endothelial cell function, which we studied in 17 children with iPAH...
  74. ncbi request reprint Cellular and molecular pathobiology of pulmonary arterial hypertension
    Marc Humbert
    Service de Pneumologie et Reanimation Respiratoire, Centre des Maladies Vasculaires Pulmonaires, UPRES EA2705, Hopital Antoine Beclere, Universite Paris Sud, Clamart, France
    J Am Coll Cardiol 43:13S-24S. 2004
    ..Disordered proteolysis of the extracellular matrix is also evident in PAH. Future studies are required to find which if any of these abnormalities initiates PAH and which ones are best targeted to cure the disease...