MARGARET VIZZARD

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation
    Lauren Arms
    Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 305:F111-22. 2013
  2. ncbi request reprint Neuropeptide/Receptor expression and plasticity in micturition pathways
    Liana Merrill
    University of Vermont College of Medicine, Department of Neurology and Anatomy and Neurobiology, Given Building, D411, Burlington, VT 05405, USA
    Curr Pharm Des 19:4411-22. 2013
  3. pmc Expression and response of acid-sensing ion channels in urinary bladder to cyclophosphamide-induced cystitis
    Kimberly Corrow
    Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 298:F1130-9. 2010
  4. pmc Exogenous overexpression of nerve growth factor in the urinary bladder produces bladder overactivity and altered micturition circuitry in the lumbosacral spinal cord
    Peter Zvara
    Department of Surgery, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    BMC Physiol 7:9. 2007
  5. ncbi request reprint Expression of cyclooxygenase-2 in urinary bladder in rats with cyclophosphamide-induced cystitis
    Mary Beth Klinger
    Univ of Vermont College of Medicine, Dept of Neurology, D415A Given Research Bldg, Burlington, VT 05405
    Am J Physiol Regul Integr Comp Physiol 293:R677-85. 2007
  6. pmc Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 300:F345-55. 2011
  7. ncbi request reprint Changes in pituitary adenylate cyclase activating polypeptide expression in urinary bladder pathways after spinal cord injury
    Katarina Zvarova
    Department of Neurology, University of Vermont, College of Medicine, D411 Given Building, Burlington, VT 05405, USA
    Exp Neurol 192:46-59. 2005
  8. pmc Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors (VEGFR-2, Npn-1, and Npn-2) in rats with cyclophosphamide-induced cystitis
    Bopaiah P Cheppudira
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 295:F826-36. 2008
  9. pmc Role for pituitary adenylate cyclase activating polypeptide in cystitis-induced plasticity of micturition reflexes
    Karen M Braas
    University of Vermont College of Medicine, Department of Anatomy and Neurobiology, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 290:R951-62. 2006
  10. ncbi request reprint Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis
    Jennifer LaBerge
    Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006

Research Grants

  1. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET VIZZARD; Fiscal Year: 2007
  2. Neurotrophic Mechanisms in LUT Plasticity with Cystitis
    MARGARET VIZZARD; Fiscal Year: 2007
  3. Developmental plasticity of micturation reflexes
    MARGARET VIZZARD; Fiscal Year: 2009
  4. Developmental plasticity of micturation reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
  5. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
  6. Developmental Plasticity of Micturition Reflexes
    MARGARET VIZZARD; Fiscal Year: 2005
  7. PLASTICITY OF LUT INTERNEURONS FOLLOWING SPINAL CORD INJ
    MARGARET VIZZARD; Fiscal Year: 2004
  8. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010

Collaborators

  • Peter Zvara
  • L Birder
  • RICHARD GALBRAITH
  • R L Parsons
  • L-Y Qiao
  • G Apodaca
  • Beatrice M Girard
  • Lauren Arms
  • Susan E Malley
  • Victor May
  • Bopaiah P Cheppudira
  • Karen M Braas
  • Mary Beth Klinger
  • Jennifer LaBerge
  • Simon Studeny
  • Kimberly Corrow
  • Kimberly A Corrow
  • Katarina Zvarova
  • Liana Merrill
  • Beatrice Girard
  • John D Tompkins
  • Kristin C Schutz
  • Abbey Dattilio
  • Ruhin Yuridullah
  • Gerald M Herrera
  • J Dana Dunleavy
  • Pierre Guertin
  • James A Waschek
  • Susan Meyers
  • Elena M Balestreire
  • Amanda Wolf-Johnston
  • Jan Kliment
  • Mark T Nelson
  • Bernhard Nausch
  • Ali Torabi

Detail Information

Publications27

  1. pmc Expression and function of CCL2/CCR2 in rat micturition reflexes and somatic sensitivity with urinary bladder inflammation
    Lauren Arms
    Department of Neurological Sciences, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 305:F111-22. 2013
    ..These studies suggest that chemokines/receptors may be novel targets with therapeutic potential in the context of urinary bladder inflammation. ..
  2. ncbi request reprint Neuropeptide/Receptor expression and plasticity in micturition pathways
    Liana Merrill
    University of Vermont College of Medicine, Department of Neurology and Anatomy and Neurobiology, Given Building, D411, Burlington, VT 05405, USA
    Curr Pharm Des 19:4411-22. 2013
    ..LUT neuropeptide/receptor systems in LUT pathways may thus represent potential targets for therapeutic intervention...
  3. pmc Expression and response of acid-sensing ion channels in urinary bladder to cyclophosphamide-induced cystitis
    Kimberly Corrow
    Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 298:F1130-9. 2010
    ..Future studies are necessary to determine ASIC isoform contributions to micturition reflexes in control and inflamed urinary bladder...
  4. pmc Exogenous overexpression of nerve growth factor in the urinary bladder produces bladder overactivity and altered micturition circuitry in the lumbosacral spinal cord
    Peter Zvara
    Department of Surgery, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
    BMC Physiol 7:9. 2007
    ....
  5. ncbi request reprint Expression of cyclooxygenase-2 in urinary bladder in rats with cyclophosphamide-induced cystitis
    Mary Beth Klinger
    Univ of Vermont College of Medicine, Dept of Neurology, D415A Given Research Bldg, Burlington, VT 05405
    Am J Physiol Regul Integr Comp Physiol 293:R677-85. 2007
    ..COX-2-IR macrophages (CD86+) were present throughout the urinary bladder with acute and chronic CYP-induced cystitis. These studies demonstrate cellular targets in the urinary bladder where COX-2 inhibitors may act...
  6. pmc Neurotrophin/receptor expression in urinary bladder of mice with overexpression of NGF in urothelium
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 300:F345-55. 2011
    ..01) increased in urinary bladder of NGF-OE mice. The NGF-OE-induced changes in neurotrophic factor/receptor expression in urinary bladder may represent compensatory changes to reduce voiding frequency in the NGF-OE mouse...
  7. ncbi request reprint Changes in pituitary adenylate cyclase activating polypeptide expression in urinary bladder pathways after spinal cord injury
    Katarina Zvarova
    Department of Neurology, University of Vermont, College of Medicine, D411 Given Building, Burlington, VT 05405, USA
    Exp Neurol 192:46-59. 2005
    ..These studies demonstrate changes in PACAP expression in micturition reflex pathways after SCI that may contribute to urinary bladder dysfunction or reemergence of primitive voiding reflexes after SCI...
  8. pmc Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors (VEGFR-2, Npn-1, and Npn-2) in rats with cyclophosphamide-induced cystitis
    Bopaiah P Cheppudira
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 295:F826-36. 2008
    ..Functional role(s) for the VEGF-VEGF receptor system in urinary bladder inflammation remain to be determined...
  9. pmc Role for pituitary adenylate cyclase activating polypeptide in cystitis-induced plasticity of micturition reflexes
    Karen M Braas
    University of Vermont College of Medicine, Department of Anatomy and Neurobiology, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 290:R951-62. 2006
    ..In summary, these studies support roles for PACAP in micturition and suggest that inflammation-induced plasticity in PACAP expression in peripheral and central micturition pathways contribute to bladder dysfunction with cystitis...
  10. ncbi request reprint Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis
    Jennifer LaBerge
    Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006
    ..CRF may contribute to urinary bladder overactivity and altered sensory processing with CYP-induced cystitis...
  11. ncbi request reprint Phosphorylation of extracellular signal-regulated kinases in urinary bladder in rats with cyclophosphamide-induced cystitis
    Kimberly A Corrow
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 293:R125-34. 2007
    ..01) increased bladder capacity in CYP-treated rats (48 h). These studies suggest that therapies targeted at pERK pathways may improve urinary bladder function in CYP-treated rats...
  12. ncbi request reprint Prolonged retention of the anorectic cobalt protoporphyrin in the hypothalamus and the resulting expression of Fos
    Richard A Galbraith
    Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
    Am J Physiol Regul Integr Comp Physiol 287:R465-71. 2004
    ..Thus CoPP remains in the hypothalamus for prolonged periods and activates Fos expression in the hypothalamus...
  13. pmc VIP and PACAP effects on mouse major pelvic ganglia neurons
    John D Tompkins
    Departments of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 42:390-6. 2010
    ..The results suggest that VIP has a role in the neural control of pelvic organ function and activation of VPAC and/or PAC1 receptors can modulate the activity of the autonomic neurons innervating pelvic organs...
  14. ncbi request reprint Increased expression of neuronal nitric oxide synthase in bladder afferent cells in the lumbosacral dorsal root ganglia after chronic bladder outflow obstruction
    Peter Zvara
    Department of Surgery, University of Vermont, D319 Given Bldg, 89 Beaumont Ave, Burlington, VT 05405, USA
    Brain Res 1002:35-42. 2004
    ..8-fold in males and 1.9-fold in females) and S1 (2.8-fold in males and 5.3-fold in females) DRG. In contrast, no changes in nNOS-IR in neurons or fiber distribution were observed in any spinal cord segments examined...
  15. ncbi request reprint Up-regulation of tyrosine kinase (Trka, Trkb) receptor expression and phosphorylation in lumbosacral dorsal root ganglia after chronic spinal cord (T8-T10) injury
    Liya Qiao
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    J Comp Neurol 449:217-30. 2002
    ..Neuroplasticity of lower urinary tract reflexes after SCI may be mediated by both nerve growth factor and brain-derived neurotrophic factor...
  16. pmc PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis
    Beatrice M Girard
    Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
    J Mol Neurosci 36:310-20. 2008
    ..The current data demonstrate PACAP and PAC1 regulation in micturition pathways with inflammation and PACAP-mediated ATP release from urothelium...
  17. ncbi request reprint Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injury
    Margaret A Vizzard
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Prog Brain Res 152:97-115. 2006
    ....
  18. pmc Postnatal expression of corticotropin releasing factor (CRF) in rat urinary bladder
    Jennifer LaBerge
    Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
    Auton Neurosci 141:83-93. 2008
    ..Changes in CRF expression and neuropeptide expression in general in the urinary bladder may contribute to the emergence of mature voiding reflexes...
  19. pmc Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats
    Bopaiah P Cheppudira
    Dept of Neurology, Univ of Vermont College of Medicine, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 297:F1038-44. 2009
    ..These studies demonstrate a potential role for JAK-STAT signaling pathways in bladder hyperreflexia and referred pain induced by CYP-induced bladder inflammation...
  20. pmc Expression of fractalkine and fractalkine receptor in urinary bladder after cyclophosphamide (CYP)-induced cystitis
    Ruhin Yuridullah
    University of Vermont College of Medicine, Department of Neurology, Burlington, VT 05405, USA
    Auton Neurosci 126:380-9. 2006
    ....
  21. ncbi request reprint PACAP enhances mouse urinary bladder contractility and is upregulated in micturition reflex pathways after cystitis
    Gerald M Herrera
    University of Vermont College of Medicine, Department of Neurology, D411 Given Building, Burlington, VT 05405, USA
    Ann N Y Acad Sci 1070:330-6. 2006
    ..PACAP immunoreactivity (IR) is increased in micturition reflex pathways following cystitis. PACAP may contribute to altered sensation and bladder overactivity in the chronic bladder inflammatory syndrome, interstitial cystitis...
  22. pmc P2X2 and P2X3 receptor expression in postnatal and adult rat urinary bladder and lumbosacral spinal cord
    Simon Studeny
    University of Vermont College of Medicine, Department of Neurology, Burlington, VT 05405, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1155-68. 2005
    ..These studies demonstrate plastic expression of P2X2 and P2X3 receptors in bladder and spinal cord during early postnatal development at times coincident with appearance of mature voiding patterns...
  23. pmc Role of p75NTR in female rat urinary bladder with cyclophosphamide-induced cystitis
    Mary Beth Klinger
    Dept of Neurology, Univ of Vermont College of Medicine, D415A Given Research Bldg, Burlington, VT 05405, USA
    Am J Physiol Renal Physiol 295:F1778-89. 2008
    ..The overall activity of the urinary bladder reflects the balance of NGF-p75(NTR) and NGF-TrkA signaling...
  24. pmc Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- mice
    Simon Studeny
    Department of Neurology, University of Vermont College of Medicine, D415A Given Research Building, Burlington, VT 05405, USA
    J Mol Neurosci 36:175-87. 2008
    ..Thus, these changes may further regulate the neural control of micturition...
  25. ncbi request reprint A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI)
    Peter Zvara
    University of Vermont College of Medicine, Department of Neurology, D411 Given Building, Burlington, VT 05405, USA
    Ann N Y Acad Sci 1070:622-8. 2006
    ..PACAP may contribute to detrusor hyperreflexia induced by SCI and PACAP antagonists may be a novel approach to reduce detrusor hyperreflexia after SCI...
  26. pmc Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis
    Lauren Arms
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 301:F252-62. 2011
    ..These results demonstrate increased AKT phosphorylation in the urinary bladder with urinary bladder inflammation and that blockade of AKT phosphorylation in the urothelium improves overall bladder function...
  27. pmc Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitis
    Lauren Arms
    Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
    Am J Physiol Renal Physiol 298:F589-600. 2010
    ..01) increases in intercontraction interval, bladder capacity, and void volume. These results suggest a role for CXCL12/CXCR4 signaling in both normal micturition and with bladder hyperreflexia following bladder inflammation...

Research Grants26

  1. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET VIZZARD; Fiscal Year: 2007
    ..Axons of these neurons terminate in the inflamed urinary bladder and these cells are also likely to be influenced by the inflammatory milieu. ..
  2. Neurotrophic Mechanisms in LUT Plasticity with Cystitis
    MARGARET VIZZARD; Fiscal Year: 2007
    ..3). To evaluate the physiological roles of PACAP and neurotrophins in the micturition reflex pathway using PACAP knockout mice. ..
  3. Developmental plasticity of micturation reflexes
    MARGARET VIZZARD; Fiscal Year: 2009
    ..It is anticipated that these studies will provide insights into potential targets and therapeutic interventions for childhood and adult voiding dysfunctions. ..
  4. Developmental plasticity of micturation reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..It is anticipated that these studies will provide insights into potential targets and therapeutic interventions for childhood and adult voiding dysfunctions. ..
  5. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..These studies will contribute to the understanding of inflammation-induced changes in chronic bladder inflammation and may provide insights into potential targets and therapeutic interventions for PBS/IC in the future. ..
  6. Developmental Plasticity of Micturition Reflexes
    MARGARET VIZZARD; Fiscal Year: 2005
    ..Anatomical studies will be combined with immunoassay for CRF in the lumbosacral spinal cord. ..
  7. PLASTICITY OF LUT INTERNEURONS FOLLOWING SPINAL CORD INJ
    MARGARET VIZZARD; Fiscal Year: 2004
    ....
  8. Cystitis-Induced Plasticity of Micturition Reflexes
    MARGARET ANN VIZZARD; Fiscal Year: 2010
    ..These studies will contribute to the understanding of inflammation-induced changes in chronic bladder inflammation and may provide insights into potential targets and therapeutic interventions for PBS/IC in the future. ..