Research Topics
Species | M A VizzardSummaryAffiliation: University of Vermont Country: USA Publications
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Publications
Increased expression of neuronal nitric oxide synthase in bladder afferent and spinal neurons following spinal cord injuryM A Vizzard
College of Medicine, University of Vermont, Department of Neurology 0540, USA
Dev Neurosci 19:232-46. 1997..Changes in the neurochemical properties of these neurons after SCI may be mediated by pathological changes in the target organ (i.e., urinary bladder) and/or spinal cord...- Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitisM A Vizzard
Department of Anatomy and Neurology, University of Vermont College of Medicine, E219 Given Building, Burlington, VT 05405, USA
J Chem Neuroanat 21:125-38. 2001..Changes in CGRP or SP expression following cystitis may contribute to the altered visceral sensation (allodynia) and/or urinary bladder hyperreflexia in the clinical syndrome, interstitial cystitis... - Increased expression of spinal cord Fos protein induced by bladder stimulation after spinal cord injuryM A Vizzard
University of Vermont College of Medicine, Departments of Neurology and Anatomy and Neurobiology, Burlington, Vermont 05405, USA
Am J Physiol Regul Integr Comp Physiol 279:R295-305. 2000..These data suggest that SCI can reveal an altered Fos expression pattern in response to a nonnoxious bladder stimulus that is partially mediated by capsaicin-sensitive bladder afferents... - Up-regulation of pituitary adenylate cyclase-activating polypeptide in urinary bladder pathways after chronic cystitisM A Vizzard
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Comp Neurol 420:335-48. 2000..Changes in PACAP expression after cystitis may play a role in altered visceral sensation (allodynia) and/or urinary bladder hyperreflexia in the clinical syndrome, interstitial cystitis... - Alterations in spinal cord Fos protein expression induced by bladder stimulation following cystitisM A Vizzard
University of Vermont College of Medicine, Departments of Neurology and Anatomy and Neurobiology, Burlington, Vermont 05405, USA
Am J Physiol Regul Integr Comp Physiol 278:R1027-39. 2000..These data suggest that chronic cystitis can reveal a nociceptive Fos expression pattern in the spinal cord in response to a non-noxious bladder stimulus that is partially mediated by capasaicin-sensitive bladder afferents... - Developmental expression of urinary bladder neurotrophic factor mRNA and protein in the neonatal ratM A Vizzard
University of Vermont College of Medicine, Departments of Neurology and Anatomy and Neurobiology, E219 Given Building, Burlington, VT 05405, USA
Brain Res Dev Brain Res 119:217-24. 2000..Relatively high expression of NT-3 and NT-4 protein in the adult urinary bladder suggests a potential importance of these factors in the adult lower urinary tract... - Transneuronal labeling of neurons in the adult rat central nervous system following inoculation of pseudorabies virus into the colonM A Vizzard
University of Vermont, College of Medicine, Department of Neurology, Burlington 05405, USA
Cell Tissue Res 299:9-26. 2000.... - Alterations in growth-associated protein (GAP-43) expression in lower urinary tract pathways following chronic spinal cord injuryM A Vizzard
Department of Neurology and Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington 05405, USA
Somatosens Mot Res 16:369-81. 1999.... - Increased expression of growth-associated protein (GAP-43) in lower urinary tract pathways following cyclophosphamide (CYP)-induced cystitisM A Vizzard
Departments of Neurology and Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Brain Res 844:174-87. 1999.... - Changes in galanin immunoreactivity in rat lumbosacral spinal cord and dorsal root ganglia after spinal cord injuryK Zvarova
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Comp Neurol 475:590-603. 2004..Changes in galanin expression in micturition pathways after SCI may be mediated by changing neurotrophic factor expression, particularly BDNF. These changes may contribute to urinary bladder dysfunction after SCI... 
Phosphorylation of extracellular signal-regulated kinases in bladder afferent pathways with cyclophosphamide-induced cystitisK A Corrow
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Neuroscience 163:1353-62. 2009..These studies suggest that activation of the ERK pathway in lumbosacral DRG may play a role in neuroplasticity in micturition reflexes with CYP-induced cystitis...- Changes in galanin immunoreactivity in rat micturition reflex pathways after cyclophosphamide-induced cystitisK Zvarova
Departments of Neurology and Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
Cell Tissue Res 324:213-24. 2006..Galanin-IR was observed encircling DRG cells after chronic cystitis. These changes may contribute to urinary bladder dysfunction, altered sensation, and referred somatic hyperalgesia after cystitis... - Changes in pituitary adenylate cyclase activating polypeptide expression in urinary bladder pathways after spinal cord injuryKatarina Zvarova
Department of Neurology, University of Vermont, College of Medicine, D411 Given Building, Burlington, VT 05405, USA
Exp Neurol 192:46-59. 2005..These studies demonstrate changes in PACAP expression in micturition reflex pathways after SCI that may contribute to urinary bladder dysfunction or reemergence of primitive voiding reflexes after SCI... - Phosphorylation of CREB in thoracolumbar spinal neurons and dorsal root ganglia after renal artery occlusion in ratT S Lishnak
Department of Neurology, College of Medicine, University of Vermont, Burlington 05405, USA
Auton Neurosci 94:62-73. 2001..In addition, expression of p-CREB-IR may be coupled to late response genes that may exert long-term changes in neuronal function after RAO... - Up-regulation of phosphorylated CREB but not c-Jun in bladder afferent neurons in dorsal root ganglia after cystitisLi-Ya Qiao
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Comp Neurol 469:262-74. 2004..Colocalization of p-CREB and Trk receptor(s) showed that a subpopulation of p-CREB-IR cells expressed p-Trk with cystitis. These results suggest that up-regulation of p-CREB may be mediated by a neurotrophin/Trk signaling pathway... - Cystitis-induced upregulation of tyrosine kinase (TrkA, TrkB) receptor expression and phosphorylation in rat micturition pathwaysLi-Ya Qiao
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Comp Neurol 454:200-11. 2002.... - Upregulation of vascular endothelial growth factor isoform VEGF-164 and receptors (VEGFR-2, Npn-1, and Npn-2) in rats with cyclophosphamide-induced cystitisBopaiah P Cheppudira
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Physiol Renal Physiol 295:F826-36. 2008..Functional role(s) for the VEGF-VEGF receptor system in urinary bladder inflammation remain to be determined... - Role for pituitary adenylate cyclase activating polypeptide in cystitis-induced plasticity of micturition reflexesKaren M Braas
University of Vermont College of Medicine, Department of Anatomy and Neurobiology, Burlington, VT 05405, USA
Am J Physiol Regul Integr Comp Physiol 290:R951-62. 2006..In summary, these studies support roles for PACAP in micturition and suggest that inflammation-induced plasticity in PACAP expression in peripheral and central micturition pathways contribute to bladder dysfunction with cystitis... - Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitisJennifer LaBerge
Dept of Anatomy, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Physiol Regul Integr Comp Physiol 291:R692-703. 2006..CRF may contribute to urinary bladder overactivity and altered sensory processing with CYP-induced cystitis... - Spinal cord injury-induced expression of TrkA, TrkB, phosphorylated CREB, and c-Jun in rat lumbosacral dorsal root gangliaLi-Ya Qiao
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Comp Neurol 482:142-54. 2005..However, CREB or c-Jun may not be downstream transcription factors in Trk-mediated signaling cascades in micturition reflex pathways after SCI but may play a role in other, nonbladder SCI-induced changes... - Phosphorylation of extracellular signal-regulated kinases in urinary bladder in rats with cyclophosphamide-induced cystitisKimberly A Corrow
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Physiol Regul Integr Comp Physiol 293:R125-34. 2007..01) increased bladder capacity in CYP-treated rats (48 h). These studies suggest that therapies targeted at pERK pathways may improve urinary bladder function in CYP-treated rats... - PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitisBeatrice M Girard
Department of Anatomy and Neurobiology, University of Vermont, Burlington, VT 05405, USA
J Mol Neurosci 36:310-20. 2008..The current data demonstrate PACAP and PAC1 regulation in micturition pathways with inflammation and PACAP-mediated ATP release from urothelium... - Expression and function of CXCL12/CXCR4 in rat urinary bladder with cyclophosphamide-induced cystitisLauren Arms
Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
Am J Physiol Renal Physiol 298:F589-600. 2010..01) increases in intercontraction interval, bladder capacity, and void volume. These results suggest a role for CXCL12/CXCR4 signaling in both normal micturition and with bladder hyperreflexia following bladder inflammation... - Expression of cyclooxygenase-2 in urinary bladder in rats with cyclophosphamide-induced cystitisMary Beth Klinger
Univ of Vermont College of Medicine, Dept of Neurology, D415A Given Research Bldg, Burlington, VT 05405
Am J Physiol Regul Integr Comp Physiol 293:R677-85. 2007..COX-2-IR macrophages (CD86+) were present throughout the urinary bladder with acute and chronic CYP-induced cystitis. These studies demonstrate cellular targets in the urinary bladder where COX-2 inhibitors may act... 
Exogenous overexpression of nerve growth factor in the urinary bladder produces bladder overactivity and altered micturition circuitry in the lumbosacral spinal cordPeter Zvara
Department of Surgery, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT 05405, USA
BMC Physiol 7:9. 2007....
p75NTR expression in rat urinary bladder sensory neurons and spinal cord with cyclophosphamide-induced cystitisMary Beth Klinger
Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Comp Neurol 507:1379-92. 2008..The functional significance of p75(NTR) expression in micturition reflexes remains to be determined...- Neurochemical plasticity and the role of neurotrophic factors in bladder reflex pathways after spinal cord injuryMargaret A Vizzard
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Prog Brain Res 152:97-115. 2006.... - Prolonged retention of the anorectic cobalt protoporphyrin in the hypothalamus and the resulting expression of FosRichard A Galbraith
Department of Medicine, University of Vermont, Burlington, Vermont 05405, USA
Am J Physiol Regul Integr Comp Physiol 287:R465-71. 2004..Thus CoPP remains in the hypothalamus for prolonged periods and activates Fos expression in the hypothalamus... - VIP and PACAP effects on mouse major pelvic ganglia neuronsJohn D Tompkins
Departments of Anatomy and Neurobiology, College of Medicine, University of Vermont, Burlington, VT 05405, USA
J Mol Neurosci 42:390-6. 2010..The results suggest that VIP has a role in the neural control of pelvic organ function and activation of VPAC and/or PAC1 receptors can modulate the activity of the autonomic neurons innervating pelvic organs... - Up-regulation of tyrosine kinase (Trka, Trkb) receptor expression and phosphorylation in lumbosacral dorsal root ganglia after chronic spinal cord (T8-T10) injuryLiya Qiao
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
J Comp Neurol 449:217-30. 2002..Neuroplasticity of lower urinary tract reflexes after SCI may be mediated by both nerve growth factor and brain-derived neurotrophic factor... - Increased expression of neuronal nitric oxide synthase in bladder afferent cells in the lumbosacral dorsal root ganglia after chronic bladder outflow obstructionPeter Zvara
Department of Surgery, University of Vermont, D319 Given Bldg, 89 Beaumont Ave, Burlington, VT 05405, USA
Brain Res 1002:35-42. 2004..8-fold in males and 1.9-fold in females) and S1 (2.8-fold in males and 5.3-fold in females) DRG. In contrast, no changes in nNOS-IR in neurons or fiber distribution were observed in any spinal cord segments examined... - COX-2 and prostanoid expression in micturition pathways after cyclophosphamide-induced cystitis in the ratV Y Hu
Departments of Neurology, Anatomy and Neurobiology, and Surgery, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
Am J Physiol Regul Integr Comp Physiol 284:R574-85. 2003..These studies suggest an involvement of urinary bladder COX-2 and its metabolites in altered micturition reflexes with CYP-induced cystitis... - Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female ratsBopaiah P Cheppudira
Dept of Neurology, Univ of Vermont College of Medicine, Burlington, VT 05405, USA
Am J Physiol Renal Physiol 297:F1038-44. 2009..These studies demonstrate a potential role for JAK-STAT signaling pathways in bladder hyperreflexia and referred pain induced by CYP-induced bladder inflammation... - Corticotropin-releasing factor (CRF) expression in postnatal and adult rat sacral parasympathetic nucleus (SPN)Simon Studeny
Department of Neurology, University of Vermont College of Medicine, D415A Given Research Building, Burlington, VT, 05405, USA
Cell Tissue Res 322:339-52. 2005..The upregulation of CRF-IR in bulbospinal projections to the SPN may contribute to mature voiding reflexes... - Distribution and fate of cocaine- and amphetamine-regulated transcript peptide (CARTp)-expressing cells in rat urinary bladder: a developmental studyKatarina Zvarova
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Comp Neurol 489:501-17. 2005..This study demonstrates that CARTp-IR intramural ganglia and CARTp-IR paraganglion or SIF cells exist in the postnatal and adult rat bladder, although the role of these cell types remains to be determined... - Up-regulation of protease activated receptors in bladder after cyclophosphamide induced cystitis and colocalization with capsaicin receptor (VR1) in bladder nerve fibersAbbey Dattilio
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Urol 173:635-9. 2005..These results suggest the involvement of PARs in bladder inflammation that contributes to altered sensory processing and reflex function... - Postnatal expression of corticotropin releasing factor (CRF) in rat urinary bladderJennifer LaBerge
Department of Neurology, University of Vermont College of Medicine, Burlington, VT 05405, USA
Auton Neurosci 141:83-93. 2008..Changes in CRF expression and neuropeptide expression in general in the urinary bladder may contribute to the emergence of mature voiding reflexes... - The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamusMuyao Li
Department of Medicine, University of Vermont, C209 Given Bldg, 89 Beaumont Ave, Burlington, Vermont 05405, USA
J Appl Physiol 100:1983-91. 2006..We also demonstrate that CoPP decreases NOS activity but that it paradoxically increases neuronal NOS transcript expression and increases neuronal NOS protein content on Western blotting... - Cyclophosphamide induced cystitis alters neurotrophin and receptor tyrosine kinase expression in pelvic ganglia and bladderElaine Murray
Department of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Urol 172:2434-9. 2004..This increase may reflect a shift in Trk staining from urothelium to detrusor muscle and nerve fibers with cystitis. Neurotrophin/Trk interactions in the bladder and MPG may contribute to bladder overactivity with cystitis... - Electrical properties of neurons in the intact rat major pelvic ganglionH Tan
Department of Neurology, University of Vermont College of Medicine, Burlington, VT, 05045, United States
Auton Neurosci 134:26-37. 2007..A small percentage (<6%) of neurons exhibited spontaneous activity. Taken together these findings are consistent with the concept that neurons in the MPG exhibit heterogeneous electrical properties... - Changes in urinary bladder cytokine mRNA and protein after cyclophosphamide-induced cystitisSusan E Malley
University of Vermont, College of Medicine, Department of Neurology, Burlington, Vermont 05405, USA
Physiol Genomics 9:5-13. 2002..Increased cytokine expression after CYP-induced cystitis, alone or in combination with other inflammatory mediators or growth factors, may contribute to altered lower urinary tract function after cystitis... - P2X2 and P2X3 receptor expression in postnatal and adult rat urinary bladder and lumbosacral spinal cordSimon Studeny
University of Vermont College of Medicine, Department of Neurology, Burlington, VT 05405, USA
Am J Physiol Regul Integr Comp Physiol 289:R1155-68. 2005..These studies demonstrate plastic expression of P2X2 and P2X3 receptors in bladder and spinal cord during early postnatal development at times coincident with appearance of mature voiding patterns... - Role of p75NTR in female rat urinary bladder with cyclophosphamide-induced cystitisMary Beth Klinger
Dept of Neurology, Univ of Vermont College of Medicine, D415A Given Research Bldg, Burlington, VT 05405, USA
Am J Physiol Renal Physiol 295:F1778-89. 2008..The overall activity of the urinary bladder reflects the balance of NGF-p75(NTR) and NGF-TrkA signaling... - Expression of fractalkine and fractalkine receptor in urinary bladder after cyclophosphamide (CYP)-induced cystitisRuhin Yuridullah
University of Vermont College of Medicine, Department of Neurology, Burlington, VT 05405, USA
Auton Neurosci 126:380-9. 2006.... - Differential expression of bladder neurotrophic factor mRNA in male and female rats after bladder outflow obstructionPeter Zvara
Department of Surgery, University of Vermont College of Medicine, Burlington, USA
J Urol 168:2682-8. 2002..We validated a male rat model of bladder outflow obstruction and compared the expression of bladder neurotrophic factor mRNA in male and female rats 6 weeks after bladder outlet obstruction... - Exaggerated expression of inflammatory mediators in vasoactive intestinal polypeptide knockout (VIP-/-) mice with cyclophosphamide (CYP)-induced cystitisBeatrice M Girard
Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, VT, USA
J Mol Neurosci 36:188-99. 2008..This shift in balance may contribute to increased bladder dysfunction in VIP(-/-) mice with bladder inflammation and altered neurochemical expression in micturition pathways... - PACAP enhances mouse urinary bladder contractility and is upregulated in micturition reflex pathways after cystitisGerald M Herrera
University of Vermont College of Medicine, Department of Neurology, D411 Given Building, Burlington, VT 05405, USA
Ann N Y Acad Sci 1070:330-6. 2006..PACAP immunoreactivity (IR) is increased in micturition reflex pathways following cystitis. PACAP may contribute to altered sensation and bladder overactivity in the chronic bladder inflammatory syndrome, interstitial cystitis... - Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitisVivian Y Hu
Departments of Neurology, University of Vermont College of Medicine, Burlington, Vermont 05405, USA
J Urol 173:1016-21. 2005..REN1820 may prove to be a novel therapeutic in individuals with the chronic inflammatory bladder syndrome interstitial cystitis... - Urinary bladder function and somatic sensitivity in vasoactive intestinal polypeptide (VIP)-/- miceSimon Studeny
Department of Neurology, University of Vermont College of Medicine, D415A Given Research Building, Burlington, VT 05405, USA
J Mol Neurosci 36:175-87. 2008..Thus, these changes may further regulate the neural control of micturition... - A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord injury (SCI)Peter Zvara
University of Vermont College of Medicine, Department of Neurology, D411 Given Building, Burlington, VT 05405, USA
Ann N Y Acad Sci 1070:622-8. 2006..PACAP may contribute to detrusor hyperreflexia induced by SCI and PACAP antagonists may be a novel approach to reduce detrusor hyperreflexia after SCI...