Anuradha Vivekanandan-Giri

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Control of cell survival by IGF signaling pathways
    Andrea M Vincent
    Department of Neurology, University of Michigan, Room 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Growth Horm IGF Res 12:193-7. 2002
  2. doi Diabetic neuropathy: cellular mechanisms as therapeutic targets
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, 48109 0588, USA
    Nat Rev Neurol 7:573-83. 2011
  3. doi Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Acta Neuropathol 120:477-89. 2010
  4. doi Hyperlipidemia: a new therapeutic target for diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    J Peripher Nerv Syst 14:257-67. 2009
  5. pmc Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 58:2376-85. 2009
  6. pmc Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Antioxid Redox Signal 11:425-38. 2009
  7. ncbi The antioxidant response as a drug target in diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Drug Targets 9:94-100. 2008
  8. ncbi Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress
    Andrea M Vincent
    Department of Neurology, Room 5017 BSRB, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
    Endocrinology 148:548-58. 2007
  9. ncbi Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Antioxid Redox Signal 7:1494-506. 2005
  10. ncbi Identification of candidate drugs for the treatment of ALS
    Andrea M Vincent
    Department of Neorology, University of Michigan, Ann Arbor, Michigan, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:29-36. 2005

Collaborators

Detail Information

Publications20

  1. ncbi Control of cell survival by IGF signaling pathways
    Andrea M Vincent
    Department of Neurology, University of Michigan, Room 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Growth Horm IGF Res 12:193-7. 2002
    ..This review describes current knowledge of the mechanisms utilized by the IGF system to promote cell survival...
  2. doi Diabetic neuropathy: cellular mechanisms as therapeutic targets
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, 48109 0588, USA
    Nat Rev Neurol 7:573-83. 2011
    ..We highlight the pathways to cellular injury, thereby identifying promising therapeutic targets, including mitochondrial function and inflammation...
  3. doi Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Acta Neuropathol 120:477-89. 2010
    ..Our data suggest that an imbalance between mitochondrial biogenesis and fission may play a role in the pathogenesis of diabetic neuropathy...
  4. doi Hyperlipidemia: a new therapeutic target for diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    J Peripher Nerv Syst 14:257-67. 2009
    ..We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration...
  5. pmc Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
    Diabetes 58:2376-85. 2009
    ..Dyslipidemia also correlates with the development of neuropathy, even in pre-diabetic patients. This study was designed to explore the contribution of dyslipidemia in neuropathy...
  6. pmc Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Antioxid Redox Signal 11:425-38. 2009
    ..Multiple cellular targets exist for the prevention of hyperglycemic oxidative stress in DRG neurons, and these form the basis for new therapeutic strategies against diabetic neuropathy...
  7. ncbi The antioxidant response as a drug target in diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Drug Targets 9:94-100. 2008
    ..In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes...
  8. ncbi Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stress
    Andrea M Vincent
    Department of Neurology, Room 5017 BSRB, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
    Endocrinology 148:548-58. 2007
    ..Our data indicate that therapies aimed at decreasing RAGE ligands, blocking RAGE signaling, or preventing oxidative stress could significantly decrease the development of neuropathy in diabetic patients...
  9. ncbi Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Antioxid Redox Signal 7:1494-506. 2005
    ..The data strengthen the rationale for the current clinical trial. In addition, we describe an effective tool for rapid preclinical testing of novel therapies against diabetic neuropathy...
  10. ncbi Identification of candidate drugs for the treatment of ALS
    Andrea M Vincent
    Department of Neorology, University of Michigan, Ann Arbor, Michigan, USA
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:29-36. 2005
    ..These data extend the understanding of motor neuron degeneration and identify a number of cellular targets for the improvement of combined therapies for neurodegenerative disease...
  11. ncbi Short-term hyperglycemia produces oxidative damage and apoptosis in neurons
    Andrea M Vincent
    University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109, USA
    FASEB J 19:638-40. 2005
    ..Since oxidative stress is a common feature of the micro- and macrovascular complications of diabetes, the present findings have broad application to the treatment of diabetic patients...
  12. ncbi Oxidative stress in the pathogenesis of diabetic neuropathy
    Andrea M Vincent
    Department of Neurology, University of Michigan, Room 4414, Kresge III, 200 Zina Pitcher Place, Ann Arbor 48109, USA
    Endocr Rev 25:612-28. 2004
    ..We conclude that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients...
  13. ncbi IGF-I prevents glutamate-induced motor neuron programmed cell death
    Andrea M Vincent
    Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
    Neurobiol Dis 16:407-16. 2004
    ..We discuss our results in terms of novel strategies for ALS therapy...
  14. pmc Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes
    Lucy M Hinder
    Department of Neurology, University of Michigan, AATBSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Endocrinol 216:1-11. 2013
    ....
  15. doi High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis
    Anuradha Vivekanandan-Giri
    Division of Nephrology, University of Michigan, Ann Arbor, MI 48105, USA
    Ann Rheum Dis 72:1725-31. 2013
    ..In this study, we investigated whether MPO can oxidise HDL and determined MPO-specific oxidative signature by apoA-1 by peptide mapping in RA subjects with and without known cardiovascular disease (CVD)...
  16. doi Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitus
    Rodica Pop-Busui
    Department of Internal Medicine, Division of Metabolism, University of Michigan, Ann Arbor, MI 48109, USA
    Metabolism 58:989-94. 2009
    ..Rosiglitazone, but not glyburide, ameliorated markers of nitrosative stress and inflammation in subjects with T2DM without impairing myocardial perfusion...
  17. ncbi Long-Chain Acyl Coenzyme A Synthetase 1 Overexpression in Primary Cultured Schwann Cells Prevents Long Chain Fatty Acid-Induced Oxidative Stress and Mitochondrial Dysfunction
    Lucy M Hinder
    1 Department of Neurology, University of Michigan, Ann Arbor, Michigan
    Antioxid Redox Signal . 2013
    ..Therefore, targeted improvement in Schwann cell metabolic disposal of LCFAs may improve DN phenotypes. Antioxid. Redox Signal. 00, 000-000...
  18. pmc Quantitative analysis of amino Acid oxidation markers by tandem mass spectrometry
    Anuradha Vivekanandan-Giri
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Methods Enzymol 491:73-89. 2011
    ..The ability to quantify these changes and assess response to therapies will be pivotal in understanding disease mechanisms and monitoring efficacy of therapy...
  19. pmc Urine glycoprotein profile reveals novel markers for chronic kidney disease
    Anuradha Vivekanandan-Giri
    Division of Nephrology, University of Michigan, Ann Arbor, MI 48105, USA
    Int J Proteomics 2011:214715. 2011
    ..Collectively, our observations suggest that the human urinary glycoproteome may serve as a discovery source for novel mechanism-based biomarkers of CKD...
  20. pmc Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis
    Seth G Thacker
    National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA
    Arthritis Rheum 64:2975-85. 2012
    ..This study was undertaken to examine the role of type I IFNs in endothelial dysfunction, aberrant vascular repair, and atherothrombosis in murine models of lupus and atherosclerosis...