Research Topics
Species | Anuradha Vivekanandan-GiriSummaryAffiliation: University of Michigan Country: USA Publications
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Detail Information
Publications
Control of cell survival by IGF signaling pathwaysAndrea M Vincent
Department of Neurology, University of Michigan, Room 4414 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109, USA
Growth Horm IGF Res 12:193-7. 2002..This review describes current knowledge of the mechanisms utilized by the IGF system to promote cell survival...
Hyperlipidemia: a new therapeutic target for diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
J Peripher Nerv Syst 14:257-67. 2009..We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration...
Dyslipidemia-induced neuropathy in mice: the role of oxLDL/LOX-1Andrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA
Diabetes 58:2376-85. 2009..Dyslipidemia also correlates with the development of neuropathy, even in pre-diabetic patients. This study was designed to explore the contribution of dyslipidemia in neuropathy...- Diabetic neuropathy: cellular mechanisms as therapeutic targetsAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, 48109 0588, USA
Nat Rev Neurol 7:573-83. 2011..We highlight the pathways to cellular injury, thereby identifying promising therapeutic targets, including mitochondrial function and inflammation... - Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanismsAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109, USA
Antioxid Redox Signal 11:425-38. 2009..Multiple cellular targets exist for the prevention of hyperglycemic oxidative stress in DRG neurons, and these form the basis for new therapeutic strategies against diabetic neuropathy... - The antioxidant response as a drug target in diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Curr Drug Targets 9:94-100. 2008..In combination with antihyperglycemic agents, agents that regulate the antioxidant response may afford superior protection against cellular oxidative injury in diabetes... - Receptor for advanced glycation end products activation injures primary sensory neurons via oxidative stressAndrea M Vincent
Department of Neurology, Room 5017 BSRB, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109, USA
Endocrinology 148:548-58. 2007..Our data indicate that therapies aimed at decreasing RAGE ligands, blocking RAGE signaling, or preventing oxidative stress could significantly decrease the development of neuropathy in diabetic patients... - Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injuryAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Antioxid Redox Signal 7:1494-506. 2005..The data strengthen the rationale for the current clinical trial. In addition, we describe an effective tool for rapid preclinical testing of novel therapies against diabetic neuropathy... - Identification of candidate drugs for the treatment of ALSAndrea M Vincent
Department of Neorology, University of Michigan, Ann Arbor, Michigan, USA
Amyotroph Lateral Scler Other Motor Neuron Disord 6:29-36. 2005..These data extend the understanding of motor neuron degeneration and identify a number of cellular targets for the improvement of combined therapies for neurodegenerative disease... - Short-term hyperglycemia produces oxidative damage and apoptosis in neuronsAndrea M Vincent
University of Michigan, Department of Neurology, Ann Arbor, Michigan 48109, USA
FASEB J 19:638-40. 2005..Since oxidative stress is a common feature of the micro- and macrovascular complications of diabetes, the present findings have broad application to the treatment of diabetic patients... - Oxidative stress in the pathogenesis of diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Room 4414, Kresge III, 200 Zina Pitcher Place, Ann Arbor 48109, USA
Endocr Rev 25:612-28. 2004..We conclude that striving for superior antioxidative therapies remains essential for the prevention of neuropathy in diabetic patients... - IGF-I prevents glutamate-induced motor neuron programmed cell deathAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Neurobiol Dis 16:407-16. 2004..We discuss our results in terms of novel strategies for ALS therapy... - Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathyAndrea M Vincent
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA
Acta Neuropathol 120:477-89. 2010..Our data suggest that an imbalance between mitochondrial biogenesis and fission may play a role in the pathogenesis of diabetic neuropathy... - Impact of rosiglitazone and glyburide on nitrosative stress and myocardial blood flow regulation in type 2 diabetes mellitusRodica Pop-Busui
Department of Internal Medicine, Division of Metabolism, University of Michigan, Ann Arbor, MI 48109, USA
Metabolism 58:989-94. 2009..Rosiglitazone, but not glyburide, ameliorated markers of nitrosative stress and inflammation in subjects with T2DM without impairing myocardial perfusion... - Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetesLucy M Hinder
Department of Neurology, University of Michigan, AATBSRB, 109 Zina Pitcher Place, Ann Arbor, Michigan 48109 2200, USA Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
J Endocrinol 216:1-11. 2013.... - Quantitative analysis of amino Acid oxidation markers by tandem mass spectrometryAnuradha Vivekanandan-Giri
Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Methods Enzymol 491:73-89. 2011..The ability to quantify these changes and assess response to therapies will be pivotal in understanding disease mechanisms and monitoring efficacy of therapy... - Urine glycoprotein profile reveals novel markers for chronic kidney diseaseAnuradha Vivekanandan-Giri
Division of Nephrology, University of Michigan, Ann Arbor, MI 48105, USA
Int J Proteomics 2011:214715. 2011..Collectively, our observations suggest that the human urinary glycoproteome may serve as a discovery source for novel mechanism-based biomarkers of CKD... - Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosisSeth G Thacker
National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA
Arthritis Rheum 64:2975-85. 2012..This study was undertaken to examine the role of type I IFNs in endothelial dysfunction, aberrant vascular repair, and atherothrombosis in murine models of lupus and atherosclerosis...