Michele I Vitolo

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells
    Michele I Vitolo
    University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 69:8275-83. 2009
  2. pmc Knockin of mutant PIK3CA activates multiple oncogenic pathways
    John P Gustin
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:2835-40. 2009
  3. doi request reprint The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence
    Keyata N Thompson
    University of Maryland School of Medicine, Marlene and Stewart Greenebaum National Cancer Institute Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Oncotarget 6:35231-46. 2015
  4. pmc P21 gene knock down does not identify genetic effectors seen with gene knock out
    Bedri Karakas
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 6:1025-30. 2007
  5. pmc Tamoxifen-stimulated growth of breast cancer due to p21 loss
    Abde M Abukhdeir
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:288-93. 2008
  6. pmc ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells
    Lekhana Bhandary
    University of Maryland School of Medicine, Marlene and Stewart Greenebaum National Cancer Institute Cancer Center, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    Oncotarget 6:6251-66. 2015
  7. pmc α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration
    Amanda E Boggs
    University of Maryland, Baltimore, Graduate Program in Life Sciences, Baltimore, Maryland University of Maryland Marlene and Stewart Greenebaum NCI Cancer Center, Baltimore, Maryland
    Cancer Res 75:203-15. 2015
  8. pmc Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment
    Monica S Charpentier
    Authors Affiliations Marlene and Stewart Greenebaum National Cancer Institute Cancer Center Program in Molecular Medicine and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland
    Cancer Res 74:1250-60. 2014
  9. pmc Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype
    Adam D Pierce
    The Graduate Program in Life Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Cell Biochem 113:282-92. 2012
  10. doi request reprint Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment
    Kristi R Chakrabarti
    University of Maryland School of Medicine, Marlene and Stewart Greenebaum National Cancer Institute Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Oncotarget 6:36292-307. 2015

Collaborators

Detail Information

Publications16

  1. pmc Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells
    Michele I Vitolo
    University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Cancer Res 69:8275-83. 2009
    ..Finally, MCF-10A cells with the reduction or loss of PTEN showed increased susceptibility to the chemotherapeutic drug doxorubicin but not paclitaxel...
  2. pmc Knockin of mutant PIK3CA activates multiple oncogenic pathways
    John P Gustin
    The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 106:2835-40. 2009
    ..Our findings suggest GSK3beta is an important effector of mutant PIK3CA, and that lithium, an FDA-approved therapy for bipolar disorders, has selective antineoplastic properties against cancers that harbor these mutations...
  3. doi request reprint The combinatorial activation of the PI3K and Ras/MAPK pathways is sufficient for aggressive tumor formation, while individual pathway activation supports cell persistence
    Keyata N Thompson
    University of Maryland School of Medicine, Marlene and Stewart Greenebaum National Cancer Institute Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Oncotarget 6:35231-46. 2015
    ..This could have important implications in determining recurrence risk and disease progression in tumor subtypes where these mutations are common...
  4. pmc P21 gene knock down does not identify genetic effectors seen with gene knock out
    Bedri Karakas
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 6:1025-30. 2007
    ..We conclude that gene knock out can yield additional vital information that may be missed with gene knock down strategies...
  5. pmc Tamoxifen-stimulated growth of breast cancer due to p21 loss
    Abde M Abukhdeir
    The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 105:288-93. 2008
    ..These data reveal a previously uncharacterized molecular mechanism of tamoxifen resistance and have potential clinical implications for the management of tamoxifen-resistant breast cancers...
  6. pmc ROCK inhibition promotes microtentacles that enhance reattachment of breast cancer cells
    Lekhana Bhandary
    University of Maryland School of Medicine, Marlene and Stewart Greenebaum National Cancer Institute Cancer Center, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    Oncotarget 6:6251-66. 2015
    ..Although ROCK inhibitors may be effective in reducing adherent tumor cell behavior, our results indicate that they could inadvertently increase metastatic potential of non-adherent CTCs by increasing their reattachment efficacy. ..
  7. pmc α-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration
    Amanda E Boggs
    University of Maryland, Baltimore, Graduate Program in Life Sciences, Baltimore, Maryland University of Maryland Marlene and Stewart Greenebaum NCI Cancer Center, Baltimore, Maryland
    Cancer Res 75:203-15. 2015
    ....
  8. pmc Curcumin targets breast cancer stem-like cells with microtentacles that persist in mammospheres and promote reattachment
    Monica S Charpentier
    Authors Affiliations Marlene and Stewart Greenebaum National Cancer Institute Cancer Center Program in Molecular Medicine and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland
    Cancer Res 74:1250-60. 2014
    ..Together, our results support a model in which breast CSCs with cytoskeletal alterations that promote McTNs can mediate attachment and metastasis but might be targeted by curcumin as an antimetastatic strategy...
  9. pmc Glucose-activated RUNX2 phosphorylation promotes endothelial cell proliferation and an angiogenic phenotype
    Adam D Pierce
    The Graduate Program in Life Sciences, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Cell Biochem 113:282-92. 2012
    ..These data suggest that inhibition of RUNX2 expression or DNA binding may be a useful strategy to inhibit EC proliferation in tumor angiogenesis...
  10. doi request reprint Pharmacologic regulation of AMPK in breast cancer affects cytoskeletal properties involved with microtentacle formation and re-attachment
    Kristi R Chakrabarti
    University of Maryland School of Medicine, Marlene and Stewart Greenebaum National Cancer Institute Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA
    Oncotarget 6:36292-307. 2015
    ..These results support a model where AMPK activators may be used therapeutically to reduce the metastatic efficiency of breast tumor cells...
  11. pmc Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK
    Kira G Hartman
    From the Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201
    J Biol Chem 289:12886-95. 2014
    ..Additionally, the overexpression of S100B sequesters RSK into the cytosol and prevents it from acting on nuclear targets. Thus, elevated S100B contributes to abnormal ERK/RSK signaling and increased cell survival in malignant melanoma. ..
  12. ncbi request reprint The RUNX2 transcription factor cooperates with the YES-associated protein, YAP65, to promote cell transformation
    Michele I Vitolo
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Cancer Biol Ther 6:856-63. 2007
    ..Therefore, these results reveal a novel function of the RUNX2 and YAP65 interaction in oncogenic transformation that may be mediated by modulation of p21(CIP1) protein expression...
  13. pmc Epithelial-to-mesenchymal transition promotes tubulin detyrosination and microtentacles that enhance endothelial engagement
    Rebecca A Whipple
    Marlene and Stewart Greenebaum National Cancer Institute Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Cancer Res 70:8127-37. 2010
    ....
  14. pmc Loss of the obscurin-RhoGEF downregulates RhoA signaling and increases microtentacle formation and attachment of breast epithelial cells
    Nicole A Perry
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD
    Oncotarget 5:8558-68. 2014
    ....
  15. pmc Quantitative imaging of mitochondrial and cytosolic free zinc levels in an in vitro model of ischemia/reperfusion
    Bryan J McCranor
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 N Greene St, Baltimore, MD 21201, USA
    J Bioenerg Biomembr 44:253-63. 2012
    ..The increase in intramitochondrial zinc observed during reoxygenation after OGD may contribute to bioenergetic dysfunction and cell death that occurs with both in vitro and in vivo models of reperfusion...
  16. ncbi request reprint Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells
    Abde M Abukhdeir
    Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Breast Cancer Res Treat 99:23-33. 2006
    ....