Research Topics
Species | ROSE MARIE VISCARDISummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
Developmental changes in phosphatidylinositol transfer protein concentration and phospholipid transfer activities in rat type II cellsR M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
Exp Lung Res 25:561-76. 1999....
Ureaplasma species: role in diseases of prematurityRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, 29 South Greene Street, Rm GS110, Baltimore, MD 21201, USA
Clin Perinatol 37:393-409. 2010..Appropriate methods for detecting these fastidious organisms and potential strategies to prevent or ameliorate the effects of Ureaplasma infection are discussed...- Role of Ureaplasma species in neonatal chronic lung disease: epidemiologic and experimental evidenceROSE MARIE VISCARDI
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Pediatr Res 65:84R-90R. 2009..Potential strategies to prevent or ameliorate the effects of Ureaplasma infection in utero and in the preterm lung are discussed... 
Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhageR M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Perinatol 28:759-65. 2008....- Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lungRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Pediatr Res 60:141-6. 2006..Collectively, these data suggest that a prolonged proinflammatory response initiated by intrauterine Ureaplasma infection contributes to early fibrosis and altered developmental signaling in the immature lung... - Disordered pulmonary myofibroblast distribution and elastin expression in preterm infants with Ureaplasma urealyticum pneumonitisRose Viscardi
Department of Pediatrics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, 21201, USA
Pediatr Dev Pathol 9:143-51. 2006.... - Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infantsRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Pediatr Res 55:1009-17. 2004..05 each case) but not >/=28 wk GA. These data suggest that in infants </=28 wks GA, BPD may be initiated by inflammatory mediators in amniotic fluid, but brain injury may involve variations in the systemic inflammatory response... - Perinatal inflammation and lung injuryROSE MARIE VISCARDI
Department of Pediatrics, University of Maryland School of Medicine, 29 S Greene St, Rm GS110, Baltimore, MD 21201, USA
Semin Fetal Neonatal Med 17:30-5. 2012.... - Characterization of a murine model of Ureaplasma urealyticum pneumoniaRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
Infect Immun 70:5721-9. 2002.... - Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalitiesR M Viscardi
Department of Pediatrics, University of Maryland Hospital, Room N5W68, 22 S Greene Street, Baltimore, MD 21201, USA
Early Hum Dev 62:1-10. 2001.... - Lung pathology in premature infants with Ureaplasma urealyticum infectionRose M Viscardi
Department of Pediatrics, University of Maryland School of Medicine, 22 S. Greene Street, Baltimore, MD 21201, USA
Pediatr Dev Pathol 5:141-50. 2002..We conclude that persistent lung U. urealyticum infection may contribute to chronic inflammation and early fibrosis in the preterm lung... - Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infantsAdora C Okogbule-Wonodi
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Pediatr Res 69:442-7. 2011..Ureaplasma may be a factor in NEC pathogenesis in preterm infants by contributing to intestinal mucosal injury and/or altering systemic or local immune responses... - Surfactant protein-A limits Ureaplasma-mediated lung inflammation in a murine pneumonia modelMobolaji E Famuyide
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Pediatr Res 66:162-7. 2009..SP-A deficiency may contribute to the prolonged inflammatory response in the Ureaplasma-infected preterm lung, but other factors may contribute to the impaired Ureaplasma clearance... - Discrepancy in pathologic diagnosis of placental lesionsChen Chih J Sun
Department of Pathology, University of Maryland, Baltimore 21201, USA
Arch Pathol Lab Med 126:706-9. 2002..Placentas are routinely examined by surgical pathologists, but peer review of placental diagnosis is rarely performed... - Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicityJeffrey D Hasday
Divisions of Pulmonary and Critical Care Medicine, Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
Am J Pathol 162:2005-17. 2003..In certain conditions, such as in the hyperoxic lung, this process may be deleterious... - Hypothermia prolongs activation of NF-kappaB and augments generation of inflammatory cytokinesKaren D Fairchild
Department of Pediatrics, Division of Neonatology, Rm N5W68, University of Maryland Hospital, 22 S Greene Street, Baltimore, MD 21201, USA
Am J Physiol Cell Physiol 287:C422-31. 2004.... - Pharmacokinetics, safety, and biologic effects of azithromycin in extremely preterm infants at risk for ureaplasma colonization and bronchopulmonary dysplasiaHazem E Hassan
Pharmacokinetics and Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA
J Clin Pharmacol 51:1264-75. 2011..These results demonstrated the safety of azithromycin and developed a pharmacokinetic model that is useful for future simulation-based clinical trials for eradicating Ureaplasma and preventing BPD in preterm neonates...
Research Grants
- Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung InjuryRose Viscardi; Fiscal Year: 2007..The proposed study will determine if defects in the babies' immune system (ability to fight infection) increase the risk for this infection and the detrimental effects on lung development and may lead to new therapies to prevent BPD. ..
- Azithromycin to prevent BPD in Ureaplasma-infected Preterms: Single Dose PK studyRose Viscardi; Fiscal Year: 2007..This study will evaluate the safety and pharmacokinetics (how the body processes the drug) of the antibiotic azithromycin in preterm babies at risk for the Ureaplasma infection and the complication BPD. ..
- Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung InjuryRose Viscardi; Fiscal Year: 2009....
- Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung InjuryROSE MARIE VISCARDI; Fiscal Year: 2010....
- Determinants of Ureaplasma-mediated neonatal lung injuryRose Viscardi; Fiscal Year: 2003..These studies will provide new insights into how certain serovars contribute to the prolonged inflammatory process in BPD. ..