ROSE MARIE VISCARDI

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Antimicrob Agents Chemother 57:2127-33. 2013
  2. ncbi request reprint Developmental changes in phosphatidylinositol transfer protein concentration and phospholipid transfer activities in rat type II cells
    R M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Exp Lung Res 25:561-76. 1999
  3. pmc Perinatal inflammation and lung injury
    ROSE MARIE VISCARDI
    Department of Pediatrics, University of Maryland School of Medicine, 29 S Greene St, Rm GS110, Baltimore, MD 21201, USA
    Semin Fetal Neonatal Med 17:30-5. 2012
  4. pmc Ureaplasma species: role in diseases of prematurity
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, 29 South Greene Street, Rm GS110, Baltimore, MD 21201, USA
    Clin Perinatol 37:393-409. 2010
  5. pmc Role of Ureaplasma species in neonatal chronic lung disease: epidemiologic and experimental evidence
    ROSE MARIE VISCARDI
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 65:84R-90R. 2009
  6. doi request reprint Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage
    R M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Perinatol 28:759-65. 2008
  7. ncbi request reprint Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatr Res 60:141-6. 2006
  8. ncbi request reprint Disordered pulmonary myofibroblast distribution and elastin expression in preterm infants with Ureaplasma urealyticum pneumonitis
    Rose Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, 21201, USA
    Pediatr Dev Pathol 9:143-51. 2006
  9. ncbi request reprint Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatr Res 55:1009-17. 2004
  10. ncbi request reprint Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities
    R M Viscardi
    Department of Pediatrics, University of Maryland Hospital, Room N5W68, 22 S Greene Street, Baltimore, MD 21201, USA
    Early Hum Dev 62:1-10. 2001

Collaborators

Detail Information

Publications19

  1. pmc Azithromycin to prevent bronchopulmonary dysplasia in ureaplasma-infected preterm infants: pharmacokinetics, safety, microbial response, and clinical outcomes with a 20-milligram-per-kilogram single intravenous dose
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Antimicrob Agents Chemother 57:2127-33. 2013
    ..Ureaplasma was eradicated in all treated Ureaplasma-positive subjects. Simulations suggest that a multiple-dose regimen may be efficacious for microbial clearance, but the effect on BPD remains to be determined...
  2. ncbi request reprint Developmental changes in phosphatidylinositol transfer protein concentration and phospholipid transfer activities in rat type II cells
    R M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Exp Lung Res 25:561-76. 1999
    ....
  3. pmc Perinatal inflammation and lung injury
    ROSE MARIE VISCARDI
    Department of Pediatrics, University of Maryland School of Medicine, 29 S Greene St, Rm GS110, Baltimore, MD 21201, USA
    Semin Fetal Neonatal Med 17:30-5. 2012
    ....
  4. pmc Ureaplasma species: role in diseases of prematurity
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, 29 South Greene Street, Rm GS110, Baltimore, MD 21201, USA
    Clin Perinatol 37:393-409. 2010
    ..Appropriate methods for detecting these fastidious organisms and potential strategies to prevent or ameliorate the effects of Ureaplasma infection are discussed...
  5. pmc Role of Ureaplasma species in neonatal chronic lung disease: epidemiologic and experimental evidence
    ROSE MARIE VISCARDI
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 65:84R-90R. 2009
    ..Potential strategies to prevent or ameliorate the effects of Ureaplasma infection in utero and in the preterm lung are discussed...
  6. doi request reprint Incidence of invasive ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage
    R M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Perinatol 28:759-65. 2008
    ....
  7. ncbi request reprint Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatr Res 60:141-6. 2006
    ..Collectively, these data suggest that a prolonged proinflammatory response initiated by intrauterine Ureaplasma infection contributes to early fibrosis and altered developmental signaling in the immature lung...
  8. ncbi request reprint Disordered pulmonary myofibroblast distribution and elastin expression in preterm infants with Ureaplasma urealyticum pneumonitis
    Rose Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, 21201, USA
    Pediatr Dev Pathol 9:143-51. 2006
    ....
  9. ncbi request reprint Inflammatory markers in intrauterine and fetal blood and cerebrospinal fluid compartments are associated with adverse pulmonary and neurologic outcomes in preterm infants
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Pediatr Res 55:1009-17. 2004
    ..05 each case) but not >/=28 wk GA. These data suggest that in infants </=28 wks GA, BPD may be initiated by inflammatory mediators in amniotic fluid, but brain injury may involve variations in the systemic inflammatory response...
  10. ncbi request reprint Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities
    R M Viscardi
    Department of Pediatrics, University of Maryland Hospital, Room N5W68, 22 S Greene Street, Baltimore, MD 21201, USA
    Early Hum Dev 62:1-10. 2001
    ....
  11. pmc Characterization of a murine model of Ureaplasma urealyticum pneumonia
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, USA
    Infect Immun 70:5721-9. 2002
    ....
  12. doi request reprint Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infants
    Adora C Okogbule-Wonodi
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 69:442-7. 2011
    ..Ureaplasma may be a factor in NEC pathogenesis in preterm infants by contributing to intestinal mucosal injury and/or altering systemic or local immune responses...
  13. ncbi request reprint Lung pathology in premature infants with Ureaplasma urealyticum infection
    Rose M Viscardi
    Department of Pediatrics, University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Pediatr Dev Pathol 5:141-50. 2002
    ..We conclude that persistent lung U. urealyticum infection may contribute to chronic inflammation and early fibrosis in the preterm lung...
  14. ncbi request reprint Discrepancy in pathologic diagnosis of placental lesions
    Chen Chih J Sun
    Department of Pathology, University of Maryland, Baltimore 21201, USA
    Arch Pathol Lab Med 126:706-9. 2002
    ..Placentas are routinely examined by surgical pathologists, but peer review of placental diagnosis is rarely performed...
  15. pmc Surfactant protein-A limits Ureaplasma-mediated lung inflammation in a murine pneumonia model
    Mobolaji E Famuyide
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Pediatr Res 66:162-7. 2009
    ..SP-A deficiency may contribute to the prolonged inflammatory response in the Ureaplasma-infected preterm lung, but other factors may contribute to the impaired Ureaplasma clearance...
  16. pmc Febrile-range hyperthermia augments pulmonary neutrophil recruitment and amplifies pulmonary oxygen toxicity
    Jeffrey D Hasday
    Divisions of Pulmonary and Critical Care Medicine, Department of Pathology, University of Maryland, Baltimore, Maryland 21201, USA
    Am J Pathol 162:2005-17. 2003
    ..In certain conditions, such as in the hyperoxic lung, this process may be deleterious...
  17. ncbi request reprint Hypothermia prolongs activation of NF-kappaB and augments generation of inflammatory cytokines
    Karen D Fairchild
    Department of Pediatrics, Division of Neonatology, Rm N5W68, University of Maryland Hospital, 22 S Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 287:C422-31. 2004
    ....
  18. doi request reprint Ureaplasma species: role in neonatal morbidities and outcomes
    ROSE MARIE VISCARDI
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Arch Dis Child Fetal Neonatal Ed 99:F87-92. 2014
    ....
  19. doi request reprint Pharmacokinetics, safety, and biologic effects of azithromycin in extremely preterm infants at risk for ureaplasma colonization and bronchopulmonary dysplasia
    Hazem E Hassan
    Pharmacokinetics and Biopharmaceutics Laboratory, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA
    J Clin Pharmacol 51:1264-75. 2011
    ..These results demonstrated the safety of azithromycin and developed a pharmacokinetic model that is useful for future simulation-based clinical trials for eradicating Ureaplasma and preventing BPD in preterm neonates...

Research Grants9

  1. Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung Injury
    Rose Viscardi; Fiscal Year: 2007
    ..The proposed study will determine if defects in the babies' immune system (ability to fight infection) increase the risk for this infection and the detrimental effects on lung development and may lead to new therapies to prevent BPD. ..
  2. Azithromycin to prevent BPD in Ureaplasma-infected Preterms: Single Dose PK study
    Rose Viscardi; Fiscal Year: 2007
    ..This study will evaluate the safety and pharmacokinetics (how the body processes the drug) of the antibiotic azithromycin in preterm babies at risk for the Ureaplasma infection and the complication BPD. ..
  3. Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung Injury
    Rose Viscardi; Fiscal Year: 2009
    ....
  4. Role of TLR Signaling in Ureaplasma-Mediated Neonatal Lung Injury
    ROSE MARIE VISCARDI; Fiscal Year: 2010
    ....
  5. Determinants of Ureaplasma-mediated neonatal lung injury
    Rose Viscardi; Fiscal Year: 2003
    ..These studies will provide new insights into how certain serovars contribute to the prolonged inflammatory process in BPD. ..