Research Topics
| Sophia VinogradovSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric geneticsAlan R Sanders
Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
Am J Psychiatry 165:497-506. 2008....- Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophreniaMelissa Fisher
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 email
Annu Rev Clin Psychol 9:435-63. 2013.... 
Cognitive training for impaired neural systems in neuropsychiatric illnessSophia Vinogradov
Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94122, USA
Neuropsychopharmacology 37:43-76. 2012..We summarize work to date using such neuroscience-informed methods and indicate some of the exciting future directions of this field...- The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophreniaSophia Vinogradov
Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, CA, USA
Am J Psychiatry 166:1055-62. 2009..The authors examined the relationship between serum anticholinergic activity and baseline cognitive performance and response to computerized cognitive training in outpatients with schizophrenia... - Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?Sophia Vinogradov
Department of Psychiatry, School of Medicine, University of California San Francisco, California 94121, USA
Biol Psychiatry 66:549-53. 2009..We asked: would neuroplasticity-based cognitive training in schizophrenia result in increased serum BDNF?.. 
Brain activation patterns during memory of cognitive agencySophia Vinogradov
Department of Psychiatry, University of California, San Francisco and San Francisco VA Medical Center 116C, 4150 Clement Street, San Francisco, CA 94121, USA
Neuroimage 31:896-905. 2006..Our data extend the function of mPFC into the domain of memory and the accurate retrieval of the sense of cognitive agency under conditions where agency was encoded implicitly...- Deficit in a neural correlate of reality monitoring in schizophrenia patientsSophia Vinogradov
Department of Psychiatry, University of California, San Francisco, CA 94121, USA
Cereb Cortex 18:2532-9. 2008..Impairment in rostral mPFC function likely plays a key role in the profound subjective disturbances that characterize schizophrenia and that are the aspect of the disorder most troubling to patients and to society at large... - When top-down meets bottom-up: auditory training enhances verbal memory in schizophreniaR Alison Adcock
Duke University Department of Psychiatry and Center for Cognitive Neuroscience, University of California, San Francisco, CA, USA
Schizophr Bull 35:1132-41. 2009..We conclude with the observation that neuroplasticity-based cognitive training brings patients closer to physiological patterns seen in healthy participants, suggesting that it changes the brain in an adaptive manner in schizophrenia... - Computerized cognitive training restores neural activity within the reality monitoring network in schizophreniaKaruna Subramaniam
San Francisco Department of Veterans Affairs Medical Center and Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94121, USA
Neuron 73:842-53. 2012..These findings demonstrate that a serious behavioral deficit in schizophrenia, and its underlying neural dysfunction, can be improved by well-designed computerized cognitive training, resulting in better quality of life... - Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatmentLeighton B N Hinkley
Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, USA
Biol Psychiatry 70:1134-42. 2011.... - Self and other in schizophrenia: a cognitive neuroscience perspectiveMelissa Fisher
Department of Psychiatry, University of California, San Francisco, CA 94121, USA
Am J Psychiatry 165:1465-72. 2008..The authors assessed self-referential source memory and social cognition in a large sample of schizophrenia outpatients and healthy comparison subjects in order to compare how these critical processes are associated in the two groups... - Neuroplasticity-based cognitive training in schizophrenia: an interim report on the effects 6 months laterMelissa Fisher
Department of Psychiatry, University of California, San Francisco and San Francisco VA Medical Center, CA 94121, USA
Schizophr Bull 36:869-79. 2010..Using an innovative neuroplasticity-based cognitive training approach, we report our interim findings on the effects on cognition and functional outcome at 6 months after treatment... - Timing is everything: neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjectsCorby L Dale
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
Int J Psychophysiol 75:183-93. 2010.... - Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort studyWilliam S Kremen
Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA, United States
Schizophr Res 118:1-5. 2010.... - Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophreniaAlan S Brown
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY, USA
Psychiatry Res 188:179-86. 2011..Although independent replications are warranted, maternal G/R infections were associated with verbal memory and motor function deficits in African-American patients with schizophrenia... - Evidence for an emotion maintenance deficit in schizophreniaDavid E Gard
Department of Psychology, San Francisco State University, San Francisco, CA, USA
Psychiatry Res 187:24-9. 2011..These findings suggest that some aspects of impaired emotion maintenance in schizophrenia may be related to deficits in motivated behavior... - Using neuroplasticity-based auditory training to improve verbal memory in schizophreniaMelissa Fisher
Department of Psychiatry, UCSF SFVAMC, Mail Code 116c, 4150 Clement St, San Francisco, CA 94121, USA
Am J Psychiatry 166:805-11. 2009..The authors report interim findings in this ongoing study... - Association of anticholinergic load with impairment of complex attention and memory in schizophreniaMichael J Minzenberg
Department of Psychiatry, Mount Sinai School of Medicine and VA Medical Center, Bronx, NY, USA
Am J Psychiatry 161:116-24. 2004.... - A neurocognitive model of borderline personality disorder: effects of childhood sexual abuse and relationship to adult social attachment disturbanceMichael J Minzenberg
University of California, Sacramento, CA 95817, USA
Dev Psychopathol 20:341-68. 2008.... - Error monitoring dysfunction across the illness course of schizophreniaVeronica B Perez
Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
J Abnorm Psychol 121:372-87. 2012..Brain regions subserving response monitoring may be compromised early in the illness and possibly during its clinical prodrome... - Social-emotion recognition in borderline personality disorderMichael J Minzenberg
University of California, Davis Medical Center, Sacramento, CA 95817, USA
Compr Psychiatry 47:468-74. 2006..These results suggest that patients with BPD have deficits in higher order integration of social information, which may be related to some of the more serious symptoms of the disorder... - Cognitive training in schizophrenia: a neuroscience-based approachAlexander Genevsky
Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, California 94121, USA
Dialogues Clin Neurosci 12:416-21. 2010..These cognitive improvements were accompanied by neurobiological findings suggestive of learning-induced cortical plasticity. Future directions for research and essential remaining questions are discussed... - Reduced Self-Referential Source Memory Performance is Associated with Interpersonal Dysfunction in Borderline Personality DisorderMichael J Minzenberg
University of California, Davis Medical Center, Sacramento, CA 95817, USA
J Pers Disord 20:42-54. 2006..Heterogeneity in source memory function may be specifically related to some of the hallmark interpersonal disturbances of BPD, independent of the effects of general negative affect or general memory impairment... - Both processing speed and semantic memory organization predict verbal fluency in schizophreniaSophia Vinogradov
Department of Psychiatry, University of California San Francisco and Department of Veterans Affairs Medical Center, 116C SFVAMC, 4150 Clement Street, San Francisco, CA 94121, USA
Schizophr Res 59:269-75. 2003..The statistical independence of the retrieval speed and organizational factors suggests that individuals with schizophrenia differ in the underlying processes that contribute to their reduced verbal fluency... - Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosisVeronica B Perez
Department of Psychiatry, University of California, San Francisco UCSF, San Francisco, CA 94121, USA
Schizophr Bull 38:1216-24. 2012..Whether this abnormality precedes psychosis onset, emerges early in the illness, and/or progressively worsens with illness chronicity, is unknown... - Adult social attachment disturbance is related to childhood maltreatment and current symptoms in borderline personality disorderMichael J Minzenberg
University of California, Davis Medical Center, Sacramento, California 95817, USA
J Nerv Ment Dis 194:341-8. 2006.... - Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B)Rachel L Loewy
Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, United States
Schizophr Res 129:42-6. 2011..These results suggest that the PQ-B may be used as an effective, efficient self-report screen for prodromal psychosis syndromes when followed by diagnostic interview, in a two-stage evaluation process in help-seeking populations... - Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigreesNadine Melhem
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 70:1115-21. 2011.... - Prenatal infection and cavum septum pellucidum in adult schizophreniaAlan S Brown
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA
Schizophr Res 108:285-7. 2009.... - Anterior hippocampal volume reduction in male patients with schizophreniaMary P Pegues
Psychiatry Service, Department of Veterans Affairs Medical Center, 94121, San Francisco, CA, USA
Schizophr Res 60:105-15. 2003..These preliminary findings support a significant anterior hippocampal volume reduction in men with schizophrenia as well as a similar hippocampal volume asymmetry in both male controls and schizophrenics... - Cognitive Impairments in Schizophrenia as Assessed Through Activation and Connectivity Measures of Magnetoencephalography (MEG) DataLeighton B N Hinkley
Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
Front Hum Neurosci 3:73. 2010.... - Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot studyElysa J Marco
University of California, Langley Porter Psychiatric Institute, San Francisco, USA
World J Biol Psychiatry 3:156-61. 2002..Further studies with larger sample sizes, more extensive endocrine assessments and longer duration of drug administration seem warranted... - N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSIAngela Jakary
Psychiatry Service, 116-N, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Schizophr Res 76:173-85. 2005.... - Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproductionAlexander B Herman
Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, and Departments of Otolaryngology Head and Neck Surgery and Psychiatry, University of California, San Francisco, San Francisco, California 94143
J Neurosci 33:5439-53. 2013.... - Semantic priming in schizophrenia: a review and synthesisMichael J Minzenberg
Department of Psychiatry, University of California, San Francisco, USA
J Int Neuropsychol Soc 8:699-720. 2002..We also describe associations with other neurocognitive dysfunction, neurochemical and electrophysiological disturbances, and clinical manifestations (such as thought disorder)... - Automatic relevance determination for identifying thalamic regions implicated in schizophreniaAntony Browne
Computing Department, School of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, U K
IEEE Trans Neural Netw 19:1101-7. 2008....
Research Grants
- Cognitive Remediation of Schizophrenia in a Community Mental Health SettingSophia Vinogradov; Fiscal Year: 2010....
- Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisSophia Vinogradov; Fiscal Year: 2010....
- Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisSophia Vinogradov; Fiscal Year: 2009..If this intervention proves useful, it will provide a non- pharmacological treatment approach for young people that is safe and easy to apply, and that may reduce the risk for serious mental illness as well as improve long-term outcome. ..
- Optimizing Cognitive Remediation Outcomes in SchizophreniaSophia Vinogradov; Fiscal Year: 2010....
- Optimizing Cognitive Remediation Outcomes in SchizophreniaSophia Vinogradov; Fiscal Year: 2009....
- Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for PsychosisSophia Vinogradov; Fiscal Year: 2009....
- Cognitive Remediation in SchizophreniaSophia Vinogradov; Fiscal Year: 2007..5. To examine factors that influence the response to training: -- Individual subject differences at study entry (cognitive and clinical status)-- Pharmacologic status (serum anticholinergicity and plasma neuroleptic levels). ..
- Cognitive Remediation in Schizophrenia: SupplementSophia Vinogradov; Fiscal Year: 2006..We will also study how the brain changes in people with schizophrenia as they undertake this training. ..
- Cognitive Remediation of Schizophrenia in a Community Mental Health SettingSophia Vinogradov; Fiscal Year: 2011....