Sophia Vinogradov

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
  2. pmc Cognitive training in schizophrenia: a neuroscience-based approach
    Alexander Genevsky
    Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, California 94121, USA
    Dialogues Clin Neurosci 12:416-21. 2010
  3. pmc Cognitive training for impaired neural systems in neuropsychiatric illness
    Sophia Vinogradov
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94122, USA
    Neuropsychopharmacology 37:43-76. 2012
  4. doi request reprint Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?
    Sophia Vinogradov
    Department of Psychiatry, School of Medicine, University of California San Francisco, California 94121, USA
    Biol Psychiatry 66:549-53. 2009
  5. pmc Deficit in a neural correlate of reality monitoring in schizophrenia patients
    Sophia Vinogradov
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Cereb Cortex 18:2532-9. 2008
  6. pmc The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia
    Sophia Vinogradov
    Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, CA, USA
    Am J Psychiatry 166:1055-62. 2009
  7. ncbi request reprint Brain activation patterns during memory of cognitive agency
    Sophia Vinogradov
    Department of Psychiatry, University of California, San Francisco and San Francisco VA Medical Center 116C, 4150 Clement Street, San Francisco, CA 94121, USA
    Neuroimage 31:896-905. 2006
  8. pmc When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia
    R Alison Adcock
    Duke University Department of Psychiatry and Center for Cognitive Neuroscience, University of California, San Francisco, CA, USA
    Schizophr Bull 35:1132-41. 2009
  9. pmc Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis
    Veronica B Perez
    Department of Psychiatry, University of California, San Francisco UCSF, San Francisco, CA 94121, USA
    Schizophr Bull 38:1216-24. 2012
  10. pmc Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia
    Karuna Subramaniam
    San Francisco Department of Veterans Affairs Medical Center and Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94121, USA
    Neuron 73:842-53. 2012

Collaborators

Detail Information

Publications41

  1. doi request reprint No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics
    Alan R Sanders
    Department of Psychiatry and Behavioural Sciences, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201 3137, USA
    Am J Psychiatry 165:497-506. 2008
    ....
  2. pmc Cognitive training in schizophrenia: a neuroscience-based approach
    Alexander Genevsky
    Mental Health Service, San Francisco Department of Veterans Affairs Medical Center, California 94121, USA
    Dialogues Clin Neurosci 12:416-21. 2010
    ..These cognitive improvements were accompanied by neurobiological findings suggestive of learning-induced cortical plasticity. Future directions for research and essential remaining questions are discussed...
  3. pmc Cognitive training for impaired neural systems in neuropsychiatric illness
    Sophia Vinogradov
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94122, USA
    Neuropsychopharmacology 37:43-76. 2012
    ..We summarize work to date using such neuroscience-informed methods and indicate some of the exciting future directions of this field...
  4. doi request reprint Is serum brain-derived neurotrophic factor a biomarker for cognitive enhancement in schizophrenia?
    Sophia Vinogradov
    Department of Psychiatry, School of Medicine, University of California San Francisco, California 94121, USA
    Biol Psychiatry 66:549-53. 2009
    ..We asked: would neuroplasticity-based cognitive training in schizophrenia result in increased serum BDNF?..
  5. pmc Deficit in a neural correlate of reality monitoring in schizophrenia patients
    Sophia Vinogradov
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Cereb Cortex 18:2532-9. 2008
    ..Impairment in rostral mPFC function likely plays a key role in the profound subjective disturbances that characterize schizophrenia and that are the aspect of the disorder most troubling to patients and to society at large...
  6. pmc The cognitive cost of anticholinergic burden: decreased response to cognitive training in schizophrenia
    Sophia Vinogradov
    Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, CA, USA
    Am J Psychiatry 166:1055-62. 2009
    ..The authors examined the relationship between serum anticholinergic activity and baseline cognitive performance and response to computerized cognitive training in outpatients with schizophrenia...
  7. ncbi request reprint Brain activation patterns during memory of cognitive agency
    Sophia Vinogradov
    Department of Psychiatry, University of California, San Francisco and San Francisco VA Medical Center 116C, 4150 Clement Street, San Francisco, CA 94121, USA
    Neuroimage 31:896-905. 2006
    ..Our data extend the function of mPFC into the domain of memory and the accurate retrieval of the sense of cognitive agency under conditions where agency was encoded implicitly...
  8. pmc When top-down meets bottom-up: auditory training enhances verbal memory in schizophrenia
    R Alison Adcock
    Duke University Department of Psychiatry and Center for Cognitive Neuroscience, University of California, San Francisco, CA, USA
    Schizophr Bull 35:1132-41. 2009
    ..We conclude with the observation that neuroplasticity-based cognitive training brings patients closer to physiological patterns seen in healthy participants, suggesting that it changes the brain in an adaptive manner in schizophrenia...
  9. pmc Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis
    Veronica B Perez
    Department of Psychiatry, University of California, San Francisco UCSF, San Francisco, CA 94121, USA
    Schizophr Bull 38:1216-24. 2012
    ..Whether this abnormality precedes psychosis onset, emerges early in the illness, and/or progressively worsens with illness chronicity, is unknown...
  10. pmc Computerized cognitive training restores neural activity within the reality monitoring network in schizophrenia
    Karuna Subramaniam
    San Francisco Department of Veterans Affairs Medical Center and Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94121, USA
    Neuron 73:842-53. 2012
    ..These findings demonstrate that a serious behavioral deficit in schizophrenia, and its underlying neural dysfunction, can be improved by well-designed computerized cognitive training, resulting in better quality of life...
  11. pmc Clinical symptoms and alpha band resting-state functional connectivity imaging in patients with schizophrenia: implications for novel approaches to treatment
    Leighton B N Hinkley
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94143, USA
    Biol Psychiatry 70:1134-42. 2011
    ....
  12. pmc Neuroplasticity-based cognitive training in schizophrenia: an interim report on the effects 6 months later
    Melissa Fisher
    Department of Psychiatry, University of California, San Francisco and San Francisco VA Medical Center, CA 94121, USA
    Schizophr Bull 36:869-79. 2010
    ..Using an innovative neuroplasticity-based cognitive training approach, we report our interim findings on the effects on cognition and functional outcome at 6 months after treatment...
  13. doi request reprint Self and other in schizophrenia: a cognitive neuroscience perspective
    Melissa Fisher
    Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Am J Psychiatry 165:1465-72. 2008
    ..The authors assessed self-referential source memory and social cognition in a large sample of schizophrenia outpatients and healthy comparison subjects in order to compare how these critical processes are associated in the two groups...
  14. pmc Timing is everything: neural response dynamics during syllable processing and its relation to higher-order cognition in schizophrenia and healthy comparison subjects
    Corby L Dale
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Int J Psychophysiol 75:183-93. 2010
    ....
  15. pmc Cognitive decline in schizophrenia from childhood to midlife: a 33-year longitudinal birth cohort study
    William S Kremen
    Department of Psychiatry, Center for Behavioral Genomics, University of California, San Diego, CA, United States
    Schizophr Res 118:1-5. 2010
    ....
  16. pmc Relationship of age to impulsivity and decision making: a baseline secondary analysis of a behavioral treatment study in stimulant use disorders
    Raj K Kalapatapu
    Department of Psychiatry, University of California, San Francisco, CA, USA
    J Addict Dis 32:206-16. 2013
    ..An important direction for future research is the development of cognitively remediating treatments for impaired cognitive domains in aging adults with stimulant use disorders. ..
  17. pmc Using neuroplasticity-based auditory training to improve verbal memory in schizophrenia
    Melissa Fisher
    Department of Psychiatry, UCSF SFVAMC, Mail Code 116c, 4150 Clement St, San Francisco, CA 94121, USA
    Am J Psychiatry 166:805-11. 2009
    ..The authors report interim findings in this ongoing study...
  18. pmc Association of maternal genital and reproductive infections with verbal memory and motor deficits in adult schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, New York, NY, USA
    Psychiatry Res 188:179-86. 2011
    ..Although independent replications are warranted, maternal G/R infections were associated with verbal memory and motor function deficits in African-American patients with schizophrenia...
  19. pmc Evidence for an emotion maintenance deficit in schizophrenia
    David E Gard
    Department of Psychology, San Francisco State University, San Francisco, CA, USA
    Psychiatry Res 187:24-9. 2011
    ..These findings suggest that some aspects of impaired emotion maintenance in schizophrenia may be related to deficits in motivated behavior...
  20. ncbi request reprint Association of anticholinergic load with impairment of complex attention and memory in schizophrenia
    Michael J Minzenberg
    Department of Psychiatry, Mount Sinai School of Medicine and VA Medical Center, Bronx, NY, USA
    Am J Psychiatry 161:116-24. 2004
    ....
  21. pmc Parsing the phonological loop: activation timing in the dorsal speech stream determines accuracy in speech reproduction
    Alexander B Herman
    Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 33:5439-53. 2013
    ....
  22. doi request reprint A neurocognitive model of borderline personality disorder: effects of childhood sexual abuse and relationship to adult social attachment disturbance
    Michael J Minzenberg
    University of California, Sacramento, CA 95817, USA
    Dev Psychopathol 20:341-68. 2008
    ....
  23. pmc Symptom dimensions and functional impairment in early psychosis: more to the story than just negative symptoms
    Daniel Fulford
    Department of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue Box PAR 0984, CA, USA
    Schizophr Res 147:125-31. 2013
    ..These results suggest the need for phase-specific treatment in early psychosis, with a focus on symptom dimensions to improve functional outcomes for CHR individuals...
  24. pmc Error monitoring dysfunction across the illness course of schizophrenia
    Veronica B Perez
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143, USA
    J Abnorm Psychol 121:372-87. 2012
    ..Brain regions subserving response monitoring may be compromised early in the illness and possibly during its clinical prodrome...
  25. ncbi request reprint Social-emotion recognition in borderline personality disorder
    Michael J Minzenberg
    University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Compr Psychiatry 47:468-74. 2006
    ..These results suggest that patients with BPD have deficits in higher order integration of social information, which may be related to some of the more serious symptoms of the disorder...
  26. pmc Alcohol use biomarkers predicting cognitive performance: a secondary analysis in veterans with alcohol dependence and posttraumatic stress disorder
    Raj K Kalapatapu
    Department of Psychiatry, University of California, 401 Parnassus Avenue, San Francisco, CA 94143, USA
    Mil Med 178:974-80. 2013
    ....
  27. ncbi request reprint Reduced Self-Referential Source Memory Performance is Associated with Interpersonal Dysfunction in Borderline Personality Disorder
    Michael J Minzenberg
    University of California, Davis Medical Center, Sacramento, CA 95817, USA
    J Pers Disord 20:42-54. 2006
    ..Heterogeneity in source memory function may be specifically related to some of the hallmark interpersonal disturbances of BPD, independent of the effects of general negative affect or general memory impairment...
  28. ncbi request reprint Both processing speed and semantic memory organization predict verbal fluency in schizophrenia
    Sophia Vinogradov
    Department of Psychiatry, University of California San Francisco and Department of Veterans Affairs Medical Center, 116C SFVAMC, 4150 Clement Street, San Francisco, CA 94121, USA
    Schizophr Res 59:269-75. 2003
    ..The statistical independence of the retrieval speed and organizational factors suggests that individuals with schizophrenia differ in the underlying processes that contribute to their reduced verbal fluency...
  29. doi request reprint Cognitive interventions targeting brain plasticity in the prodromal and early phases of schizophrenia
    Melissa Fisher
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143, USA
    Annu Rev Clin Psychol 9:435-63. 2013
    ....
  30. pmc Psychosis risk screening with the Prodromal Questionnaire--brief version (PQ-B)
    Rachel L Loewy
    Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94143 0984, United States
    Schizophr Res 129:42-6. 2011
    ..These results suggest that the PQ-B may be used as an effective, efficient self-report screen for prodromal psychosis syndromes when followed by diagnostic interview, in a two-stage evaluation process in help-seeking populations...
  31. ncbi request reprint Adult social attachment disturbance is related to childhood maltreatment and current symptoms in borderline personality disorder
    Michael J Minzenberg
    University of California, Davis Medical Center, Sacramento, California 95817, USA
    J Nerv Ment Dis 194:341-8. 2006
    ....
  32. pmc Associations of schizophrenia symptoms and neurocognition with physical activity in older adults with schizophrenia
    Heather Leutwyler
    1Department of Physiological Nursing, University of California, San Francisco, CA, USA
    Biol Res Nurs 16:23-30. 2014
    ..03).Conclusion:Physical activity interventions for this population are imperative. In order for a physical activity intervention to be successful, it must include components to enhance cognition and diminish psychiatric symptoms. ..
  33. pmc "We're not just sitting on the periphery": a staff perspective of physical activity in older adults with schizophrenia
    Heather Leutwyler
    Department of Physiological Nursing, University of California, 2 Koret Way, N631A, Box 0610, San Francisco, CA 94143 0610, USA
    Gerontologist 53:474-83. 2013
    ..It is necessary to consider the perspective of the mental health staff about barriers and facilitators to physical activity to design a feasible intervention...
  34. pmc Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees
    Nadine Melhem
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 70:1115-21. 2011
    ....
  35. ncbi request reprint Anterior hippocampal volume reduction in male patients with schizophrenia
    Mary P Pegues
    Psychiatry Service, Department of Veterans Affairs Medical Center, 94121, San Francisco, CA, USA
    Schizophr Res 60:105-15. 2003
    ..These preliminary findings support a significant anterior hippocampal volume reduction in men with schizophrenia as well as a similar hippocampal volume asymmetry in both male controls and schizophrenics...
  36. pmc Prenatal infection and cavum septum pellucidum in adult schizophrenia
    Alan S Brown
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA
    Schizophr Res 108:285-7. 2009
    ....
  37. ncbi request reprint Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study
    Elysa J Marco
    University of California, Langley Porter Psychiatric Institute, San Francisco, USA
    World J Biol Psychiatry 3:156-61. 2002
    ....
  38. ncbi request reprint N-acetylaspartate reductions in the mediodorsal and anterior thalamus in men with schizophrenia verified by tissue volume corrected proton MRSI
    Angela Jakary
    Psychiatry Service, 116 N, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Schizophr Res 76:173-85. 2005
    ..We therefore examined schizophrenia-related alterations in brain metabolite levels specifically in the mediodorsal and anterior thalamic subregions...
  39. pmc Cognitive Impairments in Schizophrenia as Assessed Through Activation and Connectivity Measures of Magnetoencephalography (MEG) Data
    Leighton B N Hinkley
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
    Front Hum Neurosci 3:73. 2010
    ....
  40. ncbi request reprint Semantic priming in schizophrenia: a review and synthesis
    Michael J Minzenberg
    Department of Psychiatry, University of California, San Francisco, USA
    J Int Neuropsychol Soc 8:699-720. 2002
    ..We also describe associations with other neurocognitive dysfunction, neurochemical and electrophysiological disturbances, and clinical manifestations (such as thought disorder)...
  41. ncbi request reprint Automatic relevance determination for identifying thalamic regions implicated in schizophrenia
    Antony Browne
    Computing Department, School of Engineering and Physical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, U K
    IEEE Trans Neural Netw 19:1101-7. 2008
    ....

Research Grants15

  1. Cognitive Remediation of Schizophrenia in a Community Mental Health Setting
    Sophia Vinogradov; Fiscal Year: 2010
    ....
  2. Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for Psychosis
    Sophia Vinogradov; Fiscal Year: 2010
    ....
  3. Cognitive Remediation in Schizophrenia
    Sophia Vinogradov; Fiscal Year: 2004
    ..5. To examine factors that influence the response to training: -- Individual subject differences at study entry (cognitive and clinical status)-- Pharmacologic status (serum anticholinergicity and plasma neuroleptic levels). ..
  4. Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for Psychosis
    Sophia Vinogradov; Fiscal Year: 2009
    ..If this intervention proves useful, it will provide a non- pharmacological treatment approach for young people that is safe and easy to apply, and that may reduce the risk for serious mental illness as well as improve long-term outcome. ..
  5. Optimizing Cognitive Remediation Outcomes in Schizophrenia
    Sophia Vinogradov; Fiscal Year: 2010
    ....
  6. Neuroscience-Guided Cognitive Remediation in Adolescents at Risk for Psychosis
    Sophia Vinogradov; Fiscal Year: 2009
    ....
  7. Cognitive Remediation of Schizophrenia in a Community Mental Health Setting
    Sophia Vinogradov; Fiscal Year: 2011
    ....
  8. Cognitive Remediation in Schizophrenia: Supplement
    Sophia Vinogradov; Fiscal Year: 2006
    ..We will also study how the brain changes in people with schizophrenia as they undertake this training. ..
  9. Cognitive Remediation in Schizophrenia
    Sophia Vinogradov; Fiscal Year: 2006
    ..5. To examine factors that influence the response to training: -- Individual subject differences at study entry (cognitive and clinical status)-- Pharmacologic status (serum anticholinergicity and plasma neuroleptic levels). ..
  10. Optimizing Cognitive Remediation Outcomes in Schizophrenia
    Sophia Vinogradov; Fiscal Year: 2009
    ....
  11. Cognitive Remediation in Schizophrenia
    Sophia Vinogradov; Fiscal Year: 2007
    ..5. To examine factors that influence the response to training: -- Individual subject differences at study entry (cognitive and clinical status)-- Pharmacologic status (serum anticholinergicity and plasma neuroleptic levels). ..
  12. Cognitive Remediation in Schizophrenia
    Sophia Vinogradov; Fiscal Year: 2005
    ..5. To examine factors that influence the response to training: -- Individual subject differences at study entry (cognitive and clinical status)-- Pharmacologic status (serum anticholinergicity and plasma neuroleptic levels). ..