Research Topics
| JOHN BERTRAM VINCENTSummaryAffiliation: University of Alabama Country: USA Publications
Research Grants
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Detail Information
Publications
The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agentJohn B Vincent
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, Alabama 35487 0336, USA
Sports Med 33:213-30. 2003..Potential neurological effects (both beneficial and deleterious) from Cr(pic)(3) supplementation require further study...
The binding and transport of alternative metals by transferrinJohn B Vincent
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
Biochim Biophys Acta 1820:362-78. 2012....- The need for combined inorganic, biochemical, and nutritional studies of chromium(III)John B Vincent
Department of Chemistry, The University of Alabama, Tucaloosa, AL 35487 0336, USA
Chem Biodivers 9:1923-41. 2012.... - Chromium: celebrating 50 years as an essential element?John B Vincent
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
Dalton Trans 39:3787-94. 2010..This review considers research on the biochemistry of Cr(III) over the last two decades and how the results have affected the current status of Cr as an essential element... - Recent advances in the nutritional biochemistry of trivalent chromiumJohn B Vincent
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
Proc Nutr Soc 63:41-7. 2004..An examination of the nutritional supplement chromium picolinate illustrates some of the difficulties associated with these biochemical studies... - High-dose chromium(III) supplementation has no effects on body mass and composition while altering plasma hormone and triglycerides concentrationsRandall Bennett
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487-0158, USA
Biol Trace Elem Res 113:53-66. 2006.... - In vivo distribution of chromium from chromium picolinate in rats and implications for the safety of the dietary supplementDion D D Hepburn
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, Alabama 35487-0336, USA
Chem Res Toxicol 15:93-100. 2002.... - The biomimetic [Cr(3)O(O(2)CCH(2)CH(3))(6)(H(2)O)(3)](+ )decreases plasma insulin, cholesterol, and triglycerides in healthy and type II diabetic rats but not type I diabetic ratsYanjie Sun
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487-0336, USA
J Biol Inorg Chem 7:852-62. 2002..The lowering of plasma insulin concentrations with little effect on glucose concentrations suggests that the supplement increases insulin sensitivity... - A comparison of the insulin-sensitive transport of chromium in healthy and model diabetic ratsBuffie J Clodfelder
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, P.O. Box 870336, Tuscaloosa, AL 35487-0336, USA
J Inorg Biochem 98:522-33. 2004..Diabetic rats had greater urinary chromium loss, greater movement of chromium from the blood to the tissues, most notably to the skeletal muscle, and an alteration of the distribution of chromium in the blood plasma... - The fate of the biomimetic cation triaqua-mu-oxohexapropionatotrichromium(III) in ratsAmanda A Shute
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa 35487-0336, USA
J Inorg Biochem 89:272-8. 2002..The complex appears to be readily incorporated into tissues and cells. In hepatocytes, the cation is efficiently transported into microsomes where its concentration reaches a maximum in approximately 2 h... - Urinary chromium loss associated with diabetes is offset by increases in absorptionNicholas R Rhodes
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487, USA
J Inorg Biochem 104:790-7. 2010..These beneficial effects must arise from pharmacological effects of high dose Cr(III) administration... - Mass spectrometric and spectroscopic studies of the nutritional supplement chromium(III) nicotinateNicholas R Rhodes
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
Biol Trace Elem Res 130:114-30. 2009..Implications for interpreting results of nutritional studies of "chromium nicotinate" are discussed... - Oral administration of the biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic ratsBuffie J Clodfelder
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, 35487-0336, USA
J Biol Inorg Chem 10:119-30. 2005..05) fasting plasma glycated hemoglobin levels in the Zucker diabetic and Zucker obese rats, respectively, and thus can improve the glucose status of the diabetic models. The effects cannot be attributed to the propionate ligand... 
Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogasterDion D D Hepburn
Department of Chemistry, University of Alabama, Tuscaloosa, AL 35487, USA
Proc Natl Acad Sci U S A 100:3766-71. 2003..X-linked lethal analysis indicates that the supplement greatly enhances the rate of appearance of lethal mutations and dominant female sterility...- Absorption of the biomimetic chromium cation triaqua-mu3-oxo-mu-hexapropionatotrichromium(III) in ratsBuffie J Clodfelder
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487-0336, USA
Biol Trace Elem Res 98:159-69. 2004..The difference in degree of absorption is readily explained by the stability and solubility of the cation... - The time-dependent transport of chromium in adult rats from the bloodstream to the urineBuffie J Clodfelder
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, AL 35487-0336, USA
J Biol Inorg Chem 10:383-93. 2005..Insulin stimulates the processing of Cr in the tissues... - Recent developments in the biochemistry of chromium(III)John B Vincent
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
Biol Trace Elem Res 99:1-16. 2004..quot; A discussion of these three events allows the current understanding of the nutritional biochemistry of Cr to be outlined... - Chromium-containing biomimetic cation triaqua-mu3-oxo-mu-hexapropionatotrichromium(III) inhibits colorectal tumor formation in ratsAlison Pickering
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Box 870336, Tuscaloosa, AL 35487-0336, USA
J Inorg Biochem 98:1303-6. 2004..Gavage administration of aqueous solutions of the complex (1000 microg Cr/kg body mass daily for 6 months) resulted in significantly decreased colon tumor incidence (P<0.003)... - Low-molecular-weight chromium-binding substance from chicken liver and American alligator liverM Jason Hatfield
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487-0336, USA
Comp Biochem Physiol B Biochem Mol Biol 144:423-31. 2006..The chicken and alligator oligopeptides may possess intrinsic phosphotyrosine phosphatase activity... - Effects of pre- and postnatal exposure to chromium picolinate or picolinic acid on neurological development in CD-1 miceMelissa M Bailey
Department of Biological Sciences, The University of Alabama, Box 870344, Tuscaloosa, AL 35487 0344, USA
Biol Trace Elem Res 124:70-82. 2008..The results indicate that there were no significant effects on the offspring with regard to neurological development from supplementation of the dams with either Cr(pic)3 or picolinic acid... - The effects of chromium(III) coordination on the dissociation of acidic peptidesDan Pu
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
J Mass Spectrom 43:773-81. 2008..This is consistent with deprotonated carboxylic acid groups being involved in chromium(III) coordination and with chromium existing in the 3 + state in the gas-phase ions... - Nutritional supplement chromium picolinate generates chromosomal aberrations and impedes progeny development in Drosophila melanogasterDontarie M Stallings
Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487-0336, USA
Mutat Res 610:101-13. 2006..The results suggest that human consumption of the supplement should be a matter of concern and continued investigation to provide insight into the requirements of chromium-containing supplements to give rise to genotoxic effects... - Tissue and subcellular distribution of chromium picolinate with time after entering the bloodstreamDion D D Hepburn
Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487-0336, USA
J Inorg Biochem 94:86-93. 2003..The significance of the lifetime and distribution of [Cr(pic)(3)] in relationship to recent reported potential DNA damage from the supplement is discussed...
Research Grants
- Elucidating the properties of low-molecular-weight chromuim-binding substanceJohn Vincent; Fiscal Year: 2007..The approach will employ two advancing methodologies in mass spectrometry: electrospray ionization Fourier transform ion cyclotron resonance (ESI/FT-ICR) and matrix-assisted laser desorption ionization time-of-flight (MALDI/TOF). ..