JOHN BERTRAM VINCENT

Summary

Affiliation: University of Alabama
Country: USA

Publications

  1. ncbi request reprint The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, Alabama 35487 0336, USA
    Sports Med 33:213-30. 2003
  2. doi request reprint Chromium: is it essential, pharmacologically relevant, or toxic?
    John B Vincent
    Department of Chemistry, University of Alabama, Tuscaloosa, AL, 35487 0336, USA
    Met Ions Life Sci 13:171-98. 2013
  3. doi request reprint The binding and transport of alternative metals by transferrin
    John B Vincent
    Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Biochim Biophys Acta 1820:362-78. 2012
  4. doi request reprint The need for combined inorganic, biochemical, and nutritional studies of chromium(III)
    John B Vincent
    Department of Chemistry, The University of Alabama, Tucaloosa, AL 35487 0336, USA
    Chem Biodivers 9:1923-41. 2012
  5. doi request reprint Chromium: celebrating 50 years as an essential element?
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Dalton Trans 39:3787-94. 2010
  6. ncbi request reprint Recent advances in the nutritional biochemistry of trivalent chromium
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Proc Nutr Soc 63:41-7. 2004
  7. ncbi request reprint High-dose chromium(III) supplementation has no effects on body mass and composition while altering plasma hormone and triglycerides concentrations
    Randall Bennett
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0158, USA
    Biol Trace Elem Res 113:53-66. 2006
  8. ncbi request reprint In vivo distribution of chromium from chromium picolinate in rats and implications for the safety of the dietary supplement
    Dion D D Hepburn
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, Alabama 35487 0336, USA
    Chem Res Toxicol 15:93-100. 2002
  9. ncbi request reprint The biomimetic [Cr(3)O(O(2)CCH(2)CH(3))(6)(H(2)O)(3)](+ )decreases plasma insulin, cholesterol, and triglycerides in healthy and type II diabetic rats but not type I diabetic rats
    Yanjie Sun
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    J Biol Inorg Chem 7:852-62. 2002
  10. ncbi request reprint Absorption of the biomimetic chromium cation triaqua-mu3-oxo-mu-hexapropionatotrichromium(III) in rats
    Buffie J Clodfelder
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Biol Trace Elem Res 98:159-69. 2004

Collaborators

  • Yasmin Neggers
  • H C Lukaski
  • R G Upchurch
  • Buffie J Clodfelder
  • Dion D D Hepburn
  • Nicholas R Rhodes
  • Carolyn J Cassady
  • Jane F Rasco
  • Melissa M Bailey
  • Amanda A Shute
  • Dan Pu
  • Yuan Chen
  • M Jason Hatfield
  • Dontarie M Stallings
  • Randall Bennett
  • Janis O'Donnell
  • Christine Chang
  • Alison Pickering
  • Yanjie Sun
  • Paul Lara
  • Sharifa Love
  • Kirsten Ansorge
  • DeAna McAdory
  • Naomi Kern
  • Kristin R Di Bona
  • Julia Kent
  • Jasmina Hira
  • Tatyana Konovalova
  • Qiaoli Liang
  • Ronald D Hood
  • Peter L Jernigan
  • Megan B Townsend
  • John Sturdivant
  • Jonathan G Boohaker
  • Zhong Li
  • Bobbi Adams
  • Meredith Hannah
  • Shanna Gillespie
  • Amanda French
  • Bryan M Gullick
  • Sharell Bindom
  • Jiarong Xiao
  • Turkessa Irvin

Detail Information

Publications24

  1. ncbi request reprint The potential value and toxicity of chromium picolinate as a nutritional supplement, weight loss agent and muscle development agent
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, Alabama 35487 0336, USA
    Sports Med 33:213-30. 2003
    ..Potential neurological effects (both beneficial and deleterious) from Cr(pic)(3) supplementation require further study...
  2. doi request reprint Chromium: is it essential, pharmacologically relevant, or toxic?
    John B Vincent
    Department of Chemistry, University of Alabama, Tuscaloosa, AL, 35487 0336, USA
    Met Ions Life Sci 13:171-98. 2013
    ..Mechanisms have been proposed for these pharmacological effects, but all suffer from a lack of consistent supporting evidence. ..
  3. doi request reprint The binding and transport of alternative metals by transferrin
    John B Vincent
    Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Biochim Biophys Acta 1820:362-78. 2012
    ....
  4. doi request reprint The need for combined inorganic, biochemical, and nutritional studies of chromium(III)
    John B Vincent
    Department of Chemistry, The University of Alabama, Tucaloosa, AL 35487 0336, USA
    Chem Biodivers 9:1923-41. 2012
    ....
  5. doi request reprint Chromium: celebrating 50 years as an essential element?
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Dalton Trans 39:3787-94. 2010
    ..This review considers research on the biochemistry of Cr(III) over the last two decades and how the results have affected the current status of Cr as an essential element...
  6. ncbi request reprint Recent advances in the nutritional biochemistry of trivalent chromium
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Proc Nutr Soc 63:41-7. 2004
    ..An examination of the nutritional supplement chromium picolinate illustrates some of the difficulties associated with these biochemical studies...
  7. ncbi request reprint High-dose chromium(III) supplementation has no effects on body mass and composition while altering plasma hormone and triglycerides concentrations
    Randall Bennett
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0158, USA
    Biol Trace Elem Res 113:53-66. 2006
    ....
  8. ncbi request reprint In vivo distribution of chromium from chromium picolinate in rats and implications for the safety of the dietary supplement
    Dion D D Hepburn
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, Alabama 35487 0336, USA
    Chem Res Toxicol 15:93-100. 2002
    ....
  9. ncbi request reprint The biomimetic [Cr(3)O(O(2)CCH(2)CH(3))(6)(H(2)O)(3)](+ )decreases plasma insulin, cholesterol, and triglycerides in healthy and type II diabetic rats but not type I diabetic rats
    Yanjie Sun
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    J Biol Inorg Chem 7:852-62. 2002
    ..The lowering of plasma insulin concentrations with little effect on glucose concentrations suggests that the supplement increases insulin sensitivity...
  10. ncbi request reprint Absorption of the biomimetic chromium cation triaqua-mu3-oxo-mu-hexapropionatotrichromium(III) in rats
    Buffie J Clodfelder
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Biol Trace Elem Res 98:159-69. 2004
    ..The difference in degree of absorption is readily explained by the stability and solubility of the cation...
  11. ncbi request reprint The fate of the biomimetic cation triaqua-mu-oxohexapropionatotrichromium(III) in rats
    Amanda A Shute
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa 35487 0336, USA
    J Inorg Biochem 89:272-8. 2002
    ..The complex appears to be readily incorporated into tissues and cells. In hepatocytes, the cation is efficiently transported into microsomes where its concentration reaches a maximum in approximately 2 h...
  12. doi request reprint Urinary chromium loss associated with diabetes is offset by increases in absorption
    Nicholas R Rhodes
    Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487, USA
    J Inorg Biochem 104:790-7. 2010
    ..These beneficial effects must arise from pharmacological effects of high dose Cr(III) administration...
  13. doi request reprint Mass spectrometric and spectroscopic studies of the nutritional supplement chromium(III) nicotinate
    Nicholas R Rhodes
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Biol Trace Elem Res 130:114-30. 2009
    ..Implications for interpreting results of nutritional studies of "chromium nicotinate" are discussed...
  14. ncbi request reprint The time-dependent transport of chromium in adult rats from the bloodstream to the urine
    Buffie J Clodfelder
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, AL 35487 0336, USA
    J Biol Inorg Chem 10:383-93. 2005
    ..Insulin stimulates the processing of Cr in the tissues...
  15. pmc Nutritional supplement chromium picolinate causes sterility and lethal mutations in Drosophila melanogaster
    Dion D D Hepburn
    Department of Chemistry, University of Alabama, Tuscaloosa, AL 35487, USA
    Proc Natl Acad Sci U S A 100:3766-71. 2003
    ..X-linked lethal analysis indicates that the supplement greatly enhances the rate of appearance of lethal mutations and dominant female sterility...
  16. ncbi request reprint A comparison of the insulin-sensitive transport of chromium in healthy and model diabetic rats
    Buffie J Clodfelder
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, P O Box 870336, Tuscaloosa, AL 35487 0336, USA
    J Inorg Biochem 98:522-33. 2004
    ..Diabetic rats had greater urinary chromium loss, greater movement of chromium from the blood to the tissues, most notably to the skeletal muscle, and an alteration of the distribution of chromium in the blood plasma...
  17. ncbi request reprint Oral administration of the biomimetic [Cr3O(O2CCH2CH3)6(H2O)3]+ increases insulin sensitivity and improves blood plasma variables in healthy and type 2 diabetic rats
    Buffie J Clodfelder
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, 35487 0336, USA
    J Biol Inorg Chem 10:119-30. 2005
    ..05) fasting plasma glycated hemoglobin levels in the Zucker diabetic and Zucker obese rats, respectively, and thus can improve the glucose status of the diabetic models. The effects cannot be attributed to the propionate ligand...
  18. ncbi request reprint Recent developments in the biochemistry of chromium(III)
    John B Vincent
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Biol Trace Elem Res 99:1-16. 2004
    ..A discussion of these three events allows the current understanding of the nutritional biochemistry of Cr to be outlined...
  19. ncbi request reprint Nutritional supplement chromium picolinate generates chromosomal aberrations and impedes progeny development in Drosophila melanogaster
    Dontarie M Stallings
    Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Mutat Res 610:101-13. 2006
    ..The results suggest that human consumption of the supplement should be a matter of concern and continued investigation to provide insight into the requirements of chromium-containing supplements to give rise to genotoxic effects...
  20. ncbi request reprint Low-molecular-weight chromium-binding substance from chicken liver and American alligator liver
    M Jason Hatfield
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    Comp Biochem Physiol B Biochem Mol Biol 144:423-31. 2006
    ..The chicken and alligator oligopeptides may possess intrinsic phosphotyrosine phosphatase activity...
  21. doi request reprint Effects of pre- and postnatal exposure to chromium picolinate or picolinic acid on neurological development in CD-1 mice
    Melissa M Bailey
    Department of Biological Sciences, The University of Alabama, Box 870344, Tuscaloosa, AL 35487 0344, USA
    Biol Trace Elem Res 124:70-82. 2008
    ..The results indicate that there were no significant effects on the offspring with regard to neurological development from supplementation of the dams with either Cr(pic)3 or picolinic acid...
  22. ncbi request reprint Tissue and subcellular distribution of chromium picolinate with time after entering the bloodstream
    Dion D D Hepburn
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    J Inorg Biochem 94:86-93. 2003
    ..The significance of the lifetime and distribution of [Cr(pic)(3)] in relationship to recent reported potential DNA damage from the supplement is discussed...
  23. ncbi request reprint Chromium-containing biomimetic cation triaqua-mu3-oxo-mu-hexapropionatotrichromium(III) inhibits colorectal tumor formation in rats
    Alison Pickering
    Department of Chemistry and Coalition for Biomolecular Products, The University of Alabama, Box 870336, Tuscaloosa, AL 35487 0336, USA
    J Inorg Biochem 98:1303-6. 2004
    ..Gavage administration of aqueous solutions of the complex (1000 microg Cr/kg body mass daily for 6 months) resulted in significantly decreased colon tumor incidence (P<0.003)...
  24. doi request reprint The effects of chromium(III) coordination on the dissociation of acidic peptides
    Dan Pu
    Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487 0336, USA
    J Mass Spectrom 43:773-81. 2008
    ..This is consistent with deprotonated carboxylic acid groups being involved in chromium(III) coordination and with chromium existing in the 3 + state in the gas-phase ions...

Research Grants2

  1. Elucidating the properties of low-molecular-weight chromuim-binding substance
    John Vincent; Fiscal Year: 2007
    ..The approach will employ two advancing methodologies in mass spectrometry: electrospray ionization Fourier transform ion cyclotron resonance (ESI/FT-ICR) and matrix-assisted laser desorption ionization time-of-flight (MALDI/TOF). ..