Alejandro V Villarino

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi IL-27 limits IL-2 production during Th1 differentiation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:237-47. 2006
  2. ncbi Positive and negative regulation of the IL-27 receptor during lymphoid cell activation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, and Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 174:7684-91. 2005
  3. doi IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Int Immunol 20:739-52. 2008
  4. pmc Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Exp Med 204:65-71. 2007
  5. ncbi Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
  6. ncbi TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development
    Jie Sun
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 174:742-51. 2005
  7. pmc Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27
    Alejandro V Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Arthritis Res Ther 6:225-33. 2004
  8. ncbi Understanding the pro- and anti-inflammatory properties of IL-27
    Alejandro V Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:715-20. 2004
  9. pmc Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
    Jens Lohr
    Department of Pathology, University of California, San Francisco School of Medicine, San Francisco, CA 94143, USA
    J Exp Med 203:2785-91. 2006

Detail Information

Publications9

  1. ncbi IL-27 limits IL-2 production during Th1 differentiation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:237-47. 2006
    ....
  2. ncbi Positive and negative regulation of the IL-27 receptor during lymphoid cell activation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, and Wistar Institute, Philadelphia, PA 19104, USA
    J Immunol 174:7684-91. 2005
    ....
  3. doi IL-27R deficiency delays the onset of colitis and protects from helminth-induced pathology in a model of chronic IBD
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    Int Immunol 20:739-52. 2008
    ..Taken together, these studies demonstrate that, in the absence of IL-10, IL-27 can promote T(h)1-type and suppress T(h)2-type intestinal inflammation but, ultimately, is not required for the development of inflammatory bowel disease...
  4. pmc Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Exp Med 204:65-71. 2007
    ....
  5. ncbi Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    Jason S Stumhofer
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6008, USA
    Nat Immunol 7:937-45. 2006
    ..Thus IL-27, a potent inhibitor of T(H)-17 cell development, may be a useful target for treating inflammatory diseases mediated by these cells...
  6. ncbi TLR ligands can activate dendritic cells to provide a MyD88-dependent negative signal for Th2 cell development
    Jie Sun
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    J Immunol 174:742-51. 2005
    ..Our findings indicate that DCs can provide potent negative as well as positive instruction for Th response polarization, and that these instructional signals are distinct and independent...
  7. pmc Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27
    Alejandro V Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Arthritis Res Ther 6:225-33. 2004
    ....
  8. ncbi Understanding the pro- and anti-inflammatory properties of IL-27
    Alejandro V Villarino
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 173:715-20. 2004
    ..Thus, the aim of this review is to discuss the pleotropic nature of the IL-27/IL-27R interaction and attempt to reconcile the pro- and anti-inflammatory properties of this immunomodulator...
  9. pmc Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease
    Jens Lohr
    Department of Pathology, University of California, San Francisco School of Medicine, San Francisco, CA 94143, USA
    J Exp Med 203:2785-91. 2006
    ..Thus, the pathogenic or protective effects of cytokines and the therapeutic capacity of regulatory T cells are crucially dependent on the timing and the nature of the disease...