Research Topics
Genomes and Genes | AMPARO C contact VILLABLANCASummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Coronary heart disease in women. Gender differences and effects of menopauseA C Villablanca
Division of Cardiovascular Medicine, University of California, Davis, School of Medicine 95616, USA
Postgrad Med 100:191-6, 201-2. 1996..An understanding of gender differences in CHD, together with new data from current and future investigative studies, should lead to improved outcomes for women with CHD...
Atherosclerosis and sex hormones: current conceptsAmparo C Villablanca
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, Davis, CA 95616, USA
Clin Sci (Lond) 119:493-513. 2010..Future studies in this field will contribute to guiding clinical treatment recommendations for women and help define research priorities...
Maternal and neonatal exposure to environmental tobacco smoke targets pro-inflammatory genes in neonatal arteriesAmparo C Villablanca
Department of Internal Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616 8636, USA
J Cardiovasc Transl Res 3:696-703. 2010..Prenatal and postnatal exposure to ETS increases expression of pro-inflammatory genes and may be responsible for early arterial vascular remodeling that is predisposing to a subsequent vascular disease...
Outcomes of comprehensive heart care programs in high-risk womenAmparo C Villablanca
University of California, Davis, California 95616 8636, USA
J Womens Health (Larchmt) 19:1313-25. 2010..The purpose of this study was to improve the fund of knowledge, reduce cardiovascular disease (CVD) risk, and attain Healthy People 2010 objectives among women in model women's heart programs...
17beta-estradiol prevents early-stage atherosclerosis in estrogen receptor-alpha deficient female miceAmparo C Villablanca
Department of Internal Medicine, University of California, Davis, Davis, CA, USA
J Cardiovasc Transl Res 2:289-99. 2009..Our findings may contribute to future improved clinical decision-making concerning the use of hormone therapy...
Outcomes of national community organization cardiovascular prevention programs for high-risk womenAmparo C Villablanca
Cardiovascular Medicine, University of California, Davis, One Shields Ave, TB 172, Davis, CA 95616 8636, USA
J Cardiovasc Transl Res 2:306-20. 2009....
Career flexibility and family-friendly policies: an NIH-funded study to enhance women's careers in biomedical sciencesAmparo C Villablanca
Department of Internal Medicine, University of California, Davis, California, USA
J Womens Health (Larchmt) 20:1485-96. 2011....
Susceptibility to early atherosclerosis in male mice is mediated by estrogen receptor alphaAmparo Villablanca
Department of Internal Medicine, University of California, Davis, One Shields Ave, TB 172, Davis, CA 95616 8636, USA
Arterioscler Thromb Vasc Biol 24:1055-61. 2004..Their role in early atherosclerosis remains poorly understood, particularly in males. We developed and characterized an atherosclerosis model in ERalpha knockout male mice to investigate directly its role in atheroma...
Differential regulation of gene expression by ovariectomy in mouse aortaAmparo C Villablanca
Division of Cardiovascular Medicine, University of California, Davis, California 95616 8636, USA
Physiol Genomics 12:175-85. 2003..These studies have implications for our understanding of hormonal regulation of vascular gene expression and the therapeutic targeting of specific vascular genetic sequences by female sex steroid hormones...
17beta-estradiol stimulates substance P receptor gene expressionA C Villablanca
Department of Internal Medicine, University of California, Davis 95616, USA
Mol Cell Endocrinol 135:109-17. 1997..Increased SPR mRNA levels in response to E2 were linearly related to increased [3H]SP binding to the SPR. This study has implications for understanding molecular mechanisms of hormonal control of receptor gene expression...
Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitroA C Villablanca
Division of Cardiovascular Medicine, University of California, Davis, California 95616, USA
J Appl Physiol 84:2089-98. 1998..This study has implications for understanding cellular mechanisms of nicotine action. The results may be important in tumor angiogenesis, atherogenesis, and vascular dysfunction in smokers...
Heart disease during pregnancy. Which cardiovascular changes are normal or transient?A C Villablanca
Division of Cardiovascular Medicine, University of California, School of Medicine, Davis 90272, USA
Postgrad Med 104:183-4, 187-92. 1998..Hypertension, one of the most common complications of pregnancy, may be transient and benign, or it may be chronic or gestational. Early recognition and intervention are beneficial to both the mother and the child...
Heart disease during pregnancy. Which cardiovascular changes reflect disease?A C Villablanca
Division of Cardiovascular Medicine, University of California, Davis, School of Medicine 90272, USA
Postgrad Med 104:149-56. 1998..Pregnancy in women with prosthetic cardiac valves may expose mother and child to risks that can be minimized with appropriate safeguards...
Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal womenFrancene M Steinberg
Department of Nutrition, University of California, Davis, 95616, USA
Am J Clin Nutr 78:123-30. 2003..Controversy exists about the ability of soy protein and isoflavones to modulate vascular reactivity and biochemical cardiovascular disease risk markers in healthy, normolipidemic postmenopausal women...
Cardiovascular actions of selective estrogen receptor modulators and phytoestrogensRadhika Nandur
Division of Cardiovascular Medicine, University of California, Davis, Davis, CA 95616, USA
Prev Cardiol 7:73-9. 2004..In addition, the authors' current understanding of the mechanism of action of these agents is discussed and recommendations for clinical practice are reviewed...
Compromised aortic vasoreactivity in male estrogen receptor-alpha-deficient mice during acute lipopolysaccharide-induced inflammationAna M Corbacho
Center for Biophotonics Science and Technology CBST, University of California Davis, One Shields Avenue, Hunt Hall 225, Davis, CA 95616, USA
Endocrinology 148:1403-11. 2007..e. endothelial NOS) and the vascular responses to NO (i.e. soluble guanylate cyclase)...
Chronic consumption of flavanol-rich cocoa improves endothelial function and decreases vascular cell adhesion molecule in hypercholesterolemic postmenopausal womenJanice F Wang-Polagruto
Department of Nutrition, University of California, Davis, CA 95616, USA
J Cardiovasc Pharmacol 47:S177-86; discussion S206-9. 2006..In addition, our results suggest that reductions in plasma soluble vascular cell adhesion molecule-1 after chronic consumption of a flavanol-rich cocoa may be mechanistically linked to improved vascular reactivity...
Time- and dose-dependent differential upregulation of three genes by 17 beta-estradiol in endothelial cellsAmparo C Villablanca
Division of Cardiovascular Medicine, University of California, Davis, California 95616 8636, USA
J Appl Physiol 92:1064-73. 2002..Our results describe previously uncharacterized estradiol-sensitive time- and dose-dependent regulation of genes with potential importance to vascular function in human endothelial cells...
Hyperglycemia and loss of ovarian hormones mediate atheroma formation through endothelial layer disruption and increased permeabilityJeana Benton
School of Medicine, University of California, Davis, CA 95616, USA
Am J Physiol Regul Integr Comp Physiol 292:R723-30. 2007....
Estrogens and lipids. Can HRT designer estrogens, and phytoestrogens reduce cardiovascular risk markers after menopause?Abraham A Ariyo
Division of Cardiovascular Medicine, University of California, Davis, Medical Center, Sacramento, USA
Postgrad Med 111:23-30; quiz 3. 2002..Nonetheless, physicians should consider the use of HRT, SERMs, and phytoestrogens for lowering lipid levels and reducing cardiovascular risk in women...
Research Grants
- GENETIC MECHANISMS OF ESTROGEN ATHEROPROTECTIONAmparo Villablanca; Fiscal Year: 2003..Advances in our basic understanding of mechanisms of hormone action could lead to more effective strategies for treatment of coronary artery disease in both men and women. ..
- Women's Careers in the Medical Sciences and Family Friendly PoliciesAmparo Villablanca; Fiscal Year: 2009....
- Women's Careers in the Medical Sciences and Family Friendly PoliciesAMPARO C contact VILLABLANCA; Fiscal Year: 2010....
