Daniel B Vigneron

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors
    D Vigneron
    Department of Radiology, University of California, San Francisco, CA 94143, USA
    Magn Reson Imaging 19:89-101. 2001
  2. pmc Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice
    Matthew L Zierhut
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94143 2532, USA
    J Magn Reson 202:85-92. 2010
  3. pmc (1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques
    Matthew L Zierhut
    University of California, Joint Graduate Group in Bioengineering, San Francisco, CA, USA
    J Magn Reson Imaging 30:473-80. 2009
  4. ncbi request reprint 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, California 94158 2532, USA
    J Magn Reson Imaging 26:23-30. 2007
  5. pmc In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Mol Imaging Biol 11:399-407. 2009
  6. pmc Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:582-91. 2010
  7. ncbi request reprint High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding
    Albert P Chen
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Magn Reson Imaging 25:1288-92. 2007
  8. pmc Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
    J Magn Reson Imaging 33:692-7. 2011
  9. ncbi request reprint Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns
    Savannah C Partridge
    Department of Radiology, University of California San Francisco, San Francisco, California 94143 2512, USA
    J Magn Reson Imaging 22:467-74. 2005
  10. pmc Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo
    David M Wilson
    Department of Radiology, University of California San Francisco UCSF, San Francisco, CA, United States
    J Magn Reson 205:141-7. 2010

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors
    D Vigneron
    Department of Radiology, University of California, San Francisco, CA 94143, USA
    Magn Reson Imaging 19:89-101. 2001
    ..The results of this study indicate that 3D MRSI of brain tumors can detect abnormal metabolite levels in regions of viable cancer and grades and can differentiate cancer from necrosis and/or normal brain tissue...
  2. pmc Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice
    Matthew L Zierhut
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94143 2532, USA
    J Magn Reson 202:85-92. 2010
    ....
  3. pmc (1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques
    Matthew L Zierhut
    University of California, Joint Graduate Group in Bioengineering, San Francisco, CA, USA
    J Magn Reson Imaging 30:473-80. 2009
    ..To investigate the signal-to-noise-ratio (SNR) and data quality of time-reduced three-dimensional (3D) proton magnetic resonance spectroscopic imaging ((1)H MRSI) techniques in the human brain at 3 Tesla...
  4. ncbi request reprint 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, University of California San Francisco, San Francisco, California 94158 2532, USA
    J Magn Reson Imaging 26:23-30. 2007
    ..To implement proton magnetic resonance spectroscopic imaging (1H MRSI) at 3 Tesla (3T) using an eight-channel phased-array head coil in a population of brain-tumor patients...
  5. pmc In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Mol Imaging Biol 11:399-407. 2009
    ....
  6. pmc Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:582-91. 2010
    ..The results of this study demonstrated the potential of this new hyperpolarized MR dynamic method for improved cancer detection and characterization...
  7. ncbi request reprint High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding
    Albert P Chen
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA
    J Magn Reson Imaging 25:1288-92. 2007
    ..The short acquisition time provided by this method reduces the 3T prostate MRI/MRSI exam time, allows longer repetition times, and/or allows the acquisition of additional MR acquisitions within the same exam...
  8. pmc Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
    J Magn Reson Imaging 33:692-7. 2011
    ..To demonstrate dynamic imaging of a diffusible perfusion tracer, hyperpolarized [(13)C]urea, for regional measurement of blood flow in preclinical cancer models...
  9. ncbi request reprint Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns
    Savannah C Partridge
    Department of Radiology, University of California San Francisco, San Francisco, California 94143 2512, USA
    J Magn Reson Imaging 22:467-74. 2005
    ..To evaluate the feasibility of performing diffusion tensor tractography (DTT) to map and quantify the pyramidal white matter tracts of premature newborns...
  10. pmc Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo
    David M Wilson
    Department of Radiology, University of California San Francisco UCSF, San Francisco, CA, United States
    J Magn Reson 205:141-7. 2010
    ....
  11. pmc Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading
    Mark J Albers
    Department of Bioengineering, University of California San Francisco, San Francisco, California 94158 2330, USA
    Cancer Res 68:8607-15. 2008
    ....
  12. pmc High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patients
    Meredith Metcalf
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94017, USA
    J Neuroimaging 20:141-7. 2010
    ..Clear involvement of the GM was observed with improved morphological detail in comparison to imaging at lower-field strength...
  13. pmc Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer
    Janine M Lupo
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 28:153-62. 2010
    ..The MLS was significantly higher in TRAMP mice that had advanced disease...
  14. pmc In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-(13)C]alanine
    Simon Hu
    Department of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 29:1035-40. 2011
    ..The intracellular lactate-to-pyruvate ratio of normal rat tissue measured with hyperpolarized [1-(13)C]alanine was 4.89±0.61 (mean±S.E.) as opposed to a ratio of 0.41±0.03 when hyperpolarized [1-(13)C]pyruvate was injected...
  15. pmc Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging
    Ilwoo Park
    Department of Radiology and Biomedical Imaging, Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, California, USA
    Magn Reson Med 70:33-9. 2013
    ..The results from pathology confirmed the different characteristics of (13)C metabolic profiles between viable, non-necrotic, nonhypoxic tumor, and necrotic, hypoxic tissue...
  16. ncbi request reprint Comparing microstructural and macrostructural development of the cerebral cortex in premature newborns: diffusion tensor imaging versus cortical gyration
    Amy R Deipolyi
    Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94143, USA
    Neuroimage 27:579-86. 2005
    ..0001) but not in the tangential diffusivities (P > 0.05)...
  17. pmc A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th St, San Francisco, CA 94158, USA
    J Magn Reson 225:71-80. 2012
    ..Generally, MAD-STEAM can be applied to any system in which spins undergo a frequency shift...
  18. pmc Flexible transceiver array for ultrahigh field human MR imaging
    Bing Wu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 68:1332-8. 2012
    ..Seven Tesla parallel imaging with generalized autocalibrating partially parallel acquisitions (GRAPPA) performed using this flexible transceiver array was also presented...
  19. pmc Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 30:305-11. 2012
    ..A strong and significant correlation (R=0.73, P=.02) detected between the urea and HP001 data confirmed the value of copolarizing urea with pyruvate for simultaneous assessment of perfusion and metabolism...
  20. pmc Generating super stimulated-echoes in MRI and their application to hyperpolarized C-13 diffusion metabolic imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    IEEE Trans Med Imaging 31:265-75. 2012
    ....
  21. pmc Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, Byers Hall 203, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:18606-11. 2011
    ..More broadly, these findings suggest a prognostic role for this new redox sensor in determining vulnerability of both normal and abnormal tissues to ROS...
  22. pmc 3D sensitivity encoded ellipsoidal MR spectroscopic imaging of gliomas at 3T
    Esin Ozturk-Isik
    Margaret Hart Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 27:1249-57. 2009
    ..The goal of this study was to implement time efficient data acquisition and reconstruction methods for 3D magnetic resonance spectroscopic imaging (MRSI) of gliomas at a field strength of 3T using parallel imaging techniques...
  23. pmc 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158 2512, USA
    Magn Reson Med 63:312-21. 2010
    ....
  24. ncbi request reprint Pyramidal tract maturation after brain injury in newborns with heart disease
    Savannah C Partridge
    Department of Radiology, University of California, San Francisco, San Francisco, CA, USA
    Ann Neurol 59:640-51. 2006
    ..Our objective was to quantify white matter tract development in term newborns with congenital heart disease, a population at high risk for perioperative brain injury, using magnetic resonance imaging diffusion tensor tractography (DTT)...
  25. pmc Design of cosine modulated very selective suppression pulses for MR spectroscopic imaging at 3T
    Joseph A Osorio
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, California 94158 2532, USA
    Magn Reson Med 61:533-40. 2009
    ..This provided improved coverage and suppression of unwanted lipid signals with a smaller number of pulses. The use of the improved pulse sequence was validated in volunteer studies, and in clinical 3D MRSI exams of brain tumors...
  26. ncbi request reprint Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants
    Jeffrey I Berman
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuroimage 27:862-71. 2005
    ..In summary, deterministic and probabilistic DTI fiber tracking methods were used to quantify the developmental changes of motor and somatosensory pathways in premature infants...
  27. pmc Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA
    J Magn Reson 211:109-13. 2011
    ..The multi-band frequency encoding technique enabled rapid metabolic imaging of hyperpolarized (13)C compounds with important advantages over prior approaches, including less complicated acquisition and reconstruction methods...
  28. pmc Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues
    May Britt Tessem
    Department of Radiology, University of California San Francisco, San Francisco, California 94158 2330, USA
    Magn Reson Med 60:510-6. 2008
    ..The significant increase in the concentration of both lactate and alanine in biopsy tissue containing as little as 5% cancer could be exploited in hyperpolarized (13)C spectroscopic imaging (SI) studies of prostate cancer patients...
  29. ncbi request reprint Quantitative analysis of prostate metabolites using 1H HR-MAS spectroscopy
    Mark G Swanson
    Department of Radiology, University of California San Francisco, 94107, USA
    Magn Reson Med 55:1257-64. 2006
    ..7, P < 0.01; [PAs](mean) = 5.28 +/- 5.44, P < 0.01). Serial spectra acquired over 12 hr indicated that the degradation of Cho-containing metabolites was minimized by acquiring HR-MAS data at 1 degree C compared to 20 degrees C...
  30. doi request reprint GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T
    Janine M Lupo
    Department of Radiology, Surbeck Laboratory of Advanced Imaging, University of California, San Francisco, CA 94158 2532, USA
    Magn Reson Imaging 27:480-8. 2009
    ..GRAPPA-based SWI at 7 T revealed regions of microvascularity, hemorrhage and calcification within heterogeneous brain tumors that may aid in characterizing active or necrotic tumor and monitoring treatment effects...
  31. ncbi request reprint Abnormal brain development in newborns with congenital heart disease
    Steven P Miller
    Department of Neurology, University of California at San Francisco, San Francisco, USA
    N Engl J Med 357:1928-38. 2007
    ..We characterized brain metabolism and microstructure, as measures of brain maturation, in newborns with congenital heart disease before they underwent heart surgery...
  32. pmc A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate
    Galen D Reed
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    J Magn Reson 217:41-7. 2012
    ..Dynamic imaging is demonstrated in a transgenic mouse model, and phantom validations of the RF pulse frequency selectivity were performed...
  33. pmc Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans
    Bing Wu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    IEEE Trans Med Imaging 31:183-91. 2012
    ..In addition, it also provides a simple approach to readily upgrade the channels of a conventional primary resonator microstrip array to a larger number for faster imaging...
  34. pmc Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients
    Ilwoo Park
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94158, USA
    Ann Biomed Eng 39:193-204. 2011
    ..The implementation of this technique means that brain lactate can be evaluated in a routine clinical setting to study its potential as a marker for prognosis and response to therapy...
  35. pmc Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI
    Simon Hu
    Department of Radiology, University of California, Box 2512, 1700 4th Street, QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
    J Magn Reson 192:258-64. 2008
    ..Phantom tests validated the accuracy of the compressed sensing approach and initial mouse experiments demonstrated in vivo feasibility...
  36. doi request reprint High-resolution intracranial MRA at 7T using autocalibrating parallel imaging: initial experience in vascular disease patients
    Cornelius Von Morze
    Department of Radiology, University of California, San Francisco, CA 94143 2512, USA
    Magn Reson Imaging 26:1329-33. 2008
    ..In this study, we applied parallel imaging to 7T TOF MRA studies of normal volunteers and patients with vascular disease, in order to obtain very high resolution (0.12 mm(3)) images within a reasonable scan time...
  37. pmc Hyperpolarized [2-13C]-fructose: a hemiketal DNP substrate for in vivo metabolic imaging
    Kayvan R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco UCSF, 1700 fourth St, Byers Hall 203, San Francisco, California 94158, USA
    J Am Chem Soc 131:17591-6. 2009
    ..Thus, this study demonstrates the first hyperpolarization of a carbohydrate carbon with a sufficient T(1) and solution state polarization for ex vivo spectroscopy and in vivo spectroscopic imaging studies...
  38. doi request reprint Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging
    Ilwoo Park
    Surbeck Laboratory of Advanced Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Magn Reson Imaging 33:1284-90. 2011
    ..To demonstrate the feasibility of using DNP hyperpolarized [1-(13)C]-pyruvate to measure early response to temozolomide (TMZ) therapy using an orthotopic human glioblastoma xenograft model...
  39. pmc Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 65:610-9. 2011
    ..This approach has enabled the monitoring of perfusion and uptake of the pyruvate, and the conversion dynamics to lactate and alanine throughout a volume with high spatial and temporal resolution...
  40. ncbi request reprint Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns
    Savannah C Partridge
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuroimage 22:1302-14. 2004
    ..This work contributes to the understanding of normal white matter development in the preterm neonatal brain, an important step toward the use of DTI for the improved evaluation and treatment of white matter injury of prematurity...
  41. pmc Hyperpolarized 13C spectroscopic imaging informs on hypoxia-inducible factor-1 and myc activity downstream of platelet-derived growth factor receptor
    Hagit Dafni
    Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, USA
    Cancer Res 70:7400-10. 2010
    ..Our results indicate that hyperpolarized (13)C MRSI could potentially detect the molecular effect of various cell signaling inhibitors, thus providing a radiation-free method to predict tumor response...
  42. pmc Non-invasive in vivo assessment of IDH1 mutational status in glioma
    Myriam M Chaumeil
    Department of Radiology and Biomedical Imaging, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    Nat Commun 4:2429. 2013
    ..In contrast, in cells that express mutant IDH1, hyperpolarized [1-(13)C] 2-hydroxyglutarate is also observed, both in cell lysates and in vivo in orthotopic tumours. ..
  43. pmc Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer
    Simon Hu
    Dept of Radiology and Biomedical Imaging, Box 2512, University of California, San Francisco, 1700 4th St QB3 Building, Suite 102, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 31:490-6. 2013
    ..Dramatic increases in (13)C-bicarbonate were detected just 1 min (as well as 6 min) after DCA administration...
  44. pmc Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 31:635-42. 2013
    ..This was shown in STEAM images that highlighted abnormal cancer cell metabolism and suppressed vascular (13)C metabolite signals...
  45. pmc Frequency-specific SSFP for hyperpolarized ¹³C metabolic imaging at 14.1 T
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 31:163-70. 2013
    ..1-T animal magnetic resonance imaging scanner. This acquisition was tested in thermal and hyperpolarized phantom imaging studies and in a transgenic mouse with prostate cancer...
  46. pmc A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7 T
    Chunsheng Wang
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 30:78-84. 2012
    ..Finite difference time domain method simulations for evaluating the design and 7-T MR experiment results acquired using the prototype coil are presented...
  47. pmc 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Cell Metab 14:131-42. 2011
    ..These results demonstrate that metabolic changes precede tumor formation and regression and are directly linked to the activity of a single oncogene...
  48. ncbi request reprint Prostate depiction at endorectal MR spectroscopic imaging: investigation of a standardized evaluation system
    Juyoung A Jung
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143, USA
    Radiology 233:701-8. 2004
    ..To investigate the accuracy and interobserver variability of a standardized evaluation system for endorectal three-dimensional (3D) magnetic resonance (MR) spectroscopic imaging of the prostate...
  49. pmc Phased array 3D MR spectroscopic imaging of the brain at 7 T
    Duan Xu
    Joint UCSF UC Berkeley Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94143, USA
    Magn Reson Imaging 26:1201-6. 2008
    ..The new 7 T MRSI sequence was tested in volunteer studies and demonstrated the feasibility of obtaining high-SNR phased-array 3D MRSI from the human brain...
  50. ncbi request reprint High-resolution 3D MR spectroscopic imaging of the prostate at 3 T with the MLEV-PRESS sequence
    Albert P Chen
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143 2512, USA
    Magn Reson Imaging 24:825-32. 2006
    ..5 t mrsi...
  51. pmc 7T human spine imaging arrays with adjustable inductive decoupling
    Bing Wu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    IEEE Trans Biomed Eng 57:397-403. 2010
    ..Preliminary results of human spine images acquired using the transceiver arrays demonstrate the feasibility of the design for ultrahigh-field MR applications and its robust performance for parallel imaging...
  52. pmc Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI)
    Michael A Ohliger
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA
    J Magn Reson Imaging 38:701-13. 2013
    ..Human applications additionally require rapid imaging to permit breath-holding and to minimize the effects of physiologic motion...
  53. ncbi request reprint Considerations in applying 3D PRESS H-1 brain MRSI with an eight-channel phased-array coil at 3 T
    Yan Li
    UCSF UCB Joint Graduate Group in Bioengineering, San Francisco, CA 94720, USA
    Magn Reson Imaging 24:1295-302. 2006
    ..5 T with a quadrature head coil. This is expected to be critical for clinical applications of MRSI in patients with brain tumors because it can be used to either decrease acquisition time or improve spatial resolution...
  54. pmc Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies
    Albert P Chen
    Department of Radiology, University of California, Box 2512, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 26:721-6. 2008
    ..This study also demonstrated the potential value of this hyperpolarized agent to investigate in vivo lactate uptake and metabolism in preclinical animal models...
  55. pmc Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases
    Kathryn E Hammond
    University of California San Francisco Berkeley Joint Graduate Group in Bioengineering, San Francisco, CA 94158 2532, USA
    Neuroimage 39:1682-92. 2008
    ..5 T. The clinical images showed novel contrast in MS plaques and depicted microhemorrhages and abnormal vasculature in brain tumors with unsurpassed resolution and contrast...
  56. pmc A clinical comparison of rigid and inflatable endorectal-coil probes for MRI and 3D MR spectroscopic imaging (MRSI) of the prostate
    Susan M Noworolski
    Department of Radiology, University of California, San Francisco, San Francisco, California 94107, USA
    J Magn Reson Imaging 27:1077-82. 2008
    ..To compare the data quality and ease of use of four endorectal-coil probe setups for prostate MRI...
  57. doi request reprint Evaluation of intracranial stenoses and aneurysms with accelerated 4D flow
    Thomas A Hope
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Magn Reson Imaging 28:41-6. 2010
    ..In the aneurysm patients, visualization of flow patterns may help to provide prognostic information about future risk of rupture...
  58. pmc Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors
    Ilwoo Park
    Joint Graduate Group in Bioengineering, Surbeck Laboratory of Advanced Imaging, University of California San Francisco Berkeley, 1700 4th Street, Byers Hall, Room BH 303, San Francisco, CA 94158 2532, USA
    Neuro Oncol 12:133-44. 2010
    ..These results suggest that hyperpolarized MR metabolic imaging may be valuable for assessing prognosis and monitoring response to therapy for patients with brain tumors...
  59. pmc Multiband excitation pulses for hyperpolarized 13C dynamic chemical-shift imaging
    Peder E Z Larson
    Department of Radiology and Biomedical Imaging, University of California San Francisco, Byers Hall, Suite 102, 1700 4th Street, San Francisco, CA 94158, USA
    J Magn Reson 194:121-7. 2008
    ..The metabolic products are observable for a longer window because the low pyruvate flip angle preserves magnetization, allowing for improved observation of spatially varying metabolic reactions...
  60. pmc Dynamic contrast-enhanced MRI and MR diffusion imaging to distinguish between glandular and stromal prostatic tissues
    Susan Moyher Noworolski
    Department of Radiology and Biomedical Imaging, The University of California, San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 26:1071-80. 2008
    ....
  61. pmc Cerebellar development in the preterm neonate: effect of supratentorial brain injury
    Emily W Y Tam
    Department of Neurology and Pediatrics, University of California San Francisco, 521 Parnassus Ave, San Francisco, CA 94143, USA
    Pediatr Res 66:102-6. 2009
    ..DTI studies may provide an early indicator for cerebellar injury and abnormal cerebellar development in preterm neonates...
  62. ncbi request reprint Neonatal encephalopathy: association of cytokines with MR spectroscopy and outcome
    Agnes I Bartha
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Pediatr Res 56:960-6. 2004
    ..Understanding the link between elevated cytokines and outcome would inform novel strategies of cerebral protection...
  63. pmc Use of hyperpolarized [1-13C]pyruvate and [2-13C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158 2512, USA
    Magn Reson Imaging 30:1367-72. 2012
    ..004), acetoacetate (+504±281%, P=.009) and acetylcarnitine (+377±157%, P=.003) were detected when [2-(13)C]pyruvate was used...
  64. pmc A dual-tuned quadrature volume coil with mixed λ/2 and λ/4 microstrip resonators for multinuclear MRSI at 7 T
    Yong Pang
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158 2330, USA
    Magn Reson Imaging 30:290-8. 2012
    ..A preliminary proton image of a mouse on the sagittal plane is also acquired using the proposed dual-tuned volume coil at 7 T, illustrating a fairly uniform B(1) field and sufficient image coverage for imaging in mice...
  65. pmc Ultrashort echo time MRI of cortical bone at 7 tesla field strength: a feasibility study
    Roland Krug
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Magn Reson Imaging 34:691-5. 2011
    ..To implement and examine the feasibility of a three-dimensional (3D) ultrashort TE (UTE) sequence on a 7 Tesla (T) clinical MR scanner in comparison with 3T MRI at high isotropic resolution...
  66. ncbi request reprint Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T
    Yan Li
    University of California, San Francisco University of California, Berkeley Joint Graduate Group in Bioengineering, San Francisco, California 94143 2532, USA
    Magn Reson Med 58:886-92. 2007
    ..17 Hz. This technique also enables the evaluation of the changes in metabolite T(2). Compared with the values in normal white matter, the T(2) values of Cho and Cr were statistically significantly increased in regions of glioma...
  67. pmc Development and initial evaluation of 7-T q-ball imaging of the human brain
    Pratik Mukherjee
    Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Magn Reson Imaging 26:171-80. 2008
    ....
  68. pmc White-matter injury is associated with impaired gaze in premature infants
    Hannah C Glass
    Department of Neurology, University of California at San Francisco, San Francisco, California, USA
    Pediatr Neurol 38:10-5. 2008
    ..These preliminary findings suggest that white-matter injury affects visual function even before term equivalent postmenstrual age...
  69. pmc Hyperpolarized (13)C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism
    Kayvan R Keshari
    Department of Radiology, University of California San Francisco, SanFrancisco, California, USA
    Magn Reson Med 63:322-9. 2010
    ..Although this preliminary study involved immortalized cells, this combination of technologies can be extended to the real-time metabolic exploration of primary benign and cancerous cells and tissues prior to and after therapy...
  70. ncbi request reprint Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome
    Steven P Miller
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    J Pediatr 147:609-16. 2005
    ..To determine the neurodevelopmental outcome of prematurely born newborns with magnetic resonance imaging (MRI) abnormalities...
  71. doi request reprint Rapid in vivo musculoskeletal MR with parallel imaging at 7T
    Suchandrima Banerjee
    Radiology, University of California, San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 59:655-60. 2008
    ..Robust quantification of bone and cartilage metrics could be derived from accelerated ankle and knee acquisitions. PI can enhance the clinical feasibility of in vivo bone and cartilage HR-MRI for osteoporosis and osteoarthritis at 7T...
  72. ncbi request reprint Feasibility of magnetic resonance spectroscopy for evaluating fetal lung maturity
    Matthew S Clifton
    Department of Surgery, University of California San Francisco, San Francisco, CA 94143 0570, USA
    J Pediatr Surg 41:768-73. 2006
    ..The purpose of this study was to test the feasibility of assessing fetal lung maturity in vivo and ex vivo using MR spectroscopy to determine differences in amniotic fluid choline concentrations between the second and third trimesters...
  73. ncbi request reprint Relationship of MR-derived lactate, mobile lipids, and relative blood volume for gliomas in vivo
    Xiaojuan Li
    Center of Functional and Molecular Imaging and Department of Radiology, University of California, San Francisco, CA 94107, USA
    AJNR Am J Neuroradiol 26:760-9. 2005
    ....
  74. ncbi request reprint Endorectal MR imaging and MR spectroscopic imaging for locally recurrent prostate cancer after external beam radiation therapy: preliminary experience
    Fergus V Coakley
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, M 372, San Francisco, CA 94143 0628, USA
    Radiology 233:441-8. 2004
    ..To evaluate endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging for the depiction of locally recurrent prostate cancer after external beam radiation therapy...
  75. ncbi request reprint Single-shot fast spin-echo diffusion tensor imaging of the lumbar spine at 1.5 and 3 T
    Julio Carballido-Gamio
    Department of Radiology, University of California San Francisco, CA 94158, USA
    Magn Reson Imaging 25:665-70. 2007
    ..Results indicate that DTI-SSFSE is a candidate as a clinical sequence for obtaining diffusion tensor images of the lumbar intervertebral discs with scan times shorter than 4 min...
  76. pmc Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride
    David M Wilson
    Department of Radiology, University of California San Francisco, San Francisco, CA 94158 2330, USA
    Proc Natl Acad Sci U S A 106:5503-7. 2009
    ..This study demonstrates the feasibility of using prepolarized [1,1-(13)C] acetic anhydride and rapid chemical reactions to provide high SNR NMR spectra of amino acid derivatives and other biomolecules...
  77. pmc Post-processing correction of the endorectal coil reception effects in MR spectroscopic imaging of the prostate
    Susan M Noworolski
    The Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, The University of California, San Francisco, California 94107, USA
    J Magn Reson Imaging 32:654-62. 2010
    ..To develop and validate a post-processing correction algorithm to remove the effect of the inhomogeneous reception profile of the endorectal coil on MR spectroscopic imaging (MRSI) data...
  78. pmc Respiratory motion-corrected proton magnetic resonance spectroscopy of the liver
    Susan M Noworolski
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    Magn Reson Imaging 27:570-6. 2009
    ..To develop a post-processing, respiratory-motion correction algorithm for magnetic resonance spectroscopy (MRS) of the liver and to determine the incidence and impact of respiratory motion in liver MRS...
  79. ncbi request reprint Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience
    Albert P Chen
    Department of Radiology, University of California San Francisco, San Francisco, California, USA
    Magn Reson Med 58:1099-106. 2007
    ..135 cm(3) nominal spatial resolution. Elevated (13)C lactate (lac) was observed in both primary and metastatic tumors, demonstrating the feasibility of studying cellular bioenergetics in vivo with DNP hyperpolarized (13)C MRSI...
  80. ncbi request reprint Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants
    Luis C Maas
    Department of Radiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuroimage 22:1134-40. 2004
    ..Automated segmentation of diffusion tensor images to reveal the laminar architecture of the developing human cerebrum is also demonstrated...
  81. pmc Improved spatial coverage for brain 3D PRESS MRSI by automatic placement of outer-volume suppression saturation bands
    Eugene Ozhinsky
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    J Magn Reson Imaging 33:792-802. 2011
    ....
  82. pmc Quantitative analysis of spatial distortions of diffusion techniques at 3T
    Duan Xu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA
    Magn Reson Imaging 28:451-4. 2010
    ..These methods have confirmed the SSFSE based diffusion method is less distorted than the EPI based one, which is generally accepted through visual inspection...
  83. ncbi request reprint Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors
    Steven P Miller
    Department of Neurology, University of California San Francisco, San Francisco, California 94143, USA
    Pediatr Res 52:71-7. 2002
    ....
  84. pmc Combined magnetic resonance imaging and spectroscopic imaging approach to molecular imaging of prostate cancer
    John Kurhanewicz
    Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, San Francisco, California 94143 1290, USA
    J Magn Reson Imaging 16:451-63. 2002
    ....
  85. ncbi request reprint Proton HR-MAS spectroscopy and quantitative pathologic analysis of MRI/3D-MRSI-targeted postsurgical prostate tissues
    Mark G Swanson
    Department of Radiology, University of California San Francisco, San Francisco, California 94143 1290, USA
    Magn Reson Med 50:944-54. 2003
    ....
  86. ncbi request reprint In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI
    Sarah J Nelson
    Mgnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94143, USA
    J Magn Reson Imaging 16:464-76. 2002
    ..Further work is required to integrate the results of the H-MRSI examination into the treatment planning workstation, and to improve the quality of the data using more sensitive phased array coils and higher field strength magnets...
  87. ncbi request reprint Inverse planning for HDR prostate brachytherapy used to boost dominant intraprostatic lesions defined by magnetic resonance spectroscopy imaging
    Jean Pouliot
    Department of Radiation Oncology, University of California San Francisco, 1600 Divisadero Street, Suite H1031, San Francisco, CA 94143 1708, USA
    Int J Radiat Oncol Biol Phys 59:1196-207. 2004
    ..To dose escalate selected regions inside the prostate without compromising the dose coverage of the prostate and the protection to the urethra, rectum, and bladder for prostate cancer patients treated with high-dose-rate brachytherapy...
  88. ncbi request reprint Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence
    Tracy R McKnight
    Department of Radiology, Biostatistics Core, Comprehensive Cancer Center, University of California, San Francisco 94143, USA
    J Neurosurg 97:794-802. 2002
    ..The information gleaned from the biopsy correlation study was used to test the hypothesis that there is metabolically active tumor in nonenhancing regions of the T2-hyperintense lesion that can be detected using MR spectroscopy...
  89. ncbi request reprint DTI-based three-dimensional tractography detects differences in the pyramidal tracts of infants and children with congenital hemiparesis
    Orit A Glenn
    Department of Radiology, University of California San Francisco, San Francisco, California 94143, USA
    J Magn Reson Imaging 18:641-8. 2003
    ..To test the hypothesis that there is greater asymmetry in diffusion properties between right and left pyramidal tracts in patients with congenital hemiparesis than in patients with normal motor function...
  90. pmc Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research
    John Kurhanewicz
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94158 2330, USA
    Neoplasia 13:81-97. 2011
    ..Nevertheless, there are no fundamental barriers to rapid translation of this exciting technology to clinical research and perhaps clinical care...
  91. pmc MR spectroscopy of normative premature newborns
    Duan Xu
    Department of Radiology and Biomedical Imaging, University of San Francisco, California, USA
    J Magn Reson Imaging 33:306-11. 2011
    ..To establish normative metabolite ratios throughout the newborn brain using three-dimensional (3D) MR spectroscopic imaging (MRSI)...
  92. ncbi request reprint Magnetic resonance spectroscopic imaging of human brain development
    Daniel B Vigneron
    Department of Radiology, University of California at San Francisco, CA 94143 2512, USA
    Neuroimaging Clin N Am 16:75-85, viii. 2006
    ..This article includes the description of MRS techniques for neonatal studies and results in the study of the premature and term newborn brain...
  93. pmc Current and potential applications of clinical 13C MR spectroscopy
    John Kurhanewicz
    University of California San Francisco, San Francisco, California 94158 2330, USA
    J Nucl Med 49:341-4. 2008
    ..Preliminary preclinical studies in a model of prostate cancer have demonstrated the potential clinical utility of hyperpolarized (13)C MRS...
  94. pmc Advances in MR spectroscopy of the prostate
    John Kurhanewicz
    University of California, San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging Clin N Am 16:697-710, ix-x. 2008
    ..Accuracy can be improved by performing MR imaging/MRSI at higher magnetic field strengths, using more sensitive hyperpolarized (13)C MRSI techniques and through the addition of other functional MR techniques...
  95. ncbi request reprint Intracranial time-of-flight MR angiography at 7T with comparison to 3T
    Cornelius Von Morze
    Department of Radiology, UCSF, San Francisco, California, USA
    J Magn Reson Imaging 26:900-4. 2007
    ..To establish the feasibility of intracranial time-of-flight (TOF) MR angiography (MRA) at 7T using phased array coils and to compare its performance to 3T...
  96. ncbi request reprint Spectroscopic imaging of the brain with phased-array coils at 3.0 T
    Duan Xu
    Joint UCSF UCB Graduate Group in Bioengineering, University of California, San Francisco and Berkeley, CA 94143, USA
    Magn Reson Imaging 24:69-74. 2006
    ..The use of low peak power, dual-band spectral-spatial pulses was also investigated for application to 3 T MRSI of the brain using the body coil for radiofrequency excitation and PA coils for signal reception...
  97. ncbi request reprint Expandable and rigid endorectal coils for prostate MRI: impact on prostate distortion and rigid image registration
    Yongbok Kim
    Department of Radiation Oncology, University of California, San Francisco, Comprehensive Cancer Center 1600 Divisadero Street, Suite H1031, San Francisco, California 94143 1708, USA
    Med Phys 32:3569-78. 2005
    ..941 +/- 0.008 vs 0.899 +/- 0.033, for the rigid and expandable coils, respectively). In conclusion, the manual rigid-body alignment of prostate MR images acquired with and without the ERC can be improved through the use of a rigid ERC...
  98. ncbi request reprint Partially-parallel, susceptibility-weighted MR imaging of brain vasculature at 7 Tesla using sensitivity encoding and an autocalibrating parallel technique
    Janine M Lupo
    University of California San Francisco, CA, USA
    Conf Proc IEEE Eng Med Biol Soc 1:747-50. 2006
    ....
  99. ncbi request reprint Preoperative brain injury in newborns with transposition of the great arteries
    Steven P Miller
    Department of Pediatrics, University of California, San Francisco, CA 94143 0663, USA
    Ann Thorac Surg 77:1698-706. 2004
    ....
  100. pmc Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products
    Charles H Cunningham
    Department of Medical Biophysics and Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ont, Canada M4N 3M5
    J Magn Reson 193:139-46. 2008
    ..5s. This high frame rate was used to measure the different lactate dynamics in different tissues in a normal rat model and a mouse model of prostate cancer...
  101. ncbi request reprint Serial quantitative diffusion tensor MRI of the premature brain: development in newborns with and without injury
    Steven P Miller
    Department of Neurology, University of California, San Francisco, California, USA
    J Magn Reson Imaging 16:621-32. 2002
    ..To determine the change over time of the apparent diffusion coefficient (ADC) and relative anisotropy of cerebral water in a cohort of premature newborns serially studied near birth and again near term...