V J Vieland

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Two novel quantitative trait linkage analysis statistics based on the posterior probability of linkage: application to the COGA families
    Christopher W Bartlett
    Center for Statistical Genetics Research, College of Public Health and Roy J and Lucille A Carver of Medicine, The University of Iowa, Iowa City, IA, USA
    BMC Genet 6:S121. 2005
  2. pmc Performance comparison of two-point linkage methods using microsatellite markers flanking known disease locations
    Mark W Logue
    Center for Statistical Genetics Research, College of Public Health, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    BMC Genet 6:S141. 2005
  3. pmc Calculation of multipoint likelihoods using flanking marker data: a simulation study
    Andrew W George
    Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    BMC Genet 6:S44. 2005
  4. pmc The problem of ascertainment for linkage analysis
    V J Vieland
    Department of Preventive Medicine and Environmental Health, University of Iowa College of Medicine, Iowa City 52242 1008, USA
    Am J Hum Genet 58:1072-84. 1996
  5. ncbi request reprint Thermometers: something for statistical geneticists to think about
    Veronica J Vieland
    College of Public Health and Carver College of Medicine, 2190 Westlawn Building, University of Iowa, Iowa City, IA 52242, USA
    Hum Hered 61:144-56. 2006
  6. pmc Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data
    Veronica J Vieland
    Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, 52242 1008, USA
    Am J Hum Genet 73:223-32. 2003
  7. ncbi request reprint HLODs, trait models, and ascertainment: implications of admixture for parameter estimation and linkage detection
    Veronica J Vieland
    Department of Biostatistics, Division of Statistical Genetics, Center for Statistical Genetics Research, University of Iowa, Iowa City 52240, USA
    Hum Hered 53:23-35. 2002
  8. ncbi request reprint Heterogeneity: GAW Group 15
    Veronica J Vieland
    Program in Public Health Genetics and Center for Statistical Genetics Research, University of Iowa Colleges of Public Health and Medicine, Iowa City, Iowa 52245, USA
    Genet Epidemiol 29:S110-5. 2005
  9. ncbi request reprint Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data
    V J Vieland
    Department of Biostatistics, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 51:199-208. 2001
  10. pmc Statistical evaluation of age-at-onset anticipation: a new test and evaluation of its behavior in realistic applications
    V J Vieland
    Department of Preventive Medicine, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 62:1212-27. 1998

Detail Information

Publications41

  1. pmc Two novel quantitative trait linkage analysis statistics based on the posterior probability of linkage: application to the COGA families
    Christopher W Bartlett
    Center for Statistical Genetics Research, College of Public Health and Roy J and Lucille A Carver of Medicine, The University of Iowa, Iowa City, IA, USA
    BMC Genet 6:S121. 2005
    ....
  2. pmc Performance comparison of two-point linkage methods using microsatellite markers flanking known disease locations
    Mark W Logue
    Center for Statistical Genetics Research, College of Public Health, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    BMC Genet 6:S141. 2005
    ..The pooling of the four datasets in each replicate (n = 350 pedigrees) greatly improved the chance of detecting the major genes using all five methods, but failed to increase the chance to detect D5 and D6...
  3. pmc Calculation of multipoint likelihoods using flanking marker data: a simulation study
    Andrew W George
    Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    BMC Genet 6:S44. 2005
    ..The flanking marker procedure performs well, even when missing data and genotyping errors are introduced...
  4. pmc The problem of ascertainment for linkage analysis
    V J Vieland
    Department of Preventive Medicine and Environmental Health, University of Iowa College of Medicine, Iowa City 52242 1008, USA
    Am J Hum Genet 58:1072-84. 1996
    ..On the other hand, virtually all linkage data sets are collected under PD sampling. Thus, the existence of this bias will be the rule rather than the exception in the usual applications...
  5. ncbi request reprint Thermometers: something for statistical geneticists to think about
    Veronica J Vieland
    College of Public Health and Carver College of Medicine, 2190 Westlawn Building, University of Iowa, Iowa City, IA 52242, USA
    Hum Hered 61:144-56. 2006
    ..I speculate that measures of evidence that come closer to meeting these requirements will do a better job of finding and characterizing genes, and I propose an alternative evidence metric as a step in this direction...
  6. pmc Two-locus heterogeneity cannot be distinguished from two-locus epistasis on the basis of affected-sib-pair data
    Veronica J Vieland
    Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, 52242 1008, USA
    Am J Hum Genet 73:223-32. 2003
    ....
  7. ncbi request reprint HLODs, trait models, and ascertainment: implications of admixture for parameter estimation and linkage detection
    Veronica J Vieland
    Department of Biostatistics, Division of Statistical Genetics, Center for Statistical Genetics Research, University of Iowa, Iowa City 52240, USA
    Hum Hered 53:23-35. 2002
    ..These findings have important implications for the optimal handling of nuisance parameters in linkage analysis, particularly when evaluating the evidence for or against linkage based on multiple independent heterogeneous sets of data...
  8. ncbi request reprint Heterogeneity: GAW Group 15
    Veronica J Vieland
    Program in Public Health Genetics and Center for Statistical Genetics Research, University of Iowa Colleges of Public Health and Medicine, Iowa City, Iowa 52245, USA
    Genet Epidemiol 29:S110-5. 2005
    ....
  9. ncbi request reprint Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data
    V J Vieland
    Department of Biostatistics, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 51:199-208. 2001
    ....
  10. pmc Statistical evaluation of age-at-onset anticipation: a new test and evaluation of its behavior in realistic applications
    V J Vieland
    Department of Preventive Medicine, College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 62:1212-27. 1998
    ..When the type I error rate of the test is high relative to the power, interpretation of test results becomes problematic. We conclude that, in many applications, AOA tests based on APCPs may not yield meaningful results...
  11. ncbi request reprint Examination of AVPR1a as an autism susceptibility gene
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Mol Psychiatry 9:968-72. 2004
    ..Given the emerging biological, animal model, and now genetic data, AVPR1a and genes in the AVP system remain strong candidates for involvement in autism susceptibility and deserve continued scrutiny...
  12. ncbi request reprint The null distribution of the heterogeneity lod score does depend on the assumed genetic model for the trait
    J Huang
    Department of Statistics and Actuarial Science, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 52:217-22. 2001
    ..05 is 3.01, while for the LOD it is 3.00, and for the HLOD/R it is 3.27. For general pedigrees, explicit analytical expression of the null HLOD distribution does not appear possible, but it will still depend on the assumed genetic model...
  13. ncbi request reprint Comparison of 'model-free' and 'model-based' linkage statistics in the presence of locus heterogeneity: single data set and multiple data set applications
    J Huang
    Department of Statistics and Actuarial Science, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 51:217-25. 2001
    ..We confirm that the HLOD/C maintains higher power than these 'model-free' methods when applied to multiple heterogeneous data sets, even when it is calculated assuming the wrong genetic model...
  14. ncbi request reprint The consistency of the posterior probability of linkage
    K Wang
    Department of Biostatistics, College of Public Health, The University of Iowa, Iowa City 52242, USA
    Ann Hum Genet 64:533-53. 2000
    ..5, even when the admixture model misrepresents the true model...
  15. ncbi request reprint Effect of allelic heterogeneity on the power of the transmission disequilibrium test
    S L Slager
    Department of Preventive Medicine and Environmental Health, Division of Biostatistics, University of Iowa, Iowa City 52242, USA
    Genet Epidemiol 18:143-56. 2000
    ..Thus, the TDT may not be an optimal test in the context of genomic screens under more biologically realistic assumptions...
  16. ncbi request reprint Power comparisons between the TDT and two likelihood-based methods
    S L Slager
    Department of Biostatistics, University of Iowa, Iowa City, Iowa, USA
    Genet Epidemiol 20:192-209. 2001
    ..The LOD score provides the lowest power in the presence of LD for the range of GRR considered here...
  17. ncbi request reprint Drawbacks of GENEHUNTER for larger pedigrees: application to panic disorder
    R Goedken
    Department of Psychiatry, The University of Iowa College of Medicine, Iowa City, Iowa 52242 1000, USA
    Am J Med Genet 96:781-3. 2000
    ..Careful consideration must be given when selecting linkage analysis programs. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:781-783, 2000...
  18. ncbi request reprint A posterior probability of linkage-based re-analysis of schizophrenia data yields evidence of linkage to chromosomes 1 and 17
    M W Logue
    Program for Public Health Genetics, Center for Statistical Genetics Research, Iowa City, IA 52242, USA
    Hum Hered 62:47-54. 2006
    ..8 [Brzustowicz et al. 2000]. In the current study, we revisited this data set using a Bayesian linkage analysis technique, namely the posterior probability of linkage (PPL)...
  19. ncbi request reprint Evidence supporting WNT2 as an autism susceptibility gene
    T H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med Genet 105:406-13. 2001
    ....
  20. ncbi request reprint The incorporation of prior genomic information does not necessarily improve the performance of Bayesian linkage methods: an example involving sex-specific recombination and the two-point PPL
    Mark W Logue
    Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 60:196-205. 2005
    ..We present a two-point PPL allowing for unequal male and female recombination fractions, thetaM and thetaF, and consider alternative priors on thetaM, thetaF...
  21. ncbi request reprint Accumulating quantitative trait linkage evidence across multiple datasets using the posterior probability of linkage
    Christopher W Bartlett
    Center for Statistical Genetics Research, College of Public Health and Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Genet Epidemiol 31:91-102. 2007
    ....
  22. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  23. ncbi request reprint Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky
    Christopher W Bartlett
    Center for Quantitative and Computational Biology and Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, OH, USA
    Genet Epidemiol 31:S61-7. 2007
    ..The difficulty of using (primarily) affected sib pair data in a gene x gene interaction analysis is explored...
  24. doi request reprint Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Psychiatr Genet 18:85-91. 2008
    ..To apply phenotypic and statistical methods designed to account for heterogeneity to linkage analyses of the autism Collaborative Linkage Study of Autism (CLSA) affected sibling pair families...
  25. pmc A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications
    Veronica J Vieland
    Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children s Hospital, Columbus, OH 43205, USA
    Am J Hum Genet 82:1349-56. 2008
    ..This model has several clinical implications, which we believe will prove relevant to other complex diseases as well...
  26. pmc MLIP: using multiple processors to compute the posterior probability of linkage
    Manika Govil
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    BMC Bioinformatics 9:S2. 2008
    ..This paper describes MLIP, a multiprocessor two-point genetic linkage analysis system that supports statistical calculations, such as the PPL, based on the full parameter space implicit in the linkage likelihood...
  27. ncbi request reprint The posterior probability of linkage allowing for linkage disequilibrium and a new estimate of disequilibrium between a trait and a marker
    Xinqun Yang
    Center for Statistical Genetics Research, The University of Iowa, Iowa City, Iowa 52242, USA
    Hum Hered 59:210-9. 2005
    ..The estimate of D' also behaves well even in relatively small, heterogeneous samples...
  28. ncbi request reprint Evaluation of the chromosome 2q37.3 gene CENTG2 as an autism susceptibility gene
    Thomas H Wassink
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 136:36-44. 2005
    ..We conclude, therefore, that 2q37.3 continues to be a region of interest for autism susceptibility, and that CENTG2 is an intriguing candidate gene that merits further scrutiny for its role in autism...
  29. pmc A major susceptibility locus for specific language impairment is located on 13q21
    Christopher W Bartlett
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Piscataway, NJ 08854 8095, USA
    Am J Hum Genet 71:45-55. 2002
    ..86, genomic P value <.06 under the recessive language impairment model). Our findings underscore the utility of traditional LOD-score-based methods in finding genes for complex diseases, specifically, SLI...
  30. ncbi request reprint Evaluation of FOXP2 as an autism susceptibility gene
    Thomas H Wassink
    Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Am J Med Genet 114:566-9. 2002
    ..We conclude that FOXP2 is unlikely to contribute significantly to autism susceptibility...
  31. pmc Is schizophrenia linked to chromosome 1q?
    Anne S Bassett
    Department of Psychiatry, University of Torontoand Clinical Genetics Research Program, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario M6J 1H4, Canada
    Science 298:2277; author reply 2277. 2002
  32. ncbi request reprint Bayesian analysis of a previously published genome screen for panic disorder reveals new and compelling evidence for linkage to chromosome 7
    Mark W Logue
    Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet B Neuropsychiatr Genet 121:95-9. 2003
    ..The results for the remainder of the genome are consistently low. The two loci identified here are also supported by independent evidence from other studies...
  33. pmc A model-integrated multipoint Bayesian analysis of hypertension in the Framingham Heart Study data finds little evidence of linkage
    Mark W Logue
    Division of Statistical Genetics, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
    BMC Genet 4:S75. 2003
    ..While the PPL analysis of this data remains inconclusive, Bayesian methodology gives us a clear mechanism for using the information gained here in further studies...
  34. pmc Genome-wide linkage analysis of blood pressure under locus heterogeneity
    Xinqun Yang
    Department of Biostatistics, Division of Statistical Genetics, The University of Iowa, Iowa City, USA
    BMC Genet 4:S78. 2003
    ..01. Two of them (GATA14E09 and 049xd2) seem to overlap with linkage signals reported previously, while the other two are not linked to any known signals...
  35. ncbi request reprint A case of autism and uniparental disomy of chromosome 1
    Thomas H Wassink
    Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Hum Genet 117:200-6. 2005
    ..In agreement with this, one of the regions of isodisomy overlaps an emerging chromosome 1 region of interest in autism located at 150-160 Mb...
  36. pmc Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment
    Christopher W Bartlett
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ, USA
    Hum Hered 57:10-20. 2004
    ..2003). Our results indicate that using samples selected for components of the autism phenotype may be a useful adjunct to autism genetics...
  37. ncbi request reprint A new method for computing the multipoint posterior probability of linkage
    Mark W Logue
    Program in Public Health Genetics, College of Public Health, University of Iowa, Iowa City, IA 52242, USA
    Hum Hered 57:90-9. 2004
    ..This version, which we call the imputed PPL, is shown to be superior to previously developed versions...
  38. ncbi request reprint Ascertainment bias in linkage analysis: comments on Ginsburg et al
    Veronica J Vieland
    Genet Epidemiol 28:283-5; author reply 286-7. 2005
  39. pmc Effects of updating linkage evidence across subsets of data: reanalysis of the autism genetic resource exchange data set
    Christopher W Bartlett
    Center for Statistical Genetics Research, College of Public Health, and Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
    Am J Hum Genet 76:688-95. 2005
    ..This analysis illustrates that the way in which heterogeneity is addressed in linkage analysis can dramatically affect the overall conclusions of a linkage study...
  40. pmc HLODs remain powerful tools for detection of linkage in the presence of genetic heterogeneity
    Susan E Hodge
    Am J Hum Genet 70:556-9. 2002
  41. pmc The emperor's new methods
    M Anne Spence
    Am J Hum Genet 72:1084-7. 2003