Research Topics
Genomes and GenesSpecies | ALEXANDRE VIEIRASummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE reviewAlexandre R Vieira
Department of Oral Medicine and Pathology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
Am J Epidemiol 163:790-810. 2006..In the aggregate, TGFA is probably a genetic modifier of clefting in humans, which is consistent with the oligogenic model suggested for nonsyndromic oral clefts...- Studies of palatine rugae and interferon regulatory factor 6 variations in a group of families with sporadic hypodontiaAlys M Murdoch
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
J Oral Sci 51:521-6. 2009..07). However, no specific pattern of tooth agenesis was associated with the palatine rugae patterns studied. Our data suggest that IRF6 may contribute to specific palatine rugae patterns in humans... - Unraveling human cleft lip and palate researchA R Vieira
Departments of Oral Biology and Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
J Dent Res 87:119-25. 2008..The latest approaches in cleft research include the analysis of several additional phenotypical features of the population, with the goal of increasing the statistical power of genetics studies... - Reduced folate carrier 1 (RFC1) is associated with cleft of the lip onlyA R Vieira
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
Braz J Med Biol Res 41:689-93. 2008..Our results provide a new indication that variation in RFC1 may contribute to cleft lip only. Future studies should investigate the association between oral clefts and RFC1 based on more discrete phenotypes... 
Evidence of linkage disequilibrium between polymorphisms at the IRF6 locus and isolate tooth agenesis, in a Turkish populationAlexandre R Vieira
Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsbergh, PA 15261, USA
Arch Oral Biol 53:780-4. 2008..006). An association could still be seen when only cases with at least one missing incisor (p=0.01) and cases with at least one missing premolar (p=0.004) were included in the analysis...
Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesisAlexandre R Vieira
Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Am J Med Genet A 143:538-45. 2007..014) and IRF6 (P = 0.002) markers. There were statistically significant data suggesting that IRF6 interacts not only with MSX1 (P = 0.001), but also with TGFA (P = 0.03)...- Interferon regulatory factor 6 (IRF6) is associated with oral-facial cleft in individuals that originate in South AmericaAlexandre R Vieira
Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Med Genet A 143:2075-8. 2007 - A genome wide linkage scan for cleft lip and palate and dental anomaliesAlexandre R Vieira
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Med Genet A 146:1406-13. 2008..Our preliminary results support the hypothesis that some loci may contribute to both clefts and congenital dental anomalies. Also, adding dental anomalies information will provide new opportunities to map susceptibility loci for clefts... - Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for cleftsAlexandre R Vieira
Department of 1Oral Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Genet Med 10:668-74. 2008..Complete dental information was collected to test the hypothesis that dental anomalies are part of the cleft phenotype spectrum, and can provide new opportunities for identification of cleft susceptibility genes... - AXIN2 and CDH1 polymorphisms, tooth agenesis, and oral cleftsAriadne Letra
Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, 3501 Terrace St, Pittsburgh, PA 15261, USA
Birth Defects Res A Clin Mol Teratol 85:169-73. 2009..Oral clefts have been associated with tooth agenesis. We investigated if AXIN2 and CDH1 polymorphisms were associated with clefts or with any associated dental subphenotypes... - TLR4 as a risk factor for periodontal disease: a reappraisalAyla Ozturk
Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
J Clin Periodontol 36:279-86. 2009..To determine whether genetic variants of the TLR4 gene are associated with either chronic or aggressive periodontitis... - Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association resultsMary L Marazita
Department of Oral Biology, Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Hum Hered 68:151-70. 2009..Non-syndromic orofacial clefts, i.e. cleft lip (CL) and cleft palate (CP), are among the most common birth defects. The goal of this study was to identify genomic regions and genes for CL with or without CP (CL/P)... - Whorl patterns on the lower lip are associated with nonsyndromic cleft lip with or without cleft palateKatherine Neiswanger
Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 14219, USA
Am J Med Genet A 149:2673-9. 2009..As such, they may eventually be useful in a clinical setting, allowing recurrence risk calculations to incorporate individual phenotypic information in addition to family history data... - Mutational analysis of the Sonic Hedgehog gene in 220 newborns with oral clefts in a South American (ECLAMC) populationIeda M Orioli
Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Am J Med Genet 108:12-5. 2002..Thus, we did not identify any clearly disease-causing mutation in SHH in these patients, and conclude that SHH mutations are not a frequent cause of isolated oral clefts in humans... - Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palateAriadne Letra
Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, PA 15261, USA
Am J Med Genet A 152:1701-10. 2010..32-34.1 region harbors cleft susceptibility genes. Additional studies with other populations should focus on these loci to further investigate the participation of these genes in human clefting... - Candidate genes for oral-facial clefts in Guatemalan familiesKatherine Neiswanger
Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA
Ann Plast Surg 56:518-21; discussion 521. 2006..02, broad). Association with JAG2 improved from P = 0.09 under the narrow definition to P = 0.04 under the broad definition. Broadening the oral-facial cleft phenotype to include subclinical variants may improve power in genetic studies... - Transforming growth factor-alfa gene (TGFA), human tooth agenesis, and evidence of segmental uniparental isodisomyNicholas Callahan
Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA 15261, USA
Eur J Oral Sci 117:20-6. 2009..Finally, we excluded that a TGFA microdeletion could cause sporadic agenesis in a case of upper lateral incisors and lower second premolars and suggest this case may be consequence of a segmental uniparental isodisomy... - Studies of genes in the FGF signaling pathway and oral clefts with or without dental anomaliesRenato Menezes
Department of Oral Biology, School of Dental Medicine, University of Pittsburgh 15261, USA
Am J Med Genet A 146:1614-7. 2008 - Rethinking isolated cleft palate: evidence of occult lip defects in a subset of casesSeth M Weinberg
Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15090, USA
Am J Med Genet A 146:1670-5. 2008..Such diagnostic errors could have important implications for recurrence risk estimation and studies aimed at discovering etiology. (c) 2008 Wiley-Liss, Inc... - Caries and periodontal disease: insights from two U.S. populations living a century apartErin K Rose
Center for Craniofacial and Dental Genetics and Department of Oral Biology, University of Pittsburgh School of Dental Medicine, 3501 Terrace Street, Pittsburgh, PA 15261, USA
Oral Health Prev Dent 6:23-8. 2008..To compare caries experience and periodontal status between two U.S. populations that lived a century apart... - Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997Alexandre Rezende Vieira
Department of Pediatrics, University of Iowa, USA
Pesqui Odontol Bras 17:161-5. 2003.... - Dental anomalies as part of the cleft spectrumRenato Menezes
Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
Cleft Palate Craniofac J 45:414-9. 2008..Dental phenotypes (tooth agenesis, supernumerary and impacted teeth, transposition, and structural anomalies) outside the cleft area in the permanent dentition of oral cleft individuals were investigated... - Assessing the proposed association between tooth agenesis and taurodontism in 975 paediatric subjectsErika Calvano Küchler
Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Int J Paediatr Dent 18:231-4. 2008..The identification of subpopulations with specific associated dental anomalies (subphenotype) would allow testing of the specific hypothesis that certain genetic factors contribute to the specific subphenotype...
Research Grants
- Dental anomalies as an extended phenotype for cleftsALEXANDRE VIEIRA; Fiscal Year: 2005..Dental exams could be applied as screening tool for modifying population risks for cleft lip and palate. ..
- Genetics of CariesALEXANDRE VIEIRA; Fiscal Year: 2009..This new knowledge could provide the basis for suggesting genes to be used as new prevention strategies for caries. ..
- Genetics of CariesAlexandre Rezende Vieira; Fiscal Year: 2010..This new knowledge could provide the basis for suggesting genes to be used as new prevention strategies for caries. ..