A R Vieira

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint MSX1, PAX9, and TGFA contribute to tooth agenesis in humans
    A R Vieira
    Department of Pediatrics, University of Iowa, Iowa City 52242 1083, USA
    J Dent Res 83:723-7. 2004
  2. ncbi request reprint Inheritance of cleft palate in South America: evidence for a major locus recessive
    A R Vieira
    Latin American Collaborative Study of Congenital Malformations ECLAMC, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Orthod Craniofac Res 6:83-7. 2003
  3. ncbi request reprint Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis
    A R Vieira
    Department of Pediatrics ML 2182, The University of Iowa, Iowa City, IA 52242, USA
    J Dent Res 82:162-5. 2003
  4. ncbi request reprint Birth order and oral clefts: a meta analysis
    Alexandre R Vieira
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Teratology 66:209-16. 2002
  5. ncbi request reprint Candidate genes for nonsyndromic cleft lip and palate
    A R Vieira
    Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    ASDC J Dent Child 68:272-9, 229. 2001
  6. ncbi request reprint MSX1 and TGFB3 contribute to clefting in South America
    A R Vieira
    Departments of Pediatrics, 2613 JCP, University of Iowa, Iowa City, 52242 1083, USA
    J Dent Res 82:289-92. 2003
  7. pmc Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate
    P A Jezewski
    Department of Periodontics, College of Dentistry, University of Iowa, Iowa City 52242, USA
    J Med Genet 40:399-407. 2003
  8. ncbi request reprint Genetic origins in a South American clefting population
    A R Vieira
    Department of Pediatrics, University of Iowa, Iowa City 52242 1083, USA
    Clin Genet 62:458-63. 2002
  9. pmc A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23
    B M Riley
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 143:846-52. 2007
  10. ncbi request reprint Birth order and neural tube defects: a reappraisal
    Alexandre R Vieira
    Department of Pediatrics, ML 2182, The University of Iowa, Iowa City, IA 52242, USA
    J Neurol Sci 217:65-72. 2004

Collaborators

Detail Information

Publications29

  1. ncbi request reprint MSX1, PAX9, and TGFA contribute to tooth agenesis in humans
    A R Vieira
    Department of Pediatrics, University of Iowa, Iowa City 52242 1083, USA
    J Dent Res 83:723-7. 2004
    ..No mutations were found in MSX1 or PAX9 coding regions. There were statistically significant data suggesting that MSX1 interacts with PAX9. These findings suggest that MSX1, PAX9, and TGFA play a role in isolated dental agenesis...
  2. ncbi request reprint Inheritance of cleft palate in South America: evidence for a major locus recessive
    A R Vieira
    Latin American Collaborative Study of Congenital Malformations ECLAMC, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Orthod Craniofac Res 6:83-7. 2003
    ..Determine the model of inheritance of non-syndromic cleft palate in humans...
  3. ncbi request reprint Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis
    A R Vieira
    Department of Pediatrics ML 2182, The University of Iowa, Iowa City, IA 52242, USA
    J Dent Res 82:162-5. 2003
    ..Oral clefts and syndromic forms of tooth agenesis may be the best models for isolated tooth agenesis. In the future, a precise description of the missing teeth in syndromes involving tooth agenesis may be useful...
  4. ncbi request reprint Birth order and oral clefts: a meta analysis
    Alexandre R Vieira
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Teratology 66:209-16. 2002
    ..A meta-analysis of published data on cleft lip or cleft palate (CL/P and CP) was carried out to ascertain whether there is an increased risk for children of high birth order to have an oral cleft...
  5. ncbi request reprint Candidate genes for nonsyndromic cleft lip and palate
    A R Vieira
    Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    ASDC J Dent Child 68:272-9, 229. 2001
    ..These efforts are justified, however, because of the possibility of being able to predict more accurately the risk of such defects occurring...
  6. ncbi request reprint MSX1 and TGFB3 contribute to clefting in South America
    A R Vieira
    Departments of Pediatrics, 2613 JCP, University of Iowa, Iowa City, 52242 1083, USA
    J Dent Res 82:289-92. 2003
    ..These results suggest that MSX1 and TGFB3 mutations make a contribution to clefts in South American populations...
  7. pmc Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate
    P A Jezewski
    Department of Periodontics, College of Dentistry, University of Iowa, Iowa City 52242, USA
    J Med Genet 40:399-407. 2003
    ....
  8. ncbi request reprint Genetic origins in a South American clefting population
    A R Vieira
    Department of Pediatrics, University of Iowa, Iowa City 52242 1083, USA
    Clin Genet 62:458-63. 2002
    ..The implications of this finding include the possibility of using admixture mapping approaches to this population...
  9. pmc A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23
    B M Riley
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 143:846-52. 2007
    ..Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 (recessive multipoint HLOD 1.07) and BAG4 (recessive multipoint HLOD 1.31)...
  10. ncbi request reprint Birth order and neural tube defects: a reappraisal
    Alexandre R Vieira
    Department of Pediatrics, ML 2182, The University of Iowa, Iowa City, IA 52242, USA
    J Neurol Sci 217:65-72. 2004
    ..These results suggest the compilation of anencephaly and spina bifida data can be the explanation for the controversies seen in the literature...
  11. ncbi request reprint [Maternal age and neural tube defects: evidence for a greater effect in spina bifida than in anencephaly]
    Alexandre R Vieira
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Rev Med Chil 133:62-70. 2005
    ..Recent evidence from birth order data suggest that maternal factors can differently influence anencephaly and spina bifida...
  12. doi request reprint MMP13 polymorphism decreases risk for dental caries
    P N Tannure
    Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Rio de Janeiro, Brazil
    Caries Res 46:401-7. 2012
    ..Genetic variations in MMP13 may contribute to individual differences in caries susceptibility. Our findings reinforce that susceptibility to caries results from gene-environment interactions...
  13. ncbi request reprint Maternal age and oral clefts: a reappraisal
    Alexandre R Vieira
    Department of Pediatrics, University of Iowa, Iowa City 52242 1083, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94:530-5. 2002
    ..The aim of the study was to test the hypothesis that increased maternal age is associated with a higher risk of having a child with oral clefts...
  14. ncbi request reprint Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
    Theresa M Zucchero
    University of Iowa, Iowa City 52242, USA
    N Engl J Med 351:769-80. 2004
    ..We searched for a specific genetic factor contributing to this complex trait by examining large numbers of affected patients and families and evaluating a specific candidate gene...
  15. pmc Impaired FGF signaling contributes to cleft lip and palate
    Bridget M Riley
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 104:4512-7. 2007
    ..The data suggest that the FGF signaling pathway may contribute to as much as 3-5% of NS CLP and will be a consideration in the clinical management of CLP...
  16. ncbi request reprint Mutational analysis of the Sonic Hedgehog gene in 220 newborns with oral clefts in a South American (ECLAMC) population
    Ieda M Orioli
    Department of Pediatrics, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Am J Med Genet 108:12-5. 2002
    ..Thus, we did not identify any clearly disease-causing mutation in SHH in these patients, and conclude that SHH mutations are not a frequent cause of isolated oral clefts in humans...
  17. pmc Medical sequencing of candidate genes for nonsyndromic cleft lip and palate
    Alexandre R Vieira
    Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA
    PLoS Genet 1:e64. 2005
    ..This study also illustrates the need to test large numbers of controls to distinguish rare polymorphic variants and prioritize functional studies for rare point mutations...
  18. ncbi request reprint [Mutational analysis of the muscle segment homeobox gene 1 (MSX1) in Chilean patients with cleft lip/palate]
    Alexandre R Vieira
    Department of Pediatrics, University of Iowa, Iowa City, IA 52242, USA
    Rev Med Chil 132:816-22. 2004
    ..Mutations of the MSX1 gene may contribute to non-syndromic forms of cleft lip and/or cleft palate...
  19. ncbi request reprint Association between the transforming growth factor alpha gene and nonsyndromic oral clefts: a HuGE review
    Alexandre R Vieira
    Department of Oral Medicine and Pathology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Am J Epidemiol 163:790-810. 2006
    ..In the aggregate, TGFA is probably a genetic modifier of clefting in humans, which is consistent with the oligogenic model suggested for nonsyndromic oral clefts...
  20. doi request reprint Rethinking isolated cleft palate: evidence of occult lip defects in a subset of cases
    Seth M Weinberg
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15090, USA
    Am J Med Genet A 146:1670-5. 2008
    ..Such diagnostic errors could have important implications for recurrence risk estimation and studies aimed at discovering etiology. (c) 2008 Wiley-Liss, Inc...
  21. ncbi request reprint Interferon regulatory factor 6 (IRF6) is associated with oral-facial cleft in individuals that originate in South America
    Alexandre R Vieira
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet A 143:2075-8. 2007
  22. ncbi request reprint [Genetic studies of a Chilean family with three different dental anomalies]
    Rosa Andrea Pardo V
    Unidad de Genetica, Hospital Dr Sotero del Rio, Santiago, Chile
    Rev Med Chil 134:1541-8. 2006
    ..Congenital dental anomalies can affect up to 25% of the population...
  23. pmc Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis
    Alexandre R Vieira
    Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet A 143:538-45. 2007
    ..014) and IRF6 (P = 0.002) markers. There were statistically significant data suggesting that IRF6 interacts not only with MSX1 (P = 0.001), but also with TGFA (P = 0.03)...
  24. ncbi request reprint Studies of reduced folate carrier 1 (RFC1) A80G and 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms with neural tube and orofacial cleft defects
    Alexandre R Vieira
    Am J Med Genet A 135:220-3. 2005
  25. pmc PVRL1 variants contribute to non-syndromic cleft lip and palate in multiple populations
    Joseph R Avila
    Department of Cytokine Biology, The Forsyth Institute and Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    Am J Med Genet A 140:2562-70. 2006
    ..Together these data suggest that both rare and common mutations within PVRL1 make a minor contribution to disrupting the initiation and regulation of cell-to-cell adhesion and downstream morphogenesis of the embryonic face...
  26. ncbi request reprint Caries and periodontal disease: insights from two U.S. populations living a century apart
    Erin K Rose
    Center for Craniofacial and Dental Genetics and Department of Oral Biology, University of Pittsburgh School of Dental Medicine, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Oral Health Prev Dent 6:23-8. 2008
    ..To compare caries experience and periodontal status between two U.S. populations that lived a century apart...
  27. pmc A genome wide linkage scan for cleft lip and palate and dental anomalies
    Alexandre R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Am J Med Genet A 146:1406-13. 2008
    ..Our preliminary results support the hypothesis that some loci may contribute to both clefts and congenital dental anomalies. Also, adding dental anomalies information will provide new opportunities to map susceptibility loci for clefts...
  28. ncbi request reprint Candidate genes for oral-facial clefts in Guatemalan families
    Katherine Neiswanger
    Center for Craniofacial and Dental Genetics, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Ann Plast Surg 56:518-21; discussion 521. 2006
    ..02, broad). Association with JAG2 improved from P = 0.09 under the narrow definition to P = 0.04 under the broad definition. Broadening the oral-facial cleft phenotype to include subclinical variants may improve power in genetic studies...
  29. ncbi request reprint Studies with His475Tyr glutamate carboxipeptidase II polymorphism and neural tube defects
    Alexandre R Vieira
    Am J Med Genet 111:218-9. 2002