A R Vieira

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Genome wide association scan for chronic periodontitis implicates novel locus
    Ping Feng
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    BMC Oral Health 14:84. 2014
  2. pmc Caries is Associated with Asthma and Epilepsy
    Ida Anjomshoaa
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, PA, USA
    Eur J Dent 3:297-303. 2009
  3. pmc Explaining gender differences in caries: a multifactorial approach to a multifactorial disease
    Maria Ferraro
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Dent 2010:649643. 2010
  4. pmc FAM5C contributes to aggressive periodontitis
    Flavia M Carvalho
    Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 5:e10053. 2010
  5. pmc Detection of Streptococcus mutans Genomic DNA in Human DNA Samples Extracted from Saliva and Blood
    Alexandre R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    ISRN Dent 2011:543561. 2011
  6. pmc Women are more susceptible to caries but individuals born with clefts are not
    Aditi Jindal
    Departments of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Dent 2011:454532. 2011
  7. pmc Failure to Control Caries in an AIDS-Affected Individual: A Case Report
    Karen A Nedwick-Castro
    Department of Operative Dentistry Comprehensive Care, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, 3074 Salk Annex, Pittsburgh, PA 15261, USA
    Case Rep Dent 2012:643436. 2012
  8. pmc Enamel formation genes influence enamel microhardness before and after cariogenic challenge
    Takehiko Shimizu
    Department of Pediatric Dentistry, Nihon University of Dentistry at Matsudo, Matsudo, Chiba, Japan
    PLoS ONE 7:e45022. 2012
  9. pmc Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate
    Ariadne Letra
    Department of Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA, USA
    PLoS ONE 7:e45441. 2012
  10. pmc Genetic mapping of high caries experience on human chromosome 13
    Erika C Küchler
    Department of Oral Biology, University of Pittsburgh, 614 Salk Hall, Pittsburgh, PA, USA
    BMC Med Genet 14:116. 2013

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Genome wide association scan for chronic periodontitis implicates novel locus
    Ping Feng
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    BMC Oral Health 14:84. 2014
    ....
  2. pmc Caries is Associated with Asthma and Epilepsy
    Ida Anjomshoaa
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, PA, USA
    Eur J Dent 3:297-303. 2009
    ..The aim of this work was to evaluate whether self-reported systemic diseases were associated with caries experience...
  3. pmc Explaining gender differences in caries: a multifactorial approach to a multifactorial disease
    Maria Ferraro
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Dent 2010:649643. 2010
    ..Further research in these areas could be done in the future to explain their contribution, or lack thereof, to a higher caries rate in women...
  4. pmc FAM5C contributes to aggressive periodontitis
    Flavia M Carvalho
    Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
    PLoS ONE 5:e10053. 2010
    ..No correlations were found between FAM5C levels and the presence and load of red complex periodontopathogens or Aggregatibacter actinomycetemcomitans. This study provides evidence that FAM5C contributes to aggressive periodontitis...
  5. pmc Detection of Streptococcus mutans Genomic DNA in Human DNA Samples Extracted from Saliva and Blood
    Alexandre R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    ISRN Dent 2011:543561. 2011
    ..Values of the threshold cycle of the real-time PCR reaction correlate with higher levels of caries experience in children, but this correlation could not be detected for adults...
  6. pmc Women are more susceptible to caries but individuals born with clefts are not
    Aditi Jindal
    Departments of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Int J Dent 2011:454532. 2011
    ..Women tend to present higher caries rates in comparison to men. Our work provides strong evidence that individuals born with clefts are not at higher risk to caries; however, women tend to have more severe caries experience...
  7. pmc Failure to Control Caries in an AIDS-Affected Individual: A Case Report
    Karen A Nedwick-Castro
    Department of Operative Dentistry Comprehensive Care, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, 3074 Salk Annex, Pittsburgh, PA 15261, USA
    Case Rep Dent 2012:643436. 2012
    ..It is also common sense that just performing restorations to decayed teeth is not enough to control the disease, but recommending a personalized preventive maintenance program to the patient is a must...
  8. pmc Enamel formation genes influence enamel microhardness before and after cariogenic challenge
    Takehiko Shimizu
    Department of Pediatric Dentistry, Nihon University of Dentistry at Matsudo, Matsudo, Chiba, Japan
    PLoS ONE 7:e45022. 2012
    ..006) and TUIP11 (p=0.0006) with enamel microhardness. Our results suggest that the influence of genetic variation of enamel formation genes may influence the dynamic interactions between the enamel surface and the oral cavity...
  9. pmc Interaction between IRF6 and TGFA genes contribute to the risk of nonsyndromic cleft lip/palate
    Ariadne Letra
    Department of Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, PA, USA
    PLoS ONE 7:e45441. 2012
    ..Moreover, this potential IRF6-TGFA interaction may account for as much as 1% to 10% of CL/P cases. The Irf6-knockout model further supports the evidence of IRF6-TGFA interaction found in humans...
  10. pmc Genetic mapping of high caries experience on human chromosome 13
    Erika C Küchler
    Department of Oral Biology, University of Pittsburgh, 614 Salk Hall, Pittsburgh, PA, USA
    BMC Med Genet 14:116. 2013
    ..Our previous genome-wide linkage scan mapped five loci for caries experience. The purpose of this study was to fine map one of these loci, the locus 13q31.1, in order to identify genetic contributors to caries...
  11. pmc Candidate gene studies in hypodontia suggest role for FGF3
    A R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 614 Salk Hall, Pittsburgh, PA, 15261, USA
    Eur Arch Paediatr Dent 14:405-10. 2013
    ..From this, we hypothesise that most cases of tooth agenesis fit a polygenic mode of inheritance, where several genes with small effects cause a variety of varying phenotypes...
  12. pmc Genome-wide association scan of dental caries in the permanent dentition
    Xiaojing Wang
    Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA
    BMC Oral Health 12:57. 2012
    ..Therefore, we conducted the first genome-wide association study (GWAS) to identify genes affecting susceptibility to caries in adults...
  13. pmc Genetics and caries: prospects
    Alexandre Rezende Vieira
    Departments of Oral Biology and Pediatric Dentistry, and Center for Craniofacial and Dental Genetics, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Braz Oral Res 26:7-9. 2012
    ..We have pioneered the work on genetic studies to identify genes and genetic markers of diagnostic, prognostic, and therapeutic value. This paper summarizes a presentation that elaborated on these initial findings...
  14. doi request reprint Summary of the IADR Cariology Research Group Symposium, Barcelona, Spain, July 2010: new directions in cariology research
    A R Vieira
    University of Pittsburgh School of Dental Medicine, Pittsburgh, PA, USA
    Caries Res 46:346-52. 2012
    ..This paper summarizes these presentations...
  15. doi request reprint Genetic and environmental factors in human cleft lip and palate
    Alexandre R Vieira
    Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA, USA
    Front Oral Biol 16:19-31. 2012
    ..21 are highlighted, as well as the latest insight from more sophisticated phenotypical characterization and the inclusion of covariables related to the environment in the analysis of genetic variation...
  16. ncbi request reprint Genome-wide scan finds suggestive caries loci
    A R Vieira
    Department of Oral Biology, Universityof Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA
    J Dent Res 87:435-9. 2008
    ..1 and 14q24.3). Genes that may be related to saliva flow and diet preferences are proposed as possible candidates. A protective locus for caries in the X chromosome may explain the gender differences seen in caries frequency...
  17. pmc Novel cleft susceptibility genes in chromosome 6q
    A Letra
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, University of Pittsburgh, 614 Salk Hall, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    J Dent Res 89:927-32. 2010
    ..We provide further evidence of the involvement of chromosome 6q in cleft lip/palate and suggest PRSS35 as a novel candidate gene...
  18. doi request reprint MMP13 polymorphism decreases risk for dental caries
    P N Tannure
    Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Rio de Janeiro, Brazil
    Caries Res 46:401-7. 2012
    ..Genetic variations in MMP13 may contribute to individual differences in caries susceptibility. Our findings reinforce that susceptibility to caries results from gene-environment interactions...
  19. ncbi request reprint Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only
    A R Vieira
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    Braz J Med Biol Res 41:689-93. 2008
    ..Our results provide a new indication that variation in RFC1 may contribute to cleft lip only. Future studies should investigate the association between oral clefts and RFC1 based on more discrete phenotypes...
  20. doi request reprint Tooth agenesis association with self-reported family history of cancer
    E C Küchler
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    J Dent Res 92:149-55. 2013
    ..Prospective studies are needed to confirm if tooth agenesis can be used as a risk marker for cancer...
  21. ncbi request reprint Candidate genes for nonsyndromic cleft lip and palate
    A R Vieira
    Department of Genetics, Institute of Biology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    ASDC J Dent Child 68:272-9, 229. 2001
    ..These efforts are justified, however, because of the possibility of being able to predict more accurately the risk of such defects occurring...
  22. doi request reprint The antimicrobial peptide DEFB1 is associated with caries
    A Ozturk
    Department of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 89:631-6. 2010
    ..No association between DEFB1 genetic markers and periodontal disease was found. Our results suggest that functional polymorphisms of DEFB1 are potential markers for caries...
  23. pmc Axis inhibition protein 2 (AXIN2) polymorphisms and tooth agenesis
    N Callahan
    Center for Craniofacial and Dental Genetics, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA
    Arch Oral Biol 54:45-9. 2009
    ..A sub-set of these cases could have an increased susceptibility for colon cancer or other types of tumours and this knowledge would have significant clinical implications...
  24. pmc Fine-mapping of 5q12.1-13.3 unveils new genetic contributors to caries
    T Shimizu
    Department of Pediatric Dentistry, Nihon University of Dentistry at Matsudo, Matsudo, Japan
    Caries Res 47:273-83. 2013
    ..We detected PART1 and BTF3 expression in whole saliva, and the expression of BTF3 was associated with caries experience. Our results suggest BTF3 may have a functional role in protecting against caries. ..
  25. pmc Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population
    K Deeley
    Department of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Caries Res 42:8-13. 2008
    ..The approach of comparing individuals with extremely distinct caries experiences could be valuable for decreasing the potential influence of environmental factors on genetic studies of caries...
  26. pmc Insights from studies with oral cleft genes suggest associations between WNT-pathway genes and risk of oral cancer
    P A Andrade Filho
    Department of Otolaryngology and Immunology, Hillman Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Dent Res 90:740-6. 2011
    ..001). Additional studies should focus on the identification of potentially functional variants in these genes as contributors to human clefting and oral cancer...
  27. pmc Defining subphenotypes for oral clefts based on dental development
    A Letra
    Department of Oral Biology and Center for Craniofacial and Dental Genetics, School of Dental Medicine, 614 Salk Hall, University of Pittsburgh, 3501 Terrace Street, Pittsburgh, PA 15261, USA
    J Dent Res 86:986-91. 2007
    ..Agenesis of the lateral incisor on the non-cleft side was the most remarkable observation, and may suggest that such cases could be considered incomplete forms of bilateral clefts of the lip...
  28. ncbi request reprint Unraveling human cleft lip and palate research
    A R Vieira
    Departments of Oral Biology and Pediatric Dentistry, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
    J Dent Res 87:119-25. 2008
    ..The latest approaches in cleft research include the analysis of several additional phenotypical features of the population, with the goal of increasing the statistical power of genetics studies...
  29. ncbi request reprint Inheritance of cleft palate in South America: evidence for a major locus recessive
    A R Vieira
    Latin American Collaborative Study of Congenital Malformations ECLAMC, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    Orthod Craniofac Res 6:83-7. 2003
    ..Determine the model of inheritance of non-syndromic cleft palate in humans...
  30. ncbi request reprint Molecular factors resulting in tooth agenesis and contemporary approaches for regeneration: a review
    S M Cudney
    Department of Oral Biology, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA 15261, USA
    Eur Arch Paediatr Dent 13:297-304. 2012
    ..Proposed treatment options are presented, including signaling factor supplementation and stem cell isolation for bioengineering new teeth...
  31. ncbi request reprint The endangered clinical teacher scholar: will this eliminate discovery from the dental school environment?
    M Oakley
    Department of Restorative Dentistry Comprehensive Care, University of Pittsburgh School of Dental Medicine, PA 15261, USA
    J Dent Res 87:200-2. 2008
    ..Without a definitive plan, the clinical scholar will become an endangered species, and the research innovations and discovery of our profession will fall short in addressing the needs of the public's oral and systemic health...
  32. ncbi request reprint The many faces of the genetics contribution to temporomandibular joint disorder
    M Oakley
    Department of Restorative Dentistry Comprehensive Care, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Orthod Craniofac Res 11:125-35. 2008
    ..Review the literature on candidate genes for temporomandibular joint disorder (TMD). Setting and Sample Population - Literature review...
  33. pmc Genome-wide association scan for childhood caries implicates novel genes
    J R Shaffer
    Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    J Dent Res 90:1457-62. 2011
    ..Verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries...
  34. ncbi request reprint MSX1 and TGFB3 contribute to clefting in South America
    A R Vieira
    Departments of Pediatrics, 2613 JCP, University of Iowa, Iowa City, 52242 1083, USA
    J Dent Res 82:289-92. 2003
    ..These results suggest that MSX1 and TGFB3 mutations make a contribution to clefts in South American populations...
  35. pmc A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23
    B M Riley
    Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 143:846-52. 2007
    ..Linkage and association analyses of these SNPs yield suggestive results for markers in FGFR1 (recessive multipoint HLOD 1.07) and BAG4 (recessive multipoint HLOD 1.31)...
  36. ncbi request reprint Oral clefts and syndromic forms of tooth agenesis as models for genetics of isolated tooth agenesis
    A R Vieira
    Department of Pediatrics ML 2182, The University of Iowa, Iowa City, IA 52242, USA
    J Dent Res 82:162-5. 2003
    ..Oral clefts and syndromic forms of tooth agenesis may be the best models for isolated tooth agenesis. In the future, a precise description of the missing teeth in syndromes involving tooth agenesis may be useful...
  37. pmc Complete sequencing shows a role for MSX1 in non-syndromic cleft lip and palate
    P A Jezewski
    Department of Periodontics, College of Dentistry, University of Iowa, Iowa City 52242, USA
    J Med Genet 40:399-407. 2003
    ....
  38. ncbi request reprint Genetic origins in a South American clefting population
    A R Vieira
    Department of Pediatrics, University of Iowa, Iowa City 52242 1083, USA
    Clin Genet 62:458-63. 2002
    ..The implications of this finding include the possibility of using admixture mapping approaches to this population...
  39. pmc Genetic evidence for the role of loci at 19q13 in cleft lip and palate
    A Warrington
    J Med Genet 43:e26. 2006
    ..Clefts of the lip and palate are common birth defects, affecting approximately 1 in 700 births worldwide. The aetiology of clefting is complex, with multiple genetic and environmental influences...