Research Topics
Species | R G VictorSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Publications
The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular healthRonald G Victor
Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8586, USA
Am J Cardiol 93:1473-80. 2004....- Pathophysiology of target-organ disease: does angiotensin II remain the key?Ronald G Victor
Hypertension Division, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 8586, USA
J Clin Hypertens (Greenwich) 9:4-10. 2007..New outcomes trials are under way to explore the full potential of more complete RAS blockade with regard to cardiovascular target-organ protection... 
Factors associated with hypertension awareness, treatment, and control in Dallas County, TexasRonald G Victor
Division of Hypertension, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Room J4 134, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Arch Intern Med 168:1285-93. 2008..Hypertension (HTN) control rates in the United States remain lower in black than white persons, particularly before 65 years of age. Potential sociocultural factors have not been sufficiently addressed...- Sympathetic neural mechanisms in human hypertensionRonald G Victor
Internal Medicine, Hypertension Division, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Curr Hypertens Rep 10:241-7. 2008..New outcomes trials are needed if we are to translate this largely theoretical body of research into clinical practice... 
A barber-based intervention for hypertension in African American men: design of a group randomized trialRonald G Victor
Division of Hypertension, Department of Internal Medicine, and Donald W Reynolds Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8586, USA
Am Heart J 157:30-6. 2009..Barbershops constitute potential sites for community health promotion programs targeting hypertension (HTN) in African American men but such programs previously have not been formally evaluated...- Differential sympathetic neural control of oxygenation in resting and exercising human skeletal muscleJ Hansen
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 8573, USA
J Clin Invest 98:584-96. 1996..These events are different from those involved in either metaboreceptor muscle afferent activation or reactive hyperemia... - ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscleG D Thomas
Department of Internal Medicine, Molecular Cardiology Laboratories, The University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
J Clin Invest 99:2602-9. 1997..We conclude that contraction-induced activation of KATP channels is a major mechanism underlying metabolic inhibition of sympathetic vasoconstriction in exercising skeletal muscle... - Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscleG D Thomas
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
J Physiol 506:817-26. 1998..Although the underlying mechanism is not known, it may involve NO-induced activation of vascular KATP channels... - Epithelial sodium channel allele T594M is not associated with blood pressure or blood pressure response to amilorideJohn M Hollier
Division of Hypertension, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8857, USA
Hypertension 47:428-33. 2006..8). We conclude that the T594M allele does not contribute significantly to BP in blacks and does not predict a significantly superior response to amiloride therapy... - Sympathetic neural mechanisms of cyclosporine-induced hypertensionM Sander
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8573, USA
Am J Hypertens 9:121S-138S. 1996..The elucidation of novel CsA-sensitive cellular signaling pathways has lead to the search for the ideal immunosuppressant drug, one which retains CsA's immunosuppressive efficacy but without its toxicity... - Transdermal estrogen replacement therapy decreases sympathetic activity in postmenopausal womenW Vongpatanasin
Division of Hypertension, Donald W. Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
Circulation 103:2903-8. 2001..Because the effects of transdermal ERT are larger than those of oral ERT, the route of administration may be an important consideration in optimizing the beneficial effects of ERT on BP and overall cardiovascular health... - Impaired modulation of sympathetic vasoconstriction in contracting skeletal muscle of rats with chronic myocardial infarctions: role of oxidative stressG D Thomas
Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Circ Res 88:816-23. 2001..These data suggest that impaired metabolic modulation of sympathetic vasoconstriction in contracting skeletal muscle of MI rats is a consequence of superoxide-mediated disruption of the NO pathway... - Overweight and sympathetic overactivity in black AmericansN I Abate
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390-8586, USA
Hypertension 38:379-83. 2001..These data provide the first microneurographic evidence for tonic central sympathetic overactivity in blacks, both adiposity-related sympathetic overactivity in black women and adiposity-independent sympathetic overactivity in black men... - Adenovirus-mediated leptin expression normalises hypertension associated with diet-induced obesityW Zhang
Department of Internal Medicine Hypertension Division, The University of Texas Southwestern Medical Center, Dallas, TX, USA
J Neuroendocrinol 22:175-80. 2010..This is the first study to demonstrate that further increases in circulating leptin levels by leptin gene transfer during obesity could reduce blood pressure... - Impaired metabolic modulation of alpha-adrenergic vasoconstriction in dystrophin-deficient skeletal muscleG D Thomas
Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75235, USA
Proc Natl Acad Sci U S A 95:15090-5. 1998..Similar results were obtained in mutant mice that lack the gene encoding nNOS. Together these data suggest a specific role for nNOS in the local metabolic inhibition of alpha-adrenergic vasoconstriction in active skeletal muscle... - Measurement of 18-hydroxycorticosterone during adrenal vein sampling for primary aldosteronismRichard J Auchus
Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8857, USA
J Clin Endocrinol Metab 92:2648-51. 2007.... - Functional sympatholysis is impaired in hypertensive humansWanpen Vongpatanasin
Hypertension Section, Cardiology Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, U9 400, Dallas, TX 75390 8586, USA
J Physiol 589:1209-20. 2011..These data provide the first evidence that functional sympatholysis is impaired in hypertensive humans by a mechanism that appears to involve an angiotensin-dependent increase in sympathetic vasoconstriction in the exercising muscles... - Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertensionDaniel L Dries
Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas at Southwestern Medical Center, Dallas, USA
Circulation 112:2403-10. 2005..The natriuretic peptide system contributes to blood pressure regulation. Atrial and brain natriuretic peptides are cleaved into smaller biologically active molecules by corin, a transmembrane serine protease expressed in cardiomyocytes... - Left ventricular hypertrophy is more prevalent in blacks than whites in the general population: the Dallas Heart StudyMark H Drazner
Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
Hypertension 46:124-9. 2005..The ethnic differences in left ventricular mass are independent of differences in body composition... - Reversible sympathetic overactivity in hypertensive patients with primary aldosteronismAndrew C Kontak
Cardiology Division, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8586, USA
J Clin Endocrinol Metab 95:4756-61. 2010..Aldosterone has been shown to exert a central sympathoexcitatory action in multiple animal models, but evidence in humans is still lacking... - Blunted circadian variation in autonomic regulation of sinus node function in veterans with Gulf War syndromeRobert W Haley
Divisions of Epidemiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8874, USA
Am J Med 117:469-78. 2004..To test the hypothesis that subtle abnormalities of the autonomic nervous system underlie the chronic symptoms reported by many Gulf War veterans, such as chronic diarrhea, dizziness, fatigue, and sexual dysfunction... - Barbershops as hypertension detection, referral, and follow-up centers for black menPaul L Hess
Division of Hypertension, Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 8586, USA
Hypertension 49:1040-6. 2007..01). Taken together, these data suggest that black-owned barbershops can be transformed into effective HTN detection, referral, and follow-up centers. Further research is warranted... - Effects of cocaine on heart rate variability in healthy subjectsWanpen Vongpatanasin
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
Am J Cardiol 93:385-8. 2004..However, the results of our autonomic blocking studies indicated the opposite, suggesting a major influence of cardiac sympathetic drive on the high-frequency power of heart rate variability... - Mechanism of the blood pressure--raising effect of cocaine in humansMeryem Tuncel
Department of Internal Medicine, Hypertension Division, and Donald W. Reynolds Cardiovascular Clinical Research Center, UT Southwestern Medical Center, Dallas, TX 75390-8586, USA
Circulation 105:1054-9. 2002..However, this mechanism does not contribute importantly to the blood pressure-raising effect of cocaine because activation of baroreceptor reflexes decreases SNA, the neural stimulus for NE release... - Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imagingLidia S Szczepaniak
Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, USA
Magn Reson Med 49:417-23. 2003..Increased myocardial triglyceride content was accompanied by elevated LV mass and suppressed septal wall thickening as measured by cardiac imaging... - Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks?Jia Ling Li
Division of Hypertension, Department of Internal Medicine, Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, USA
Hypertension 47:1140-6. 2006..Both the DraI restriction fragment length polymorphism in ADRA2A and the ADRA2C (Del 322 to 325) can be excluded as major candidate alleles for hypertension in blacks... - Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy studyJonathan M McGavock
Department of Internal Medicine, Divisions of Hypertension, University of Texas Southwestern Medical Center at Dallas, Dallas, Tex, USA
Circulation 116:1170-5. 2007..Whether cardiac steatosis precedes the onset of cardiomyopathy in individuals with impaired glucose tolerance or in patients with type 2 diabetes mellitus is unknown... - Pathogenesis of hypertension in African AmericansShawna Nesbitt
Internal Medicine/Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Congest Heart Fail 10:24-9. 2004..Obesity, especially in African-American women, may be closely related to hypertension as a result of sympathetic nervous system stimulation... - Mechanism of cocaine-induced hyperthermia in humansCraig G Crandall
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
Ann Intern Med 136:785-91. 2002..However, because cocaine-induced hyperthermia occurs primarily in hot weather, it is hypothesized that cocaine also impairs thermoregulatory adjustments that mediate heat dissipation... - Oral direct renin inhibition: premise, promise, and potential limitations of a new antihypertensive drugMoiz M Shafiq
Hypertension Division, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8586, USA
Am J Med 121:265-71. 2008..The results of outcomes trials are eagerly awaited... - Sympathetic overactivity as a cause of hypertension in chronic renal failureRobert A Augustyniak
Department of Internal Medicine, Division of Hypertension, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8586, USA
J Hypertens 20:3-9. 2002..Future clinical studies are needed to determine whether normalization of sympathetic activity should constitute an important therapeutic goal in this high-risk patient population... - Adiposity of the heart, revisitedJonathan M McGavock
University of Texas Southwestern Medical Center, Dallas, Texas 75390-8899, USA
Ann Intern Med 144:517-24. 2006..These studies parallel the observations in obese animals and provide evidence that myocardial lipid content may be a biomarker and putative therapeutic target for cardiac disease in obese patients... - Determination of triglyceride in the human myocardium by magnetic resonance spectroscopy: reproducibility and sensitivity of the methodJason S Reingold
Department of Internal Medicine, Univ. of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-8899, USA
Am J Physiol Endocrinol Metab 289:E935-9. 2005..60). 1H-MRS is a reliable method for the determination of myocardial TG in humans and is relatively unaffected by the consumption of one high-fat meal but sensitive to changes following a prolonged fast... - Calcineurin inhibitors cause renal afferent activation in rats: a novel mechanism of cyclosporine-induced hypertensionW Zhang
Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas 75390-8586, USA
Am J Hypertens 13:999-1004. 2000.... - Reflex sympathetic activation during static exercise is severely impaired in patients with myophosphorylase deficiencyPaul J Fadel
Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center, Dallas, USA
J Physiol 548:983-93. 2003..Together these data indicate that appropriate activation of glycogenolytic pathways is obligatory for normal metaboreflex-mediated sympathoexcitation during static exercise in humans... - Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotensionRonald G Victor
Donald W. Reynolds Clinical Cardiovascular Research Center, Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75235-8586, USA
Am J Med 112:361-8. 2002..Further studies are needed to determine if venoconstrictor agents are of greater therapeutic benefit in this condition than are pure arterial vasoconstrictors... - Differential modulation of cortical synaptic activity by calcineurin (phosphatase 2B) versus phosphatases 1 and 2AG D Thomas
The University of Texas Southwestern Medical Center, Molecular Cardiology Laboratories, Dallas 75235 8573, USA
Brain Res 749:101-8. 1997..Thus, in rat cortical neurons, glutamatergic neurotransmission appears to be frequency-modulated through a presynaptic mechanism by calcineurin, and amplitude-modulated through a postsynaptic mechanism by phosphatases 1 and 2A... - Identifying gaps between guidelines and clinical practice in the evaluation and treatment of patients with hypertensionCathy B Spranger
Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas 75235-8586, USA
Am J Med 117:14-8. 2004..Overcoming these practice defects will require innovative multilevel interventions... - Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in AmericaLidia S Szczepaniak
Department of Internal Medicine, Division of Hypertension, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
Circ Res 101:759-67. 2007.... - Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humansDileep V Menon
Hypertension Division and the Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8586, USA
J Am Coll Cardiol 50:626-33. 2007..The aim of this study was to determine whether cocaine's sympathomimetic actions can be reversed by a potent centrally acting alpha2 adrenergic receptor (AR) agonist (dexmedetomidine)... - Nitric oxide-dependent modulation of sympathetic neural control of oxygenation in exercising human skeletal muscleBahman Chavoshan
Department of Internal Medicine, Hypertension Division, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Physiol 540:377-86. 2002..These data advance the hypothesis that NO plays an important role in modulating sympathetic vasoconstriction in the microcirculation of exercising muscle, because such modulation is abrogated by NO synthase inhibition with L-NAME... - Sympathetic nervous system function in renal hypertensionMeryem Tuncel
Hypertension Division, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room J4.134, Dallas, TX 75390-8586, USA
Curr Hypertens Rep 4:229-36. 2002..Future clinical trials are needed to determine whether normalization of sympathetic activity should constitute an important therapeutic goal to improve renal and cardiovascular outcomes in patients with chronic renal failure... - L-NAME- and ADMA-induced sympathetic neural activation in conscious ratsRobert A Augustyniak
Department of Internal Medicine, Division of Hypertension, The University of Texas Southwestern Medical Center at Dallas, USA
Am J Physiol Regul Integr Comp Physiol 290:R726-32. 2006..These data confirm and extend the concept that circulating endogenous NOS inhibitors can constitute an excitatory signal to SNA... - Alpha2cDel322-325 and beta1Arg389 adrenergic polymorphisms are not associated with reduced left ventricular ejection fraction or increased left ventricular volumeRussell M Canham
J Am Coll Cardiol 49:274-6. 2007 - The ASCOT Trial--are beta-blockers still useful as antihypertensive medication?Marvin Moser
Yale University School of Medicine, New Haven, CT, USA
J Clin Hypertens (Greenwich) 8:723-8. 2006 - Lay beliefs about high blood pressure in a low- to middle-income urban African-American community: an opportunity for improving hypertension controlRuth P Wilson
Department of African American Studies (RPW, San Jose State University, San Jose, California, USA
Am J Med 112:26-30. 2002..Lack of appreciation of these lay beliefs by providers may contribute to noncompliance and poor rates of hypertension control... - Nitric oxide pathway as new drug targets for refractory hypertensionRobert A Augustyniak
The Donald W. Reynolds Cardiovascular Clinical Research Center and the Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Texas 75390-8586, USA
Curr Pharm Des 11:3307-15. 2005..The purpose of this article is to show how emerging basic research on the NO pathway is elucidating novel antihypertensive drug targets that are on the cusp of clinical application... - Fractal properties of human muscle sympathetic nerve activityPaul J Fadel
Dept. of Pharmacology and Toxicology, Michigan State Univ, East Lansing, MI 48824, USA
Am J Physiol Heart Circ Physiol 286:H1076-87. 2004..Whether sympathetic outflow to the heart also is fractal and contributes to the fractal component of heart rate variability remains an open question... - Basis for the cardiac-related rhythm in muscle sympathetic nerve activity of humansSusan M Barman
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824, USA
Am J Physiol Heart Circ Physiol 284:H584-97. 2003..These results support the view that the cardiac-related rhythm in MSNA reflects forcing of a nonlinear oscillator rather than periodic inhibition of unstructured, random activity... - How to treat hypertension in patients with coronary heart disease diseaseMarvin Moser
Yale University School of Medicine, New Haven, CT, USA
J Clin Hypertens (Greenwich) 10:390-7. 2008.... - Abdominal obesity, liver fat, and muscle composition in survivors of childhood acute lymphoblastic leukemiaPeter M Janiszewski
School of Kinesiology and Health Studies, Queen s University, Kingston, Ontario, Canada K7L 3N6
J Clin Endocrinol Metab 92:3816-21. 2007..Survivors of childhood acute lymphoblastic leukemia (ALL) become obese, and are at increased risk for morbidity and mortality post therapy...
Research Grants
- Barber-Based Intervention for Hypertension in Black MenRonald Victor; Fiscal Year: 2007..A detailed dissemination plan is proposed as the potential for dissemination is high; there are over 18,000 Black barbershops in major urban centers across the United States. ..