Charles S Via

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint In vivo neutralization of TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL
    C S Via
    Research Service, Department of Veterans Affairs Medical Center and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 167:6821-6. 2001
  2. pmc Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus
    Charles S Via
    Research Service, Department of Veteran Affairs Medical Center, Baltimore, Maryland, USA
    Environ Health Perspect 111:1273-7. 2003
  3. ncbi request reprint T cell TRAIL promotes murine lupus by sustaining effector CD4 Th cell numbers and by inhibiting CD8 CTL activity
    Violeta Rus
    Research Service, Department of Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    J Immunol 178:3962-72. 2007
  4. ncbi request reprint Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose) polymerase 1 in a murine model of lupus
    Thomas Grader-Beck
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Immunol 178:95-102. 2007
  5. ncbi request reprint Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease
    Florin Niculescu
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Baltimore, MD 21201, USA
    Exp Mol Pathol 79:136-45. 2005
  6. ncbi request reprint Increased severity of murine lupus in female mice is due to enhanced expansion of pathogenic T cells
    Thomas J Lang
    Research Service, Baltimore Veterans Affairs Medical Center, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 171:5795-801. 2003
  7. ncbi request reprint Differential requirement for IFN-gamma in CTL maturation in acute murine graft-versus-host disease
    Roman Puliaev
    Research Service, Baltimore Veterans Affairs Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 173:910-9. 2004
  8. ncbi request reprint Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
    Florin Niculescu
    University of Maryland School of Medicine, Baltimore, USA
    Arthritis Rheum 48:1071-9. 2003
  9. pmc Implications of the parent-into-F1 model for human lupus pathogenesis: roles for cytotoxic T lymphocytes and viral pathogens
    Charles S Via
    Pathology Department, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA
    Curr Opin Rheumatol 22:493-8. 2010
  10. ncbi request reprint In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function
    Thomas J Lang
    Research Service, Baltimore Veterans Affairs Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 168:3786-92. 2002

Collaborators

Detail Information

Publications17

  1. ncbi request reprint In vivo neutralization of TNF-alpha promotes humoral autoimmunity by preventing the induction of CTL
    C S Via
    Research Service, Department of Veterans Affairs Medical Center and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 167:6821-6. 2001
    ..These results suggest that a therapeutic TNF-alpha blockade may promote humoral autoimmunity by selectively inhibiting the induction of a CTL response that would normally suppress autoreactive B cells...
  2. pmc Low-dose exposure to inorganic mercury accelerates disease and mortality in acquired murine lupus
    Charles S Via
    Research Service, Department of Veteran Affairs Medical Center, Baltimore, Maryland, USA
    Environ Health Perspect 111:1273-7. 2003
    ..These results are consistent with the hypothesis that low-level, nontoxic iHg preexposure may interact with other risk factors, genetic or acquired, to promote subsequent autoimmune disease development...
  3. ncbi request reprint T cell TRAIL promotes murine lupus by sustaining effector CD4 Th cell numbers and by inhibiting CD8 CTL activity
    Violeta Rus
    Research Service, Department of Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    J Immunol 178:3962-72. 2007
    ....
  4. ncbi request reprint Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose) polymerase 1 in a murine model of lupus
    Thomas Grader-Beck
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Immunol 178:95-102. 2007
    ....
  5. ncbi request reprint Both apoptosis and complement membrane attack complex deposition are major features of murine acute graft-vs.-host disease
    Florin Niculescu
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Baltimore, MD 21201, USA
    Exp Mol Pathol 79:136-45. 2005
    ..These results indicate a role for both adaptive immunity and innate immunity in this model of GVHD and support its use in modeling human acute GVHD in the nonmyeloablative setting...
  6. ncbi request reprint Increased severity of murine lupus in female mice is due to enhanced expansion of pathogenic T cells
    Thomas J Lang
    Research Service, Baltimore Veterans Affairs Medical Center, Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 171:5795-801. 2003
    ..These results demonstrate that the sex of the recipient can influence the expansion of pathogenic T cells, thus increasing long-term the burden of autoreactive T cells and resulting in greater disease severity...
  7. ncbi request reprint Differential requirement for IFN-gamma in CTL maturation in acute murine graft-versus-host disease
    Roman Puliaev
    Research Service, Baltimore Veterans Affairs Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 173:910-9. 2004
    ..Thus, both IFN-gamma-dependent induction of Fas/FasL and IFN-gamma-independent induction of perforin contribute to CTL-mediated elimination of host B cells in AGVHD. Suppression of both pathways is required for typical CGVHD development...
  8. ncbi request reprint Pathogenic T cells in murine lupus exhibit spontaneous signaling activity through phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways
    Florin Niculescu
    University of Maryland School of Medicine, Baltimore, USA
    Arthritis Rheum 48:1071-9. 2003
    ..To determine the activation status of two cytoplasmic signaling pathways, phosphatidylinositol 3-kinase (PI 3-kinase) and the mitogen-activated protein kinase (MAPK) family...
  9. pmc Implications of the parent-into-F1 model for human lupus pathogenesis: roles for cytotoxic T lymphocytes and viral pathogens
    Charles S Via
    Pathology Department, Uniformed Services University of Health Sciences, Bethesda, Maryland, USA
    Curr Opin Rheumatol 22:493-8. 2010
    ..This review examines mechanisms elucidated in the parent-into-F1 model of lupus and their possible parallels in human lupus pathogenesis...
  10. ncbi request reprint In vivo CD86 blockade inhibits CD4+ T cell activation, whereas CD80 blockade potentiates CD8+ T cell activation and CTL effector function
    Thomas J Lang
    Research Service, Baltimore Veterans Affairs Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 168:3786-92. 2002
    ..In contrast, CD86 is critical for the activation of naive CD4(+) T cells in either a Th1 or a Th2 cytokine-mediated response...
  11. ncbi request reprint Increased expression and release of functional tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by T cells from lupus patients with active disease
    Violeta Rus
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland at Baltimore, 21201, USA
    Clin Immunol 117:48-56. 2005
    ..5-fold higher compared to that of sTRAIL. These results indicate that IFNalpha-induced enhancement of TRAIL expression and of TRAIL-mediated apoptosis may amplify the abnormal apoptotic process in SLE...
  12. ncbi request reprint Expression of cytokine- and chemokine-related genes in peripheral blood mononuclear cells from lupus patients by cDNA array
    Violeta Rus
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland Medical School, Baltimore, Maryland 21201, USA
    Clin Immunol 102:283-90. 2002
    ..These results highlight the potential use of the microarray data in identifying genes associated with SLE, which could become candidate molecular markers or future therapeutic targets...
  13. ncbi request reprint A major role for the Fas pathway in acute graft-versus-host disease
    C S Via
    Research Service, Department of Veteran Affairs Medical Center, and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore 21201, USA
    J Immunol 157:5387-93. 1996
    ..These findings not only indicate that the Fas ligand is an important effector molecule in acute GVHD, but also provide in vivo evidence supporting a role for Fas/Fas ligand interactions in T cell expansion and maturation...
  14. ncbi request reprint IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease
    C S Via
    Research Service, Loch Raven VA Medical Center, Baltimore, MD
    J Immunol 153:4040-7. 1994
    ..2) This effect is IFN-gamma-independent. 3) IL-12 needs to be present during the initial differentiation of T cells in this system to have this effect...
  15. ncbi request reprint Gene expression profiling in peripheral blood mononuclear cells from lupus patients with active and inactive disease
    Violeta Rus
    Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Clin Immunol 112:231-4. 2004
    ..These results highlight the potential use of microarray data in identifying genes associated with disease activity in SLE, which could become potential biomarkers or future therapeutic targets...
  16. pmc Boswellia carterii extract inhibits TH1 cytokines and promotes TH2 cytokines in vitro
    Marc R Chevrier
    Research Service, Baltimore VAMHCS and Division of Rheumatology and Clinical Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Clin Diagn Lab Immunol 12:575-80. 2005
    ..These results indicate that a purified mixture of BAs from B. carterii plant resin exhibits carrier-dependent immunomodulatory properties in vitro...
  17. pmc CTL-promoting effects of CD40 stimulation outweigh B cell-stimulatory effects resulting in B cell elimination and disease improvement in a murine model of lupus
    Roman Puliaev
    Pathology Department, Uniformed Services University of Health Sciences, Bethesda, MD 20814, USA
    J Immunol 181:47-61. 2008
    ....