Chad M Vezina
Affiliation: University of Wisconsin
Wegner K, Mehta V, Johansson J, Mueller B, Keil K, Abler L, et al
. Edar is a downstream target of beta-catenin and drives collagen accumulation in the mouse prostate. Biol Open. 2019;8: pubmed publisher
..This article has an associated First Person interview with the first author of the paper. ..
Joseph D, Chandrashekar A, Abler L, Chu L, Thomson J, Vezina C. Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds. Dev Biol. 2019;447:157-169 pubmed publisher
..In addition, our results show that prostatic buds consist of two epithelial cell populations with distinct molecular and functional characteristics that could potentially contribute to specialized lineages in the adult prostate. ..
Joseph D, Chandrashekar A, Abler L, Chu L, Thomson J, Mendelsohn C, et al
. In vivo replacement of damaged bladder urothelium by Wolffian duct epithelial cells. Proc Natl Acad Sci U S A. 2018;115:8394-8399 pubmed publisher
..This is evidence that Wolffian duct epithelial cells are summoned in vivo to replace damaged bladder epithelium and function as a reservoir of cells for bladder regeneration. ..
Mulligan W, Wegner K, Keil K, Mehta V, Taketo M, Vezina C. Beta-catenin and estrogen signaling collaborate to drive cyclin D1 expression in developing mouse prostate. Differentiation. 2017;93:66-71 pubmed publisher
..Together, our results are consistent with an epithelial proliferative growth mechanism linking CTNNB1-driven Ccnd1 transcription and estrogen-mediated CCND1 protein stabilization. ..
Abler L, Vezina C. Links between lower urinary tract symptoms, intermittent hypoxia and diabetes: Causes or cures?. Respir Physiol Neurobiol. 2018;256:87-96 pubmed publisher
..New tools, models, or reappropriation of existing ones, especially rodent models, is required to parse the associations between IH/OSA, LUTS and obesity/diabetes and to elucidate their underlying, and potentially shared, etiologies. ..