Zinaida Vexler

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Does inflammation after stroke affect the developing brain differently than adult brain?
    Zinaida S Vexler
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Dev Neurosci 31:378-93. 2009
  2. ncbi request reprint Differential vulnerability of immature murine neurons to oxygen-glucose deprivation
    Xiangning Jiang
    Department of Neurology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0663, USA
    Exp Neurol 190:224-32. 2004
  3. ncbi request reprint Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model
    Dezhi Mu
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Neurobiol Dis 14:524-34. 2003
  4. ncbi request reprint Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke
    Fernando F Gonzalez
    Department of Pediatrics, University of California, San Francisco, Calif 94143 0663, USA
    Dev Neurosci 29:321-30. 2007
  5. pmc Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke
    Janet Shimotake
    Department of Pediatrics, University of California, San Francisco, San Francisco Calif 94143 0663, USA
    Stroke 41:343-9. 2010
  6. ncbi request reprint Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, Box 0114, 521 Parnassus Ave, San Francisco, CA, USA
    Brain Res 960:90-8. 2003
  7. ncbi request reprint Manipulation of antioxidant pathways in neonatal murine brain
    R Ann Sheldon
    Department of Neurology, University of California San Francisco, San Francisco, California 94143
    Pediatr Res 56:656-62. 2004
  8. ncbi request reprint Translational stroke research in the developing brain
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, San Francisco, California 94143 0663, USA
    Pediatr Neurol 34:459-63. 2006
  9. ncbi request reprint Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia
    Andra Dingman
    Department of Neurology, University of California San Francisco, California 94143 0663, USA
    J Neurochem 96:1467-79. 2006
  10. ncbi request reprint Erythropoietin improves functional and histological outcome in neonatal stroke
    Yun Sil Chang
    Departments of Neurology and Pediatrics, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0663, USA
    Pediatr Res 58:106-11. 2005

Collaborators

Detail Information

Publications19

  1. pmc Does inflammation after stroke affect the developing brain differently than adult brain?
    Zinaida S Vexler
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Dev Neurosci 31:378-93. 2009
    ..Finally, we discuss emerging data on both the supportive and adverse roles of inflammation in plasticity and repair after stroke...
  2. ncbi request reprint Differential vulnerability of immature murine neurons to oxygen-glucose deprivation
    Xiangning Jiang
    Department of Neurology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0663, USA
    Exp Neurol 190:224-32. 2004
    ....
  3. ncbi request reprint Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model
    Dezhi Mu
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Neurobiol Dis 14:524-34. 2003
    ..The presence of HIF-1alpha and VEGF after moderate ischemia-reperfusion injury suggests potential avenues to exploit for neuroprotection...
  4. ncbi request reprint Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke
    Fernando F Gonzalez
    Department of Pediatrics, University of California, San Francisco, Calif 94143 0663, USA
    Dev Neurosci 29:321-30. 2007
    ..These results suggest that EPO may neuroprotect and direct cell fate toward neurogenesis and away from gliogenesis in neonatal stroke...
  5. pmc Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke
    Janet Shimotake
    Department of Pediatrics, University of California, San Francisco, San Francisco Calif 94143 0663, USA
    Stroke 41:343-9. 2010
    ..Vascular endothelial growth factor is upregulated after a hypoxic insult and is involved in neuronal survival, angiogenesis, and neurogenesis during the recovery process...
  6. ncbi request reprint Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, Box 0114, 521 Parnassus Ave, San Francisco, CA, USA
    Brain Res 960:90-8. 2003
    ..The efficacy of FBP depended on duration of hypoxia and was associated with higher intracellular GSH concentration, an effect partly mediated via increased glutathione reductase activity...
  7. ncbi request reprint Manipulation of antioxidant pathways in neonatal murine brain
    R Ann Sheldon
    Department of Neurology, University of California San Francisco, San Francisco, California 94143
    Pediatr Res 56:656-62. 2004
    ..008). These findings support the hypothesis that the immature brain has limited GPX activity and is more susceptible to oxidative damage and may explain the paradoxical effect seen in ischemic neonatal brain when SOD1 is overexpressed...
  8. ncbi request reprint Translational stroke research in the developing brain
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, San Francisco, California 94143 0663, USA
    Pediatr Neurol 34:459-63. 2006
    ..These issues need to be carefully addressed in designing future clinical trials...
  9. ncbi request reprint Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia
    Andra Dingman
    Department of Neurology, University of California San Francisco, California 94143 0663, USA
    J Neurochem 96:1467-79. 2006
    ....
  10. ncbi request reprint Erythropoietin improves functional and histological outcome in neonatal stroke
    Yun Sil Chang
    Departments of Neurology and Pediatrics, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0663, USA
    Pediatr Res 58:106-11. 2005
    ..This functional improvement directly correlated with the amount of preserved hemispheric volume. These results suggest EPO may be a candidate in the treatment of neonatal stroke...
  11. doi request reprint Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents
    Michael F Wendland
    University California San Francisco, Department of Neurology, Box 0663, 521 Parnassus Ave, San Francisco, CA 94143 0663, USA
    Stroke 39:1862-8. 2008
    ..We asked whether the extent of injury depicted on DWI can predict the presence of caspase-3 activation, a quantitative marker of apoptotic injury, after hypoxia-ischemia (H-I) in postnatal day 7 rats...
  12. ncbi request reprint Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke
    Dezhi Mu
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    Exp Neurol 195:407-15. 2005
    ..These results suggest that DFO is protective when administered after neonatal ischemic stroke and that this protection may be like that afforded by preconditioning through the upregulation of similar downstream pathways...
  13. ncbi request reprint Magnetic resonance imaging as a surrogate measure for histological sub-chronic endpoint in a neonatal rat stroke model
    Nikita Derugin
    Department of Neurosurgery, University of California, San Francisco, CA 94143, USA
    Brain Res 1066:49-56. 2005
    ..The inclusion of magnetic resonance imaging (MRI) as a surrogate measure of stroke progression has provided useful information in adult models, but the benefit for neonatal stroke studies is yet to be established...
  14. ncbi request reprint Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70
    Yasuhiko Matsumori
    Department of Neurological Surgery, University of California, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Stroke 37:507-12. 2006
    ....
  15. pmc Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke
    Sheryl P Denker
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 0663, USA
    J Neurochem 100:893-904. 2007
    ..Our findings show that despite profound increases in MCP-1 in injured regions, monocyte infiltration is low and the majority of macrophages in acutely injured regions are microglia...
  16. ncbi request reprint Rat forebrain neurogenesis and striatal neuron replacement after focal stroke
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, 4412 Kresge III, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0585, USA
    Ann Neurol 52:802-13. 2002
    ..Moreover, neuroblasts in the injured neostriatum appear to differentiate into a region-appropriate phenotype, which suggests that the mature brain is capable of replacing some neurons lost after ischemic injury...
  17. pmc Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion
    Christine Fox
    Department of Neurology, University of California, San Francisco, California 94143 0663, USA
    J Cereb Blood Flow Metab 25:1138-49. 2005
    ..Therefore, minocycline provides early but transient protection, which is largely independent of microglial activation or activation of the MAPK p38 pathway...
  18. ncbi request reprint Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, Caifornia 94121, USA
    Ann N Y Acad Sci 1053:74-83. 2005
    ..We suggest that HSPs are capable of protecting brain cells from lethal insults through a variety of mechanisms and should be explored as a potential therapy against stroke and other neurodegenerative diseases...
  19. ncbi request reprint Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury
    Yasuhiko Matsumori
    Department of Neurological Surgery, University of California at San Francisco 94121, USA
    J Cereb Blood Flow Metab 25:899-910. 2005
    ..Our results suggest that interaction between Hsp70 and AIF might have reduced downstream events leading to cell death, including the reduction of nuclear AIF translocation in the neonatal brains of Hsp70 Tg mice after H/I...

Research Grants11

  1. Neonatal Stroke: the Role of Microglia
    Zinaida Vexler; Fiscal Year: 2010
    ..Understanding the mechanisms of brain injury in the neonatal brain is an important step in the identification of therapeutic targets that protect the newborn from the lifelong consequences of stroke. ..
  2. CINC-1 as a modulator of blood-brain barrier integrity after neonatal stroke
    Zinaida Vexler; Fiscal Year: 2009
    ..We will use several experimental approaches, including flow cylometry, immunohistochemistry, cytokine multiplex, and MRi in animals with manipulated systemic CINCl levels, or manipulated neutrophils. ..
  3. Neonatal Stroke: the Role of Microglia
    Zinaida Vexler; Fiscal Year: 2007
    ..Understanding the mechanisms of brain injury in the neonatal brain is an important step in the identification of therapeutic targets that protect the newborn from the lifelong consequences of stroke. ..
  4. Neonatal Stroke: the role of MAPK p38 and microglia
    Zinaida Vexler; Fiscal Year: 2005
    ..abstract_text> ..
  5. CINC-1 as a modulator of blood-brain barrier integrity after neonatal stroke
    Zinaida Vexler; Fiscal Year: 2010
    ..We will use several experimental approaches, including flow cylometry, immunohistochemistry, cytokine multiplex, and MRi in animals with manipulated systemic CINCl levels, or manipulated neutrophils. ..