Hubert J Vesselle

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung
    Alexander Salskov
    Division of Nuclear Medicine, Department of Radiology, Box 357115, School of Medicine, University of Washington, Seattle, WA 98195 7115, USA
    J Oncol 2011:950140. 2011
  2. ncbi request reprint Lung cancer proliferation correlates with [F-18]fluorodeoxyglucose uptake by positron emission tomography
    H Vesselle
    Department of Radiology, University of Washington, Seattle 98195 USA
    Clin Cancer Res 6:3837-44. 2000
  3. ncbi request reprint Relationship between non-small cell lung cancer FDG uptake at PET, tumor histology, and Ki-67 proliferation index
    Hubert Vesselle
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Thorac Oncol 3:971-8. 2008
  4. ncbi request reprint Relationship between non-small cell lung cancer fluorodeoxyglucose uptake at positron emission tomography and surgical stage with relevance to patient prognosis
    Hubert Vesselle
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 10:4709-16. 2004
  5. ncbi request reprint Application of a neural network to improve nodal staging accuracy with 18F-FDG PET in non-small cell lung cancer
    Hubert Vesselle
    Division of Nuclear Medicine, University of Washington, Seattle, Washington 98195, USA
    J Nucl Med 44:1918-26. 2003
  6. ncbi request reprint 18F-Fluorothymidine radiation dosimetry in human PET imaging studies
    Hubert Vesselle
    Department of Radiology, Division of Nuclear Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
    J Nucl Med 44:1482-8. 2003
  7. ncbi request reprint Fluorodeoxyglucose uptake of primary non-small cell lung cancer at positron emission tomography: new contrary data on prognostic role
    Hubert Vesselle
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 13:3255-63. 2007
  8. ncbi request reprint In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors
    Hubert Vesselle
    Department of Radiology, Division of Nuclear Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 8:3315-23. 2002
  9. ncbi request reprint PET-CT image registration in the chest using free-form deformations
    David Mattes
    The Boeing Company, Phantom Works, M and CT, Advanced Systems Laboratory, PO Box 3707, MC 7L 40, Seattle, WA 98124 2207, USA
    IEEE Trans Med Imaging 22:120-8. 2003
  10. ncbi request reprint The impact of fluorodeoxyglucose F 18 positron-emission tomography on the surgical staging of non-small cell lung cancer
    Hubert Vesselle
    Divisions of Nuclear Medicine and Thoracic Surgery, University of Washington, Seattle, Wash 98195, USA
    J Thorac Cardiovasc Surg 124:511-9. 2002

Research Grants

Detail Information

Publications24

  1. pmc Hypermethylation of CCND2 May Reflect a Smoking-Induced Precancerous Change in the Lung
    Alexander Salskov
    Division of Nuclear Medicine, Department of Radiology, Box 357115, School of Medicine, University of Washington, Seattle, WA 98195 7115, USA
    J Oncol 2011:950140. 2011
    ..Hypermethylation of CCND2 may reflect a smoking-induced precancerous change in the lung...
  2. ncbi request reprint Lung cancer proliferation correlates with [F-18]fluorodeoxyglucose uptake by positron emission tomography
    H Vesselle
    Department of Radiology, University of Washington, Seattle 98195 USA
    Clin Cancer Res 6:3837-44. 2000
    ..FDG PET may be used to noninvasively assess NSCLC proliferation in vivo, identifying rapidly growing NSCLCs with poor prognosis that could benefit from preoperative chemotherapy...
  3. ncbi request reprint Relationship between non-small cell lung cancer FDG uptake at PET, tumor histology, and Ki-67 proliferation index
    Hubert Vesselle
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Thorac Oncol 3:971-8. 2008
    ..This large, prospectively-recruited patient cohort has previously been analyzed based on differences in FDG uptake across stage groups; the current analysis adds further dimensions to this characterization...
  4. ncbi request reprint Relationship between non-small cell lung cancer fluorodeoxyglucose uptake at positron emission tomography and surgical stage with relevance to patient prognosis
    Hubert Vesselle
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 10:4709-16. 2004
    ....
  5. ncbi request reprint Application of a neural network to improve nodal staging accuracy with 18F-FDG PET in non-small cell lung cancer
    Hubert Vesselle
    Division of Nuclear Medicine, University of Washington, Seattle, Washington 98195, USA
    J Nucl Med 44:1918-26. 2003
    ..We plan to show that an aNN trained on (18)F-FDG PET- and CT-derived data is more accurate in predicting the true surgicopathologic nodal stage than a human reader...
  6. ncbi request reprint 18F-Fluorothymidine radiation dosimetry in human PET imaging studies
    Hubert Vesselle
    Department of Radiology, Division of Nuclear Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
    J Nucl Med 44:1482-8. 2003
    ..We estimated the radiation dosimetry for this tracer from data gathered in patient studies...
  7. ncbi request reprint Fluorodeoxyglucose uptake of primary non-small cell lung cancer at positron emission tomography: new contrary data on prognostic role
    Hubert Vesselle
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Clin Cancer Res 13:3255-63. 2007
    ....
  8. ncbi request reprint In vivo validation of 3'deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) as a proliferation imaging tracer in humans: correlation of [(18)F]FLT uptake by positron emission tomography with Ki-67 immunohistochemistry and flow cytometry in human lung tumors
    Hubert Vesselle
    Department of Radiology, Division of Nuclear Medicine, University of Washington, Seattle, Washington 98195, USA
    Clin Cancer Res 8:3315-23. 2002
    ....
  9. ncbi request reprint PET-CT image registration in the chest using free-form deformations
    David Mattes
    The Boeing Company, Phantom Works, M and CT, Advanced Systems Laboratory, PO Box 3707, MC 7L 40, Seattle, WA 98124 2207, USA
    IEEE Trans Med Imaging 22:120-8. 2003
    ..The visually reported errors are in the 0- to 6-mm range and the average computation time is 100 min on a moderate-performance workstation...
  10. ncbi request reprint The impact of fluorodeoxyglucose F 18 positron-emission tomography on the surgical staging of non-small cell lung cancer
    Hubert Vesselle
    Divisions of Nuclear Medicine and Thoracic Surgery, University of Washington, Seattle, Wash 98195, USA
    J Thorac Cardiovasc Surg 124:511-9. 2002
    ....
  11. ncbi request reprint The Ki-67 index and survival in non-small cell lung cancer: a review and relevance to positron emission tomography
    Jeffrey M Pugsley
    Department of Radiology, University of Washington Medical Center, Seattle 98195, USA
    Cancer J 8:222-33. 2002
    ..We reviewed the current literature to discover the range of studies covering tissue-based and noninvasive methods for determining tumor stage and the prognostic value of staging in non-small cell lung cancer...
  12. ncbi request reprint FLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3'-deoxy-3'-[18F]fluorothymidine
    Alexander Salskov
    Division of Nuclear Medicine, Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Semin Nucl Med 37:429-39. 2007
    ....
  13. pmc Thymidine kinase 1 and thymidine phosphorylase expression in non-small-cell lung carcinoma in relation to angiogenesis and proliferation
    J Scott Brockenbrough
    Division of Nuclear Medicine, Department of Radiology, University of Washington Medical Center, Seattle, WA 98195 7115, USA
    J Histochem Cytochem 57:1087-97. 2009
    ..08). Tumor size was not found to be associated with TK1, TP, Ki-67, or Chalkley score. These findings provide additional evidence for the role of thymidine metabolism in the complex interaction of proliferation and angiogenesis in NSCLC...
  14. doi request reprint Neural networks for nodal staging of non-small cell lung cancer with FDG PET and CT: importance of combining uptake values and sizes of nodes and primary tumor
    Lauren K Toney
    From the Division of Nuclear Medicine, Department of Radiology, University of Washington, 1959 NE Pacific St, RR 215, UW Mailbox 357115, Seattle, WA 98195 7115
    Radiology 270:91-8. 2014
    ..The goal was to allow the resulting ANN structure to relate lymph node uptake for size to primary tumor uptake for size in the determination of the status of nodes as human readers do...
  15. pmc DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type
    Stephen E Hawes
    Department of Epidemiology, School of Public Health, University of Washington, Box 359933, Seattle, WA 98195, USA
    Lung Cancer 69:172-9. 2010
    ..Detection of methylation profiles of genes in NSCLC could provide insight into differential pathways to malignancy and lead to strategies for better treatment of individuals with NSCLC...
  16. ncbi request reprint Kinetic modeling of 3'-deoxy-3'-fluorothymidine in somatic tumors: mathematical studies
    Mark Muzi
    Department of Radiology, University of Washington, Seattle, Washington 98195 6465, USA
    J Nucl Med 46:371-80. 2005
    ..The model reflects the retention of FLT-monophosphate (FLTMP), which is generated by the phosphorylation of FLT by thymidine kinase 1 (TK1), the initial step in the exogenous pathway...
  17. pmc DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients
    Qinghua Feng
    Department of Pathology, School of Medicine, University of Washington, Box 357115, Seattle, WA 98195 7115, USA
    Cancer Epidemiol Biomarkers Prev 17:645-54. 2008
    ..Detection of methylation of these genes in blood might have utility in monitoring and detecting tumor recurrence in early-stage NSCLC after curative surgical resection...
  18. ncbi request reprint Kinetic analysis of 3'-deoxy-3'-fluorothymidine PET studies: validation studies in patients with lung cancer
    Mark Muzi
    Department of Radiology, University of Washington, Seattle, Washington 98195 6465, USA
    J Nucl Med 46:274-82. 2005
    ..Compartmental modeling results were compared with simple model-independent methods of estimating FLT uptake...
  19. ncbi request reprint A simple quantitative assay for the activity of thymidine kinase 1 in solid tumors
    J Scott Brockenbrough
    Division of Nuclear Medicine, Department of Radiology, University of Washington School of Medicine, Box 356113, Seattle, WA 98195, USA
    Nucl Med Biol 34:619-23. 2007
    ..We present a refined TK1 in vitro assay and method of analysis which address these problems...
  20. ncbi request reprint Evaluation of 5'-deoxy-5'-[F-18]fluorothymidine as a tracer of intracellular thymidine phosphorylase activity
    John R Grierson
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Nucl Med Biol 34:471-8. 2007
    ..Our results indicate that [F-18]DFT would not be effective for imaging TP expression because its initial metabolite undergoes further conversion to a diffusible secondary metabolite, allowing activity loss from cells...
  21. ncbi request reprint Detection of locoregional and distant recurrences in breast cancer patients by using FDG PET
    William B Eubank
    Department of Radiology S 113 RAD, Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108 1597, USA
    Radiographics 22:5-17. 2002
    ..FDG PET has been proved accurate in restaging cases of recurrent breast cancer and will likely aid in directing therapy in these cases...
  22. ncbi request reprint Phenotypic heterogeneity of end-stage prostate carcinoma metastatic to bone
    Martine P Roudier
    Department of Urology, University of Washington, and Puget Sound VA Medical Center, Seattle, 98195, USA
    Hum Pathol 34:646-53. 2003
    ..Consequently, therapy directed to the phenotype of 1 metastasis may have no effect on other metastases in the same patient because of phenotypic heterogeneity...
  23. pmc Synthesis and in vitro evaluation of 5-fluoro-6-[(2-iminopyrrolidin-1-YL)methyl]uracil, TPI(F): an inhibitor of human thymidine phosphorylase (TP)
    John R Grierson
    Department of Radiology, Division of Nuclear Medicine, University of Washington, Seattle, Washington, USA
    Nucleosides Nucleotides Nucleic Acids 29:49-54. 2010
    ..5 nM, 2.7 nM, and 9.0 nM for TPI, TPI(Br), and TPI(F), respectively. The results indicate that further studies to develop (18)F-labeled TPI(F) as a potential radiopharmaceutical for PET imaging of TP expression in vivo are warranted...
  24. ncbi request reprint PET/CT scanner instrumentation, challenges, and solutions
    Adam M Alessio
    Department of Radiology, University of Washington, 1959 NE Pacific Street, Box 356004, Seattle, WA 98195 6004, USA
    Radiol Clin North Am 42:1017-32, vii. 2004
    ..This article provides an overview of current PET/CT scanner technology, a discussion of challenges faced by these systems, and pending solutions...

Research Grants15

  1. Lung Cancer Prognosis: FLT PET and DNA Hypermethylation
    Hubert Vesselle; Fiscal Year: 2007
    ..This prognostic information will permit individualization and optimization of therapy for the 41,000 early stage NSCLC patients undergoing surgical resection each year in the United States. ..
  2. Lung Cancer Prognosis: FLT PET and DNA Hypermethylation
    Hubert Vesselle; Fiscal Year: 2005
    ..This prognostic information will permit individualization and optimization of therapy for the 41,000 early stage NSCLC patients undergoing surgical resection each year in the United States. ..
  3. Lung Cancer Prognosis: FLT PET and DNA Hypermethylation
    Hubert Vesselle; Fiscal Year: 2006
    ..This prognostic information will permit individualization and optimization of therapy for the 41,000 early stage NSCLC patients undergoing surgical resection each year in the United States. ..
  4. FLT PET to Plan the Best Therapy for Lung Cancer
    Hubert Vesselle; Fiscal Year: 2007
    ..At the conclusion of this study, the insight gained in the response of stage III NSCLCs will allow clinicians to plan the best therapy for these patients. ..
  5. Lung Cancer Prognosis: FLT PET and DNA Hypermethylation
    Hubert Vesselle; Fiscal Year: 2009
    ..This prognostic information will permit individualization and optimization of therapy for the 41,000 early stage NSCLC patients undergoing surgical resection each year in the United States. ..
  6. FLT PET to Plan the Best Therapy for Lung Cancer
    Hubert Vesselle; Fiscal Year: 2005
    ..At the conclusion of this study, the insight gained in the response of stage III NSCLCs will allow clinicians to plan the best therapy for these patients. ..
  7. FLT PET to Plan the Best Therapy for Lung Cancer
    Hubert Vesselle; Fiscal Year: 2004
    ..At the conclusion of this study, the insight gained in the response of stage III NSCLCs will allow clinicians to plan the best therapy for these patients. ..
  8. THE BIOLOGY OF LUNG CANCER-- FDG AND FLUOROTHYMIDINE PET
    Hubert Vesselle; Fiscal Year: 2004
    ..By performing a biologic grading of resectable NSCLC with FDG PET, we will predict which patients will have a worse outcome. This information will allow individualized therapy. ..
  9. FLT PET to Plan the Best Therapy for Lung Cancer
    Hubert Vesselle; Fiscal Year: 2006
    ..At the conclusion of this study, the insight gained in the response of stage III NSCLCs will allow clinicians to plan the best therapy for these patients. ..
  10. THE BIOLOGY OF LUNG CANCER-- FDG AND FLUOROTHYMIDINE PET
    Hubert Vesselle; Fiscal Year: 2003
    ..By performing a biologic grading of resectable NSCLC with FDG PET, we will predict which patients will have a worse outcome. This information will allow individualized therapy. ..
  11. THE BIOLOGY OF LUNG CANCER-- FDG AND FLUOROTHYMIDINE PET
    Hubert Vesselle; Fiscal Year: 2002
    ..By performing a biologic grading of resectable NSCLC with FDG PET, we will predict which patients will have a worse outcome. This information will allow individualized therapy. ..
  12. THE BIOLOGY OF LUNG CANCER-- FDG AND FLUOROTHYMIDINE PET
    Hubert Vesselle; Fiscal Year: 2001
    ..By performing a biologic grading of resectable NSCLC with FDG PET, we will predict which patients will have a worse outcome. This information will allow individualized therapy. ..
  13. THE BIOLOGY OF LUNG CANCER-- FDG AND FLUOROTHYMIDINE PET
    Hubert Vesselle; Fiscal Year: 2000
    ..By performing a biologic grading of resectable NSCLC with FDG PET, we will predict which patients will have a worse outcome. This information will allow individualized therapy. ..