P M Vespa

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    Paul Vespa
    1David Geffen School of Medicine at UCLA, UCLA Medical Center, University of California, Los Angeles, 90095, USA
    J Cereb Blood Flow Metab 25:763-74. 2005
  2. doi request reprint Hormonal dysfunction in neurocritical patients
    Paul M Vespa
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Opin Crit Care 19:107-12. 2013
  3. doi request reprint Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial
    Paul Vespa
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Crit Care Med 40:1923-9. 2012
  4. pmc Intensive glycemic control in traumatic brain injury: what is the ideal glucose range?
    Paul M Vespa
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, 757 Westwood Blvd, Suite 6236A, Los Angeles, CA 90095, USA
    Crit Care 12:175. 2008
  5. doi request reprint High-volume centers
    P Vespa
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California, Room 6236A Ronald Reagan UCLA Medical Center, 750 Westwood Blvd, Los Angeles, CA 90095, USA
    Neurocrit Care 15:369-72. 2011
  6. ncbi request reprint What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury?
    Paul Vespa
    Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, USA
    Neurosurg Focus 15:E4. 2003
  7. doi request reprint Deep venous thrombosis prophylaxis
    Paul Vespa
    Division of Neurosurgery, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neurocrit Care 15:295-7. 2011
  8. pmc Robotic telepresence in the intensive care unit
    Paul Vespa
    David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    Crit Care 9:319-20. 2005
  9. ncbi request reprint Multimodality monitoring and telemonitoring in neurocritical care: from microdialysis to robotic telepresence
    Paul M Vespa
    Department of Neurology, Division of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    Curr Opin Crit Care 11:133-8. 2005
  10. ncbi request reprint Continuous EEG monitoring for the detection of seizures in traumatic brain injury, infarction, and intracerebral hemorrhage: "to detect and protect"
    Paul Vespa
    Division of Neurosurgery, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    J Clin Neurophysiol 22:99-106. 2005

Detail Information

Publications67

  1. ncbi request reprint Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    Paul Vespa
    1David Geffen School of Medicine at UCLA, UCLA Medical Center, University of California, Los Angeles, 90095, USA
    J Cereb Blood Flow Metab 25:763-74. 2005
    ..001), but not with OEF or CvO(2). Traumatic brain injury leads to a state of persistent metabolic crisis as reflected by abnormal cerebral microdialysis LPR that is not related to ischemia...
  2. doi request reprint Hormonal dysfunction in neurocritical patients
    Paul M Vespa
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Opin Crit Care 19:107-12. 2013
    ..We review the existing literature on incidence, type and duration of endocrine dysfunction with special focus on the pituitary dependent function...
  3. doi request reprint Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial
    Paul Vespa
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Crit Care Med 40:1923-9. 2012
    ..To determine the effects of tight glycemic control on brain metabolism after traumatic brain injury using brain positron emission tomography and microdialysis...
  4. pmc Intensive glycemic control in traumatic brain injury: what is the ideal glucose range?
    Paul M Vespa
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, 757 Westwood Blvd, Suite 6236A, Los Angeles, CA 90095, USA
    Crit Care 12:175. 2008
    ..The present article explores existing literature surrounding this controversy, and outlines the literature that raises concern. Finally, I suggest an alternative course of action that may enable control of glucose in an optimal range...
  5. doi request reprint High-volume centers
    P Vespa
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California, Room 6236A Ronald Reagan UCLA Medical Center, 750 Westwood Blvd, Los Angeles, CA 90095, USA
    Neurocrit Care 15:369-72. 2011
    ..Furthermore, transfer to high-volume centers may be inadequately arranged. Several factors may influence the better outcome at high-volume centers, including the availability of neurointensivists and interventional neuroradiologists...
  6. ncbi request reprint What is the optimal threshold for cerebral perfusion pressure following traumatic brain injury?
    Paul Vespa
    Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, USA
    Neurosurg Focus 15:E4. 2003
    ..The use of brain monitors of cerebral metabolism and oxygen supply may assist the clinician in the selection of the optimal CPP for an individual patient...
  7. doi request reprint Deep venous thrombosis prophylaxis
    Paul Vespa
    Division of Neurosurgery, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neurocrit Care 15:295-7. 2011
    ..Low molecular weight heparin has been linked to an increased risk for intracranial hemorrhage. Limited data are available to direct the timing and duration of prophylactic therapies...
  8. pmc Robotic telepresence in the intensive care unit
    Paul Vespa
    David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    Crit Care 9:319-20. 2005
  9. ncbi request reprint Multimodality monitoring and telemonitoring in neurocritical care: from microdialysis to robotic telepresence
    Paul M Vespa
    Department of Neurology, Division of Neurosurgery, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    Curr Opin Crit Care 11:133-8. 2005
    ..This review will highlight the state-of-the-art in brain monitoring in neurointensive care and define methods of integrating this technology into patient care using telemedicine methods...
  10. ncbi request reprint Continuous EEG monitoring for the detection of seizures in traumatic brain injury, infarction, and intracerebral hemorrhage: "to detect and protect"
    Paul Vespa
    Division of Neurosurgery, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095, USA
    J Clin Neurophysiol 22:99-106. 2005
    ..e., to detect seizures and protect the brain from seizure-related injury in critically ill patients, whose brains are often in a particularly vulnerable state...
  11. ncbi request reprint Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduction of hemorrhage volume and neurological improvement
    Paul Vespa
    University of California, Los Angeles, David Geffen School of Medicine, USA
    Neurocrit Care 2:274-81. 2005
    ..This is a phase-2 safety trial to demonstrate the ability of frameless stereotactic aspiration and thrombolysis of ICH to safely remove blood...
  12. ncbi request reprint Neurogenic pulmonary edema and other mechanisms of impaired oxygenation after aneurysmal subarachnoid hemorrhage
    Paul M Vespa
    Division of Neurosurgery, Department of Neurology, University of California, Los Angeles 90028, USA
    Neurocrit Care 1:157-70. 2004
    ..Aneurysmal subarachnoid hemorrhage (SAH) affects 30,000 patients per year, causing neurologic morbidity and mortality. The etiology of hypoxemia and its role in comorbidity are controversial and unknown...
  13. ncbi request reprint The implications of cerebral ischemia and metabolic dysfunction for treatment strategies in neurointensive care
    Paul M Vespa
    David Geffen School of Medicine at UCLA, University of California, Los Angeles, 90095, USA
    Curr Opin Crit Care 12:119-23. 2006
    ..The intent is to guide clinicians in considering how best to monitor and treat brain metabolism in the intensive care unit...
  14. ncbi request reprint Nonconvulsive electrographic seizures after traumatic brain injury result in a delayed, prolonged increase in intracranial pressure and metabolic crisis
    Paul M Vespa
    Department of Neurosurgery, University of California Los Angeles, Los Angeles, CA, USA
    Crit Care Med 35:2830-6. 2007
    ..To determine whether nonconvulsive electrographic post-traumatic seizures result in increases in intracranial pressure and microdialysis lactate/pyruvate ratio...
  15. ncbi request reprint Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure
    Paul M Vespa
    UCLA, Division of Neurosurgery, USA
    Crit Care Med 35:1153-60. 2007
    ..To determine whether pericontusional tissue exhibits neurochemical responsiveness to changes in cerebral perfusion pressure as measured by microdialysis lactate/pyruvate ratio...
  16. ncbi request reprint Regional heterogeneity of post-traumatic brain metabolism as studied by microdialysis, magnetic resonance spectroscopy and positron emission tomography
    Paul Vespa
    UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, CHS 18 218, Mail code 713909, Los Angeles, CA 90095, USA
    Brain Pathol 14:210-4. 2004
  17. doi request reprint SAH pituitary adrenal dysfunction
    P Vespa
    Department of Neurosurgery, University of California at Los Angeles, Los Angeles, CA, USA
    Neurocrit Care 15:365-8. 2011
    ..During the months to years after subarachnoid hemorrhage, pituitary deficiency may occur in up to one in three patients. Limited data suggest modest outcome benefits with fludrocortisone and no benefit or harm from corticosteroids...
  18. doi request reprint Endocrine function following acute SAH
    Paul Vespa
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California, Room 6236A Ronald Reagan UCLA Medical Center, 750 Westwood Blvd, Los Angeles, CA 90095, USA
    Neurocrit Care 15:361-4. 2011
    ..During the months to years after subarachnoid hemorrhage, pituitary deficiency may occur in one out of three patients. Limited data suggest modest outcome benefits with fludrocortisone and no benefit or harm from corticosteroids...
  19. ncbi request reprint Early and persistent impaired percent alpha variability on continuous electroencephalography monitoring as predictive of poor outcome after traumatic brain injury
    Paul M Vespa
    Department of Neurology, School of Medicine, University of California at Los Angeles, 90095, USA
    J Neurosurg 97:84-92. 2002
    ..The goal of this study was to determine the usefulness of continuous electroencephalography (EEG) monitoring in determining prognosis early after TBI, while the patient is in the intensive care unit...
  20. ncbi request reprint Intensive care unit robotic telepresence facilitates rapid physician response to unstable patients and decreased cost in neurointensive care
    Paul M Vespa
    Departments of Surgery Neurological Surgery and Neurology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, CA 90095, USA
    Surg Neurol 67:331-7. 2007
    ..The timely assessment and treatment of ICU patients is important for neurosurgeons and neurointensivists. We hypothesized that the use of RTP can improve physician rapid response to unstable ICU patients...
  21. ncbi request reprint Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study
    Paul M Vespa
    Division of Neurosurgery, David Geffen School of Medicine at University of California at Los Angeles, CA, USA
    J Cereb Blood Flow Metab 23:865-77. 2003
    ..These results suggest that the level of extracellular glucose is typically reduced after traumatic brain injury and associated with poor outcome, but is not associated with ischemia...
  22. pmc Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy
    P M Vespa
    UCLA Department of Neurosurgery, Los Angeles, CA 90095, USA
    Neurology 75:792-8. 2010
    ..To determine if posttraumatic nonconvulsive electrographic seizures result in long-term brain atrophy...
  23. ncbi request reprint Acute seizures after intracerebral hemorrhage: a factor in progressive midline shift and outcome
    P M Vespa
    Division of Neurosurgery, Department of Neurology, UCLA Stroke Center, UCLA Brain Injury Research Center, University of California Los Angeles School of Medicine, CA 90095 7039, USA
    Neurology 60:1441-6. 2003
    ..To determine whether early seizures that occur frequently after intracerebral hemorrhage (ICH) lead to increased brain edema as manifested by increased midline shift...
  24. ncbi request reprint Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury
    M Bergsneider
    UCLA Division of Neurosurgery, Harbor UCLA Medical Center, UCLA Brain Research Institute, Los Angeles, California 90095 7039, USA
    J Neurotrauma 17:389-401. 2000
    ....
  25. doi request reprint Metabolic crisis after traumatic brain injury is associated with a novel microdialysis proteome
    R Lakshmanan
    UCLA Department of Chemistry and Biochemistry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurocrit Care 12:324-36. 2010
    ..To examine if the metabolic distress after traumatic brain injury (TBI) is associated with a unique proteome...
  26. doi request reprint Partial recanalization of concomitant internal carotid-middle cerebral arterial occlusions promotes distal recanalization of residual thrombus within 24 h
    Y Loh
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurointerv Surg 3:38-42. 2011
    ..Successful recanalization of the proximal aspect of the occlusion may allow for endogenous thrombolysis and facilitate further endogenous recanalization of any residual MCA occlusion...
  27. ncbi request reprint Metabolic suppressive therapy as a treatment for intracranial hypertension--why it works and when it fails
    M Oertel
    Division of Neurosurgery, UCLA Medical Center, Los Angeles, USA
    Acta Neurochir Suppl 81:69-70. 2002
    ..In conclusion, intact CO2R, normal or only moderately elevated ICP and normal MR are predictive of ICP reduction with high dose propofol after head injury...
  28. doi request reprint Higher rates of mortality but not morbidity follow intracranial mechanical thrombectomy in the elderly
    Yince Loh
    Division of Neurosurgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA
    AJNR Am J Neuroradiol 31:1181-5. 2010
    ..Mechanical thrombectomy is a promising means of recanalizing acute cerebrovascular occlusions in certain situations. We sought to determine if increasing age adversely affects prognosis...
  29. ncbi request reprint Can hyperventilation improve cerebral microcirculation in patients with high ICP?
    M Oertel
    Division of Neurosurgery, UCLA Medical Center, Los Angeles, CA, USA
    Acta Neurochir Suppl 81:71-2. 2002
    ..Hyperventilation unexpectedly reduced PI in patients with high ICP. Because decreased PI suggests decreased CVR, it is postulated that hyperventilation in the setting of raised ICP improves cerebral microcirculation...
  30. ncbi request reprint Diffusion-perfusion MR evaluation of perihematomal injury in hyperacute intracerebral hemorrhage
    C S Kidwell
    Stroke Center, Department of Neurology, UCLA Medical Center, Los Angeles, CA 90095, USA
    Neurology 57:1611-7. 2001
    ..Diffusion-perfusion MRI provides a novel means of assessing injury in perihematomal regions in patients with ICH...
  31. ncbi request reprint Validation of computed tomographic middle cerebral artery "dot"sign: an angiographic correlation study
    Megan C Leary
    Department of Neurology, Division of Stroke and Cerebrovascular Disease, Palmer 125, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, Mass 02215, USA
    Stroke 34:2636-40. 2003
    ..The MCA dot sign has not been validated previously against the gold standard of conventional cerebral angiography...
  32. doi request reprint Recanalization rates decrease with increasing thrombectomy attempts
    Y Loh
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    AJNR Am J Neuroradiol 31:935-9. 2010
    ..We sought to determine whether there is an optimum number of retrieval attempts that yields the highest recanalization rates and after which the probability of success decreases...
  33. ncbi request reprint Perfusion-weighted magnetic resonance imaging thresholds identifying core, irreversibly infarcted tissue
    Ludy C Shih
    UCLA Stroke Center, UCLA Medical Center, Los Angeles, Calif, USA
    Stroke 34:1425-30. 2003
    ..Pretreatment perfusion MRI offers promise as a means to differentiate core from penumbral tissues...
  34. ncbi request reprint Is CPP therapy beneficial for all patients with high ICP?
    M Oertel
    Division of Neurosurgery, UCLA Medical Center, Los Angeles, CA, USA
    Acta Neurochir Suppl 81:67-8. 2002
    ..We concluded that in the majority of studies increasing MAP was followed by an increase in ICP. CPP therapy has a selective indication in patients with high GCS, low SjvO2 and increased ICP...
  35. ncbi request reprint PET investigation of post-traumatic cerebral blood volume and blood flow
    N Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Acta Neurochir Suppl 86:49-52. 2003
    ..In conclusion, regional brain edema is likely to occur in contusion and pericontusion areas, while some of the contusional tissue may show vascular engorgement...
  36. pmc Genomic profiles of damage and protection in human intracerebral hemorrhage
    S Thomas Carmichael
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Cereb Blood Flow Metab 28:1860-75. 2008
    ..These inflammatory and anti-inflammatory networks interact at several key points in neutrophil signaling, apoptotic cell death, and protease responses, and indicate that secondary damage in ICH activates opposing molecular systems...
  37. doi request reprint Surgical management of adult hydrocephalus
    Marvin Bergsneider
    Division of Neurosurgery, Department of Surgery, University of California Los Angeles, David Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, California 90095 6901, USA
    Neurosurgery 62:643-59; discussion 659-60. 2008
    ..For the condition of normal pressure hydrocephalus, recommendations are offered regarding the evaluation, surgical treatment, and postoperative management of this disorder...
  38. ncbi request reprint Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
    J Nucl Med 45:775-83. 2004
    ..The purpose of this study was to characterize contusional, pericontusional, and remote regions of TBI by estimating glucose transporter and hexokinase activities on the basis of (18)F-FDG kinetic modeling...
  39. doi request reprint Concurrent neurocysticercosis and pulmonary tuberculosis
    Chad M Miller
    Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 6236 B, Los Angeles, CA 90095, USA
    Neurocrit Care 10:344-6. 2009
    ..We discuss the case of a 24-year-old male with severe racemose neurocysticercosis...
  40. pmc Contrast agent dose effects in cerebral dynamic susceptibility contrast magnetic resonance perfusion imaging
    Jeffry R Alger
    Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
    J Magn Reson Imaging 29:52-64. 2009
    ..To study the contrast agent dose sensitivity of hemodynamic parameters derived from brain dynamic susceptibility contrast MRI (DSC-MRI)...
  41. doi request reprint Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case report
    Darrin J Lee
    Division of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 7039, USA
    Neurosurgery 63:E1004-6; discussion E1006. 2008
    ..The authors describe a case of severe traumatic arterial vasospasm and its subsequent management using angiography and multiple infusions of calcium channel blockers...
  42. pmc Predictors of subarachnoid hemorrhage in acute ischemic stroke with endovascular therapy
    Zhong Song Shi
    Division of Interventional Neuroradiology, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, Los Angeles, CA 90095 7437, USA
    Stroke 41:2775-81. 2010
    ..The purpose of this study was to describe the frequency and predictors of SAH in acute ischemic stroke patients treated endovascularly and its impact on clinical outcome...
  43. doi request reprint Ethical issues in patient-physician communication about therapy for cancer: professional responsibilities of the oncologist
    Neil S Wenger
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Oncologist 15:43-8. 2010
    ..In this way, oncologists can ensure value in cancer care...
  44. ncbi request reprint Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticus
    Lara M Schrader
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Room 1 194, Los Angeles, CA 90095, USA
    Clin Neurophysiol 117:781-8. 2006
    ..We delivered low frequency stimulation through subdural electrodes to suppress seizures in a case of refractory status epilepticus (RSE)...
  45. ncbi request reprint Routine and quantitative EEG in mild traumatic brain injury
    Marc R Nuwer
    Department of Neurology, University of California Los Angeles School of Medicine, Los Angeles, CA, USA
    Clin Neurophysiol 116:2001-25. 2005
    ..There are no proven pathognomonic signatures useful for identifying head injury as the cause of signs and symptoms, especially late after the injury...
  46. ncbi request reprint Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratios
    Chad M Miller
    Division of Neurosurgery, David Geffen School of Medicine at University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Neurocrit Care 6:22-9. 2007
    ..The purpose of this study is to characterize the neurochemical changes in perihematomal tissue during frameless minimally invasive evacuation of spontaneous hematomas...
  47. ncbi request reprint Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury after human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6901, USA
    Neurosurgery 55:1306-15; discussio 1316-7. 2004
    ..The objective was to determine the nature, extent, and degree of metabolic abnormalities in subcortical brain regions remote from hemorrhagic lesions...
  48. ncbi request reprint Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:765-70. 2004
    ..The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers...
  49. ncbi request reprint Focal meningoencephalitis and mycotic aneurysms from suspected aneurysm coil seeding
    Yince Loh
    Manhattan Beach, CA, USA
    Neurology 69:613. 2007
  50. ncbi request reprint Selective metabolic reduction in gray matter acutely following human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 21:149-61. 2004
    ..There was a selective CMRglc reduction in cortical GM following TBI. The pathophysiological basis for the reduction in GM-to-WM CMRglc ratio seen on FDG-PET imaging following TBI remains to be determined...
  51. ncbi request reprint Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke
    Victor J Marder
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles Orthopaedic Hospital, 2400 S Flower St, Los Angeles, California 90007, USA
    Stroke 37:2086-93. 2006
    ..Information regarding the histological structure of thromboemboli that cause acute stroke provides insight into pathogenesis and clinical management...
  52. doi request reprint Autopsy findings after intracranial thrombectomy for acute ischemic stroke: a clinicopathologic study of 5 patients
    Nicole S Yin
    Department of Pathology, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Stroke 41:938-47. 2010
    ..Various devices (including most extensively the Mechanical Embolus Removal in Cerebral Ischemia [MERCI] Retriever device) have been used for this...
  53. ncbi request reprint Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 44:1709-16. 2003
    ..Therefore, thalamic and brain stem CMRglc may have a closer correlation than does the cerebral cortex with depth of coma after TBI...
  54. ncbi request reprint Increased pentose phosphate pathway flux after clinical traumatic brain injury: a [1,2-13C2]glucose labeling study in humans
    Joshua R Dusick
    Division of Neurosurgery and Cerebral Blood Flow Laboratory, University of California at Los Angeles, Los Angeles, California 90095 7039, USA
    J Cereb Blood Flow Metab 27:1593-602. 2007
    ..0006). This elevation in the PPC in the acute period after severe TBI likely represents a shunting of substrate into alternative biochemical pathways that may be critical for preventing secondary injury and initiating recovery...
  55. ncbi request reprint Cortical synchrony changes detected by scalp electrode electroencephalograph as traumatic brain injury patients emerge from coma
    Donald C Shields
    Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine, UCLA Medical Center, Los Angeles, CA 90095, USA
    Surg Neurol 67:354-9. 2007
    ..This study explores the synchrony between multiple cortical surface sites as brain injury patients emerge from coma...
  56. ncbi request reprint Endovascular mechanical clot retrieval in a broad ischemic stroke cohort
    D Kim
    University of California at Los Angeles Stroke Center, Los Angeles, CA, USA
    AJNR Am J Neuroradiol 27:2048-52. 2006
    ..Our aim was to describe an expanded experience with endovascular mechanical embolectomy in a broad group of patients, including those not meeting entry criteria for the MERCI multicenter trials...
  57. pmc Impact of reperfusion after 3 hours of symptom onset on tissue fate in acute cerebral ischemia
    Oh Young Bang
    Department of Neurology, University of California, Los Angeles, CA, USA
    J Neuroimaging 19:317-22. 2009
    ..However, there has been only sparse direct evidence that reperfusion after 3 hours prevents infarct growth...
  58. ncbi request reprint Translational neurochemical research in acute human brain injury: the current status and potential future for cerebral microdialysis
    Lars Hillered
    Division of Neurosurgery, Department of Surgery, The David Geffen UCLA School of Medicine, Los Angeles, California, USA
    J Neurotrauma 22:3-41. 2005
    ..Methodological issues that appeared critical for the future success of MD as a routine intracerebral sampling method were addressed...
  59. ncbi request reprint Increased hippocampal CA3 vulnerability to low-level kainic acid following lateral fluid percussion injury
    Elisa Roncati Zanier
    Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 20:409-20. 2003
    ..Neuronal excitation during a time of cellular vulnerability may trigger or amplify the cycle of secondary damage in functionally impaired, but potentially viable, tissue...
  60. ncbi request reprint A breath of fresh air: the potential use for hyperoxia in traumatic brain injury
    Paul M Vespa
    Crit Care Med 36:363-5. 2008
  61. ncbi request reprint Impaired percent alpha variability on continuous electroencephalography is associated with thalamic injury and predicts poor long-term outcome after human traumatic brain injury
    Matthew O Hebb
    Brain Repair Centre, Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurotrauma 24:579-90. 2007
    ..PAV appears best utilized as a functional adjunct to traditional clinical and anatomical predictors...
  62. ncbi request reprint Perfusing the brain after traumatic brain injury: what clinical index should we follow?
    Paul M Vespa
    Crit Care Med 32:1621-3. 2004
  63. doi request reprint Persistent metabolic crisis as measured by elevated cerebral microdialysis lactate-pyruvate ratio predicts chronic frontal lobe brain atrophy after traumatic brain injury
    Judith Marcoux
    Department of Neurosurgery, Montreal Neurologic Institute, Montreal, QC, Canada
    Crit Care Med 36:2871-7. 2008
    ..To determine whether persistent metabolic dysfunction in normal-appearing frontal lobe tissue is correlated with long-term tissue atrophy...
  64. ncbi request reprint Treatment of critical care patients with substantial acute ischemic or traumatic brain injury
    Anthony J Strong
    Crit Care Med 33:2147-9; author reply 2149. 2005
  65. ncbi request reprint Brain tissue oxygen monitoring: a measure of supply and demand
    Paul M Vespa
    Crit Care Med 34:1850-2. 2006
  66. pmc Impact of collateral flow on tissue fate in acute ischaemic stroke
    O Y Bang
    Department of Neurology, Samsung Medical Centre, Sungkyunkwan University, Seoul, South Korea
    J Neurol Neurosurg Psychiatry 79:625-9. 2008
    ..Collaterals may sustain penumbra prior to recanalisation yet the influence of baseline collateral flow on infarct growth following endovascular therapy remains unknown...
  67. ncbi request reprint The golden day after subarachnoid hemorrhage
    Paul M Vespa
    Crit Care Med 32:902-4. 2004

Research Grants6

  1. Post Traumatic Nonconvulsive Epileptiform Activity
    Paul Vespa; Fiscal Year: 2005
    ..The hypothesis and unique approach come at a crucial time of failed clinical trials and address an important new therapeutic target. ..
  2. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2007
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..
  3. MRS Detects Metabolic Dysfunction after Brain Injury
    Paul Vespa; Fiscal Year: 2009
    ..The knowledge from the proposed studies will have widespread application to critical care of neurotrauma patients. ..