B C Verrelli

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster
    B C Verrelli
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 157:1649-63. 2001
  2. pmc The functional impact of Pgm amino acid polymorphism on glycogen content in Drosophila melanogaster
    B C Verrelli
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 159:201-10. 2001
  3. pmc Evidence for balancing selection from nucleotide sequence analyses of human G6PD
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Am J Hum Genet 71:1112-28. 2002
  4. pmc Extensive amino acid polymorphism at the pgm locus is consistent with adaptive protein evolution in Drosophila melanogaster
    B C Verrelli
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 156:1737-52. 2000
  5. pmc Historical selection, amino acid polymorphism and lineage-specific divergence at the G6pd locus in Drosophila melanogaster and D. simulans
    W F Eanes
    Department of Ecology and Evolution, State University of New York, Stony Brook 11794, USA
    Genetics 144:1027-41. 1996
  6. ncbi request reprint Lack of geographic variation in anonymous nuclear polymorphisms in the American oyster, Crassostrea virginica
    J H McDonald
    Department of Biology, University of Delaware, Newark 19716, USA
    Mol Biol Evol 13:1114-8. 1996
  7. ncbi request reprint Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzees
    Brian C Verrelli
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Tempe, Arizona, USA
    Mol Biol Evol 23:1592-601. 2006
  8. ncbi request reprint "Ground truth" for selection on CCR5-Delta32
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Trends Genet 22:293-6. 2006
  9. pmc Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster
    Efe Sezgin
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Genetics 168:923-31. 2004
  10. pmc Signatures of selection and gene conversion associated with human color vision variation
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park 20742, USA
    Am J Hum Genet 75:363-75. 2004

Collaborators

Detail Information

Publications18

  1. pmc Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster
    B C Verrelli
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 157:1649-63. 2001
    ..We propose that clinal selection at Pgm may in part explain the extensive amino acid polymorphism at this locus and is consistent with a multilocus response to selection in the glycolytic pathway...
  2. pmc The functional impact of Pgm amino acid polymorphism on glycogen content in Drosophila melanogaster
    B C Verrelli
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 159:201-10. 2001
    ..This suggests that amino acid polymorphism is under selection at this branch point and may be favored for increased metabolic storage associated with stress resistance and adaptation to temperate regions...
  3. pmc Evidence for balancing selection from nucleotide sequence analyses of human G6PD
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Am J Hum Genet 71:1112-28. 2002
    ..The present study demonstrates that nucleotide sequence analyses can reveal signatures of both historical and recent selection in the genome and may elucidate the impact that infectious disease has had during human evolution...
  4. pmc Extensive amino acid polymorphism at the pgm locus is consistent with adaptive protein evolution in Drosophila melanogaster
    B C Verrelli
    Department of Ecology and Evolution, State University of New York, Stony Brook, New York 11794 5245, USA
    Genetics 156:1737-52. 2000
    ..Like G6pd, Pgm shows strong evidence for a branch point enzyme that exhibits adaptive protein evolution...
  5. pmc Historical selection, amino acid polymorphism and lineage-specific divergence at the G6pd locus in Drosophila melanogaster and D. simulans
    W F Eanes
    Department of Ecology and Evolution, State University of New York, Stony Brook 11794, USA
    Genetics 144:1027-41. 1996
    ..Lineage-specific differences in mutation fixation are inconsistent with neutral expectations and suggest the interaction of species-specific population size differences with both weakly advantageous and deleterious selection...
  6. ncbi request reprint Lack of geographic variation in anonymous nuclear polymorphisms in the American oyster, Crassostrea virginica
    J H McDonald
    Department of Biology, University of Delaware, Newark 19716, USA
    Mol Biol Evol 13:1114-8. 1996
    ..The reason for the discrepancy between the two sets of DNA polymorphisms is unclear...
  7. ncbi request reprint Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzees
    Brian C Verrelli
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Tempe, Arizona, USA
    Mol Biol Evol 23:1592-601. 2006
    ..These comparative analyses suggest that the recent signature of positive selection at G6PD in humans is unique...
  8. ncbi request reprint "Ground truth" for selection on CCR5-Delta32
    Philip W Hedrick
    School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Trends Genet 22:293-6. 2006
    ..Interestingly, the extent of heterozygosity, differentiation across populations and linkage disequilibrium in the CCR5 region is not dissimilar to other human genomic regions, challenging claims of recent positive selection...
  9. pmc Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster
    Efe Sezgin
    Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794, USA
    Genetics 168:923-31. 2004
    ..This is consistent with a model of an Afrotropical ancestral species adapting to temperate climates through selection favoring new mutations...
  10. pmc Signatures of selection and gene conversion associated with human color vision variation
    Brian C Verrelli
    Department of Biology, University of Maryland, College Park 20742, USA
    Am J Hum Genet 75:363-75. 2004
    ..Our results suggest that subtle changes in L-cone opsin wavelength absorption may have been adaptive during human evolution...
  11. ncbi request reprint Role of evolutionary history on haplotype block structure in the human genome: implications for disease mapping
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, MD 20742, USA
    Curr Opin Genet Dev 13:569-75. 2003
    ....
  12. ncbi request reprint Patterns of human genetic diversity: implications for human evolutionary history and disease
    Sarah A Tishkoff
    Department of Biology, University of Maryland, College Park, Maryland 20742, USA
    Annu Rev Genomics Hum Genet 4:293-340. 2003
    ..We discuss these differences and their implications for mapping disease genes and for understanding how population and genomic diversity have been important in the evolution, differentiation, and adaptation of humans...
  13. ncbi request reprint Signatures of functional constraint at aye-aye opsin genes: the potential of adaptive color vision in a nocturnal primate
    George H Perry
    Center for Evolutionary Functional Genomics, The Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, USA
    Mol Biol Evol 24:1963-70. 2007
    ....
  14. ncbi request reprint Comparative analyses reveal a complex history of molecular evolution for human MYH16
    George H Perry
    Mol Biol Evol 22:379-82. 2005
    ..We also find conflicting estimates of nonsynonymous fixation rates (d(N)) across different regions of this gene, revealing a complex pattern inconsistent with a simple model of pseudogene evolution for human MYH16...
  15. ncbi request reprint Molecular characterization of G6PD deficiency in Cyprus
    Anthi Drousiotou
    Department of Biochemical Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Blood Cells Mol Dis 33:25-30. 2004
    ....
  16. ncbi request reprint Molecular evolution of the primate developmental genes MSX1 and PAX9
    George H Perry
    School of Human Evolution and Social Change, Arizona State University, USA
    Mol Biol Evol 23:644-54. 2006
    ..Our overall results provide insight into the utility of comparative species analyses of highly conserved developmental genes and their roles in the evolution of complex phenotypes...
  17. ncbi request reprint Focusing on comparative ape population genetics in the post-genomic age
    Anne C Stone
    School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287 2402, USA
    Curr Opin Genet Dev 16:586-91. 2006
    ..Historically, this research has focused on the human perspective; however, we will learn much about ourselves with a focus on genomic diversity in hominoids as a group...
  18. ncbi request reprint The evolutionary history of human and chimpanzee Y-chromosome gene loss
    George H Perry
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, AZ, USA
    Mol Biol Evol 24:853-9. 2007
    ..8 MYA, which indicates significant Y-chromosome change in the chimpanzee lineage relatively early in the evolutionary divergence of humans and chimpanzees...