Steven A Vernino

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Antibody testing in peripheral neuropathies
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Neurol Clin 25:29-46. 2007
  2. doi request reprint Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy
    Christopher H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Arch Neurol 65:213-7. 2008
  3. ncbi request reprint Immunotherapy for autoimmune autonomic ganglionopathy
    Valeria Iodice
    Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905, USA
    Auton Neurosci 146:22-5. 2009
  4. doi request reprint Autoimmune autonomic failure
    Srikanth Muppidi
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA Electronic address
    Handb Clin Neurol 117:321-7. 2013
  5. ncbi request reprint Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Neurology 65:639-41. 2005
  6. ncbi request reprint Paraneoplastic neurologic syndromes
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
    Curr Neurol Neurosci Rep 6:193-9. 2006
  7. ncbi request reprint Autoimmune and paraneoplastic channelopathies
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    Neurotherapeutics 4:305-14. 2007
  8. ncbi request reprint Autoimmune encephalopathies
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    Neurologist 13:140-7. 2007
  9. pmc Characterization of ganglionic acetylcholine receptor autoantibodies
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas Texas 75390 9036, United States
    J Neuroimmunol 197:63-9. 2008
  10. pmc Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Auton Neurosci 146:3-7. 2009

Research Grants

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Antibody testing in peripheral neuropathies
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Neurol Clin 25:29-46. 2007
    ..Detection of an autoantibody in the right clinical setting provides some evidence that the peripheral nerve disturbance is immune mediated and that immunomodulatory therapy may be of benefit...
  2. doi request reprint Combined immunomodulatory therapy in autoimmune autonomic ganglionopathy
    Christopher H Gibbons
    Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, 1 Deaconess Road, Boston, MA 02215, USA
    Arch Neurol 65:213-7. 2008
    ..Symptomatic and immunomodulatory therapy has provided limited clinical benefit in small uncontrolled studies...
  3. ncbi request reprint Immunotherapy for autoimmune autonomic ganglionopathy
    Valeria Iodice
    Mayo Clinic, Department of Neurology, 200 First Street SW, Rochester, MN 55905, USA
    Auton Neurosci 146:22-5. 2009
    ..This review summarizes current treatment options including IVIG, PE, and immunosuppressants agents, alone or in combination...
  4. doi request reprint Autoimmune autonomic failure
    Srikanth Muppidi
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA Electronic address
    Handb Clin Neurol 117:321-7. 2013
    ..Patients may respond to immunomodulatory therapies such as prednisone, intravenous immunoglobulin, plasma exchange, and oral immunosuppressants. A combination treatment is often required as well as symptomatic therapy. ..
  5. ncbi request reprint Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Neurology 65:639-41. 2005
    ..Primary CNS lymphoma regressed on withdrawal of MM. Despite minimal short-term side effects and apparent efficacy, chronic treatment of MG with MM may be associated with increased risk of lymphoproliferative disorders...
  6. ncbi request reprint Paraneoplastic neurologic syndromes
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9036, USA
    Curr Neurol Neurosci Rep 6:193-9. 2006
    ..These studies not only shed light on the pathogenesis of PND and the mechanisms of effective antitumor immunity but may eventually lead to improved treatment...
  7. ncbi request reprint Autoimmune and paraneoplastic channelopathies
    Steven Vernino
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    Neurotherapeutics 4:305-14. 2007
    ..These disabling neurological disorders may be dramatically responsive to immunomodulatory therapy. Future studies will likely lead to identification of other ion channel antibodies and other autoimmune channelopathies...
  8. ncbi request reprint Autoimmune encephalopathies
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    Neurologist 13:140-7. 2007
    ..This review describes the clinical features of these potentially reversible autoimmune encephalopathies...
  9. pmc Characterization of ganglionic acetylcholine receptor autoantibodies
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas Texas 75390 9036, United States
    J Neuroimmunol 197:63-9. 2008
    ..Muscle and ganglionic AChR antibody specificities are distinct. Antibody crossreactivity between AChRs with different alpha subunits is uncommon but can occur...
  10. pmc Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Auton Neurosci 146:3-7. 2009
    ....
  11. ncbi request reprint Neuronal acetylcholine receptor autoimmunity
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Ann N Y Acad Sci 1132:124-8. 2008
    ..For example, antibodies against alpha7-type AChRs have been identified in a few patients with encephalitis. It is still unclear if antibodies against receptors in the central nervous system can directly cause disease...
  12. doi request reprint Antibody testing as a diagnostic tool in autonomic disorders
    Steven Vernino
    Department of Neurology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Clin Auton Res 19:13-9. 2009
    ..The diagnostic antibodies most commonly associated with dysautonomia are paraneoplastic antibodies (anti-Hu and CRMP-5) and ganglionic acetylcholine receptor antibodies...
  13. doi request reprint Paraneoplastic cerebellar degeneration
    Steven Vernino
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Handb Clin Neurol 103:215-23. 2012
    ..Optimum management includes early diagnosis, treatment of cancer to remission, immunosuppression, symptomatic therapies, and compassionate support...
  14. doi request reprint Exercise-associated numbness and tingling in the legs
    Lydia Sharp
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Arch Neurol 68:1599-602. 2011
    ..Recently, he had noted some constipation as well as difficulty in initiating urination...
  15. pmc Passive transfer of autoimmune autonomic neuropathy to mice
    Steven Vernino
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosci 24:7037-42. 2004
    ..The antibody effect is potentially reversible, justifying early use of immunomodulatory therapy directed at lowering IgG levels and abrogating IgG production in patients with AAN...
  16. ncbi request reprint Ion channel and striational antibodies define a continuum of autoimmune neuromuscular hyperexcitability
    Steven Vernino
    Department of Neurology, Mayo Clinic and Mayo Foundation, 200 First Street S W, Rochester, Minnesota 55905, USA
    Muscle Nerve 26:702-7. 2002
    ..We conclude that acquired neuromuscular hyperexcitability consists of a continuum of clinical disorders with a common autoimmune pathogenesis...
  17. ncbi request reprint Neuronal ganglionic acetylcholine receptor autoimmunity
    Steven Vernino
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann N Y Acad Sci 998:211-4. 2003
    ..These patients often have a high antibody value (>0.2 nmol/L). Lower values (0.05-0.20 nmol/L) are found in approximately 10% of patients with limited AAN...
  18. doi request reprint Recent advances in autoimmune autonomic ganglionopathy
    Nicole Winston
    Department of Neurology, UT Southwestern Medical Center, Dallas, Texas 75390 9036, USA
    Curr Opin Neurol 23:514-8. 2010
    ..This review highlights recent advances in our understanding of autoimmune autonomic ganglionopathy (AAG) including serological diagnosis, clinical observations, pathophysiology, and treatment...
  19. doi request reprint Isolated neck extensor myopathy: is it responsive to immunotherapy?
    Srikanth Muppidi
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9129, USA
    J Clin Neuromuscul Dis 12:26-9. 2010
    ..To determine if isolated neck extensor myopathy (INEM) is responsive to immunosuppressive treatment...
  20. pmc Antibody-mediated impairment and homeostatic plasticity of autonomic ganglionic synaptic transmission
    Zhengbei Wang
    Department of Neurology, UT Southwestern Medical Center, Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9036, USA
    Exp Neurol 222:114-9. 2010
    ..Homeostatic plasticity in autonomic neurotransmission could help explain the spontaneous clinical recovery seen in some AAG patients and may also play an important role in regulating normal autonomic reflexes...
  21. doi request reprint Multifocal paraneoplastic cortical encephalitis associated with myasthenia gravis and thymoma
    Khaled Hammoud
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9036, USA
    Arch Neurol 66:1407-9. 2009
    ..To report a case of multifocal cortical encephalitis associated with thymoma and to establish an association of this thymoma-related paraneoplastic syndrome with voltage-gated potassium channel antibodies...
  22. ncbi request reprint The spectrum of autoimmune autonomic neuropathies
    Caroline M Klein
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA
    Ann Neurol 53:752-8. 2003
    ....
  23. pmc Dysfunction of the pupillary light reflex in experimental autoimmune autonomic ganglionopathy
    Shalini Mukherjee
    Department of Neurology UT Southwestern Medical Center 5323 Harry Hines Blvd, Dallas, Texas 75390 9036, USA
    Auton Neurosci 137:19-26. 2007
    ..These characteristic abnormalities of the pupillary light reflex may prove to have diagnostic value...
  24. ncbi request reprint Autoantibody profiles and neurological correlations of thymoma
    Steven Vernino
    Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Cancer Res 10:7270-5. 2004
    ..Determine muscle and neuronal autoantibody frequencies in patients with thymoma, with and without paraneoplastic neurological accompaniments...
  25. doi request reprint Autoimmune autonomic ganglionopathy
    Nicole Winston
    Department of Neurology, UT Southwestern Medical Center, Dallas, Tex, USA
    Front Neurol Neurosci 26:85-93. 2009
    ..Autoimmune autonomic ganglionopathy represents one of a small group of autoimmune neuromuscular disorders that are caused by antibodies against ion channels...
  26. ncbi request reprint Muscle and neuronal autoantibody markers of thymoma: neurological correlations
    Steven Vernino
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ann N Y Acad Sci 998:359-61. 2003
  27. pmc Invited Article: Autonomic ganglia: target and novel therapeutic tool
    Steven Vernino
    Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA
    Neurology 70:1926-32. 2008
    ..Recent evidence also suggests a potential role for acetylcholinesterase inhibitors in the treatment of postural tachycardia syndrome...
  28. ncbi request reprint Idiopathic autonomic neuropathy: comparison of cases seropositive and seronegative for ganglionic acetylcholine receptor antibody
    Paola Sandroni
    Department of Neurology, Mayo Foundation, Guggenheim 811, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 61:44-8. 2004
    ....
  29. ncbi request reprint Myokymia, neuromyotonia, dermatomyositis, and voltage-gated K+ channel antibodies
    Shin J Oh
    Department of Neurology, University of Alabama at Birmingham, UAB Station, Birmingham, Alabama 25294, USA
    Muscle Nerve 27:757-60. 2003
    ..The presence of antibodies to voltage-gated potassium channels and the association with dermatomyositis indicated an autoimmune cause for myokymia, which may have been due to reversible peripheral nerve hyperexcitability...
  30. pmc Immunomodulatory treatment trial for paraneoplastic neurological disorders
    Steven Vernino
    Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neuro Oncol 6:55-62. 2004
    ..Aggressive immunosuppression early in the clinical course should be considered in patients who have paraneoplastic neurological disorders, even when there is no evidence of active malignancy...
  31. pmc EBV-associated lymphoproliferative disorder of CNS associated with the use of mycophenolate mofetil
    Steven Vernino
    Department of Neurology, Mayo Clinic and Foundation and the Mayo Clinic Cancer Center, Rochester, MN 55905, USA
    Neuro Oncol 9:364-9. 2007
    ..Based on our experience presented herein, we recommend caution in patient selection for MM and strict surveillance of those patients with autoimmune disorders who receive MM...
  32. ncbi request reprint Autonomic dysfunction in peripheral nerve disease
    Phillip A Low
    Department of Neurology, Mayo Foundation, 811 Guggenheim, 200 First Street SW, Rochester, Minnesota 55905, USA
    Muscle Nerve 27:646-61. 2003
    ..Non-invasive autonomic testing complements clinical and electrophysiological characterization of the autonomic neuropathies...
  33. doi request reprint Idiopathic neuropathy: new paradigms, new promise
    Mike A Singer
    Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Peripher Nerv Syst 17:43-9. 2012
    ..Current work has focused on identifying modifiable risk factors that may be associated with idiopathic neuropathy. The results may suggest that an underlying mechanism such as oxidative stress contributes to the development of CIAP...
  34. ncbi request reprint Paraneoplastic neurological autoimmunity associated with ANNA-1 autoantibody and thymoma
    Steven Vernino
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Neurology 59:929-32. 2002
    ..Retrospective testing of stored serum from 172 patients with thymoma revealed ANNA-1 in 3%. This report extends the oncologic implications of ANNA-1 seropositivity...
  35. ncbi request reprint Neurophysiologic studies in Morvan syndrome
    Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Neurophysiol 21:440-5. 2004
    ..The absence of abnormalities on imaging studies suggests that central nervous system symptoms are related to functional rather than structural disruption of neural networks...
  36. ncbi request reprint Experimental autoimmune autonomic neuropathy
    Steven Vernino
    Department of Neurology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Neurophysiol 90:2053-9. 2003
    ..These findings define the autonomic physiology and histopathology of this novel animal model and support the concept that AAN in humans is a disorder of ganglionic cholinergic synaptic transmission caused by ganglionic nAChR antibodies...
  37. ncbi request reprint Paraneoplastic chorea associated with CRMP-5 neuronal antibody and lung carcinoma
    Steven Vernino
    Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 51:625-30. 2002
    ..Four patients improved with chemotherapy, and 2 improved with intravenous methylprednisolone...
  38. ncbi request reprint Steroid-responsive encephalopathy associated with autoimmune thyroiditis
    Pablo Castillo
    Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Arch Neurol 63:197-202. 2006
    ..Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), often termed Hashimoto encephalopathy, is a poorly understood and often misdiagnosed entity...
  39. ncbi request reprint Postural orthostatic tachycardia syndrome: the Mayo clinic experience
    Mark J Thieben
    Autonomic Disorders Center, Department of Neurology, Mayo Clinic College of Medicine, Rochester, Minn 55905, USA
    Mayo Clin Proc 82:308-13. 2007
    ..To evaluate the prevalence and pathogenetic mechanisms of postural orthostatic tachycardia syndrome (POTS)...
  40. ncbi request reprint L-DOPS therapy for refractory orthostatic hypotension in autoimmune autonomic neuropathy
    Christopher H Gibbons
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 65:1104-6. 2005
    ..L-DOPS may benefit patients with severe orthostatic intolerance and be particularly effective in patients with ganglionic NiAchR antibodies...
  41. ncbi request reprint Copper deficiency myelopathy
    Neeraj Kumar
    Department of Neurology, Mayo Clinic, Mayo Foundation, Rochester, Minn, USA
    Arch Neurol 61:762-6. 2004
    ..Myelopathy due to acquired copper deficiency is not a well-recognized entity in humans, although myelopathy due to copper deficiency is well documented in some animal species...

Research Grants5

  1. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2004
    ....
  2. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2004
    ....
  3. EXPERIMENTAL AUTOIMMUNE AUTONOMIC NEUROPATHY
    Steven Vernino; Fiscal Year: 2004
    ....
  4. Experimental Dysautonomia: Pathogenesis and Treatment
    Steven Vernino; Fiscal Year: 2006
    ....