Research Topics
Genomes and Genes | Michael R VernerisSummaryAffiliation: University of Minnesota Country: USA Publications
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Publications
Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 unitsMichael R Verneris
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Blood 114:4293-9. 2009..This trial was registered at http://clinicaltrials.gov as NCT00309842...
Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cellsMichael R Verneris
Division of Pediatric Blood and Marrow Diseases, University of Minnesota, Minneapolis, MN 55455, USA
Blood 103:3065-72. 2004..Collectively these results establish that NKG2D triggering accounts for the majority of major histocompatibility complex (MHC)-unrestricted cytotoxicity of activated and expanded CD8+ T cells, likely through DAP10-mediated signaling...- The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cellsMichael R Verneris
Department of Paediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA
Br J Haematol 147:185-91. 2009..Activation and expansion protocols for UCB NK cells are briefly reviewed. Lastly, we outline the early use of UCB NK cells in clinical trials... - Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cellsMichael R Verneris
Department of Pediatrics, Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Clin Cancer Res 11:4561-70. 2005..To identify novel treatments for pediatric solid tumors and/or for malignancies with low-level Her2/neu expression... 
Novel approaches to prevent leukemia relapse following allogeneic hematopoietic cell transplantationMichael R Verneris
Pediatric Hematology, University of Minnesota Amplatz Children s Hospital, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Curr Hematol Malig Rep 5:157-62. 2010..This article discusses the differing transplant interventions aimed at reducing relapse in each of these periods, focusing on new approaches that are currently being conceived or in early-stage clinical trials...- Recent developments in cell-based immune therapy for neuroblastomaMichael R Verneris
Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Mayo Mail Code 366, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
J Neuroimmune Pharmacol 2:134-9. 2007.... - Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factorsMargaret L Macmillan
Blood and Marrow Transplant Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Blood 113:2410-5. 2009..This study is registered at (http://www.clinicaltrials.gov) under the identifiers NCT00305682 and NCT00309842... - Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donorsAngela R Smith
Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 15:1086-93. 2009.... - Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensityClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:5628-34. 2009..8; 95% CI, 1.0-3.1; P = .05). Our results do not support the selection of UCB units based on KIR-L status and suggest that KIR-L mismatching should be avoided in reduced intensity UCB transplantation... - Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent functionBree Foley
Department of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Blood 119:2665-74. 2012..Our findings support the emerging concept that CMV-induced innate memory-cell populations may contribute to malignant disease relapse protection and infectious disease control long after transplantation... - The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulationsHongbo Wang
Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, USA
Blood 110:1530-9. 2007..Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects... - Prolonged survival in adults with acute lymphoblastic leukemia after reduced-intensity conditioning with cord blood or sibling donor transplantationVeronika Bachanova
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:2902-5. 2009..01). For adults with ALL in CR, reduced intensity conditioning allografting results in modest TRM, limited risk of relapse, and promising leukemia-free survival. Clinical trial numbers are NCT00365287, NCT00305682, and NCT00303719... - Costs of pediatric allogeneic hematopoietic-cell transplantationNavneet S Majhail
Adult Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
Pediatr Blood Cancer 54:138-43. 2010..Allogeneic hematopoietic-cell transplantation (HCT), although curative for some high-risk diseases, is a complex and costly procedure. The costs of transplantation among children have not been described previously... - Early lymphocyte recovery and outcomes after umbilical cord blood transplantation (UCBT) for hematologic malignanciesMichael J Burke
Division of Hematology Oncology and Blood and Marrow Transplantation in the Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 17:831-40. 2011..58; 95% CI: 1.01-2.49) compared to ≤200 × 10(6)/L (n = 55). There was no significant relationship between ALC and relapse. Rapid lymphocyte recovery early after UCBT predicts better survival in patients with hematologic malignancies... - Allogeneic hematopoietic cell transplantation (allogeneic HCT) for treatment of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL)Michael J Burke
Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 53:1289-94. 2009..Since the introduction of imatinib into the treatment of this disease, the role of allogeneic HCT is more uncertain... - Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord bloodClaudio G Brunstein
University of Minnesota Medical Center, Minneapolis, MN, USA
Blood 116:4693-9. 2010..For patients without an available HLA matched donor, the use of 2 partially HLA-matched UCB units is a suitable alternative... - Successful remission rates and survival after lymphodepleting chemotherapy and donor lymphocyte infusion for relapsed hematologic malignancies postallogeneic hematopoietic cell transplantationErica D Warlick
Bone Marrow Transplantation Program, University of Minnesota Medical Center, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 18:480-6. 2012..The lower DLI dose regimen improved the tolerability of this therapeutic approach, with modest rates of severe aGVHD... - Natural killer cell killing of acute myelogenous leukemia and acute lymphoblastic leukemia blasts by killer cell immunoglobulin-like receptor-negative natural killer cells after NKG2A and LIR-1 blockadeRobert Godal
Division of Adult Hematology, Oncology and Transplantation, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 16:612-21. 2010..Thus strategies to interrupt NKG2A and LIR-1 in combination with anti-KIR blockade hold promise for exploiting NK cell therapy in acute leukemias... - Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantationJill C Beck
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 16:215-22. 2010..01) and lower OS (P=.02). Thus, although recipient CMV serostatus and CMV reactivation have little demonstrable impact on UCB transplant outcomes, the development of CMV disease remains a risk, associated with inferior outcomes... - Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcomeMichael B Tomblyn
Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Oncol 27:3634-41. 2009..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care... - Umbilical cord blood T cells express multiple natural cytotoxicity receptors after IL-15 stimulation, but only NKp30 is functionalQin Tang
Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
J Immunol 181:4507-15. 2008..These results demonstrate differences between UCB and PB T cells regarding NCR expression and function. Such findings challenge the concept that NCRs are NK cell specific... - Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cellsMobin Karimi
Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA
J Immunol 175:7819-28. 2005..These studies demonstrated the importance of NKG2D, DAP10, and DAP12 in human effector cell function... - Development of IL-22-producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissueQin Tang
Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Blood 117:4052-5. 2011..Thus, IL-22-producing NK cells can be generated in the absence of SLT. HSC-derived NK22 cells will be valuable in understanding this rare NK subset and create the opportunity for human translational clinical trials... - Unrelated cord blood transplantation in adult and pediatric acute lymphoblastic leukemia: effect of minimal residual disease on relapse and survivalVeronika Bachanova
Blood and Marrow Transplant Program, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 18:963-8. 2012..05; disease-free survival, 55%; 95% CI, 43%-66%; P = .02). Our data suggest that in patients with ALL, achieving an MRD-negative state before UCBT improves outcomes... - Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activityPetter S Woll
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Blood 113:6094-101. 2009..These studies demonstrate that hESCs provide an important model to study human lymphocyte development and may serve as a novel source for antitumor immunotherapy... - NK cell education after allogeneic transplantation: dissociation between recovery of cytokine-producing and cytotoxic functionsBree Foley
Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Blood 118:2784-92. 2011..Exposure to IL-15 rapidly increased target-inducible IFNγ production, indicative of IL-15's potential as a therapeutic tool to enhance NK cell function to protect against infection and relapse after allo-HCT... - Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous systemPaul D Harker-Murray
Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 14:685-92. 2008..These data support the use of allogeneic HCT in the treatment of children with poor prognosis isolated CNS relapse... - Survival Differences between Adolescents/Young Adults and Children with B Precursor Acute Lymphoblastic Leukemia after Allogeneic Hematopoietic Cell TransplantationMichael J Burke
Division of Pediatric Hematology Oncology, University of Minnesota, Amplatz Children s Hospital, Minneapolis, Minnesota Electronic address
Biol Blood Marrow Transplant 19:138-42. 2013..Further improvements in peritransplantation care are needed to limit complications in AYA patients... - Human Cytomegalovirus (CMV)-Induced Memory-like NKG2C+ NK Cells Are Transplantable and Expand In Vivo in Response to Recipient CMV AntigenBree Foley
Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455
J Immunol 189:5082-8. 2012..We conclude that NKG2C(+) memory-like NK cells are transplantable and require active or latent (subclinical) expression of CMV Ag in the recipient for clonal expansion of NK cells previously exposed to CMV in the donor... - Use of natural killer cells as immunotherapy for leukaemiaBartosz Grzywacz
Division of Blood and Marrow Transplantation, University of Minnesota, MN, USA
Best Pract Res Clin Haematol 21:467-83. 2008..Future modifications to improve NK cell adoptive immunotherapy by means of increasing target recognition and reducing inhibitory signalling are being explored... - Natural killer-cell differentiation by myeloid progenitorsBartosz Grzywacz
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E River Road, Minneapolis, MN 55455, USA
Blood 117:3548-58. 2011..Collectively, these studies show that NK cells can be derived from the myeloid lineage... - Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemiaTheodore Honebrink
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Biol Blood Marrow Transplant 18:930-6. 2012..01). This study shows that BM hematogone percentages may be useful prognostic indicators in patients with acute myeloid leukemia after umbilical cord blood transplantation and should be routinely reported in BM differential counts... - Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9Michelle K Gleason
Adult Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 119:3064-72. 2012..In conclusion, we show that Tim-3 functions as a human NK-cell coreceptor to enhance IFN-γ production, which has important implications for control of infectious disease and cancer... - Allogeneic hematopoietic stem cell transplantation overcomes the adverse prognostic impact of CD20 expression in acute lymphoblastic leukemiaVeronika Bachanova
Blood and Marrow, Transplant Program, University of Minnesota, Minneapolis, MN, USA
Blood 117:5261-3. 2011..Clinical trial numbers for www.clinicaltrials.gov are NCT00365287, NCT00305682, and NCT00303719... - Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCTJeffery S Miller
Divisions of Adult and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Harvard Street at East River Road, Minneapolis, MN 55455, USA
Blood 109:5058-61. 2007..58, 95% CI 1.13-2.22; P = .008). These data support a genetically determined role for NK cells following unrelated HCT in myeloid leukemia... - Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI aloneJeffrey S Miller
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
Blood 110:2761-3. 2007..This trial was registered at www.clinicaltrials.gov as no. NCT00303693 and www.cancer.gov/clinicaltrials as no. NCT00167180... - O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host diseaseStephen B Harvey
Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota, USA
J Proteome Res 8:603-12. 2009.... - Bispecific and Trispecific Killer Cell Engagers Directly Activate Human NK Cells through CD16 Signaling and Induce Cytotoxicity and Cytokine ProductionMichelle K Gleason
Corresponding Author Jeffrey S Miller, University of Minnesota Masonic Cancer Center, MMC 806, Harvard Street at East River Road, Minneapolis, MN 55455
Mol Cancer Ther 11:2674-84. 2012..Mol Cancer Ther; 11(12); 2674-84. ©2012 AACR... - A Randomized Trial of One versus Two Doses of Influenza Vaccine after Allogeneic TransplantationNicole A Karras
Division of Hematology Oncology and Blood and Marrow Transplantation in the Department of Pediatrics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota
Biol Blood Marrow Transplant 19:109-16. 2013..Time from transplantation to vaccination and absolute CD19(+) cell counts were the strongest predictors of vaccine responses. Methods to improve influenza vaccine responses after allo-HCT are needed... - Treatment of relapsed acute lymphoblastic leukemia: approaches used by pediatric oncologists and bone marrow transplant physiciansMichael J Burke
Division of Pediatric Hematology Oncology, University of Minnesota, Minneapolis, MN, USA
Pediatr Blood Cancer 58:840-5. 2012..Management of relapsed B-precursor acute lymphoblastic leukemia (ALL) is challenging and varied. We hypothesized that treatment approaches differ between pediatric oncologists and bone marrow transplant (BMT) physicians... - Natural killer cell differentiation from hematopoietic stem cells: a comparative analysis of heparin- and stromal cell-supported methodsSteven A Dezell
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 18:536-45. 2012..These findings suggest that heparin-based cultures are an effective replacement for stroma and may facilitate clinical trials testing HSC-derived NK cells... - Reduced-intensity conditioning regimens for allogeneic transplantation in children with acute lymphoblastic leukemiaMichael R Verneris
University of Minnesota Medical Center, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 16:1237-44. 2010..These data indicate long-term DFS can be achieved using reduced-intensity conditioning regimens in children with acute lymphoblastic leukemia. Given the relatively small cohort, these findings must be validated in a larger population... - iTRAQ is a useful method to screen for membrane-bound proteins differentially expressed in human natural killer cell typesTroy C Lund
Department of Medicine, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 670 CCRB, 425 East River Road, Minneapolis, MN 55455, USA
J Proteome Res 6:644-53. 2007..This is the first demonstration and verification using iTRAQ to screen for membrane-bound protein differences in human NK cells and represents a powerful new tool in the field of proteomics... - Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cellsBartosz Grzywacz
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E. River Rd, Suite 660, Minneapolis, MN 55455, USA
Blood 108:3824-33. 2006..The identified stages of NK-cell differentiation provide evidence for coordinated acquisition of HLA-specific inhibitory receptors (ie, CD94/NKG2A) and function in developing human NK cells... - Killing the killer: natural killer cells to treat Ewing's sarcomaYong Oon Ahn
Hematology, Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Clin Cancer Res 16:3819-21. 2010..Using an orthotopic murine model, they also show that irradiation significantly enhances the NK-cell killing of these tumors... - Studying multiple protein profiles over time to assess biomarker validityRaj S Kasthuri
University of Minnesota, Department of Medicine, MMC 480, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Expert Rev Proteomics 3:455-64. 2006..The focus of this review is to illustrate the principle and value of serial protein profiling using a rapid protein extraction method... - Studies of ex vivo activated and expanded CD8+ NK-T cells in humans and miceMichael R Verneris
Division of Pediatric Hematology Oncology, and Bone Marrow Transplantation, Stanford, California 94305, USA
J Clin Immunol 22:131-6. 2002..We conclude that expanded CD8+ NK-T cells are a promising form of cellular therapy in the allogeneic setting... - Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic descriptionAntoinette Peters
Biol Blood Marrow Transplant 11:484-5. 2005
Research Grants
- ACTIVITY OF EXPANDED GAMMA/DELTA T CELLSMichael Verneris; Fiscal Year: 2005..Thus, the candidate will acquire the skills to secure a faculty position as a pediatric bone marrow transplantation clinical-scientist...