Michael R Verneris

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells
    Michael R Verneris
    Division of Pediatric Blood and Marrow Diseases, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 103:3065-72. 2004
  2. pmc Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units
    Michael R Verneris
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 114:4293-9. 2009
  3. ncbi request reprint Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells
    Michael R Verneris
    Department of Pediatrics, Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 11:4561-70. 2005
  4. doi request reprint Novel approaches to prevent leukemia relapse following allogeneic hematopoietic cell transplantation
    Michael R Verneris
    Pediatric Hematology, University of Minnesota Amplatz Children s Hospital, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Hematol Malig Rep 5:157-62. 2010
  5. ncbi request reprint Recent developments in cell-based immune therapy for neuroblastoma
    Michael R Verneris
    Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Mayo Mail Code 366, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 2:134-9. 2007
  6. pmc The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cells
    Michael R Verneris
    Department of Paediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA
    Br J Haematol 147:185-91. 2009
  7. pmc Unrelated cord blood transplantation in adult and pediatric acute lymphoblastic leukemia: effect of minimal residual disease on relapse and survival
    Veronika Bachanova
    Blood and Marrow Transplant Program, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:963-8. 2012
  8. doi request reprint Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemia
    Theodore Honebrink
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:930-6. 2012
  9. pmc Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors
    Margaret L Macmillan
    Blood and Marrow Transplant Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 113:2410-5. 2009
  10. doi request reprint Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donors
    Angela R Smith
    Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 15:1086-93. 2009

Research Grants

  1. ACTIVITY OF EXPANDED GAMMA/DELTA T CELLS
    Michael Verneris; Fiscal Year: 2005

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells
    Michael R Verneris
    Division of Pediatric Blood and Marrow Diseases, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 103:3065-72. 2004
    ..Collectively these results establish that NKG2D triggering accounts for the majority of major histocompatibility complex (MHC)-unrestricted cytotoxicity of activated and expanded CD8+ T cells, likely through DAP10-mediated signaling...
  2. pmc Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units
    Michael R Verneris
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 114:4293-9. 2009
    ..This trial was registered at http://clinicaltrials.gov as NCT00309842...
  3. ncbi request reprint Low levels of Her2/neu expressed by Ewing's family tumor cell lines can redirect cytokine-induced killer cells
    Michael R Verneris
    Department of Pediatrics, Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Clin Cancer Res 11:4561-70. 2005
    ..To identify novel treatments for pediatric solid tumors and/or for malignancies with low-level Her2/neu expression...
  4. doi request reprint Novel approaches to prevent leukemia relapse following allogeneic hematopoietic cell transplantation
    Michael R Verneris
    Pediatric Hematology, University of Minnesota Amplatz Children s Hospital, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Curr Hematol Malig Rep 5:157-62. 2010
    ..This article discusses the differing transplant interventions aimed at reducing relapse in each of these periods, focusing on new approaches that are currently being conceived or in early-stage clinical trials...
  5. ncbi request reprint Recent developments in cell-based immune therapy for neuroblastoma
    Michael R Verneris
    Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Mayo Mail Code 366, 420 Delaware Street, S E, Minneapolis, MN 55455, USA
    J Neuroimmune Pharmacol 2:134-9. 2007
    ....
  6. pmc The phenotypic and functional characteristics of umbilical cord blood and peripheral blood natural killer cells
    Michael R Verneris
    Department of Paediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA
    Br J Haematol 147:185-91. 2009
    ..Activation and expansion protocols for UCB NK cells are briefly reviewed. Lastly, we outline the early use of UCB NK cells in clinical trials...
  7. pmc Unrelated cord blood transplantation in adult and pediatric acute lymphoblastic leukemia: effect of minimal residual disease on relapse and survival
    Veronika Bachanova
    Blood and Marrow Transplant Program, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:963-8. 2012
    ..05; disease-free survival, 55%; 95% CI, 43%-66%; P = .02). Our data suggest that in patients with ALL, achieving an MRD-negative state before UCBT improves outcomes...
  8. doi request reprint Impact of bone marrow hematogones on umbilical cord blood transplantation outcomes in patients with acute myeloid leukemia
    Theodore Honebrink
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 18:930-6. 2012
    ..01). This study shows that BM hematogone percentages may be useful prognostic indicators in patients with acute myeloid leukemia after umbilical cord blood transplantation and should be routinely reported in BM differential counts...
  9. pmc Acute graft-versus-host disease after unrelated donor umbilical cord blood transplantation: analysis of risk factors
    Margaret L Macmillan
    Blood and Marrow Transplant Program, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Blood 113:2410-5. 2009
    ..This study is registered at (http://www.clinicaltrials.gov) under the identifiers NCT00305682 and NCT00309842...
  10. doi request reprint Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donors
    Angela R Smith
    Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 15:1086-93. 2009
    ....
  11. pmc Natural killer cell differentiation from hematopoietic stem cells: a comparative analysis of heparin- and stromal cell-supported methods
    Steven A Dezell
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 18:536-45. 2012
    ..These findings suggest that heparin-based cultures are an effective replacement for stroma and may facilitate clinical trials testing HSC-derived NK cells...
  12. pmc Negative effect of KIR alloreactivity in recipients of umbilical cord blood transplant depends on transplantation conditioning intensity
    Claudio G Brunstein
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:5628-34. 2009
    ..8; 95% CI, 1.0-3.1; P = .05). Our results do not support the selection of UCB units based on KIR-L status and suggest that KIR-L mismatching should be avoided in reduced intensity UCB transplantation...
  13. pmc Allogeneic hematopoietic cell transplantation in first remission abrogates poor outcomes associated with high-risk pediatric acute myeloid leukemia
    Michael J Burke
    Division of Pediatric Hematology Oncology, University of Minnesota Amplatz Children s Hospital, Minneapolis, MN, USA
    Biol Blood Marrow Transplant 19:1021-5. 2013
    ..62), relapse (11% versus 7%, P = .71), or treatment-related mortality (17% versus 14%, P = .89). Children and young adults with HR-AML have comparable outcomes to standard-risk patients following allo-HCT in CR1...
  14. pmc Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function
    Bree Foley
    Department of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 119:2665-74. 2012
    ..Our findings support the emerging concept that CMV-induced innate memory-cell populations may contribute to malignant disease relapse protection and infectious disease control long after transplantation...
  15. doi request reprint Costs of pediatric allogeneic hematopoietic-cell transplantation
    Navneet S Majhail
    Adult Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Pediatr Blood Cancer 54:138-43. 2010
    ..Allogeneic hematopoietic-cell transplantation (HCT), although curative for some high-risk diseases, is a complex and costly procedure. The costs of transplantation among children have not been described previously...
  16. doi request reprint Prolonged survival in adults with acute lymphoblastic leukemia after reduced-intensity conditioning with cord blood or sibling donor transplantation
    Veronika Bachanova
    Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:2902-5. 2009
    ..01). For adults with ALL in CR, reduced intensity conditioning allografting results in modest TRM, limited risk of relapse, and promising leukemia-free survival. Clinical trial numbers are NCT00365287, NCT00305682, and NCT00303719...
  17. pmc Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood
    Claudio G Brunstein
    University of Minnesota Medical Center, Minneapolis, MN, USA
    Blood 116:4693-9. 2010
    ..For patients without an available HLA matched donor, the use of 2 partially HLA-matched UCB units is a suitable alternative...
  18. pmc Early lymphocyte recovery and outcomes after umbilical cord blood transplantation (UCBT) for hematologic malignancies
    Michael J Burke
    Division of Hematology Oncology and Blood and Marrow Transplantation in the Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Biol Blood Marrow Transplant 17:831-40. 2011
    ..58; 95% CI: 1.01-2.49) compared to ≤200 × 10(6)/L (n = 55). There was no significant relationship between ALC and relapse. Rapid lymphocyte recovery early after UCBT predicts better survival in patients with hematologic malignancies...
  19. pmc The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations
    Hongbo Wang
    Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, USA
    Blood 110:1530-9. 2007
    ..Collectively, these studies show that CSA influences NK-cell function and phenotype, which may have important implications for graft-versus-leukemia effects...
  20. doi request reprint Allogeneic hematopoietic cell transplantation (allogeneic HCT) for treatment of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL)
    Michael J Burke
    Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 53:1289-94. 2009
    ..Since the introduction of imatinib into the treatment of this disease, the role of allogeneic HCT is more uncertain...
  21. pmc Survival differences between adolescents/young adults and children with B precursor acute lymphoblastic leukemia after allogeneic hematopoietic cell transplantation
    Michael J Burke
    Division of Pediatric Hematology Oncology, University of Minnesota, Amplatz Children s Hospital, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 19:138-42. 2013
    ..Further improvements in peritransplantation care are needed to limit complications in AYA patients...
  22. pmc Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen
    Bree Foley
    Division of Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 189:5082-8. 2012
    ..We conclude that NKG2C(+) memory-like NK cells are transplantable and require active or latent (subclinical) expression of CMV Ag in the recipient for clonal expansion of NK cells previously exposed to CMV in the donor...
  23. doi request reprint Successful remission rates and survival after lymphodepleting chemotherapy and donor lymphocyte infusion for relapsed hematologic malignancies postallogeneic hematopoietic cell transplantation
    Erica D Warlick
    Bone Marrow Transplantation Program, University of Minnesota Medical Center, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 18:480-6. 2012
    ..The lower DLI dose regimen improved the tolerability of this therapeutic approach, with modest rates of severe aGVHD...
  24. pmc Natural killer cell killing of acute myelogenous leukemia and acute lymphoblastic leukemia blasts by killer cell immunoglobulin-like receptor-negative natural killer cells after NKG2A and LIR-1 blockade
    Robert Godal
    Division of Adult Hematology, Oncology and Transplantation, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 16:612-21. 2010
    ..Thus strategies to interrupt NKG2A and LIR-1 in combination with anti-KIR blockade hold promise for exploiting NK cell therapy in acute leukemias...
  25. pmc Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation
    Jill C Beck
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 16:215-22. 2010
    ..01) and lower OS (P=.02). Thus, although recipient CMV serostatus and CMV reactivation have little demonstrable impact on UCB transplant outcomes, the development of CMV disease remains a risk, associated with inferior outcomes...
  26. pmc Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcome
    Michael B Tomblyn
    Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
    J Clin Oncol 27:3634-41. 2009
    ..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care...
  27. pmc Umbilical cord blood T cells express multiple natural cytotoxicity receptors after IL-15 stimulation, but only NKp30 is functional
    Qin Tang
    Department of Pediatrics, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 181:4507-15. 2008
    ..These results demonstrate differences between UCB and PB T cells regarding NCR expression and function. Such findings challenge the concept that NCRs are NK cell specific...
  28. ncbi request reprint Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells
    Mobin Karimi
    Division of Blood and Marrow Transplantation, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 175:7819-28. 2005
    ..These studies demonstrated the importance of NKG2D, DAP10, and DAP12 in human effector cell function...
  29. pmc Lineage relationships of human interleukin-22-producing CD56+ RORγt+ innate lymphoid cells and conventional natural killer cells
    Yong Oon Ahn
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA
    Blood 121:2234-43. 2013
    ..Although human ILC22 cells and cNK progenitors have a phenotype that overlaps with stage III NK progenitors, they have unique cytokine requirements and can be distinguished by LFA-1 expression...
  30. pmc Development of IL-22-producing NK lineage cells from umbilical cord blood hematopoietic stem cells in the absence of secondary lymphoid tissue
    Qin Tang
    Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Blood 117:4052-5. 2011
    ..Thus, IL-22-producing NK cells can be generated in the absence of SLT. HSC-derived NK22 cells will be valuable in understanding this rare NK subset and create the opportunity for human translational clinical trials...
  31. pmc Early hematopoietic stem cell transplant is associated with favorable outcomes in children with MDS
    Angela R Smith
    Division of Pediatric Blood and Marrow Transplantation, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Blood Cancer 60:705-10. 2013
    ..Although hematopoietic stem cell transplantation (HSCT) is the treatment of choice for childhood myelodysplastic syndrome (MDS), there is no consensus regarding patient or disease characteristics that predict outcomes...
  32. pmc Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity
    Petter S Woll
    Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 113:6094-101. 2009
    ..These studies demonstrate that hESCs provide an important model to study human lymphocyte development and may serve as a novel source for antitumor immunotherapy...
  33. doi request reprint Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous system
    Paul D Harker-Murray
    Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 14:685-92. 2008
    ..These data support the use of allogeneic HCT in the treatment of children with poor prognosis isolated CNS relapse...
  34. pmc NK cell education after allogeneic transplantation: dissociation between recovery of cytokine-producing and cytotoxic functions
    Bree Foley
    Hematology, Oncology and Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
    Blood 118:2784-92. 2011
    ..Exposure to IL-15 rapidly increased target-inducible IFNγ production, indicative of IL-15's potential as a therapeutic tool to enhance NK cell function to protect against infection and relapse after allo-HCT...
  35. pmc Natural killer-cell differentiation by myeloid progenitors
    Bartosz Grzywacz
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E River Road, Minneapolis, MN 55455, USA
    Blood 117:3548-58. 2011
    ..Collectively, these studies show that NK cells can be derived from the myeloid lineage...
  36. pmc Use of natural killer cells as immunotherapy for leukaemia
    Bartosz Grzywacz
    Division of Blood and Marrow Transplantation, University of Minnesota, MN, USA
    Best Pract Res Clin Haematol 21:467-83. 2008
    ..Future modifications to improve NK cell adoptive immunotherapy by means of increasing target recognition and reducing inhibitory signalling are being explored...
  37. pmc Bispecific and trispecific killer cell engagers directly activate human NK cells through CD16 signaling and induce cytotoxicity and cytokine production
    Michelle K Gleason
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Masonic Cancer Center, Minneapolis, Minnesota, USA
    Mol Cancer Ther 11:2674-84. 2012
    ....
  38. pmc Peripheral dose heterogeneity due to the thread effect in total marrow irradiation with helical tomotherapy
    Yutaka Takahashi
    Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota
    Int J Radiat Oncol Biol Phys 87:832-9. 2013
    ..To report potential dose heterogeneity leading to underdosing at different skeletal sites in total marrow irradiation (TMI) with helical tomotherapy due to the thread effect and provide possible solutions to reduce this effect...
  39. pmc Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition
    Andres Wiernik
    Division of Hematology, Oncology, and Transplantation, Department of Medicine, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Cancer Res 19:3844-55. 2013
    ..We determined whether a novel bispecific killer cell engager (BiKE) signaling through CD16 and targeting CD33 could activate NK cells at high potency against acute myelogenous leukemia (AML) targets...
  40. pmc A randomized trial of one versus two doses of influenza vaccine after allogeneic transplantation
    Nicole A Karras
    Division of Hematology Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biol Blood Marrow Transplant 19:109-16. 2013
    ..Time from transplantation to vaccination and absolute CD19(+) cell counts were the strongest predictors of vaccine responses. Methods to improve influenza vaccine responses after allo-HCT are needed...
  41. pmc Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
    Michelle K Gleason
    Adult Division of Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 119:3064-72. 2012
    ..In conclusion, we show that Tim-3 functions as a human NK-cell coreceptor to enhance IFN-γ production, which has important implications for control of infectious disease and cancer...
  42. pmc Lymphodepletion followed by donor lymphocyte infusion (DLI) causes significantly more acute graft-versus-host disease than DLI alone
    Jeffrey S Miller
    Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota Cancer Center, Minneapolis, MN 55455, USA
    Blood 110:2761-3. 2007
    ..This trial was registered at www.clinicaltrials.gov as no. NCT00303693 and www.cancer.gov/clinicaltrials as no. NCT00167180...
  43. doi request reprint O-glycoside biomarker of apolipoprotein C3: responsiveness to obesity, bariatric surgery, and therapy with metformin, to chronic or severe liver disease and to mortality in severe sepsis and graft vs host disease
    Stephen B Harvey
    Department of Biochemistry, University of Minnesota, Minneapolis, Minnesota, USA
    J Proteome Res 8:603-12. 2009
    ....
  44. pmc Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT
    Jeffery S Miller
    Divisions of Adult and Pediatric Hematology, Oncology and Transplantation, University of Minnesota Cancer Center, Harvard Street at East River Road, Minneapolis, MN 55455, USA
    Blood 109:5058-61. 2007
    ..58, 95% CI 1.13-2.22; P = .008). These data support a genetically determined role for NK cells following unrelated HCT in myeloid leukemia...
  45. pmc Allogeneic hematopoietic stem cell transplantation overcomes the adverse prognostic impact of CD20 expression in acute lymphoblastic leukemia
    Veronika Bachanova
    Blood and Marrow, Transplant Program, University of Minnesota, Minneapolis, MN, USA
    Blood 117:5261-3. 2011
    ..Clinical trial numbers for www.clinicaltrials.gov are NCT00365287, NCT00305682, and NCT00303719...
  46. doi request reprint Pericardial effusion after pediatric hematopoietic cell transplant
    Osamah Aldoss
    Division of Pediatric Cardiology, Department of Pediatrics, University of Minnesota Amplatz Children s Hospital, Minneapolis, MN 55454, USA
    Pediatr Transplant 17:294-9. 2013
    ..In summary, PE is a common and significant complication of pediatric allo-HCT. Prospective studies are needed to better determine the etiology and optimal method of PE treatment after HCT...
  47. doi request reprint Treatment of relapsed acute lymphoblastic leukemia: approaches used by pediatric oncologists and bone marrow transplant physicians
    Michael J Burke
    Division of Pediatric Hematology Oncology, University of Minnesota, Minneapolis, MN, USA
    Pediatr Blood Cancer 58:840-5. 2012
    ..Management of relapsed B-precursor acute lymphoblastic leukemia (ALL) is challenging and varied. We hypothesized that treatment approaches differ between pediatric oncologists and bone marrow transplant (BMT) physicians...
  48. ncbi request reprint iTRAQ is a useful method to screen for membrane-bound proteins differentially expressed in human natural killer cell types
    Troy C Lund
    Department of Medicine, Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 670 CCRB, 425 East River Road, Minneapolis, MN 55455, USA
    J Proteome Res 6:644-53. 2007
    ..This is the first demonstration and verification using iTRAQ to screen for membrane-bound protein differences in human NK cells and represents a powerful new tool in the field of proteomics...
  49. pmc Reduced-intensity conditioning regimens for allogeneic transplantation in children with acute lymphoblastic leukemia
    Michael R Verneris
    University of Minnesota Medical Center, Minneapolis, Minnesota, USA
    Biol Blood Marrow Transplant 16:1237-44. 2010
    ..These data indicate long-term DFS can be achieved using reduced-intensity conditioning regimens in children with acute lymphoblastic leukemia. Given the relatively small cohort, these findings must be validated in a larger population...
  50. pmc Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells
    Bartosz Grzywacz
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E River Rd, Suite 660, Minneapolis, MN 55455, USA
    Blood 108:3824-33. 2006
    ..The identified stages of NK-cell differentiation provide evidence for coordinated acquisition of HLA-specific inhibitory receptors (ie, CD94/NKG2A) and function in developing human NK cells...
  51. doi request reprint Killing the killer: natural killer cells to treat Ewing's sarcoma
    Yong Oon Ahn
    Hematology, Oncology and Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    Clin Cancer Res 16:3819-21. 2010
    ..Using an orthotopic murine model, they also show that irradiation significantly enhances the NK-cell killing of these tumors...
  52. ncbi request reprint Studying multiple protein profiles over time to assess biomarker validity
    Raj S Kasthuri
    University of Minnesota, Department of Medicine, MMC 480, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Expert Rev Proteomics 3:455-64. 2006
    ..The focus of this review is to illustrate the principle and value of serial protein profiling using a rapid protein extraction method...
  53. ncbi request reprint Studies of ex vivo activated and expanded CD8+ NK-T cells in humans and mice
    Michael R Verneris
    Division of Pediatric Hematology Oncology, and Bone Marrow Transplantation, Stanford, California 94305, USA
    J Clin Immunol 22:131-6. 2002
    ..We conclude that expanded CD8+ NK-T cells are a promising form of cellular therapy in the allogeneic setting...
  54. ncbi request reprint Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic description
    Antoinette Peters
    Biol Blood Marrow Transplant 11:484-5. 2005

Research Grants1

  1. ACTIVITY OF EXPANDED GAMMA/DELTA T CELLS
    Michael Verneris; Fiscal Year: 2005
    ..Thus, the candidate will acquire the skills to secure a faculty position as a pediatric bone marrow transplantation clinical-scientist...