Research Topics
Species | G N VerneSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Irritable bowel syndrome as a common precipitant of central sensitizationG Nicholas Verne
University of Florida, Malcolm Randall VAMC, Department of Medicine, Gastroenterology Section IIIC, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
Curr Rheumatol Rep 4:322-8. 2002..This suggests that abnormalities of central nociceptive processing are present in IBS...- Plasticity in brain processing and modulation of painDonald D Price
Oral and Maxillofacial Surgery, College of Dentistry, University of Florida, Gainesville, FL, USA
Prog Brain Res 157:333-352. 2006..Finally, understanding psychological modulation of pain and pain-related brain activity is optimized by a scientific framework that integrates principles of contemporary physics, neuroscience, and human experiential science... - Association of HLA-DR and -DQ alleles with idiopathic achalasiaG N Verne
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Gastroenterology 117:26-31. 1999..Peripheral blood was collected, and HLA-DR and -DQ typing by polymerase chain reaction with sequence-specific primers was performed. Results were compared with those from 268 racially matched local controls... - Autonomic dysfunction and gastroparesis in cirrhosisG Nicholas Verne
Divisions of Gastroenterology, Hepatology, and Nutrition, University of Florida, Malcom Randall VAMC, 1601 SW Archer Road, Gainesville, FL 32608, USA
J Clin Gastroenterol 38:72-6. 2004..The cause of these motility disorders in cirrhotics is unknown, however, underlying autonomic dysfunction may play a role... - Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patientsG Nicholas Verne
Malcom Randall VAMC, Research Service 151, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
Pain 105:223-30. 2003..Rectal administration of lidocaine jelly may also be a safe and effective means of reducing pain symptoms in IBS patients... - Representations of pain in the brainG Nicholas Verne
Malcom Randall VA Medical Center, 1601 SW Archer Road, Gainesville, FL 32608, USA
Curr Rheumatol Rep 6:261-5. 2004..Hyperalgesic states during clinically relevant pain are especially reflected in brain areas such as the anterior cingulate and prefrontal cortical regions... - Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndromeG Nicholas Verne
Research Service 151, Malcom Randall VAMC, Gainesville, FL 32608, USA
Pain 103:99-110. 2003..g. limbic and frontal cortical areas)... - The public awareness of the prevalence and impact of irritable bowel syndrome in the United States: perception versus realityG Nicholas Verne
Gastroenterology Section, Malcom Randall VAMC, Gainesville, FL 32608, USA
J Clin Gastroenterol 38:419-24. 2004..The objectives of this survey were to assess the public perception of irritable bowel syndrome with respect to its prevalence and impact on society and to assess the public's knowledge of this condition... - Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndromeG N Verne
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
Pain 93:7-14. 2001..This distribution is consistent with patterns of spinal hyperexcitability observed in experimentally induced persistent pain conditions... 
The dynamic mechanisms of placebo induced analgesia: Evidence of sustained and transient regional involvementJason G Craggs
Department of Clinical and Health Psychology, College of Health Professions, HPNP, Gainesville, FL 32610 0165, USA
Pain 139:660-9. 2008..Identifying brain regions associated with pain-modulation with different temporal profiles is consistent with the multidimensionality of PA and highlights the need for continued investigation of this construct...- Visceral and cutaneous hypersensitivity in Persian Gulf war veterans with chronic gastrointestinal symptomsRebecca C Dunphy
Malcom Randall VAMC, Research Service, 1601 SW Archer Road, Gainesville, FL, USA
Pain 102:79-85. 2003..These veterans also have cutaneous hypersensitivity and higher levels of anxiety and somatic focus accounting for these differences in pain reporting... - Evidence for autonomic dysregulation in the irritable bowel syndromeVishal Gupta
Department of Medicine, University of Florida, Gainesville, 32608-1197, USA
Dig Dis Sci 47:1716-22. 2002..Sex and anxiety did not explain these relationships. In conclusion, we found evidence suggestive of central autonomic dysregulation in IBS patients... - Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgiaBaharak Moshiree
Department of Medicine, University of Florida Colleges of Medicine, Dentistry, Public Health and Health Professions, Gainesville, FL 32610 0214, USA
Clin J Pain 23:323-30. 2007..Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by both visceral and somatic hyperalgesia, producing a similar effect seen with the central hypersensitivity mechanism in fibromyalgia (FM)... - Functional brain interactions that serve cognitive-affective processing during pain and placebo analgesiaJason G Craggs
Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, USA
Neuroimage 38:720-9. 2007..Although it is likely that placebo analgesia results partly from afferent inhibition of a nociceptive signal, the mechanisms likely involve the interaction of a cognitive-affective network with input from both hemispheres... - Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors: evidence from human psychophysics, animal models, and neuroimagingDonald D Price
Department of Oral Surgery, University of Florida College of Dentistry, Gainesville, Florida, USA
Neuroimage 47:995-1001. 2009..This explanatory model may be relevant to other persistent pain conditions... - Spinal NMDA NR1 subunit expression following transient TNBS colitisQiQi Zhou
Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA
Brain Res 1279:109-20. 2009..We hypothesized that NMDA NR1 subunit expression mediates hypersensitivity following transient TNBS colitis... - Intestinal membrane permeability and hypersensitivity in the irritable bowel syndromeQiQi Zhou
Department of Medicine, Ohio State University, Columbus, OH, USA
Pain 146:41-6. 2009..Thus, increased intestinal membrane permeability in D-IBS patients may lead to more severe IBS symptoms and hypersensitivity to somatic and visceral stimuli... - Thermal hypersensitivity in a subset of irritable bowel syndrome patientsQiQi Zhou
Department of Medicine, Ohio State University, Columbus, OH 43210, USA
World J Gastroenterol 15:3254-60. 2009..To characterize thermal hypersensitivity in patients with constipation- and diarrhea-predominant irritable bowel syndrome (IBS)... - Central and peripheral hypersensitivity in the irritable bowel syndromeQiQi Zhou
Department of Medicine, Ohio State University, Columbus, OH, USA
Pain 148:454-61. 2010..The results of this study suggest that a more widespread alteration in central pain processing in a subset of IBS patients may be present as they display hypersensitivity to heat, ischemic, and cold pressor stimuli... - Intrarectal lidocaine is an effective treatment for abdominal pain associated with diarrhea-predominant irritable bowel syndromeG Nicholas Verne
GenoMechanix, L.L.C, Gainesville, FL, USA
J Pain 6:493-6. 2005.... - Long-term response to subtotal colectomy in colonic inertiaG Nicholas Verne
Malcom Randall Veterans Affairs Medical Center, Gastroenterology Section, Department of Medicine, University of Florida, Gainesville, Florida 32608, USA
J Gastrointest Surg 6:738-44. 2002.... - Treatment of chronic constipation with colchicine: randomized, double-blind, placebo-controlled, crossover trialG Nicholas Verne
Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA
Am J Gastroenterol 98:1112-6. 2003..Colchicine may be an effective agent available to practitioners to treat a subset of patients with chronic constipation who are refractory to standard medical therapy... - New solutions to an old problem: acute colonic pseudo-obstructionAli Fazel
Department of Gastroenterology and Hepatology, University of Florida, Gainesville, FL, USA
J Clin Gastroenterol 39:17-20. 2005..When colonic distension persists, decompression colonoscopy is preformed. Occasionally, these measures fail necessitating surgical intervention... - Central sensitisation in visceral pain disordersB Moshiree
Department of Medicine, University of Florida College of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, 1600 SW Archer Rd, HD 602, PO Box 100214, Gainesville, FL 32610-0214, USA
Gut 55:905-8. 2006.... - Reversal of visceral and somatic hypersensitivity in a subset of hypersensitive rats by intracolonic lidocaineQiQi Zhou
Division of Gastroenterology, Hepatology, and Nutrition, Ohio State University, 395 West 12th Avenue, Office Tower 288A, Columbus, OH 43210, USA
Pain 139:218-24. 2008..This animal model may be used in the future to study the mechanisms of local anesthetic agents applied to the gut to reduce visceral pain... - Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in ratsQiQi Zhou
Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
Mol Pain 2:3. 2006.... - Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitisQiQi Zhou
Department of Medicine, Division of Gasteroenterology, Hepatology, and Nutrition, University of Florida Colleges of Medicine and Dentistry, 1600 SW Archer Road, HD 602, PO Box 100214, Gainesville, FL 32610 0214, USA
Pain 134:9-15. 2008..We have previously shown that IBS patients with visceral hypersensitivity also have evidence of thermal hyperalgesia of the hand/foot... - Revelation of a personal placebo response: its effects on mood, attitudes and future placebo respondingS Karen Chung
Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, USA
Pain 132:281-8. 2007..These studies suggest the placebo response persists even after revelation of a personal placebo response and placebo use does not appear to cause adverse effects on mood and other attitude variables assessed... - Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patientsDonald D Price
Department of Oral and Maxillofacial Surgery, University of Florida, Gainesville, FL 32610, USA
Pain 127:63-72. 2007..Although many factors influence placebo analgesia, it is accompanied by reduction in pain processing within the brain in clinically relevant conditions... - Prevalence of gastroparesis in patients with small duct chronic pancreatitisRiaz S Chowdhury
Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, Florida, USA
Pancreas 26:235-8. 2003..For patients with small-duct disease whose abdominal pain does not respond to pancreatic enzyme therapy, clinicians should consider an evaluation for gastroparesis... - Expression of the N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunit subtypes in the rat colonA Y Del Valle-Pinero
Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA
Neuroscience 147:164-73. 2007..The identification of the NMDA receptors in the enteric nervous system could lead to the development of drugs that selectively modulate bowel function... - Drug treatment options for irritable bowel syndrome: managing for successR C Dunphy
Department of Medicine, University of Florida, Gainesville, USA
Drugs Aging 18:201-11. 2001.... - MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndromeQiQi Zhou
Department of Medicine, Ohio State University, 1799 W 5th Avenue, Columbus, OH 43212, USA
Gut 59:775-84. 2010..Our goal was to evaluate the expression of glutamine synthetase and its complementary miRNA in blood microvesicles and gut tissues of IBS patients with increased intestinal membrane permeability... - Visceral and somatic hypersensitivity in TNBS-induced colitis in ratsQiQi Zhou
Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida College of Medicine, 1600 SW Archer Road, HD 602, Gainesville, FL 32610 0214, USA
Dig Dis Sci 53:429-35. 2008..TNBS colitis is associated with visceral and somatic hypersensitivity in areas of somatotopic overlap. This model of colitis should allow further investigation into the mechanisms of visceral and somatic hypersensitivity... - Treatment of pain symptoms in irritable bowel syndrome patientsVishal Gupta
University of Florida, Department of Medicine, Division of Gastroenterology, Gainesville, Florida 32608, USA
Drugs Today (Barc) 40:829-36. 2004..Through a proper understanding of the diagnostic criteria, pathophysiology and treatment options, this disorder can be treated effectively in many patients... - The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients. An empirical investigationLene Vase
Department of Psychology, University of Aarhus, Asylvej 4, 8240 Risskov, Denmark
Pain 105:17-25. 2003..Hence, the combination of expected pain levels and desire for pain relief may offer an alternative means of assessing the contribution of placebo factors during analgesia... - Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanismsLene Vase
Department of Psychology, University of Aarhus, Aarhus, Denmark
Pain 115:338-47. 2005.... - Megacolon and stercoral proctitis after frequent fecal impactions: report of an unusual case and review of the literatureJen Tzer Gau
Department of Geriatric Medicine Gerontology, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
J Am Med Dir Assoc 8:338-41. 2007..Complications and management of fecal impaction and the pathophysiology of megacolon in the literature are reviewed and discussed...