G N Verne

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. ncbi request reprint Irritable bowel syndrome as a common precipitant of central sensitization
    G Nicholas Verne
    University of Florida, Malcolm Randall VAMC, Department of Medicine, Gastroenterology Section IIIC, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Curr Rheumatol Rep 4:322-8. 2002
  2. ncbi request reprint Plasticity in brain processing and modulation of pain
    Donald D Price
    Oral and Maxillofacial Surgery, College of Dentistry, University of Florida, Gainesville, FL, USA
    Prog Brain Res 157:333-352. 2006
  3. ncbi request reprint Association of HLA-DR and -DQ alleles with idiopathic achalasia
    G N Verne
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Gastroenterology 117:26-31. 1999
  4. ncbi request reprint Autonomic dysfunction and gastroparesis in cirrhosis
    G Nicholas Verne
    Divisions of Gastroenterology, Hepatology, and Nutrition, University of Florida, Malcom Randall VAMC, 1601 SW Archer Road, Gainesville, FL 32608, USA
    J Clin Gastroenterol 38:72-6. 2004
  5. ncbi request reprint Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients
    G Nicholas Verne
    Malcom Randall VAMC, Research Service 151, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Pain 105:223-30. 2003
  6. ncbi request reprint Representations of pain in the brain
    G Nicholas Verne
    Malcom Randall VA Medical Center, 1601 SW Archer Road, Gainesville, FL 32608, USA
    Curr Rheumatol Rep 6:261-5. 2004
  7. ncbi request reprint Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome
    G Nicholas Verne
    Research Service 151, Malcom Randall VAMC, Gainesville, FL 32608, USA
    Pain 103:99-110. 2003
  8. ncbi request reprint The public awareness of the prevalence and impact of irritable bowel syndrome in the United States: perception versus reality
    G Nicholas Verne
    Gastroenterology Section, Malcom Randall VAMC, Gainesville, FL 32608, USA
    J Clin Gastroenterol 38:419-24. 2004
  9. ncbi request reprint Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome
    G N Verne
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Pain 93:7-14. 2001
  10. pmc The dynamic mechanisms of placebo induced analgesia: Evidence of sustained and transient regional involvement
    Jason G Craggs
    Department of Clinical and Health Psychology, College of Health Professions, HPNP, Gainesville, FL 32610 0165, USA
    Pain 139:660-9. 2008

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Irritable bowel syndrome as a common precipitant of central sensitization
    G Nicholas Verne
    University of Florida, Malcolm Randall VAMC, Department of Medicine, Gastroenterology Section IIIC, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Curr Rheumatol Rep 4:322-8. 2002
    ..This suggests that abnormalities of central nociceptive processing are present in IBS...
  2. ncbi request reprint Plasticity in brain processing and modulation of pain
    Donald D Price
    Oral and Maxillofacial Surgery, College of Dentistry, University of Florida, Gainesville, FL, USA
    Prog Brain Res 157:333-352. 2006
    ..Finally, understanding psychological modulation of pain and pain-related brain activity is optimized by a scientific framework that integrates principles of contemporary physics, neuroscience, and human experiential science...
  3. ncbi request reprint Association of HLA-DR and -DQ alleles with idiopathic achalasia
    G N Verne
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Gastroenterology 117:26-31. 1999
    ..Peripheral blood was collected, and HLA-DR and -DQ typing by polymerase chain reaction with sequence-specific primers was performed. Results were compared with those from 268 racially matched local controls...
  4. ncbi request reprint Autonomic dysfunction and gastroparesis in cirrhosis
    G Nicholas Verne
    Divisions of Gastroenterology, Hepatology, and Nutrition, University of Florida, Malcom Randall VAMC, 1601 SW Archer Road, Gainesville, FL 32608, USA
    J Clin Gastroenterol 38:72-6. 2004
    ..The cause of these motility disorders in cirrhotics is unknown, however, underlying autonomic dysfunction may play a role...
  5. ncbi request reprint Reversal of visceral and cutaneous hyperalgesia by local rectal anesthesia in irritable bowel syndrome (IBS) patients
    G Nicholas Verne
    Malcom Randall VAMC, Research Service 151, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Pain 105:223-30. 2003
    ..Rectal administration of lidocaine jelly may also be a safe and effective means of reducing pain symptoms in IBS patients...
  6. ncbi request reprint Representations of pain in the brain
    G Nicholas Verne
    Malcom Randall VA Medical Center, 1601 SW Archer Road, Gainesville, FL 32608, USA
    Curr Rheumatol Rep 6:261-5. 2004
    ..Hyperalgesic states during clinically relevant pain are especially reflected in brain areas such as the anterior cingulate and prefrontal cortical regions...
  7. ncbi request reprint Central representation of visceral and cutaneous hypersensitivity in the irritable bowel syndrome
    G Nicholas Verne
    Research Service 151, Malcom Randall VAMC, Gainesville, FL 32608, USA
    Pain 103:99-110. 2003
    ..g. limbic and frontal cortical areas)...
  8. ncbi request reprint The public awareness of the prevalence and impact of irritable bowel syndrome in the United States: perception versus reality
    G Nicholas Verne
    Gastroenterology Section, Malcom Randall VAMC, Gainesville, FL 32608, USA
    J Clin Gastroenterol 38:419-24. 2004
    ..The objectives of this survey were to assess the public perception of irritable bowel syndrome with respect to its prevalence and impact on society and to assess the public's knowledge of this condition...
  9. ncbi request reprint Hypersensitivity to visceral and cutaneous pain in the irritable bowel syndrome
    G N Verne
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida, 1601 SW Archer Road, Gainesville, FL 32608 1197, USA
    Pain 93:7-14. 2001
    ..This distribution is consistent with patterns of spinal hyperexcitability observed in experimentally induced persistent pain conditions...
  10. pmc The dynamic mechanisms of placebo induced analgesia: Evidence of sustained and transient regional involvement
    Jason G Craggs
    Department of Clinical and Health Psychology, College of Health Professions, HPNP, Gainesville, FL 32610 0165, USA
    Pain 139:660-9. 2008
    ..Identifying brain regions associated with pain-modulation with different temporal profiles is consistent with the multidimensionality of PA and highlights the need for continued investigation of this construct...
  11. ncbi request reprint Visceral and cutaneous hypersensitivity in Persian Gulf war veterans with chronic gastrointestinal symptoms
    Rebecca C Dunphy
    Malcom Randall VAMC, Research Service, 1601 SW Archer Road, Gainesville, FL, USA
    Pain 102:79-85. 2003
    ..These veterans also have cutaneous hypersensitivity and higher levels of anxiety and somatic focus accounting for these differences in pain reporting...
  12. ncbi request reprint Evidence for autonomic dysregulation in the irritable bowel syndrome
    Vishal Gupta
    Department of Medicine, University of Florida, Gainesville, 32608 1197, USA
    Dig Dis Sci 47:1716-22. 2002
    ..Sex and anxiety did not explain these relationships. In conclusion, we found evidence suggestive of central autonomic dysregulation in IBS patients...
  13. ncbi request reprint Thermal and visceral hypersensitivity in irritable bowel syndrome patients with and without fibromyalgia
    Baharak Moshiree
    Department of Medicine, University of Florida Colleges of Medicine, Dentistry, Public Health and Health Professions, Gainesville, FL 32610 0214, USA
    Clin J Pain 23:323-30. 2007
    ..Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by both visceral and somatic hyperalgesia, producing a similar effect seen with the central hypersensitivity mechanism in fibromyalgia (FM)...
  14. pmc Functional brain interactions that serve cognitive-affective processing during pain and placebo analgesia
    Jason G Craggs
    Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, USA
    Neuroimage 38:720-9. 2007
    ..Although it is likely that placebo analgesia results partly from afferent inhibition of a nociceptive signal, the mechanisms likely involve the interaction of a cognitive-affective network with input from both hemispheres...
  15. pmc Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors: evidence from human psychophysics, animal models, and neuroimaging
    Donald D Price
    Department of Oral Surgery, University of Florida College of Dentistry, Gainesville, Florida, USA
    Neuroimage 47:995-1001. 2009
    ..This explanatory model may be relevant to other persistent pain conditions...
  16. pmc Spinal NMDA NR1 subunit expression following transient TNBS colitis
    QiQi Zhou
    Department of Medicine, Ohio State University, Columbus, Ohio 43210, USA
    Brain Res 1279:109-20. 2009
    ..We hypothesized that NMDA NR1 subunit expression mediates hypersensitivity following transient TNBS colitis...
  17. pmc Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome
    QiQi Zhou
    Department of Medicine, Ohio State University, Columbus, OH, USA
    Pain 146:41-6. 2009
    ..Thus, increased intestinal membrane permeability in D-IBS patients may lead to more severe IBS symptoms and hypersensitivity to somatic and visceral stimuli...
  18. pmc Thermal hypersensitivity in a subset of irritable bowel syndrome patients
    QiQi Zhou
    Department of Medicine, Ohio State University, Columbus, OH 43210, USA
    World J Gastroenterol 15:3254-60. 2009
    ..To characterize thermal hypersensitivity in patients with constipation- and diarrhea-predominant irritable bowel syndrome (IBS)...
  19. pmc Central and peripheral hypersensitivity in the irritable bowel syndrome
    QiQi Zhou
    Department of Medicine, Ohio State University, Columbus, OH, USA
    Pain 148:454-61. 2010
    ..The results of this study suggest that a more widespread alteration in central pain processing in a subset of IBS patients may be present as they display hypersensitivity to heat, ischemic, and cold pressor stimuli...
  20. ncbi request reprint Intrarectal lidocaine is an effective treatment for abdominal pain associated with diarrhea-predominant irritable bowel syndrome
    G Nicholas Verne
    GenoMechanix, L L C, Gainesville, FL, USA
    J Pain 6:493-6. 2005
    ..02) for at least 4 hours. None of the patients experienced any side effects. Intrarectal lidocaine may be a potentially useful treatment for chronic abdominal pain in IBS...
  21. ncbi request reprint Long-term response to subtotal colectomy in colonic inertia
    G Nicholas Verne
    Malcom Randall Veterans Affairs Medical Center, Gastroenterology Section, Department of Medicine, University of Florida, Gainesville, Florida 32608, USA
    J Gastrointest Surg 6:738-44. 2002
    ....
  22. ncbi request reprint Treatment of chronic constipation with colchicine: randomized, double-blind, placebo-controlled, crossover trial
    G Nicholas Verne
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, Florida, USA
    Am J Gastroenterol 98:1112-6. 2003
    ..The aim of this study was to determine if p.d. colchicine will increase spontaneous bowel movements and accelerate colonic transit in patients with idiopathic chronic constipation in a randomized, placebo-controlled, crossover trial...
  23. ncbi request reprint New solutions to an old problem: acute colonic pseudo-obstruction
    Ali Fazel
    Department of Gastroenterology and Hepatology, University of Florida, Gainesville, FL, USA
    J Clin Gastroenterol 39:17-20. 2005
    ..When colonic distension persists, decompression colonoscopy is preformed. Occasionally, these measures fail necessitating surgical intervention...
  24. pmc Central sensitisation in visceral pain disorders
    B Moshiree
    Department of Medicine, University of Florida College of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, 1600 SW Archer Rd, HD 602, PO Box 100214, Gainesville, FL 32610 0214, USA
    Gut 55:905-8. 2006
    ....
  25. pmc Reversal of visceral and somatic hypersensitivity in a subset of hypersensitive rats by intracolonic lidocaine
    QiQi Zhou
    Division of Gastroenterology, Hepatology, and Nutrition, Ohio State University, 395 West 12th Avenue, Office Tower 288A, Columbus, OH 43210, USA
    Pain 139:218-24. 2008
    ..This animal model may be used in the future to study the mechanisms of local anesthetic agents applied to the gut to reduce visceral pain...
  26. pmc Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats
    QiQi Zhou
    Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Mol Pain 2:3. 2006
    ....
  27. pmc Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis
    QiQi Zhou
    Department of Medicine, Division of Gasteroenterology, Hepatology, and Nutrition, University of Florida Colleges of Medicine and Dentistry, 1600 SW Archer Road, HD 602, PO Box 100214, Gainesville, FL 32610 0214, USA
    Pain 134:9-15. 2008
    ..We have previously shown that IBS patients with visceral hypersensitivity also have evidence of thermal hyperalgesia of the hand/foot...
  28. pmc Revelation of a personal placebo response: its effects on mood, attitudes and future placebo responding
    S Karen Chung
    Department of Clinical and Health Psychology, University of Florida, Gainesville, FL 32610, USA
    Pain 132:281-8. 2007
    ..These studies suggest the placebo response persists even after revelation of a personal placebo response and placebo use does not appear to cause adverse effects on mood and other attitude variables assessed...
  29. ncbi request reprint Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients
    Donald D Price
    Department of Oral and Maxillofacial Surgery, University of Florida, Gainesville, FL 32610, USA
    Pain 127:63-72. 2007
    ..Although many factors influence placebo analgesia, it is accompanied by reduction in pain processing within the brain in clinically relevant conditions...
  30. ncbi request reprint Prevalence of gastroparesis in patients with small duct chronic pancreatitis
    Riaz S Chowdhury
    Division of Gastroenterology, Hepatology, and Nutrition, University of Florida College of Medicine, Gainesville, Florida, USA
    Pancreas 26:235-8. 2003
    ..We have observed that coexistent gastroparesis may also interfere with the effectiveness of pancreatic enzyme therapy by failing to deliver proteases into the duodenum and therefore not restoring feedback control of pancreatic secretion...
  31. pmc Expression of the N-methyl-D-aspartate receptor NR1 splice variants and NR2 subunit subtypes in the rat colon
    A Y Del Valle-Pinero
    Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Neuroscience 147:164-73. 2007
    ..The identification of the NMDA receptors in the enteric nervous system could lead to the development of drugs that selectively modulate bowel function...
  32. ncbi request reprint Drug treatment options for irritable bowel syndrome: managing for success
    R C Dunphy
    Department of Medicine, University of Florida, Gainesville, USA
    Drugs Aging 18:201-11. 2001
    ....
  33. pmc MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome
    QiQi Zhou
    Department of Medicine, Ohio State University, 1799 W 5th Avenue, Columbus, OH 43212, USA
    Gut 59:775-84. 2010
    ..Our goal was to evaluate the expression of glutamine synthetase and its complementary miRNA in blood microvesicles and gut tissues of IBS patients with increased intestinal membrane permeability...
  34. pmc Visceral and somatic hypersensitivity in TNBS-induced colitis in rats
    QiQi Zhou
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Florida College of Medicine, 1600 SW Archer Road, HD 602, Gainesville, FL 32610 0214, USA
    Dig Dis Sci 53:429-35. 2008
    ..TNBS colitis is associated with visceral and somatic hypersensitivity in areas of somatotopic overlap. This model of colitis should allow further investigation into the mechanisms of visceral and somatic hypersensitivity...
  35. ncbi request reprint Treatment of pain symptoms in irritable bowel syndrome patients
    Vishal Gupta
    University of Florida, Department of Medicine, Division of Gastroenterology, Gainesville, Florida 32608, USA
    Drugs Today (Barc) 40:829-36. 2004
    ..Through a proper understanding of the diagnostic criteria, pathophysiology and treatment options, this disorder can be treated effectively in many patients...
  36. ncbi request reprint The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients. An empirical investigation
    Lene Vase
    Department of Psychology, University of Aarhus, Asylvej 4, 8240 Risskov, Denmark
    Pain 105:17-25. 2003
    ..Hence, the combination of expected pain levels and desire for pain relief may offer an alternative means of assessing the contribution of placebo factors during analgesia...
  37. ncbi request reprint Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms
    Lene Vase
    Department of Psychology, University of Aarhus, Aarhus, Denmark
    Pain 115:338-47. 2005
    ....
  38. ncbi request reprint Megacolon and stercoral proctitis after frequent fecal impactions: report of an unusual case and review of the literature
    Jen Tzer Gau
    Department of Geriatric Medicine Gerontology, College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA
    J Am Med Dir Assoc 8:338-41. 2007
    ..Complications and management of fecal impaction and the pathophysiology of megacolon in the literature are reviewed and discussed...