KRISTEN VERHEY

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint Kinesin assembly and movement in cells
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Annu Rev Biophys 40:267-88. 2011
  2. pmc Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP
    John F Dishinger
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Cell Biol 12:703-10. 2010
  3. pmc Recycling of kinesin-1 motors by diffusion after transport
    T Lynne Blasius
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e76081. 2013
  4. pmc Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules
    Virupakshi Soppina
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    PLoS ONE 7:e48204. 2012
  5. pmc A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia
    Hooi Lynn Kee
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Cell Biol 14:431-7. 2012
  6. doi request reprint Traffic control: regulation of kinesin motors
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Nat Rev Mol Cell Biol 10:765-77. 2009
  7. ncbi request reprint Motor proteins: trafficking and signaling collide
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Curr Biol 17:R804-6. 2007
  8. ncbi request reprint The tubulin code
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cell Cycle 6:2152-60. 2007
  9. pmc Kinesin motors and primary cilia
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Biochem Soc Trans 39:1120-5. 2011
  10. ncbi request reprint Microtubule acetylation promotes kinesin-1 binding and transport
    Nathan A Reed
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    Curr Biol 16:2166-72. 2006

Research Grants

  1. Regulation of the molecular motor kinesin-1
    KRISTEN VERHEY; Fiscal Year: 2005
  2. Regulation of the molecular motor kinesin-I
    Kristen J Verhey; Fiscal Year: 2010
  3. Single-molecule analysis of kinesin motors in live cells
    KRISTEN VERHEY; Fiscal Year: 2009
  4. Single-molecule analysis of kinesin motors in live cells
    Kristen J Verhey; Fiscal Year: 2010
  5. Regulation of the molecular motor kinesin-I
    KRISTEN VERHEY; Fiscal Year: 2009
  6. Single-molecule analysis of kinesin motors in live cells
    KRISTEN VERHEY; Fiscal Year: 2007
  7. Regulation of the molecular motor kinesin-I
    Kristen J Verhey; Fiscal Year: 2010
  8. Single-molecule analysis of kinesin motors in live cells
    KRISTEN VERHEY; Fiscal Year: 2009
  9. Regulation of the molecular motor kinesin-1
    KRISTEN VERHEY; Fiscal Year: 2007
  10. Regulation of the molecular motor kinesin-I
    KRISTEN VERHEY; Fiscal Year: 2006

Collaborators

  • J Gaertig
  • BENJAMIN L MARGOLIS
  • Jennetta W Hammond
  • Dawen Cai
  • T Lynne Blasius
  • Edgar Meyhofer
  • Gloria T Jih
  • Virupakshi Soppina
  • Hooi Lynn Kee
  • John F Dishinger
  • Paul M Jenkins
  • Toby W Hurd
  • Jeffrey R Martens
  • Dyke P McEwen
  • Nathan A Reed
  • Boris M Slepchenko
  • Nathan Reed
  • Jeffrey F Herbstman
  • Chia Jen Liu
  • Georgios Skiniotis
  • Stefanie Kaech
  • Catherine Jacobson
  • Chun Fang Huang
  • Yen Nhu Thi Truong
  • Shuling Fan
  • Gary Banker
  • Yuyang Jiang
  • Jeffery R Martens
  • Zhe Li
  • Kelly Griffin
  • Jeanne Stuckey
  • Christopher P Toret
  • Joel A Swanson
  • Adam D Hoppe
  • Lian Zhang
  • R Lane Brown

Detail Information

Publications20

  1. doi request reprint Kinesin assembly and movement in cells
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Annu Rev Biophys 40:267-88. 2011
    ....
  2. pmc Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP
    John F Dishinger
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Cell Biol 12:703-10. 2010
    ..We propose that Ran has a global role in regulating cellular compartmentalization by controlling the shuttling of cytoplasmic proteins into nuclear and ciliary compartments...
  3. pmc Recycling of kinesin-1 motors by diffusion after transport
    T Lynne Blasius
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e76081. 2013
    ..These results suggest that individual kinesin-1 motors are utilized for multiple rounds of transport. ..
  4. pmc Luminal localization of α-tubulin K40 acetylation by cryo-EM analysis of fab-labeled microtubules
    Virupakshi Soppina
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA
    PLoS ONE 7:e48204. 2012
    ..This work has important implications for acetylation and deacetylation reaction mechanisms as well as for interpreting experiments based on 6-11B-1 labeling...
  5. pmc A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia
    Hooi Lynn Kee
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Cell Biol 14:431-7. 2012
    ..Together, this work demonstrates that the physical and molecular nature of the ciliary pore complex is similar to that of the nuclear pore complex, and further extends functional parallels between nuclear and ciliary import...
  6. doi request reprint Traffic control: regulation of kinesin motors
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Nat Rev Mol Cell Biol 10:765-77. 2009
    ..Recent work has revealed molecular mechanisms that control kinesin autoinhibition and subsequent activation, binding to cargos and microtubule tracks, and localization at specific sites of action...
  7. ncbi request reprint Motor proteins: trafficking and signaling collide
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Curr Biol 17:R804-6. 2007
    ..Recent work has shown that the signaling components are not just along for the ride. Rather, they can play an important role in regulating the motor that carries them...
  8. ncbi request reprint The tubulin code
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cell Cycle 6:2152-60. 2007
    ..Here we review recent progress in understanding how the tubulin code is generated, maintained, and read by microtubule effectors...
  9. pmc Kinesin motors and primary cilia
    Kristen J Verhey
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Biochem Soc Trans 39:1120-5. 2011
    ....
  10. ncbi request reprint Microtubule acetylation promotes kinesin-1 binding and transport
    Nathan A Reed
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    Curr Biol 16:2166-72. 2006
    ..These results suggest that microtubule PTMs are important markers of distinct microtubule populations and that they act to control motor-protein trafficking...
  11. pmc Posttranslational modifications of tubulin and the polarized transport of kinesin-1 in neurons
    Jennetta W Hammond
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Mol Biol Cell 21:572-83. 2010
    ....
  12. pmc Tubulin modifications and their cellular functions
    Jennetta W Hammond
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Curr Opin Cell Biol 20:71-6. 2008
    ....
  13. pmc Autoinhibition of the kinesin-2 motor KIF17 via dual intramolecular mechanisms
    Jennetta W Hammond
    Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Cell Biol 189:1013-25. 2010
    ..The latter is a new mechanism for regulation of kinesin motors. This work supports the model that autoinhibition is a general mechanism for regulation of kinesin motors involved in intracellular trafficking events...
  14. pmc Single molecule imaging reveals differences in microtubule track selection between Kinesin motors
    Dawen Cai
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    PLoS Biol 7:e1000216. 2009
    ..Furthermore, this property enables kinesin motors to segregate membrane trafficking events between stable and dynamic microtubule populations...
  15. pmc Mammalian Kinesin-3 motors are dimeric in vivo and move by processive motility upon release of autoinhibition
    Jennetta W Hammond
    Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA
    PLoS Biol 7:e72. 2009
    ..However, only dimeric motors undergo ATP-dependent processive motility. Thus, KIF1A may be uniquely suited to use both diffuse and processive motility to drive long-distance transport in neuronal cells...
  16. doi request reprint Co-operative versus independent transport of different cargoes by Kinesin-1
    Jennetta W Hammond
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Traffic 9:725-41. 2008
    ..Thus, JIP scaffolding proteins are transported in a co-operative manner, despite the independent transport of other Kinesin-1 cargoes...
  17. pmc Tracking single Kinesin molecules in the cytoplasm of mammalian cells
    Dawen Cai
    Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA
    Biophys J 92:4137-44. 2007
    ..Thus, by combining direct genetic labeling and single molecule imaging in vivo, our work establishes an important new biophysical method for observing single molecules expressed and localized in the mammalian cytoplasm...
  18. pmc Kinesin-1 structural organization and conformational changes revealed by FRET stoichiometry in live cells
    Dawen Cai
    Biophysics Research Division, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 176:51-63. 2007
    ..For Kinesin-1, activation requires a global conformational change that separates the KHC motor and tail domains and a local conformational change that moves the KHC motor domains closer together...
  19. pmc Two binding partners cooperate to activate the molecular motor Kinesin-1
    T Lynne Blasius
    Department of Cell Biology, University of Michigan, Ann Arbor, MI 48109, USA
    J Cell Biol 176:11-7. 2007
    ..We show that binding of JIP1 and FEZ1 to Kinesin-1 is sufficient to activate the motor for MT binding and motility. These results provide the first demonstration of the activation of a MT-based motor by cellular binding partners...
  20. ncbi request reprint Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17
    Paul M Jenkins
    Department of Pharmacology, University of Michigan, Ann Arbor, 48109, USA
    Curr Biol 16:1211-6. 2006
    ..Here, we demonstrate that KIF17 is required for olfactory CNG channel targeting, providing novel insights into mechanisms of mammalian ciliary transport...

Research Grants12

  1. Regulation of the molecular motor kinesin-1
    KRISTEN VERHEY; Fiscal Year: 2005
    ..This work will also increase our understanding of how the regulation of motor proteins gives rise to coordinated transport of protein complexes in cells and will suggest therapeutic targets in human disease. ..
  2. Regulation of the molecular motor kinesin-I
    Kristen J Verhey; Fiscal Year: 2010
    ..This work will also increase our understanding of how the regulation of motor proteins gives rise to coordinated transport of protein complexes in cells and will suggest therapeutic targets in human disease. ..
  3. Single-molecule analysis of kinesin motors in live cells
    KRISTEN VERHEY; Fiscal Year: 2009
    ..Understanding how molecular motors function in cells will provide important new targets for therapies aimed at these diseases. ..
  4. Single-molecule analysis of kinesin motors in live cells
    Kristen J Verhey; Fiscal Year: 2010
    ..Understanding how molecular motors function in cells will provide important new targets for therapies aimed at these diseases. ..
  5. Regulation of the molecular motor kinesin-I
    KRISTEN VERHEY; Fiscal Year: 2009
    ..This work will also increase our understanding of how the regulation of motor proteins gives rise to coordinated transport of protein complexes in cells and will suggest therapeutic targets in human disease. ..
  6. Single-molecule analysis of kinesin motors in live cells
    KRISTEN VERHEY; Fiscal Year: 2007
    ..Understanding how molecular motors function in cells will provide important new targets for therapies aimed at these diseases. ..
  7. Regulation of the molecular motor kinesin-I
    Kristen J Verhey; Fiscal Year: 2010
    ..This work will also increase our understanding of how the regulation of motor proteins gives rise to coordinated transport of protein complexes in cells and will suggest therapeutic targets in human disease. ..
  8. Single-molecule analysis of kinesin motors in live cells
    KRISTEN VERHEY; Fiscal Year: 2009
    ..Understanding how molecular motors function in cells will provide important new targets for therapies aimed at these diseases. ..
  9. Regulation of the molecular motor kinesin-1
    KRISTEN VERHEY; Fiscal Year: 2007
    ..This work will also increase our understanding of how the regulation of motor proteins gives rise to coordinated transport of protein complexes in cells and will suggest therapeutic targets in human disease. ..
  10. Regulation of the molecular motor kinesin-I
    KRISTEN VERHEY; Fiscal Year: 2006
    ..This work will also increase our understanding of how the regulation of motor proteins gives rise to coordinated transport of protein complexes in cells and will suggest therapeutic targets in human disease. ..