Research Topics
Genomes and Genes | Isabelle VergneSummaryAffiliation: University of New Mexico Country: USA Publications
| Collaborators
|
Detail Information
Publications
Control of autophagy initiation by phosphoinositide 3-phosphatase JumpyIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
EMBO J 28:2244-58. 2009....- The role of PI3P phosphatases in the regulation of autophagyIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
FEBS Lett 584:1313-8. 2010..This review sums up our knowledge on PI3P phosphatases and discusses the recent progress on their role in autophagy... 
Cell biology of mycobacterium tuberculosis phagosomeIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 001, USA
Annu Rev Cell Dev Biol 20:367-94. 2004..Here we review the fundamental trafficking processes targeted by M. tuberculosis and the mycobacterial products that interfere with phagosomal maturation...- Autophagy in immune defense against Mycobacterium tuberculosisIsabelle Vergne
Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 001, USA
Autophagy 2:175-8. 2006..Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated... - Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanismVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
Cell Microbiol 8:719-27. 2006..tuberculosis survival. This review summarizes the findings centred around the PI3P-nexus where the mycobacterial phagosome maturation block and execution stages of autophagy intersect... - Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondriaSudha B Singh
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA
Nat Cell Biol 12:1154-65. 2010..By acting on mitochondria, IRGM confers autophagic protection or cell death, explaining IRGM action both in defence against tuberculosis and in the damaging inflammation caused by Crohn's disease... - Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagyVojo Deretic
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
Curr Top Microbiol Immunol 335:169-88. 2009..This work and related studies by others have led us to propose a model of how autophagy, an ancient innate immunity defense, became integrated over the course of evolution with other immune mechanisms of ever-increasing complexity... - Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophagesGeorge B Kyei
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
J Cell Biol 186:255-68. 2009..The role of Nef in the latter process enhances yields of infectious HIV and may be of significance for progression to clinical AIDS... - Autophagy and pattern recognition receptors in innate immunityMonica Delgado
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Immunol Rev 227:189-202. 2009.... - Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial propertiesMarisa Ponpuak
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Immunity 32:329-41. 2010..tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles... 
Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomesAlexander S Davis
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America
PLoS Pathog 3:e186. 2007..Our findings are consistent with a model for the block in iNOS association with mycobacterial phagosomes as a mechanism dependent primarily on reduced EBP50 recruitment...- Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrestGeorge B Kyei
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
EMBO J 25:5250-9. 2006..Rab14 enables mycobacterial phagosomes to maintain early endosomal characteristics and avoid late endosomal/lysosomal degradative components... - Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosisIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Proc Natl Acad Sci U S A 102:4033-8. 2005..tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation... - Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIVVojo Deretic
Department of Molecular Genetics, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
Cell Microbiol 6:999-1009. 2004..We propose that interference with the endosomal sorting machinery contributes to the synergism between the two significant human diseases--AIDS and tuberculosis... - Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascadeIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
J Exp Med 198:653-9. 2003..tuberculosis residence in vacuoles sequestered away from the bactericidal and antigen-processing organelles in infected macrophages... - Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusionIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
Mol Biol Cell 15:751-60. 2004..tuberculosis has evolved a two-prong strategy to modify its intracellular niche: its products block acquisition of late endosomal/lysosomal constituents, while facilitating fusion with early endosomal compartments... - Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane traffickingIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico Medical School, Albuquerque, NM 87131, USA
Traffic 4:600-6. 2003..M. tuberculosis analogs of mammalian phosphatidylinositols interfere with these systems and associated processes... - A tale of two lipids: Mycobacterium tuberculosis phagosome maturation arrestJennifer Chua
Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131-001, USA
Curr Opin Microbiol 7:71-7. 2004..Understanding these processes could provide new targets for pharmacological intervention in tuberculosis... 
In vitro phagosome-endosome fusionIsabelle Vergne
Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
Methods Mol Biol 445:301-9. 2008..Fusion is quantified using a fluorescence-based detection method that measures the peroxidase activity associated with the beads...- Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic traffickingChengyu Liang
Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
Nat Cell Biol 10:776-87. 2008.... - Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrestRutilio A Fratti
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Proc Natl Acad Sci U S A 100:5437-42. 2003..These findings identify ManLAM as the M. tuberculosis product responsible for the inhibition of phagosomal maturation...