Isabelle Vergne

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. pmc Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    EMBO J 28:2244-58. 2009
  2. pmc The role of PI3P phosphatases in the regulation of autophagy
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    FEBS Lett 584:1313-8. 2010
  3. ncbi request reprint Cell biology of mycobacterium tuberculosis phagosome
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 001, USA
    Annu Rev Cell Dev Biol 20:367-94. 2004
  4. ncbi request reprint Autophagy in immune defense against Mycobacterium tuberculosis
    Isabelle Vergne
    Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 001, USA
    Autophagy 2:175-8. 2006
  5. ncbi request reprint Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Cell Microbiol 8:719-27. 2006
  6. pmc Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
    Sudha B Singh
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA
    Nat Cell Biol 12:1154-65. 2010
  7. pmc Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Curr Top Microbiol Immunol 335:169-88. 2009
  8. pmc Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
    George B Kyei
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Cell Biol 186:255-68. 2009
  9. pmc Autophagy and pattern recognition receptors in innate immunity
    Monica Delgado
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Immunol Rev 227:189-202. 2009
  10. pmc Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties
    Marisa Ponpuak
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Immunity 32:329-41. 2010

Collaborators

Detail Information

Publications21

  1. pmc Control of autophagy initiation by phosphoinositide 3-phosphatase Jumpy
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    EMBO J 28:2244-58. 2009
    ....
  2. pmc The role of PI3P phosphatases in the regulation of autophagy
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    FEBS Lett 584:1313-8. 2010
    ..This review sums up our knowledge on PI3P phosphatases and discusses the recent progress on their role in autophagy...
  3. ncbi request reprint Cell biology of mycobacterium tuberculosis phagosome
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 001, USA
    Annu Rev Cell Dev Biol 20:367-94. 2004
    ..Here we review the fundamental trafficking processes targeted by M. tuberculosis and the mycobacterial products that interfere with phagosomal maturation...
  4. ncbi request reprint Autophagy in immune defense against Mycobacterium tuberculosis
    Isabelle Vergne
    Departments of Molecular Genetics and Microbiology and Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 001, USA
    Autophagy 2:175-8. 2006
    ..Induction of autophagy overcomes the mycobacterial phagosome maturation block, and delivers the tubercle bacilli to degradative compartments where they are eliminated...
  5. ncbi request reprint Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Cell Microbiol 8:719-27. 2006
    ..tuberculosis survival. This review summarizes the findings centred around the PI3P-nexus where the mycobacterial phagosome maturation block and execution stages of autophagy intersect...
  6. pmc Human IRGM regulates autophagy and cell-autonomous immunity functions through mitochondria
    Sudha B Singh
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131 USA
    Nat Cell Biol 12:1154-65. 2010
    ..By acting on mitochondria, IRGM confers autophagic protection or cell death, explaining IRGM action both in defence against tuberculosis and in the damaging inflammation caused by Crohn's disease...
  7. pmc Autophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagy
    Vojo Deretic
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, NM 87131, USA
    Curr Top Microbiol Immunol 335:169-88. 2009
    ..This work and related studies by others have led us to propose a model of how autophagy, an ancient innate immunity defense, became integrated over the course of evolution with other immune mechanisms of ever-increasing complexity...
  8. pmc Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
    George B Kyei
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    J Cell Biol 186:255-68. 2009
    ..The role of Nef in the latter process enhances yields of infectious HIV and may be of significance for progression to clinical AIDS...
  9. pmc Autophagy and pattern recognition receptors in innate immunity
    Monica Delgado
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Immunol Rev 227:189-202. 2009
    ....
  10. pmc Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties
    Marisa Ponpuak
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Immunity 32:329-41. 2010
    ..tuberculosis. Thus, p62 brings cytosolic proteins to autolysosomes where they are processed from innocuous precursors into neo-antimicrobial peptides, explaining in part the unique bactericidal properties of autophagic organelles...
  11. pmc Mechanism of inducible nitric oxide synthase exclusion from mycobacterial phagosomes
    Alexander S Davis
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America
    PLoS Pathog 3:e186. 2007
    ..Our findings are consistent with a model for the block in iNOS association with mycobacterial phagosomes as a mechanism dependent primarily on reduced EBP50 recruitment...
  12. pmc Rab14 is critical for maintenance of Mycobacterium tuberculosis phagosome maturation arrest
    George B Kyei
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
    EMBO J 25:5250-9. 2006
    ..Rab14 enables mycobacterial phagosomes to maintain early endosomal characteristics and avoid late endosomal/lysosomal degradative components...
  13. pmc Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 102:4033-8. 2005
    ..tuberculosis secretes a lipid phosphatase, SapM, that hydrolyzes PI3P, inhibits phagosome-late endosome fusion in vitro, and contributes to inhibition of phagosomal maturation...
  14. ncbi request reprint Endosomal membrane traffic: convergence point targeted by Mycobacterium tuberculosis and HIV
    Vojo Deretic
    Department of Molecular Genetics, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Cell Microbiol 6:999-1009. 2004
    ..We propose that interference with the endosomal sorting machinery contributes to the synergism between the two significant human diseases--AIDS and tuberculosis...
  15. pmc Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA
    J Exp Med 198:653-9. 2003
    ..tuberculosis residence in vacuoles sequestered away from the bactericidal and antigen-processing organelles in infected macrophages...
  16. pmc Mycobacterium tuberculosis phagosome maturation arrest: mycobacterial phosphatidylinositol analog phosphatidylinositol mannoside stimulates early endosomal fusion
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, 87131, USA
    Mol Biol Cell 15:751-60. 2004
    ..tuberculosis has evolved a two-prong strategy to modify its intracellular niche: its products block acquisition of late endosomal/lysosomal constituents, while facilitating fusion with early endosomal compartments...
  17. ncbi request reprint Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico Medical School, Albuquerque, NM 87131, USA
    Traffic 4:600-6. 2003
    ..M. tuberculosis analogs of mammalian phosphatidylinositols interfere with these systems and associated processes...
  18. ncbi request reprint A tale of two lipids: Mycobacterium tuberculosis phagosome maturation arrest
    Jennifer Chua
    Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE Albuquerque, NM 87131 001, USA
    Curr Opin Microbiol 7:71-7. 2004
    ..Understanding these processes could provide new targets for pharmacological intervention in tuberculosis...
  19. doi request reprint In vitro phagosome-endosome fusion
    Isabelle Vergne
    Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
    Methods Mol Biol 445:301-9. 2008
    ..Fusion is quantified using a fluorescence-based detection method that measures the peroxidase activity associated with the beads...
  20. pmc Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
    Chengyu Liang
    Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA 90033, USA
    Nat Cell Biol 10:776-87. 2008
    ....
  21. pmc Mycobacterium tuberculosis glycosylated phosphatidylinositol causes phagosome maturation arrest
    Rutilio A Fratti
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 100:5437-42. 2003
    ..These findings identify ManLAM as the M. tuberculosis product responsible for the inhibition of phagosomal maturation...