Research Topics
Genomes and Genes | Donata VercelliSummaryAffiliation: University of Arizona Country: USA Publications
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Publications
Genetic regulation of IgE responses: Achilles and the tortoiseDonata Vercelli
Functional Genomics Laboratory, Arizona Respiratory Center, Department of Cell Biology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
J Allergy Clin Immunol 116:60-4. 2005..Here we will argue that an essential component of this integration is the functional analysis of the mechanisms through which natural variation affects pathways relevant to the pathogenesis of IgE-dependent inflammation...
Gene-environment interactions in asthma and allergy: the end of the beginning?Donata Vercelli
Arizona Respiratory Center, Arizona Center for the Biology of Complex Diseases ABCD, and Department of Cell Biology, College of Medicine, University of Arizona, Tucson, Arizona, USA
Curr Opin Allergy Clin Immunol 10:145-8. 2010..This review presents recent findings illustrating the role of gene-environment interactions in asthma/allergy susceptibility...- Mechanisms of the hygiene hypothesis--molecular and otherwiseDonata Vercelli
Arizona Respiratory Center, University of Arizona Health Science Center, Rm 2349, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
Curr Opin Immunol 18:733-7. 2006.... 
Discovering susceptibility genes for asthma and allergyDonata Vercelli
Functional Genomics Laboratory, Arizona Respiratory Center, Department of Cell Biology and The Bio5 Institute, University of Arizona, PO Box 245044, Tucson, Arizona 85724 5044, USA
Nat Rev Immunol 8:169-82. 2008..Despite the achievements made in asthma genetics formidable challenges remain. The development of novel, powerful tools for gene discovery, and a closer integration of genetics and biology, should help to overcome these challenges...- Advances in asthma and allergy genetics in 2007Donata Vercelli
Functional Genomics Laboratory, Arizona Respiratory Center, and the Department of Cell Biology, University of Arizona, Tucson, Ariz, USA
J Allergy Clin Immunol 122:267-71. 2008.... - Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammationLisa Cameron
Functional Genomics Laboratory, and Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
J Immunol 177:8633-42. 2006..Our findings suggest the nuclear milieu dictates the functional outcome of genetic variation... - IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammationFrank D Vladich
Functional Genomics Laboratory, Arizona Respiratory Center and Department of Cell Biology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
J Clin Invest 115:747-54. 2005..Collectively, our data indicate that natural variation in the coding region of IL13 may be an important genetic determinant of susceptibility to allergy... - An allergy-associated polymorphism in a novel regulatory element enhances IL13 expressionPatricia Kiesler
Functional Genomics Laboratory, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85719, USA
Hum Mol Genet 18:4513-20. 2009..Our results illustrate how a functional variant in a regulatory element enhances transcription of an allergy-associated gene, thereby modulating disease susceptibility... - NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cellsPatricia Kiesler
Functional Genomics Laboratory, Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85719, USA
J Biol Chem 285:8256-67. 2010..Collectively, our results identify NF45 and NF90 as novel regulators of HS4-dependent human IL13 transcription in response to T cell activation... - Genetics of IL-13 and functional relevance of IL-13 variantsDonata Vercelli
Arizona Respiratory Center, Tucson, USA
Curr Opin Allergy Clin Immunol 2:389-93. 2002..IL-13 is therefore an ideal model to study the impact of genetic variation on the regulation of gene expression and function in complex diseases... - Exposure to a farming environment has allergen-specific protective effects on TH2-dependent isotype switching in response to common inhalantsDebra A Stern
Functional Genomics Laboratory, Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
J Allergy Clin Immunol 119:351-8. 2007..IgE synthesis by human B cells results from allergen-dependent, T(H)2-mediated isotype switching. Exposure to a farming environment protects against IgE responses... - The human IL-13 locus in neonatal CD4+ T cells is refractory to the acquisition of a repressive chromatin architectureRobin B Webster
Functional Genomics Laboratory, University of Arizona, Tucson, Arizona 85724, USA
J Biol Chem 282:700-9. 2007.... - Phylogenetic and functional analysis identifies Ets-1 as a novel regulator of the Th2 cytokine gene locusJannine M Strempel
Functional Genomics Laboratory, Arizona Respiratory Center, Tucson, AZ 85719, USA
J Immunol 184:1309-16. 2010..Collectively, these data suggest that Ets-1 contributes to Th2 cytokine gene regulation by interacting with multiple cis-regulatory regions throughout the Th2 locus... - The functional genomics of CD14 and its role in IgE responses: an integrated viewDonata Vercelli
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson 85724, USA
J Allergy Clin Immunol 109:14-21. 2002..In this scenario, the environment is likely to play an essential role in determining the functional outcome of genetic variation... - Rethinking Th2 antibody responses and allergic sensitizationDebra Stern
Arizona Respiratory Center and Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, AZ, USA
Novartis Found Symp 257:25-37; discussion 37-50, 276-85. 2004..These results appear to recapitulate different stages of in vivo Th2-dependent sequential switching from IgG4 to IgE. These patterns of Th2-induced antibody responses may warrant a redefinition of the notion of allergen sensitization... - The farm effect, or: when, what and how a farming environment protects from asthma and allergic diseaseGabriela Wlasiuk
Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
Curr Opin Allergy Clin Immunol 12:461-6. 2012.... - Functional dissection identifies a conserved noncoding sequence-1 core that mediates IL13 and IL4 transcriptional enhancementJannine M Strempel
Functional Genomics Laboratory, Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
J Biol Chem 282:3738-46. 2007.... - Environmental determinants of and impact on childhood asthma by the bacterial community in household dustRaina M Maier
Department of Soil, Water and Environmental Science, University of Arizona, 429 Shantz Building 38, Tucson, AZ 85721, USA
Appl Environ Microbiol 76:2663-7. 2010..0103) and specific IgE (P = 0.0184). Our findings suggest that specific bacterial populations within the community are associated with either risk or protection from asthma... - The regulation of IgE synthesisDonata Vercelli
University of Arizona, Tucson, Arizona, USA
Clin Allergy Immunol 16:179-96. 2002 - Genetics, epigenetics, and the environment: switching, buffering, releasingDonata Vercelli
Functional Genomics Laboratory, Arizona Respiratory Center, Tucson, AZ 85724, USA
J Allergy Clin Immunol 113:381-6; quiz 387. 2004.... - S epsilon S mu and S epsilon S gamma switch circles in human nasal mucosa following ex vivo allergen challenge: evidence for direct as well as sequential class switch recombinationLisa Cameron
Meakins Christie Laboratories, Department of Pathology and Medicine, McGill University, Montreal, Canada
J Immunol 171:3816-22. 2003..This work strongly suggests that B cells residing within the nasal mucosa undergo switching to IgE in the context of a local immune response to allergen... - Arginase: marker, effector, or candidate gene for asthma?Donata Vercelli
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724 5030, USA
J Clin Invest 111:1815-7. 2003.... - Genetic polymorphism in allergy and asthmaDonata Vercelli
Functional Genomics Laboratory, Arizona Respiratory Center, University of Arizona Health Sciences Center, Room 2349, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
Curr Opin Immunol 15:609-13. 2003..The interplay between genes and environment adds another layer of complexity to the determination of allergic phenotypes. The complexity emerging from these studies warrants novel experimental strategies and bolder conceptual paradigms... - Myb proteins repress human Ig epsilon germline transcription by inhibiting STAT6-dependent promoter activationSilvia Monticelli
Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ 85724, USA
Mol Immunol 38:1129-38. 2002..Our results indicate that Myb proteins, which are known to act as cell cycle sensors, may play an important mechanistic role in the in vivo regulation of epsilon GL transcription in human B cells... - Innate immunity: sensing the environment and regulating the regulatorsDonata Vercelli
Funxctional Genomics Laboratory, Arizona Respiratory Center and Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, 85724, USA
Curr Opin Allergy Clin Immunol 3:343-6. 2003..Great progress has been made in the past year in characterizing the signaling pathways downstream of Toll-like receptors, and the role of Toll-like receptors in the regulation of pathogen responses... - Novel insights into class switch recombinationDonata Vercelli
Arizona Respiratory Center and Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
Curr Opin Allergy Clin Immunol 2:147-51. 2002.... - IL-21 effects on human IgE production in response to IL-4 or IL-13Nancy Wood
Wyeth Research, Cambridge, MA, USA
Cell Immunol 231:133-45. 2004..In contrast, IL-21-stimulated secretion of IgG4 from PBMC. Our findings indicate that IL-21 may influence the production of both human IgE and IgG4, and thus contribute to the regulation of atopic reactions... - Association of defensin beta-1 gene polymorphisms with asthmaHara Levy
Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
J Allergy Clin Immunol 115:252-8. 2005..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness... - Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypesBenjamin A Raby
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 166:1449-56. 2002..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility... - Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human diseaseRoss Lazarus
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Immunol Rev 190:9-25. 2002..These and other factors must be taken into account in the design and analysis of disease association studies... - TOLL-like receptor 10 genetic variation is associated with asthma in two independent samplesRoss Lazarus
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 170:594-600. 2004..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk... - Inhibition of CXCR4-tropic HIV-1 infection by lipopolysaccharide: evidence of different mechanisms in macrophages and T lymphocytesAlessia Verani
Human Virology Unit, DIBIT, San Raffaele Scientific Institute, Milan, Italy
J Immunol 168:6388-95. 2002..These results suggest the existence of potent HIV-1 inhibitory factor(s), uncharacterized to date, released by activated cells of the mononuclear phagocytic system... - Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studiesRoss Lazarus
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Genomics 81:85-91. 2003..This study suggests that there is substantial diversity in human TLR9, possibly associated with asthma in Europeans but not African Americans. No association was detected with three other diseases potentially related to innate immunity... - c-Rel is a selective activator of a novel IL-4/CD40 responsive element in the human Ig gamma4 germline promoterAlessandra Agresti
Molecular Immunoregulation Unit, San Raffaele Scientific Institute, 20132 Milan, Italy
Mol Immunol 38:849-59. 2002..These results indicate that c-Rel is selectively involved in the CD40-dependent activation of the IL-4/CD40 RE in the proximal gamma4 GL promoter... - The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enoughDonata Vercelli
J Allergy Clin Immunol 117:1303-5. 2006 - Advances in asthma, allergy mechanisms, and genetics in 2006Fred D Finkelman
Division of Immunology, University of Cincinnati, Cincinnati, Ohio, USA
J Allergy Clin Immunol 120:544-50. 2007....
Research Grants
- HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMSDonata Vercelli; Fiscal Year: 2009..abstract_text> ..
- HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMSDonata Vercelli; Fiscal Year: 2007....
- Impact of Genetic Variation on Th Cell DifferentiationDonata Vercelli; Fiscal Year: 2005....
- HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMSDonata Vercelli; Fiscal Year: 2004....
- FUNCTIONAL GENOMICS CENTER FOR INNATE IMMUNITY PGADonata Vercelli; Fiscal Year: 2003..abstract_text> ..
- HUMAN IL-13 GENE REGULATION AND IMPACT OF POLYMORPHISMSDonata Vercelli; Fiscal Year: 2011..Our studies will be the first to explore human Th2 cytokine regulation in vivo and will identify novel rational targets for effective treatments of allergic disease. ..