Senthil K Venugopal

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Curr Opin Nephrol Hypertens 14:33-7. 2005
  2. pmc Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation
    Senthil K Venugopal
    Dept of Internal Medicine, Transplant Research Program, 4635 2nd Ave, Research Bldg I, Rm 1001, UCDavis Medical Ctr, Sacramento, CA 95817, USA
    Am J Physiol Gastrointest Liver Physiol 298:G101-6. 2010
  3. doi request reprint Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis
    Sangjeong Yoon
    Department of Internal Medicine Transplant Research Program, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Liver Int 30:376-87. 2010
  4. doi request reprint A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells
    Tae Hun Kim
    Department of Internal Medicine, Transplant Research Program, University of California Davis Medical Center, 4635 2nd Ave Research Building I, Room 1001, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 379:876-81. 2009
  5. ncbi request reprint Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells
    Senthil K Venugopal
    Department of Internal Medicine, Transplant Research Program, UC Davis Medical Center, Sacramento, California 95817, USA
    J Biol Chem 282:31900-8. 2007
  6. ncbi request reprint C-reactive protein: risk marker or mediator in atherothrombosis?
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Ave, Res 1 Bldg, Rm 3000, Sacramento, Calif 95817, USA
    Hypertension 44:6-11. 2004
  7. doi request reprint miRNA regulation of liver growth after 50% partial hepatectomy and small size grafts in rats
    Xiaoli Chen
    Department of Internal Medicine, Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Transplantation 91:293-9. 2011
  8. ncbi request reprint Development of an in vitro screening assay to test the antiinflammatory properties of dietary supplements and pharmacologic agents
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, 95817, USA
    Clin Chem 51:2252-6. 2005
  9. ncbi request reprint Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms
    Yanhong Zhang
    Department of Internal Medicine, Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Cell Signal 19:2339-50. 2007
  10. ncbi request reprint Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice
    Song Qing He
    Transplant Research Institute, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Liver Transpl 12:1869-79. 2006

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Effect of C-reactive protein on vascular cells: evidence for a proinflammatory, proatherogenic role
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, Sacramento, CA 95817, USA
    Curr Opin Nephrol Hypertens 14:33-7. 2005
    ..Recent evidence from different cell types suggests that CRP is not only a risk marker but may also be a participant in atherogenesis. This review will focus on the effects of CRP on different cells involved in atherosclerosis...
  2. pmc Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation
    Senthil K Venugopal
    Dept of Internal Medicine, Transplant Research Program, 4635 2nd Ave, Research Bldg I, Rm 1001, UCDavis Medical Ctr, Sacramento, CA 95817, USA
    Am J Physiol Gastrointest Liver Physiol 298:G101-6. 2010
    ..We conclude that both miRNA-150 and miRNA-194 inhibit HSC activation and ECM production, at least in part, via inhibition of c-myb and rac 1 expression...
  3. doi request reprint Acute liver injury upregulates microRNA-491-5p in mice, and its overexpression sensitizes Hep G2 cells for tumour necrosis factor-alpha-induced apoptosis
    Sangjeong Yoon
    Department of Internal Medicine Transplant Research Program, University of California Davis Medical Center, Sacramento, CA 95817, USA
    Liver Int 30:376-87. 2010
    ..MicroRNAs (miRNAs) have emerged as novel genetic regulators of cell functions such as proliferation, apoptosis and cancer...
  4. doi request reprint A novel small molecule, LAS-0811, inhibits alcohol-induced apoptosis in VL-17A cells
    Tae Hun Kim
    Department of Internal Medicine, Transplant Research Program, University of California Davis Medical Center, 4635 2nd Ave Research Building I, Room 1001, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 379:876-81. 2009
    ..The results indicate that LAS-0811 protects VL-17A cells against ethanol-induced oxidative stress and apoptosis at least in part via nrf2 activation...
  5. ncbi request reprint Role of MAPK phosphatase-1 in sustained activation of JNK during ethanol-induced apoptosis in hepatocyte-like VL-17A cells
    Senthil K Venugopal
    Department of Internal Medicine, Transplant Research Program, UC Davis Medical Center, Sacramento, California 95817, USA
    J Biol Chem 282:31900-8. 2007
    ..Ethanol-induced oxidative stress enhanced the tyrosine phosphorylation of PKCdelta, which in turn caused the proteasomal degradation of MKP-1, leading to sustained JNK activation and increased apoptosis in VL-17A cells...
  6. ncbi request reprint C-reactive protein: risk marker or mediator in atherothrombosis?
    Ishwarlal Jialal
    Laboratory for Atherosclerosis and Metabolic Research, UC Davis Medical Center, 4635 Second Ave, Res 1 Bldg, Rm 3000, Sacramento, Calif 95817, USA
    Hypertension 44:6-11. 2004
    ..In conclusion, CRP is a risk marker for cardiovascular disease and, based on future studies, could emerge as a mediator in atherogenesis...
  7. doi request reprint miRNA regulation of liver growth after 50% partial hepatectomy and small size grafts in rats
    Xiaoli Chen
    Department of Internal Medicine, Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Transplantation 91:293-9. 2011
    ..The aim of this study is to identify critical miRNA species that modulate the growth of small grafts and the remaining livers after partial hepatectomy (PH)...
  8. ncbi request reprint Development of an in vitro screening assay to test the antiinflammatory properties of dietary supplements and pharmacologic agents
    Uma Singh
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California, Davis Medical Center, Sacramento, 95817, USA
    Clin Chem 51:2252-6. 2005
    ..The aim of this study was to develop a rapid in vitro screening assay to test the antiinflammatory effects of different compounds...
  9. ncbi request reprint Ethanol induces apoptosis in hepatocytes by a pathway involving novel protein kinase C isoforms
    Yanhong Zhang
    Department of Internal Medicine, Transplant Research Program, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Cell Signal 19:2339-50. 2007
    ..Conclusion: These results provide a newly-described mechanism by which ethanol induces apoptosis via activation of nPKC isoforms in hepatocytes...
  10. ncbi request reprint Delivery of antioxidative enzyme genes protects against ischemia/reperfusion-induced liver injury in mice
    Song Qing He
    Transplant Research Institute, University of California, Davis Medical Center, Sacramento, CA 95817, USA
    Liver Transpl 12:1869-79. 2006
    ..The protection is directly associated with elevated antioxidative enzyme activity as the result of the gene delivery. This novel approach may become a potential therapy to improve graft function and survival after liver transplantation...
  11. ncbi request reprint Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, The University of California Davis Medical Center, 4635, II Ave, Res 1 Bldg, Rm 3000, Sacramento, CA 95817, USA
    Diabetes 54:85-91. 2005
    ..Thus, inhibition of PKC-alpha and -beta can ameliorate the proinflammatory state of diabetes...
  12. pmc Macrophage conditioned medium induces the expression of C-reactive protein in human aortic endothelial cells: potential for paracrine/autocrine effects
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology and Laboratory Medicine, University of California Medical Center, Sacramento, CA 95817, USA
    Am J Pathol 166:1265-71. 2005
    ....
  13. ncbi request reprint C-reactive protein decreases prostacyclin release from human aortic endothelial cells
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, University of California Davis Medical Center, Sacramento, Calif, USA
    Circulation 108:1676-8. 2003
    ..PGI2 is a potent vasodilator and inhibitor of platelet aggregation. Hence, the aim of this study was to examine the effect of CRP on PGI2 release from HAECs and human coronary artery endothelial cells (HCAECs)...
  14. ncbi request reprint Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
    Senthil Kumar Venugopal
    Laboratory for Atherosclerosis and Metabolic Research, Department of Pathology, UC Davis Medical Center, Sacramento, Calif 95817, USA
    Circulation 106:1439-41. 2002
    ..C-reactive protein (CRP), the prototypic marker of inflammation, has been shown to be an independent predictor of cardiovascular events. Endothelial nitric oxide synthase (eNOS) deficiency is a pivotal event in atherogenesis...