R Venkataramanan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures
    R Venkataramanan
    Department of Pharmaceutical Sciences School of Pharmacy, Pennsylvania, USA
    Drug Metab Dispos 28:1270-3. 2000
  2. ncbi request reprint Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes
    V Ramachandran
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Drug Metab Dispos 27:1194-9. 1999
  3. ncbi request reprint Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats
    Hui Tian
    718 Salk Hall, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Metab Dispos 33:329-35. 2005
  4. pmc Long-term function and morphology of intestinal allografts in outbred canine transplantation model
    K Iwanami
    Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Transplant Proc 34:994-5. 2002
  5. ncbi request reprint Pharmacokinetics of mycophenolic acid after mycophenolate mofetil administration in liver transplant patients treated with tacrolimus
    A Jain
    School of Pharmacy, University of Pittsburgh, Pennsylvania 15261, USA
    J Clin Pharmacol 41:268-76. 2001
  6. pmc Bioavailability and population pharmacokinetics of voriconazole in lung transplant recipients
    K Han
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 54:4424-31. 2010
  7. ncbi request reprint The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures
    V E Kostrubsky
    University of Pittsburgh Medical Center, Department of Pathology, Pittsburgh, Pennsylvania, USA
    Drug Metab Dispos 28:1192-7. 2000
  8. ncbi request reprint Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus
    R Sindhi
    Thomas E Starzl Transplantation Institute, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Transplantation 72:851-5. 2001
  9. doi request reprint Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506)
    P N V Tata
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Xenobiotica 39:757-65. 2009
  10. ncbi request reprint Intestinal function and morphology after ex vivo irradiated small bowel transplantation
    T Ishikawa
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplant Proc 34:988-9. 2002

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures
    R Venkataramanan
    Department of Pharmaceutical Sciences School of Pharmacy, Pennsylvania, USA
    Drug Metab Dispos 28:1270-3. 2000
    ..Indiscriminate use of herbal products may lead to altered pharmacokinetics of certain drugs and may result in increased toxicity of certain drugs...
  2. ncbi request reprint Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes
    V Ramachandran
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Drug Metab Dispos 27:1194-9. 1999
    ..At concentrations of 25 microM and above, TRO was toxic to the cells, as determined by a decrease in the activity of CYP3A, a reduction in the amount of immunoreactive protein, and changes in the morphology of the cells...
  3. ncbi request reprint Pharmacokinetics of tacrolimus and mycophenolic acid are altered, but recover at different times during hepatic regeneration in rats
    Hui Tian
    718 Salk Hall, Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Metab Dispos 33:329-35. 2005
    ..Caution must be exercised in extrapolating in vitro data to in vivo conditions during hepatic regeneration...
  4. pmc Long-term function and morphology of intestinal allografts in outbred canine transplantation model
    K Iwanami
    Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Transplant Proc 34:994-5. 2002
  5. ncbi request reprint Pharmacokinetics of mycophenolic acid after mycophenolate mofetil administration in liver transplant patients treated with tacrolimus
    A Jain
    School of Pharmacy, University of Pittsburgh, Pennsylvania 15261, USA
    J Clin Pharmacol 41:268-76. 2001
    ..Changes in albumin appear to partially contribute to the variations in the pharmacokinetics of MPA in liver transplant patients...
  6. pmc Bioavailability and population pharmacokinetics of voriconazole in lung transplant recipients
    K Han
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 54:4424-31. 2010
    ..However, voriconazole levels should be monitored, and the dose should be individualized based on trough concentrations as a good measure of drug exposure...
  7. ncbi request reprint The role of conjugation in hepatotoxicity of troglitazone in human and porcine hepatocyte cultures
    V E Kostrubsky
    University of Pittsburgh Medical Center, Department of Pathology, Pittsburgh, Pennsylvania, USA
    Drug Metab Dispos 28:1192-7. 2000
    ..These results suggest that inhibition of troglitazone sulfation may result in increased hepatotoxicity due to exposure to parent drug, or increased metabolism by alternate pathways...
  8. ncbi request reprint Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimus
    R Sindhi
    Thomas E Starzl Transplantation Institute, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Transplantation 72:851-5. 2001
    ..Rescue indications for TAC toxicity were nephrotoxicity, pancreatitis, seizures, hypertrophic cardiomyopathy, and graft-versus-host disease...
  9. doi request reprint Species-dependent hepatic metabolism of immunosuppressive agent tacrolimus (FK-506)
    P N V Tata
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Xenobiotica 39:757-65. 2009
    ..From the current in-vitro metabolism studies, the pattern of tacroliums metabolism in baboons closely resembled that in humans and thus it is ideal for studying tacroliums metabolism-related work of clinical relevance...
  10. ncbi request reprint Intestinal function and morphology after ex vivo irradiated small bowel transplantation
    T Ishikawa
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplant Proc 34:988-9. 2002
  11. ncbi request reprint Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450
    E G Schuetz
    Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 276:39411-8. 2001
    ....
  12. doi request reprint Systemic delivery of atropine sulfate by the MicroDose Dry-Powder Inhaler
    T E Corcoran
    University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Aerosol Med Pulm Drug Deliv 26:46-55. 2013
    ..4 mg per dose (nominal) delivered over 12 min] and received a 2-mg IM injection via the AtroPen® auto-injector on another. Pharmacokinetics, pharmacodynamic response, and safety were studied for 12 hr...
  13. doi request reprint The impact of conversion from prograf to generic tacrolimus in liver and kidney transplant recipients with stable graft function
    J D Momper
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 11:1861-7. 2011
    ..These results suggest that transplant patients currently taking the reference tacrolimus formulation may be safely switched to the Sandoz-generic product provided trough concentrations are closely monitored following the substitution...
  14. ncbi request reprint Clinical utility of monitoring tacrolimus blood concentrations in liver transplant patients
    R Venkataramanan
    Department of Pharmaceutical Sciences, Pathology, and Surgery, University of Pittsburgh, Pennsylvania 15261, USA
    J Clin Pharmacol 41:542-51. 2001
    ....
  15. doi request reprint Treprostinil, a prostacyclin analog, ameliorates ischemia-reperfusion injury in rat orthotopic liver transplantation
    N Ghonem
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 11:2508-16. 2011
    ..Treprostinil protected the liver graft against IRI during OLT. Treprostinil has the potential to serve as a therapeutic option to protect the liver graft against I/R injury in patients undergoing OLT...
  16. pmc Voriconazole pharmacokinetics in liver transplant recipients
    H J Johnson
    University of Pittsburgh, Medical Center, Pittsburgh, PA 15232, USA
    Antimicrob Agents Chemother 54:852-9. 2010
    ..Given that trough voriconazole concentration is a good measure of drug exposure (AUC), the voriconazole dose can be individualized based on trough concentration measurements in liver transplant patients...
  17. ncbi request reprint Pharmacodynamics of sirolimus in transplanted children receiving tacrolimus
    Rakesh Sindhi
    Pediatric Transplantation, Children s Hospital of Pittsburgh, 3705 Fifth Avenue, Pittsburgh, PA 15217, USA
    Transplant Proc 34:1960. 2002
  18. pmc Pharmacotherapy in cancer patients with HIV/AIDS
    J H Beumer
    1 Molecular Therapeutics and Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA 2 Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Clin Pharmacol Ther 95:370-2. 2014
    ..Although drug interactions are a major concern when combining these agents, there is currently limited guidance on dose adjustments required to maintain safe and efficacious drug exposure. ..
  19. ncbi request reprint Interaction between tacrolimus and antiretroviral agents in human immunodeficiency virus-positive liver and kidney transplantation patients
    A K B Jain
    Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, 3601 Fifth Avenue, Falk Medical Building 4th Floor, Pittsburgh, PA 15213, USA
    Transplant Proc 34:1540-1. 2002
  20. ncbi request reprint Aerosol deposition of lipid complex amphotericin-B (Abelcet) in lung transplant recipients
    T E Corcoran
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Transplant 6:2765-73. 2006
    ..These studies provide an important precursor to studies of the efficacy of inhaled ABLC as a prophylaxis of invasive aspergillosis after lung transplant...
  21. ncbi request reprint Replacing calcineurin inhibitors with mTOR inhibitors in children
    Rakesh Sindhi
    Children s Hospital of Pittsburgh and the University of Pittsburgh, Pittsburgh, PA 15217, USA
    Pediatr Transplant 9:391-7. 2005
    ..Improvement in renal function and hypertension management, and absence of sirolimus-related adverse events argue for prospective evaluation of regimens in which mTOR inhibitors are used without calcineurin inhibitors in children...
  22. ncbi request reprint Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats
    Hui Tian
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pharm Res 22:2007-15. 2005
    ....
  23. ncbi request reprint In vitro and in vivo assessment of herb drug interactions
    Raman Venkataramanan
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh PA 15261, USA
    Life Sci 78:2105-15. 2006
    ..Further systematic studies are necessary to assess the significance of herb drug interactions...
  24. ncbi request reprint MDR1 genotype is associated with hepatic cytochrome P450 3A4 basal and induction phenotype
    Jatinder Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Clin Pharmacol Ther 79:325-38. 2006
    ..This study investigated whether common single-nucleotide polymorphisms (SNPs) in multidrug resistance 1 (MDR1), encoding P-glycoprotein, or the pregnane X receptor (PXR) were associated with basal or inducible CYP3A4 expression...
  25. doi request reprint Pharmacokinetics of mycophenolic acid in live donor liver transplant patients vs deceased donor liver transplant patients
    Ashok Jain
    University of Rochester Medical Center, Department of Surgery, Division of Solid Organ Transplantation, Rochester, NY 14642, USA
    J Clin Pharmacol 48:547-52. 2008
    ..These observations point to the need to use a lower dosage (approximately 30%) of mycophenolate mofetil in live donor liver transplant patients compared with deceased donor liver transplant patients...
  26. ncbi request reprint Sirolimus pharmacokinetic differences between children and adults
    Raman Venkataramanan
    Pediatr Transplant 10:872-4. 2006
  27. ncbi request reprint Pharmacokinetics of mycophenolic acid in liver transplant patients after intravenous and oral administration of mycophenolate mofetil
    Ashok Jain
    Department of Surgery, Division of Transplantation, University of Rochester Medical Center, Rochester, NY 14642, USA
    Liver Transpl 13:791-6. 2007
    ..In conclusion, during the early postoperative period, LTx recipients have MPA exposure with oral MMF of less than half that of IV MMF. Use of IV MMF immediately post-LTx may provide an immunological advantage...
  28. ncbi request reprint Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression
    Jatinder Lamba
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Drug Metab Dispos 36:169-81. 2008
    ....
  29. pmc Functional evolution of the vitamin D and pregnane X receptors
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Evol Biol 7:222. 2007
    ..In addition, several assays were used to search for evidence of PXR-mediated hepatic effects in three model non-mammalian species: sea lamprey (Petromyzon marinus), zebrafish (Danio rerio), and African clawed frog (Xenopus laevis)...
  30. doi request reprint Pharmacokinetics of tacrolimus in living donor liver transplant and deceased donor liver transplant recipients
    Ashok Jain
    Department of Surgery, Division of Solid Organ Transplant, University of Rochester Medical Center, Rochester, NY, USA
    Transplantation 85:554-60. 2008
    ..AIM.: The aim of the present study is to compare the dosage, concentration and pharmacokinetics parameters of tacrolimus between LDLT and deceased donor liver transplant (DDLT) recipients...
  31. ncbi request reprint Intraindividual and interindividual variations in the pharmacokinetics of mycophenolic acid in liver transplant patients
    Jaya Pisupati
    Department of Pharmaceutical Sciences and Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA
    J Clin Pharmacol 45:34-41. 2005
    ..The observations in this study support the concept of measuring the unbound concentration of mycophenolic acid to optimize immunosuppressive drug therapy with mycophenolic acid...
  32. ncbi request reprint Morphology and function of canine small intestinal autografts: with particular interest in the influence of ex vivo graft irradiation
    Takashi Ishikawa
    Thomas, E, Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Gastrointest Surg 7:662-71. 2003
    ..Graft irradiation did not induce further defects in intestinal function or cause histopathologic abnormalities...
  33. ncbi request reprint Lung deposition and pharmacokinetics of cyclosporine after aerosolization in lung transplant patients
    Gilbert J Burkart
    Department of Pharmacy and Therapeutics, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Pharm Res 20:252-6. 2003
    ..The objective of this study is to evaluate the lung deposition and systemic absorption of aCsA after aerosolized cyclosporine administration in LTx patients in the immediate postoperative period...
  34. ncbi request reprint Long-term function and morphology of intestinal autografts and allografts in outbred dogs
    Kotaro Iwanami
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Am J Transplant 3:1083-90. 2003
    ..Results also indicate that these allografts experienced low-grade chronic rejection as evidenced in the submucosa and muscle layers, despite the lack of clinical symptoms...
  35. ncbi request reprint Effect of coadministered lopinavir and ritonavir (Kaletra) on tacrolimus blood concentration in liver transplantation patients
    Ashokkumar B Jain
    Department of Surgery, Division of Transplantation, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Liver Transpl 9:954-60. 2003
    ..Great caution is required in the management of tacrolimus dosage when Kaletra is introduced or withdrawn in HIV-positive patients after liver transplantation, particularly in the presence of hepatic dysfunction...
  36. ncbi request reprint Phenytoin decreases the blood concentrations of sirolimus in a liver transplant recipient: a case report
    Jonathan A Fridell
    Department of Surgery, Indiana University School of Medicine, Indianapolis, USA
    Ther Drug Monit 25:117-9. 2003
    ..It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends...
  37. ncbi request reprint The interaction between antiretroviral agents and tacrolimus in liver and kidney transplant patients
    Ashok Kumar B Jain
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 8:841-5. 2002
    ..Great caution and frequent drug level monitoring are necessary when HAART is introduced or withdrawn in HIV-positive recipients of organ transplants...
  38. ncbi request reprint Pharmacokinetics of sirolimus and tacrolimus in pediatric transplant patients
    Marika Schubert
    Thomas E Starzl Transplantation Institute of the Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Am J Transplant 4:767-73. 2004
    ..During conversion of subjects from TAC to combined TAC and SRL, aggressive therapeutic drug monitoring must be used to individualize therapy and avoid serous adverse events...
  39. pmc Voriconazole inhibition of the metabolism of tacrolimus in a liver transplant recipient and in human liver microsomes
    Raman Venkataramanan
    School of Pharmacy, University of Pittsburgh, and Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15240, USA
    Antimicrob Agents Chemother 46:3091-3. 2002
    ..Close monitoring of the blood concentration and adjustment in the dose of tacrolimus are warranted in transplant recipients treated with voriconazole...
  40. ncbi request reprint Evaluation of renal function in transplant patients on tacrolimus therapy
    Sangeeta Agarwala
    Department of Pharmaceutical Sciences and Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pennsylvania 15261, USA
    J Clin Pharmacol 42:798-805. 2002
    ..Dosage alterations ofrenally eliminated drugs may be required for drugs with a narrow therapeutic index...
  41. ncbi request reprint Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats
    Ying Mu
    Center for Pharmacogenetics, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA
    J Pharmacol Exp Ther 316:1369-77. 2006
    ..Meanwhile, the activation of PXR and induction of detoxifying enzymes provide a molecular mechanism for the hepatoprotective effects of certain TCMs...
  42. ncbi request reprint Coordinated intrahepatic and extrahepatic regulation of cytochrome p4502D6 in healthy subjects and in patients after liver transplantation
    Joseph A Carcillo
    Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Pharmacol Ther 73:456-67. 2003
    ....
  43. ncbi request reprint Nelfinavir, a protease inhibitor, increases sirolimus levels in a liver transplantation patient: a case report
    Ashok Kumar B Jain
    Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA
    Liver Transpl 8:838-40. 2002
    ..Increase in trough concentration, peak concentration area under the curve concentration, and prolongation of half-life of sirolimus has been shown in a patient who was on a low dose (one fifth the recommended dose) of nelfinavir...
  44. ncbi request reprint Ribavirin dose modification based on renal function is necessary to reduce hemolysis in liver transplant patients with hepatitis C virus infection
    Ashok B Jain
    Transplantation Institute, The Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Liver Transpl 8:1007-13. 2002
    ..Further pharmacokinetic studies of ribavirin in LTx patients with varying degrees of renal function may allow the development of an algorithm for the safer use of ribavirin in HCV-positive LTx patients...
  45. doi request reprint A comprehensive in vitro and in silico analysis of antibiotics that activate pregnane X receptor and induce CYP3A4 in liver and intestine
    Kazuto Yasuda
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Drug Metab Dispos 36:1689-97. 2008
    ..In summary, nafcillin, dicloxacillin, cephradine, tetracycline, sulfixoxazole, erythromycin, clindamycin, and griseofulvin exhibit a clear propensity to induce CYP3A4 and warrant further clinical investigation...
  46. ncbi request reprint Pharmacokinetics of cefoperazone and sulbactam in liver transplant patients
    Robert R Muder
    Department of Medicine, VA Medical Center, Pittsburgh, PA, USA
    J Clin Pharmacol 42:644-50. 2002
    ....
  47. ncbi request reprint Mycophenolic acid pharmacodynamics and pharmacokinetics provide a basis for rational monitoring strategies
    Leslie M Shaw
    Department of Pathology and Laboratory Medicine, School of Pharmacy, University of Pittsburgh, PA 15261, USA
    Am J Transplant 3:534-42. 2003
  48. ncbi request reprint Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures
    Bernard J Komoroski
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pennsylvania 15213 1863, USA
    Clin Cancer Res 11:6972-9. 2005
    ..Because docetaxel is inactivated by CYP3A, we studied the effects of the St. John's wort constituent hyperforin on docetaxel metabolism in a human hepatocyte model...
  49. ncbi request reprint Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures
    Bernard J Komoroski
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Drug Metab Dispos 32:512-8. 2004
    ....
  50. ncbi request reprint Pharmacokinetic study of mycophenolic acid in Korean kidney transplant patients
    Eun Kyung Cho
    Graduate School of Clinical Pharmacy, Sookmyung Women s University, 53 12 Chungpadong 2 ka, Yongsan gu, Seoul, 140 742 Korea
    J Clin Pharmacol 44:743-50. 2004
    ..MPA concentrations of predose and 1- and 8-hour postdose were positively correlated with AUC...
  51. ncbi request reprint Animal models of xenobiotic receptors in drug metabolism and diseases
    Haibiao Gong
    Center for Pharmacogenetics, University of Pittsburgh, Pennsylvania, USA
    Methods Enzymol 400:598-618. 2005
    ..quot;Humanized" hPXR transgenic mice represent a major step forward in the creation and utilization of humanized rodent models for toxicological assessment that may aid in the development of safer drugs...
  52. ncbi request reprint Therapeutic monitoring of mycophenolic acid in liver transplant patients
    Raman Venkataramanan
    Liver Transpl 10:503-5. 2004
  53. pmc Intrapulmonary penetration of voriconazole in patients receiving an oral prophylactic regimen
    Blair Capitano
    School of Pharmacy, University of Pittsburgh, 720 Salk Hall, 3501 Terrace St, Pittsburgh, PA 15261, USA
    Antimicrob Agents Chemother 50:1878-80. 2006
    ..The ELF concentrations exceeded those of the plasma, with an average ELF-to-plasma ratio of 11 (+/-8). A strong association between plasma and ELF concentrations (r(2) = 0.95) was noted...
  54. ncbi request reprint An official ATS statement: hepatotoxicity of antituberculosis therapy
    Jussi J Saukkonen
    Am J Respir Crit Care Med 174:935-52. 2006
    ..Priorities for future studies to develop safer treatments for LTBI and for TB disease are presented...
  55. ncbi request reprint Tacrolimus dosage requirements after initiation of azole antifungal therapy in pediatric thoracic organ transplantation
    C Becket Mahnke
    Division of Cardiology, Children s Hospital of Pittsburgh, PA 15213, USA
    Pediatr Transplant 7:474-8. 2003
    ..An initial reduction in tacrolimus dose by one-third is insufficient, and dose reduction of at least 50% upon azole initiation seems warranted. Once azole antifungal therapy is initiated, frequent therapeutic drug monitoring is required...
  56. ncbi request reprint Determination of 13-O-demethyl tacrolimus in human liver microsomal incubates using liquid chromatography-mass spectrometric assay (LC-MS)
    Yan Feng
    Department of Pharmaceutical Sciences, School of Pharmacy, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 821:31-7. 2005
    ..6 to 9.6%. The limits of detection was 2 ng/ml. This assay has been used to evaluate the effect of three human immunodeficiency virus (HIV) protease inhibitors on the metabolism of tacrolimus in human liver microsomes...
  57. ncbi request reprint Identification of enzymes involved in the metabolism of 17alpha-hydroxyprogesterone caproate: an effective agent for prevention of preterm birth
    Shringi Sharma
    Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania 15261, USA
    Drug Metab Dispos 36:1896-902. 2008
    ..Because CYP3A is involved in the oxidative metabolism of numerous commonly used drugs, 17-OHPC may be involved in clinically relevant metabolic drug interactions with coadministered CYP3A inhibitors or inducers...