Manjeri Venkatachalam

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. pmc Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2
    Zheng Dong
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Pathol 163:663-71. 2003
  2. pmc Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas
    J Am Soc Nephrol 26:1765-76. 2015
  3. doi The conundrum of protection from AKI by adenosine in rodent clamp ischemia models
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Kidney Int 84:16-9. 2013
  4. doi New wrinkles in old receptors: core fucosylation is yet another target to inhibit TGF-β signaling
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Kidney Int 84:11-4. 2013
  5. pmc Acute kidney injury: a springboard for progression in chronic kidney disease
    Manjeri A Venkatachalam
    Dept of Pathology, Univ of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 298:F1078-94. 2010
  6. pmc PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis
    Rongpei Lan
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 302:F1210-23. 2012
  7. pmc The tubule pathology of septic acute kidney injury: a neglected area of research comes of age
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Kidney Int 81:338-40. 2012
  8. pmc Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia
    Zheng Dong
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Biochem J 364:413-21. 2002
  9. ncbi Role of apoptosis in hypoxic/ischemic damage in the kidney
    Pothana Saikumar
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Semin Nephrol 23:511-21. 2003
  10. pmc A novel wounding device suitable for quantitative biochemical analysis of wound healing and regeneration of cultured epithelium
    Rongpei Lan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Wound Repair Regen 18:159-67. 2010

Research Grants

  1. PTEN REGULATION DURING ISCHEMIC ACUTE RENAL FAILURE
    Manjeri Venkatachalam; Fiscal Year: 2008

Collaborators

  • Anil K Bidani
  • Pothana Saikumar
  • Eugene A Sprague
  • Mei Qiang
  • Z Dong
  • Eileen White
  • Rongpei Lan
  • Hui Geng
  • Joel M Weinberg
  • Thorsten Feldkamp
  • Valery Mikhailov
  • Prajjal K Singha
  • Robert Koesters
  • Donald G McEwen
  • Wilhelm Kriz
  • Karen A Griffin
  • Aaron J Polichnowski
  • Pramod Mishra
  • Wayne L Skloss
  • Yoon Hwang
  • Ruth A Senter
  • Sarah Kemner
  • Andreas Kribben
  • Nancy F Roeser
  • Itzhak Nissim
  • Kurt Degenhardt
  • Margarita Mikhailova

Detail Information

Publications12

  1. pmc Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2
    Zheng Dong
    Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Pathol 163:663-71. 2003
    ..Thus, death resistance of hypoxic cells involves multiple factors targeting different stages of apoptosis, with IAP-2 suppressing caspases in the cytosol...
  2. pmc Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas
    J Am Soc Nephrol 26:1765-76. 2015
    ..Continued investigation of these pathologic mechanisms should reveal options for preventing renal disease progression after AKI...
  3. doi The conundrum of protection from AKI by adenosine in rodent clamp ischemia models
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Kidney Int 84:16-9. 2013
    ....
  4. doi New wrinkles in old receptors: core fucosylation is yet another target to inhibit TGF-β signaling
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Kidney Int 84:11-4. 2013
    ..Fut8-shRNA interferes with core fucosylation of other receptors also. Regardless, this first attempt to capitalize on a new aspect of TGF-β receptor function provides a basis for further research. ..
  5. pmc Acute kidney injury: a springboard for progression in chronic kidney disease
    Manjeri A Venkatachalam
    Dept of Pathology, Univ of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 298:F1078-94. 2010
    ..We discuss the implications of this pathophysiology for developing efficient therapeutic strategies to delay progression and avert ESRD...
  6. pmc PTEN loss defines a TGF-β-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis
    Rongpei Lan
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Physiol Renal Physiol 302:F1210-23. 2012
    ..By preventing tubule differentiation, the low-PTEN state may provide a platform for signals initiated physiologically to persist pathologically and cause fibrosis after injury...
  7. pmc The tubule pathology of septic acute kidney injury: a neglected area of research comes of age
    Manjeri A Venkatachalam
    Department of Pathology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    Kidney Int 81:338-40. 2012
    ..Together, these findings open new avenues for research into long-unresolved issues in the pathophysiology of septic AKI...
  8. pmc Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia
    Zheng Dong
    Department of Pathology, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Biochem J 364:413-21. 2002
    ..Moreover, we have demonstrated activation of the gene promoter by severe hypoxia, a condition shown to induce IAP2. These findings provide a basis for further investigation of gene regulation of IAP2, a protein with multiple functions...
  9. ncbi Role of apoptosis in hypoxic/ischemic damage in the kidney
    Pothana Saikumar
    Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Semin Nephrol 23:511-21. 2003
    ....
  10. pmc A novel wounding device suitable for quantitative biochemical analysis of wound healing and regeneration of cultured epithelium
    Rongpei Lan
    Department of Pathology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Wound Repair Regen 18:159-67. 2010
    ..The method is versatile, easy to use and reproducible, and should facilitate biochemical, proteomic, and genomic studies of wound-induced regeneration of cultured epithelium...
  11. ncbi Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release
    Valery Mikhailov
    Department of Pathology, The University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 278:5367-76. 2003
    ..These results suggest a degree of functional cooperation between Bax and Bak in this form of cell injury, but also demonstrate an absolute requirement of Bax for mitochondrial permeabilization...
  12. ncbi Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules
    Thorsten Feldkamp
    Nephrology Div, Dept of Internal Medicine, Rm 1560, MSRB II, Univ of Michigan Medical Ctr, Ann Arbor, MI 48109 0676, USA
    Am J Physiol Renal Physiol 286:F749-59. 2004
    ..The work provides new insight into fundamental aspects of mitochondrial pathophysiology in proximal tubules during acute renal failure...

Research Grants1

  1. PTEN REGULATION DURING ISCHEMIC ACUTE RENAL FAILURE
    Manjeri Venkatachalam; Fiscal Year: 2008
    ..We will employ PTEN antisense oligonucleotides to suppress kidney PTEN in vivo to study how this intervention affects the course of proximal tubule regeneration and recovery. ..