J D Veldhuis

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replac
    J D Veldhuis
    Division of Endocrinology, National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 82:3414-20. 1997
  2. ncbi request reprint Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans
    J D Veldhuis
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Endocrine 7:41-8. 1997
  3. ncbi request reprint Hypophyseal-portal somatostatin (SRIH) and jugular venous growth hormone secretion in the conscious unrestrained ewe
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Neuroendocrinology 75:83-91. 2002
  4. ncbi request reprint Neurophysiological regulation and target-tissue impact of the pulsatile mode of growth hormone secretion in the human
    J D Veldhuis
    Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, Charlottesville 22908 0202, USA
    Growth Horm IGF Res 11:S25-37. 2001
  5. ncbi request reprint Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    J Clin Endocrinol Metab 86:529-35. 2001
  6. ncbi request reprint Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    J Clin Endocrinol Metab 87:859-66. 2002
  7. ncbi request reprint Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men
    J D Veldhuis
    Department of Internal Medicine, National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 84:3498-505. 1999
  8. ncbi request reprint Joint basal and pulsatile hypersecretory mechanisms drive the monotropic follicle-stimulating hormone (FSH) elevation in healthy older men: concurrent preservation of the orderliness of the FSH release process: a general clinical research center study
    J D Veldhuis
    Department of Internal Medicine, National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 84:3506-14. 1999
  9. ncbi request reprint Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion
    J D Veldhuis
    Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1975-85. 2001
  10. ncbi request reprint Older men manifest multifold synchrony disruption of reproductive neurohormone outflow
    J D Veldhuis
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 85:1477-86. 2000

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (growth hormone)-insulin-like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replac
    J D Veldhuis
    Division of Endocrinology, National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 82:3414-20. 1997
    ....
  2. ncbi request reprint Elements in the pathophysiology of diminished growth hormone (GH) secretion in aging humans
    J D Veldhuis
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Endocrine 7:41-8. 1997
    ..Here, the authors review these selected facets of recent experimental evaluation of the human GH insulin-like growth factor-I (GH-IGF-I) feedback axis in aging humans...
  3. ncbi request reprint Hypophyseal-portal somatostatin (SRIH) and jugular venous growth hormone secretion in the conscious unrestrained ewe
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Neuroendocrinology 75:83-91. 2002
    ..We conclude that, to the extent that in vivo sampling reflects physiological SRIH/somatotrope activity, the female sheep maintains complex time-varying interactions between SRIH and GH release...
  4. ncbi request reprint Neurophysiological regulation and target-tissue impact of the pulsatile mode of growth hormone secretion in the human
    J D Veldhuis
    Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, Charlottesville 22908 0202, USA
    Growth Horm IGF Res 11:S25-37. 2001
    ..Resultant GH pulses trigger tissue-specific gene expression, thereby promoting skeletal and muscular growth, metabolic and body compositional adaptations, and CNS reactions that jointly maintain health and homeostasis...
  5. ncbi request reprint Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    J Clin Endocrinol Metab 86:529-35. 2001
    ..The foregoing trilogy of neuroregulatory defects identifies unequivocally attenuated hypothalamo-pituitary reactivity to muting of androgen negative feedback in the aging male...
  6. ncbi request reprint Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    J Clin Endocrinol Metab 87:859-66. 2002
    ..Whether comparable dynamics mediate the effects of endogenous estrogen on the GH axis in premenopausal women or pubertal girls is not known...
  7. ncbi request reprint Disruption of the young-adult synchrony between luteinizing hormone release and oscillations in follicle-stimulating hormone, prolactin, and nocturnal penile tumescence (NPT) in healthy older men
    J D Veldhuis
    Department of Internal Medicine, National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 84:3498-505. 1999
    ..Such implicit disarray of multinodal communication is of consequence both scientifically and clinically, especially in proposing aging theories and intervention strategies...
  8. ncbi request reprint Joint basal and pulsatile hypersecretory mechanisms drive the monotropic follicle-stimulating hormone (FSH) elevation in healthy older men: concurrent preservation of the orderliness of the FSH release process: a general clinical research center study
    J D Veldhuis
    Department of Internal Medicine, National Science Foundation Center for Biological Timing, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 84:3506-14. 1999
    ..Thus, the present data illuminate an age-dependent disparity in the disruption of FSH neuroregulation in the aging male...
  9. ncbi request reprint Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion
    J D Veldhuis
    Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1975-85. 2001
    ..Thus ApEn monitors changing secretory event frequency and interpulse variability with sensitivity to starting pattern regularity, providing a mechanistic linkage between model evolution and statistical change...
  10. ncbi request reprint Older men manifest multifold synchrony disruption of reproductive neurohormone outflow
    J D Veldhuis
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 85:1477-86. 2000
    ..Whether analogous multifold uncoupling of neurohormone signals emerges in the course of reproductive aging in women or in nonhuman species is not yet known...
  11. ncbi request reprint Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    Am J Physiol Regul Integr Comp Physiol 280:R721-9. 2001
    ....
  12. ncbi request reprint Disruption of the joint synchrony of luteinizing hormone, testosterone, and androstenedione secretion in adolescents with polycystic ovarian syndrome
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:72-9. 2001
    ..Whether presumptive failure of integrative hypothalamo-pituitary-gonadal control emerges prepubertally in girls at risk for PCOS or persists in adults with PCOS is not known...
  13. ncbi request reprint Lowering total plasma insulin-like growth factor I concentrations by way of a novel, potent, and selective growth hormone (GH) receptor antagonist, pegvisomant (B2036-peg), augments the amplitude of GH secretory bursts and elevates basal/nonpulsatile GH r
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    J Clin Endocrinol Metab 86:3304-10. 2001
    ....
  14. ncbi request reprint Corticotropin secretory dynamics in humans under low glucocorticoid feedback
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    J Clin Endocrinol Metab 86:5554-63. 2001
    ....
  15. ncbi request reprint Interactive regulation of postmenopausal growth hormone insulin-like growth factor axis by estrogen and growth hormone-releasing peptide-2
    J D Veldhuis
    Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, Charlottesville 22908 0202, USA
    Endocrine 14:45-62. 2001
    ..We suggest the thesis that estrogen controls the interfaces among these pivotal regulatory peptides in hyposomatotropic postmenopausal individuals...
  16. ncbi request reprint Disruption of the synchronous secretion of leptin, LH, and ovarian androgens in nonobese adolescents with the polycystic ovarian syndrome
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center and Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:3772-8. 2001
    ..Whether analogous disruption of leptin-gonadal axis integration is ameliorated by therapy and/or persists into adulthood is not known...
  17. ncbi request reprint Developmentally delimited emergence of more orderly luteinizing hormone and testosterone secretion during late prepuberty in boys
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, Charlottesville, Virginia 22908 0202, USA
    J Clin Endocrinol Metab 86:80-9. 2001
    ..Whether analogous plasticity of hypothalamo-pituitary-gonadal interactions unfolds during female adolescence is not known...
  18. ncbi request reprint Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro
    Johannes D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, National Institutes of Health Specialized Cooperative Center in Reproductive Research, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 87:1129-33. 2002
    ....
  19. ncbi request reprint Novel modalities for appraising individual and coordinate pulsatile hormone secretion: the paradigm of luteinizing hormone and testosterone release in the aging male
    J D Veldhuis
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Mol Psychiatry 2:70-80. 1997
    ....
  20. ncbi request reprint Gender and sexual maturation-dependent contrasts in the neuroregulation of growth hormone secretion in prepubertal and late adolescent males and females--a general clinical research center-based study
    J D Veldhuis
    Department of Internal Medicine, Center for Biomathematical Technology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    J Clin Endocrinol Metab 85:2385-94. 2000
    ..Accordingly, we postulate that sex steroids supervise selectively each of the dominant facets of GH neurosecretory control across human puberty...
  21. ncbi request reprint Short-term estradiol replacement in postmenopausal women selectively mutes somatostatin's dose-dependent inhibition of fasting growth hormone secretion
    M J Bray
    Department of Obstetrics and Gynecology, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:3143-9. 2001
    ..Accordingly, we postulate that estradiol can facilitate pulsatile GH secretion, in part, by opposing the repressive actions of somatostatin...
  22. ncbi request reprint Short-term estradiol supplementation augments growth hormone (GH) secretory responsiveness to dose-varying GH-releasing peptide infusions in healthy postmenopausal women
    S M Anderson
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:551-60. 2001
    ..These data point to a facilitative interaction between E(2) and the GHRP receptor/effector pathway in driving the mass of GH secreted per burst...
  23. ncbi request reprint Continuous 24-hour intravenous infusion of recombinant human growth hormone (GH)-releasing hormone-(1-44)-amide augments pulsatile, entropic, and daily rhythmic GH secretion in postmenopausal women equally in the estrogen-withdrawn and estrogen-supplement
    W S Evans
    Division of Endocrinology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia 22908-0202, USA
    J Clin Endocrinol Metab 86:700-12. 2001
    ....
  24. ncbi request reprint Concerted regulation of low density lipoprotein receptor gene expression by follicle-stimulating hormone and insulin-like growth factor I in porcine granulosa cells: promoter activation, messenger ribonucleic acid stability, and sterol feedback
    H A LaVoie
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Endocrinology 140:178-86. 1999
    ....
  25. ncbi request reprint Alterations in growth and body composition during puberty: III. Influence of maturation, gender, body composition, fat distribution, aerobic fitness, and energy expenditure on nocturnal growth hormone release
    J N Roemmich
    University of Virginia Health Sciences Center, Department of Pediatrics, Charlottesville 22908, USA
    J Clin Endocrinol Metab 83:1440-7. 1998
    ..The influence of maturation reflects rising sex steroid concentrations, and the gender differences appear to be because of differences in estradiol concentrations rather than to body composition or body fat distribution...
  26. ncbi request reprint Mechanisms of insulin-like growth factor I augmentation of follicle-stimulating hormone-induced porcine steroidogenic acute regulatory protein gene promoter activity in granulosa cells
    H A LaVoie
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Endocrinology 140:146-53. 1999
    ....
  27. ncbi request reprint Accelerated escape from GH autonegative feedback in midpuberty in males: evidence for time-delimited GH-induced somatostatinergic outflow in adolescent boys
    E Richmond
    Division of Endocrinology and Metabolism, Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 87:3837-44. 2002
    ..This novel tripartite mechanism could engender recurrent high-amplitude GH secretory bursts that mark sex hormone-dependent activation of the human somatotropic axis...
  28. ncbi request reprint Short-term modulation of the androgen milieu alters pulsatile, but not exercise- or growth hormone (GH)-releasing hormone-stimulated GH secretion in healthy men: impact of gonadal steroid and GH secretory changes on metabolic outcomes
    D A Fryburg
    Department of Internal Medicine, General Clinical Research Center, Charlottesville, Virginia, USA
    J Clin Endocrinol Metab 82:3710-9. 1997
    ..These results have significance for both normal physiology and for the treatment of hypogonadal GH-deficient patients...
  29. ncbi request reprint Impact of experimental blockade of peripheral growth hormone (GH) receptors on the kinetics of endogenous and exogenous GH removal in healthy women and men
    J D Veldhuis
    Department of Internal Medicine, Division of Endocrinology, General Clinical Research Center, Center for Biochemical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908 2020, USA
    J Clin Endocrinol Metab 87:5737-45. 2002
    ..8 +/- 0.32 (placebo) and 3.5 +/- 0.31 (drug). In ensemble, the present data refute the a priori postulate that vascular-accessible GH receptors determine the in vivo pseudoequilibrium kinetics of GH disappearance in the human...
  30. ncbi request reprint Mechanisms of regulation of ovarian sterol metabolism by insulin-like growth factor type II: in vitro studies with swine granulosa cells
    J C Garmey
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908
    Endocrinology 133:800-8. 1993
    ..The same treatments produced 6-fold increases in the level of LDL receptor mRNA, as determined by solution hybridization/RNase protection assays.(ABSTRACT TRUNCATED AT 400 WORDS)..
  31. ncbi request reprint Regulation of porcine granulosa cell steroidogenic acute regulatory protein (StAR) by insulin-like growth factor I: synergism with follicle-stimulating hormone or protein kinase A agonist
    K Balasubramanian
    Division of Endocrinology and Metabolism, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Endocrinology 138:433-9. 1997
    ....
  32. ncbi request reprint Expression of parathyroid hormone-related peptide (PTH-rp) and its receptorin the porcine ovary: regulation by transforming growth factor-beta and possible paracrine effects of granulosa cell PTH-rp secretion on theca cells
    J C Garmey
    Division of Endocrinology, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Biol Reprod 62:334-9. 2000
    ..Alternatively, expression of mRNAs encoding PTH-rp and its receptor in corpora lutea suggests that this peptide may play a role in luteal cell function. The precise role of this intraovarian PTH-rp system will require further study...
  33. ncbi request reprint Mechanisms of conjoint failure of the somatotropic and gonadal axes in ageing men
    J D Veldhuis
    Division of Endocrinology, University of Virginia School of Medicine, Charlottesville 22908 0202, USA
    Novartis Found Symp 242:98-118; discussion 118-24. 2002
    ..According to this broader thesis, hyposomatotropism accentuates Leydig cell steroidogenic failure and, conversely, progressive androgen deficiency exacerbates the decline in GH-IGF1 output in ageing...
  34. ncbi request reprint E2 supplementation selectively relieves GH's autonegative feedback on GH-releasing peptide-2-stimulated GH secretion
    S M Anderson
    Division of Endocrinology, Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:5904-11. 2001
    ..The secretagogue specificity of E's relief of GH autoinhibition suggests that this sex steroid may enhance activity of the hypothalamopituitary GHRP-receptor/effector pathway...
  35. ncbi request reprint Unequal impact of short-term testosterone repletion on the somatotropic axis of young and older men
    A Gentili
    Department of Internal Medicine, General Clinical Research Center, Virginia Commonwealth University, Medical College of Virginia, Geriatrics and Extended Care Service Line, Richmond, Virginia 23298, USA
    J Clin Endocrinol Metab 87:825-34. 2002
    ..The mechanistic basis for the foregoing age-related distinction in GH/IGF-I axis responsivity to T is not known...
  36. ncbi request reprint Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men
    J A Schnorr
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 86:2600-6. 2001
    ....
  37. ncbi request reprint Human GH pulsatility: an ensemble property regulated by age and gender
    J D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical School of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    J Endocrinol Invest 26:799-813. 2003
    ..This unifying platform offers a convergent perspective of multivalent control of GH outflow...
  38. ncbi request reprint A construct of interactive feedback control of the GH axis in the male
    L S Farhy
    Department of Internal Medicine, Division of Endocrinology, The University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Physiol Regul Integr Comp Physiol 281:R38-51. 2001
    ..Further evolution of interactive constructs could aid in exploring more complex feedback postulates that confer the vivid sexual dimorphism of female GH profiles...
  39. ncbi request reprint Concerted transcriptional activation of the low density lipoprotein receptor gene by insulin and luteinizing hormone in cultured porcine granulosa-luteal cells: possible convergence of protein kinase a, phosphatidylinositol 3-kinase, and mitogen-activated
    N Sekar
    Division of Endocrinology and Metabolism, Department of Internal Medicine, National Institutes of Health Specialized Cooperative Center in Reproductive Research, University of Virginia Health Sciences Center, Charlottesville, Virginia 22908, USA
    Endocrinology 142:2921-8. 2001
    ....
  40. ncbi request reprint Hypothesis testing of the aging male gonadal axis via a biomathematical construct
    D M Keenan
    Department of Statistics, University of Virginia, Charlottesville, Virginia 22903, USA
    Am J Physiol Regul Integr Comp Physiol 280:R1755-71. 2001
    ..This investigative strategy should aid in exploring new postulates of disrupted feedback networks in pathophysiology...
  41. ncbi request reprint Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis
    J R Kerrigan
    Department of Pediatrics, University of Virginia Health Sciences Center, Charlottesville 22908
    J Clin Endocrinol Metab 76:1505-10. 1993
    ....
  42. ncbi request reprint Cortisol and GH secretory dynamics, and their interrelationships, in healthy aged women and men
    J A Gusenoff
    Division of Endocrinology and Metabolism, Department of Medicine, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, Baltimore, MD 21224, USA
    Am J Physiol Endocrinol Metab 280:E616-25. 2001
    ..Thus postmenopausal women appear to maintain elevated cortisol production in patterns that are relatively uncoupled from those of GH, whereas mean hormone outputs remain correlated...
  43. ncbi request reprint Disruption of the hypothalamic luteinizing hormone pulsing mechanism in aging men
    D M Keenan
    Department of Statistics, University of Virginia, Charlottesville, VA 22903, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1917-24. 2001
    ....
  44. ncbi request reprint Mechanisms of ensemble failure of the male gonadal axis in aging
    J D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    J Endocrinol Invest 28:8-13. 2005
    ..The most proximate locus of impairment is not yet known...
  45. ncbi request reprint Physiological regulation of the human growth hormone (GH)-insulin-like growth factor type I (IGF-I) axis: predominant impact of age, obesity, gonadal function, and sleep
    J D Veldhuis
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
    Sleep 19:S221-4. 1996
    ....
  46. ncbi request reprint Increased pulsatility, process irregularity, and nocturnal trough concentrations of growth hormone in amenorrheic compared to eumenorrheic athletes
    D L Waters
    Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    J Clin Endocrinol Metab 86:1013-9. 2001
    ..Accordingly, we postulate that the amenorrheic state, beyond the exercise experience per se, alters the neuroendocrine control of GH output in amenorrheic athletes...
  47. ncbi request reprint Localization and expression of low-density lipoprotein receptor, steroidogenic acute regulatory protein, cytochrome P450 side-chain cleavage and P450 17-alpha-hydroxylase/C17-20 lyase in developing swine follicles: in situ molecular hybridization and immu
    J C Garmey
    Division of Endocrinology, Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Mol Cell Endocrinol 170:57-65. 2000
    ....
  48. ncbi request reprint Longitudinal changes in growth hormone secretory process irregularity assessed transpubertally in healthy boys
    S M Pincus
    Department of Internal Medicine, General Clinical Research Center, Center for Biomathematical Technology, University of Virginia, Charlottesville 22908, USA
    Am J Physiol Endocrinol Metab 279:E417-24. 2000
    ..In addition to clinical utility, there may be added experimental merit in knowing that GH dynamics typically predict accelerated linear growth in 4-8 mo...
  49. ncbi request reprint Suppression and recovery of LH secretion by a potent and selective GnRH-receptor antagonist peptide in healthy early follicular-phase women are mediated via selective control of LH secretory burst mass
    L Gianotti
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Turin, Italy
    Clin Endocrinol (Oxf) 59:526-32. 2003
    ..The aim of this study was to evaluate the effects of a potent GnRH antagonist, Teverelix (TEV), on the gonadal axis in healthy young women...
  50. ncbi request reprint Pathophysiological features of the pulsatile secretion of biologically active luteinizing hormone in man
    J D Veldhuis
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908
    J Steroid Biochem 33:739-49. 1989
    ....
  51. ncbi request reprint Calcium ions positively modulate follicle-stimulating hormone- and exogenous cyclic 3',5'-adenosine monophosphate-driven transcription of the P450(scc) gene in porcine granulosa cells
    F C Jayes
    Department of Internal Medicine, NIH Specialized Cooperative Center in Reproduction Research, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Endocrinology 141:2377-84. 2000
    ..The agonistic impact of Ca2+ on P450(scc) promoter activity is requisite downstream of FSH-induced cAMP second-messenger signaling...
  52. ncbi request reprint Statistically accurate estimation of hormone concentrations and associated uncertainties: methodology, validation, and applications
    M Straume
    Department of Internal Medicine, National Science Foundation Center for Biological Timing, University of Virginia, Charlottesville 22903, USA
    Clin Chem 44:116-23. 1998
    ..Much-improved accuracy and estimated precision are achieved for unknown hormone concentrations, particularly extremely low concentrations, by using this variable response weighting procedure...
  53. ncbi request reprint Repeated bouts of exercise alter the blood lactate-RPE relation
    A Weltman
    Department of Internal Medicine, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Med Sci Sports Exerc 30:1113-7. 1998
    ..To examine the effects of repeated bouts of exercise on the blood lactate [HLa]-ratings of perceived exertion (RPE) relation...
  54. ncbi request reprint Body composition, physical exercise, growth hormone and obesity
    A Weltman
    Departments of Medicine and Human Services, University of Virginia, Charlottesville, VA 22903, USA
    Eat Weight Disord 6:28-37. 2001
    ..Taken as a whole, available data suggest that GH repletion regimens in combination with regular exercise and relevant dietary intervention may provide a tripartite strategy for the management of significant obesity...
  55. ncbi request reprint Is growth saltatory? The usefulness and limitations of frequency distributions in analyzing pulsatile data
    M L Johnson
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville 22908, USA
    Endocrinology 137:5197-204. 1996
    ..We conclude that FDGV analysis is not a valid method to exclude saltation and stasis growth processes in longitudinal growth studies...
  56. ncbi request reprint Intensity of acute exercise does not affect serum leptin concentrations in young men
    A Weltman
    Department of Human Services, University of Virginia, Charlottesville, USA
    Med Sci Sports Exerc 32:1556-61. 2000
    ..We examined the effects of exercise intensity on serum leptin levels...
  57. doi request reprint Pathophysiology of hypercortisolism in depression: pituitary and adrenal responses to low glucocorticoid feedback
    B J Carroll
    Pacific Behavioral Research Foundation, Carmel, CA, USA
    Acta Psychiatr Scand 125:478-91. 2012
    ..To test three theories of hypercortisolemia in depression-hypothalamic overdrive, impaired glucocorticoid feedback, or autonomous cortisol production...
  58. ncbi request reprint The nature of the gonadotropin-releasing hormone stimulus-luteinizing hormone secretory response of human gonadotrophs in vivo
    J D Veldhuis
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908
    J Clin Endocrinol Metab 68:661-70. 1989
    ..We conclude that GnRH exerts dose-dependent effects on specific attributes of the secretory response of human gonadotrophs in vivo...
  59. ncbi request reprint Neuroendocrine control of GH release during acute aerobic exercise
    A Weltman
    General Clinical Research Center, University of Virginia, Charlottesville, Virginia 22904, USA
    J Endocrinol Invest 26:843-50. 2003
    ..We will also provide an overview of the neuroendocrine control of exercise-induced GH release. Finally, information related to the effects of aging and gender on the GH response to exercise will be provided...
  60. ncbi request reprint Regulation of porcine granulosa cell 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin and insulin-like growth factor I: synergism with follicle-stimulating hormone or protein kinase A agonist
    A Maitra
    Department of Internal Medicine, University of Virginia Health Science Center, Charlottesville 22908, USA
    Endocrinology 136:5111-7. 1995
    ..We conclude that insulin alone or in combination with FSH or cAMP augments the accumulation of HMG-CoA reductase mRNA in ovarian (granulosa) cells.(ABSTRACT TRUNCATED AT 400 WORDS)..
  61. pmc A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis
    D M Keenan
    Department of Statistics, University of Virginia, Charlottesville, VA 22903, USA
    Proc Natl Acad Sci U S A 98:4028-33. 2001
    ..Explication of the core dynamics of the stress-responsive corticotropic axis based on secure physiological precepts should help to unveil new biomedical hypotheses of stressor-specific system failure...
  62. ncbi request reprint Noninvasive in vivo investigative probes of adaptive mechanisms of neuroendocrine regulation: the paradigm of the hypothalamo-pituitary-gonadal axis in the aging male
    J D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    J Endocrinol Invest 26:2-14. 2003
    ..The aging male gonadal axis provides a well studied paradigmatic platform to illustrate the formulation and implementation of analytical strategies in diverse systems...
  63. ncbi request reprint Exercise-dependent growth hormone release is linked to markers of heightened central adrenergic outflow
    A Weltman
    Department of Human Services, University of Virginia, Charlottesville 22903, USA
    J Appl Physiol 89:629-35. 2000
    ..02) could not be explained by changes in Epi alone (P = 0.77). Our results suggest that exercise intensity and GH release in the human may be coupled mechanistically by central adrenergic activation...
  64. ncbi request reprint Recent neuroendocrine facets of male reproductive aging
    J D Veldhuis
    Division of Endocrinology, Department of Internal Medicine, General Clinical Research Center, University of Virginia School of Medicine, 22908 0202, Charlottesville, VA, USA
    Exp Gerontol 35:1281-308. 2000
    ..How such alterations are related to specific hypothalamic neurotransmitter changes in aging will be critical to unravel...
  65. ncbi request reprint Nature of alpha subunit secretion in men: circadian rhythms, pulsatile release and secretory profiles
    J D Veldhuis
    Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908
    J Androl 10:248-58. 1989
    ..The remarkably similar in vivo pulse frequencies for alpha subunit, LH, and testosterone in man suggest that the release of these three hormones is coordinately regulated...
  66. ncbi request reprint Short-term testosterone supplementation does not activate GH and IGF-I production in postmenopausal women
    Cacia Soares-Welch
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Clin Endocrinol (Oxf) 63:32-8. 2005
    ..Testosterone (Te), oestradiol, GH and IGF-I concentrations fall in postmenopausal women...
  67. ncbi request reprint Aging in healthy men impairs recombinant human luteinizing hormone (LH)-stimulated testosterone secretion monitored under a two-day intravenous pulsatile LH clamp
    Peter Y Liu
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:5544-50. 2005
    ..Testosterone (Te) depletion in aging men in principle could reflect deficits in the hypothalamus, pituitary gland, or testis. Available pharmacological studies of possible failure of Leydig cell steroidogenesis remain inconclusive...
  68. ncbi request reprint Composite model of time-varying appearance and disappearance of neurohormone pulse signals in blood
    Daniel M Keenan
    Department of Statistics, University of Virginia, Charlottesville, VA 22904, USA
    J Theor Biol 236:242-55. 2005
    ..e., add/remove a pulse-time or stay the same). We apply this procedure illustratively to joint estimation of pulse times, secretion rates and elimination kinetics of selected pituitary hormones (ACTH, LH and GH)...
  69. ncbi request reprint Age-specific changes in the regulation of LH-dependent testosterone secretion: assessing responsiveness to varying endogenous gonadotropin output in normal men
    Peter Y Liu
    Endocrine Research Unit, Dept of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 289:R721-8. 2005
    ..The experimental strategy of graded suppression of neuroglandular outflow may have utility in estimating dose-response adaptations in other endocrine systems...
  70. ncbi request reprint Age diminishes the testicular steroidogenic response to repeated intravenous pulses of recombinant human LH during acute GnRH-receptor blockade in healthy men
    Johannes D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 288:E775-81. 2005
    ..Whether more prolonged pulsatile LH stimulation would normalize this inferred defect is unknown...
  71. ncbi request reprint Aging attenuates both the regularity and joint synchrony of LH and testosterone secretion in normal men: analyses via a model of graded GnRH receptor blockade
    Peter Y Liu
    Endocrine Research Unit, Dept of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Endocrinol Metab 290:E34-E41. 2006
    ..Thus the experimental strategy of stepwise silencing of an agonistic pathway may have utility in dissecting the bases of altered neurohormonal linkages in other systems...
  72. ncbi request reprint Contributions of gender and systemic estradiol and testosterone concentrations to maximal secretagogue drive of burst-like growth hormone secretion in healthy middle-aged and older adults
    Johannes D Veldhuis
    Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:6291-6. 2004
    ..86, P < 0.001) strongly predict responses to GHRP-2 only. We conclude that among healthy middle-aged and older adults, the action of GHRP is uniquely determined by gender and physiological concentrations of testosterone and estradiol...
  73. ncbi request reprint Sustained growth hormone (GH) and insulin-like growth factor I responses to prolonged high-dose twice-daily GH-releasing hormone stimulation in middle-aged and older men
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:6325-30. 2004
    ....
  74. ncbi request reprint Testosterone blunts feedback inhibition of growth hormone secretion by experimentally elevated insulin-like growth factor-I concentrations
    Johannes D Veldhuis
    Endocrine Research Unit, Mayo School of Graduate Medical Education, General Clinical Research Center, 200 First Street Southwest, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:1613-7. 2005
    ..Both effects of Te differ from those reported recently for estradiol in postmenopausal women. Accordingly, we postulate that Te and estrogen modulate IGF-I negative feedback differentially...
  75. ncbi request reprint Deterministic construct of amplifying actions of ghrelin on pulsatile growth hormone secretion
    Leon S Farhy
    Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, University of Virginia, Charlottesville, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1649-63. 2005
    ..The minimal construct of GHS-GHRH-SRIF-GH interactions should aid in integrating physiological data, testing regulatory hypotheses, and forecasting innovative experiments...
  76. pmc Gender modulates sequential suppression and recovery of pulsatile growth hormone secretion by physiological feedback signals in young adults
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:2874-81. 2005
    ..A frugal but sufficient explanation of the ensemble outcomes is that women sustain greater hypothalamo-pituitary agonist input than men...
  77. ncbi request reprint Joint mechanisms of impaired growth-hormone pulse renewal in aging men
    Johannes D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:4177-83. 2005
    ..Experimental data indicate that high-amplitude GH pulses are evoked by reversible cycles of GH-induced negative feedback. Whether aging impairs autofeedback is unknown...
  78. ncbi request reprint Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, 200 First Street Southwest, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:5753-61. 2004
    ....
  79. ncbi request reprint Pioglitazone treatment increases spontaneous growth hormone (GH) secretion and stimulated GH levels in polycystic ovary syndrome
    Dorte Glintborg
    Department of Endocrinology and Metabolism, Odense University Hospital, Denmark
    J Clin Endocrinol Metab 90:5605-12. 2005
    ..GH acts as an important ovarian cogonadotropin, and GH disturbances may be an additional pathogenic factor in PCOS. Decreased abdominal fat mass and improved insulin sensitivity during pioglitazone treatment may affect GH secretion...
  80. pmc Pituitary and/or peripheral estrogen-receptor alpha regulates follicle-stimulating hormone secretion, whereas central estrogenic pathways direct growth hormone and prolactin secretion in postmenopausal women
    Mihaela Cosma
    Endocrine Research Unit, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, 200 First Street S W, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 93:951-8. 2008
    ..Estradiol (E(2)) stimulates GH and prolactin secretion and suppresses FSH secretion in postmenopausal women. Whether central nervous system (CNS) or pituitary mechanisms (or both) mediate such actions is not known...
  81. ncbi request reprint Peripheral estrogen receptor-alpha selectively modulates the waveform of GH secretory bursts in healthy women
    Johannes D Veldhuis
    Endocrine Research Unit, Mayo Medical and Graduate Schools, Clinical Translational Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1514-21. 2007
    ..The collective data indicate that peripheral ERalpha-dependent mechanisms determine the shape (waveform) of in vivo GH secretory bursts and that such mechanisms operate with secretagogue selectivity...
  82. ncbi request reprint Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibition in healthy men
    Paul Y Takahashi
    Endocrine Research Unit, Department of Internal Medicine, General Clinical Research Center, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 92:3626-32. 2007
    ..Whether testosterone (Te) depletion in aging men reflects deficits in the testis, hypothalamus, and/or pituitary gland is unknown...
  83. ncbi request reprint Estimation of the size and shape of GH secretory bursts in healthy women using a physiological estradiol clamp and variable-waveform deconvolution model
    Johannes D Veldhuis
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1013-21. 2007
    ..001). Accordingly, age selectively determines both the size (amount) and shape (waveform) of GH secretory bursts in healthy women independently of the short-term estrogen milieu...
  84. ncbi request reprint Tripartite control of growth hormone secretion in women during controlled estradiol repletion
    Johannes D Veldhuis
    Endocrine Research Unit 9, General Clinical Research Center, Mayo Medical and Graduate Schools of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Clin Endocrinol Metab 92:2336-45. 2007
    ....
  85. ncbi request reprint Model-projected mechanistic bases for sex differences in growth hormone regulation in humans
    Leon S Farhy
    Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1577-93. 2007
    ..The proposed model platform should enhance the framing and interpretation of novel clinical hypotheses and create a basis for interspecies generalization of GH-axis regulation...
  86. ncbi request reprint Estradiol potentiates ghrelin-stimulated pulsatile growth hormone secretion in postmenopausal women
    Johannes D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 91:3559-65. 2006
    ..Ghrelin and an estrogen-rich milieu individually amplify pulsatile GH secretion by increasing the amount of hormone released per burst. However, how these distinct agonists interact in controlling pulsatile GH output is not known...
  87. ncbi request reprint GH secretory pattern in young adults who discontinued GH treatment for GH deficiency and decreased longitudinal growth in childhood
    Johan Svensson
    Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Eur J Endocrinol 155:91-9. 2006
    ..Sixteen matched healthy controls were also studied. All blood samples were analysed using an ultrasensitive GH assay and then, approximate entropy (ApEn) and deconvolution analysis were performed...
  88. ncbi request reprint Effect of pioglitazone on glucose metabolism and luteinizing hormone secretion in women with polycystic ovary syndrome
    Dorte Glintborg
    Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark
    Fertil Steril 86:385-97. 2006
    ..To thoroughly examine the mechanisms for insulin resistance in polycystic ovary syndrome (PCOS) and to evaluate the effects of pioglitazone treatment on insulin resistance, beta-cell function, LH secretion, and glucose metabolism...
  89. ncbi request reprint Somatotropic and gonadotropic axes linkages in infancy, childhood, and the puberty-adult transition
    Johannes D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo Medical School, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    Endocr Rev 27:101-40. 2006
    ..Significant advances in systems biology will be needed to address these challenges...
  90. ncbi request reprint Growth hormone response to graded exercise intensities is attenuated and the gender difference abolished in older adults
    Arthur Weltman
    Department of Human Services, University of Virginia, Charlottesville, VA 22904, USA
    J Appl Physiol 100:1623-9. 2006
    ..Attenuation of GH responses to all exercise intensities in older adults has implications for exercise prescription because higher exercise intensities may be required to stimulate GH release in older adults...
  91. ncbi request reprint Sex-steroid control of the aging somatotropic axis
    Johannes D Veldhuis
    Endocrine Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, General Clinical Research Center, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Endocrinol Metab Clin North Am 34:877-93, viii. 2005
  92. ncbi request reprint A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function
    Sekar Natesampillai
    Endocrine Research Unit and Gastroenterology Research Unit, Department of Internal Medicine, Mayo School of Graduate Medical Education, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Biol Chem 281:3040-7. 2006
    ....
  93. ncbi request reprint Testosterone supplementation in healthy older men drives GH and IGF-I secretion without potentiating peptidyl secretagogue efficacy
    Johannes D Veldhuis
    Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Eur J Endocrinol 153:577-86. 2005
    ..e. reduces opposition by hypothalamic somatostatin) and (iii) abdominal visceral fat (AVF) mass is a negative determinant of specific secretagogue-stimulated GH secretion...
  94. ncbi request reprint Age and secretagogue type jointly determine dynamic growth hormone responses to exogenous insulin-like growth factor-negative feedback in healthy men
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 89:5542-8. 2004
    ....
  95. pmc Short-term aromatase-enzyme blockade unmasks impaired feedback adaptations in luteinizing hormone and testosterone secretion in older men
    Johannes D Veldhuis
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Mayo Medical and Graduate Schools of Medicine, General Clinical Research Center, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Clin Endocrinol Metab 90:211-8. 2005
    ..Thus, aging alters expected hypothalamopituitary-gonadal adaptations to short-term partial estrogen depletion in healthy men...
  96. ncbi request reprint Endocrine and metabolic effects of growth hormone (GH) compared with GH-releasing peptide, thyrotropin-releasing hormone, and insulin infusion in a rabbit model of prolonged critical illness
    Frank Weekers
    Department of Intensive Care Medicine, Burn Unit and Center for Experimental Surgery and Anesthesiology, Catholic University of Leuven, Leuven, Belgium
    Endocrinology 145:205-13. 2004
    ..In contrast to the human model, high dose rhGH was not rapidly lethal in this rabbit model. Whether this is explained by lack of rhGH-induced insulin resistance and hyperglycemia remains unclear...
  97. ncbi request reprint Octreotide represses secretory-burst mass and nonpulsatile secretion but does not restore event frequency or orderly GH secretion in acromegaly
    Nienke R Biermasz
    Department of Metabolism and Endocrinology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Am J Physiol Endocrinol Metab 286:E25-30. 2004
    ..Presumptive tumoral autonomy is inferred by continued elevations of event frequency, overall pattern disruption (irregularity), and nonsuppressible basal GH secretion...
  98. ncbi request reprint A tripeptidyl ensemble perspective of interactive control of growth hormone secretion
    Johannes D Veldhuis
    Mayo Medical and Graduate School of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Horm Res 60:86-101. 2003
    ..This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above...
  99. ncbi request reprint Three-peptide control of pulsatile and entropic feedback-sensitive modes of growth hormone secretion: modulation by estrogen and aromatizable androgen
    Johannes D Veldhuis
    Mayo Clinic and Graduate School of Medicine, Division of Endocrinology and Metabolism, Department of Internal Medicine, Rochester, MN 55905, USA
    J Pediatr Endocrinol Metab 16:587-605. 2003
    ..The dynamic interactions in this three-peptide network, rather than the activity of any single effector, subserve core adaptations in GH secretion across development...
  100. ncbi request reprint Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men
    Kimberly T Brill
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Endocrinol Metab 87:5649-57. 2002
    ..We conclude that 1 month of GH and/or T administration improves certain measures of balance and physical performance in older men and increases muscle IGF-I gene expression...
  101. ncbi request reprint Physiological and pharmacological regulation of 20-kDa growth hormone
    Kin Chuen Leung
    Pituitary Research Unit, Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, New South Wales 2010, Australia
    Am J Physiol Endocrinol Metab 283:E836-43. 2002
    ..The 20-kDa GH level is reduced by administration of exogenous 22-kDa GH, suggesting rapid negative feedback regulation on pituitary release...