Nosratola D Vaziri

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression
    Madeleine V Pahl
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 25:205-12. 2010
  2. pmc Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease
    Stacey Ruiz
    Reata Pharmaceuticals, Irving, Texas, USA
    Kidney Int 83:1029-41. 2013
  3. ncbi request reprint Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California Irvine Medical Center, Suite 400, City Tower, 101 City Drive, Orange, CA, 92868, USA
    Clin Exp Nephrol 18:265-8. 2014
  4. doi request reprint Chronic kidney disease causes disruption of gastric and small intestinal epithelial tight junction
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Irvine, Calif 92868, USA
    Am J Nephrol 38:99-103. 2013
  5. pmc Oral activated charcoal adsorbent (AST-120) ameliorates chronic kidney disease-induced intestinal epithelial barrier disruption
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Calif, USA
    Am J Nephrol 37:518-25. 2013
  6. doi request reprint Understanding iron: promoting its safe use in patients with chronic kidney failure treated by hemodialysis
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine and Physiology and Biophysics, University of California, Irvine, Orange, CA 92868, USA
    Am J Kidney Dis 61:992-1000. 2013
  7. pmc CKD impairs barrier function and alters microbial flora of the intestine: a major link to inflammation and uremic toxicity
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine and Physiology and Biophysics, University of California, Irvine, California 92868, USA
    Curr Opin Nephrol Hypertens 21:587-92. 2012
  8. pmc Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in chronic kidney disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, CA 92868, USA
    Am J Nephrol 37:1-6. 2013
  9. doi request reprint Chronic kidney disease alters intestinal microbial flora
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, UC Irvine Medical Center, Irvine, California 92868, USA
    Kidney Int 83:308-15. 2013
  10. pmc Reasons for the lack of salutary effects of cholesterol-lowering interventions in end-stage renal disease populations
    Nosratola D Vaziri
    Departments of Medicine, Physiology and Biophysics, Division of Nephrology and Hypertension, University of California, Irvine, CA 92868, USA
    Blood Purif 35:31-6. 2013

Collaborators

Detail Information

Publications154 found, 100 shown here

  1. pmc Effect of end-stage renal disease on B-lymphocyte subpopulations, IL-7, BAFF and BAFF receptor expression
    Madeleine V Pahl
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 25:205-12. 2010
    ..Therefore, we studied the distribution of major B-cell subsets, B-cell growth, differentiation and survival factors, IL-7 and BAFF, and their receptors in 21 haemodialysis patients and 21 controls...
  2. pmc Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease
    Stacey Ruiz
    Reata Pharmaceuticals, Irving, Texas, USA
    Kidney Int 83:1029-41. 2013
    ..This article provides an overview of the role of impaired Nrf2 activity in the pathogenesis of CKD-associated oxidative stress and inflammation and the potential utility of targeting Nrf2 in the treatment of CKD...
  3. ncbi request reprint Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California Irvine Medical Center, Suite 400, City Tower, 101 City Drive, Orange, CA, 92868, USA
    Clin Exp Nephrol 18:265-8. 2014
    ..This review provides a brief overview of the role of CKD-induced lipid disorders in the pathogenesis of oxidative stress, inflammation, cardiovascular disease, impaired exercise capacity, cachexia and wasting syndrome. ..
  4. doi request reprint Chronic kidney disease causes disruption of gastric and small intestinal epithelial tight junction
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Irvine, Calif 92868, USA
    Am J Nephrol 38:99-103. 2013
    ..This observation suggests that uremia may cause disruption of the epithelial barrier in all segments of the gastrointestinal tract including the stomach, jejunum, and ileum. The present study was undertaken to explore this possibility...
  5. pmc Oral activated charcoal adsorbent (AST-120) ameliorates chronic kidney disease-induced intestinal epithelial barrier disruption
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Calif, USA
    Am J Nephrol 37:518-25. 2013
    ..We hypothesized that by adsorbing urea and urea-derived ammonia, oral activated charcoal (AST-120) may ameliorate CKD-induced intestinal epithelial barrier disruption and systemic inflammation...
  6. doi request reprint Understanding iron: promoting its safe use in patients with chronic kidney failure treated by hemodialysis
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine and Physiology and Biophysics, University of California, Irvine, Orange, CA 92868, USA
    Am J Kidney Dis 61:992-1000. 2013
    ..This review is intended to provide an overview of the nature and mechanisms of the adverse effects of iron overload and call for the judicious use of these vitally important products...
  7. pmc CKD impairs barrier function and alters microbial flora of the intestine: a major link to inflammation and uremic toxicity
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine and Physiology and Biophysics, University of California, Irvine, California 92868, USA
    Curr Opin Nephrol Hypertens 21:587-92. 2012
    ..This article is intended to provide an over view of the impact of uremia on the structure and function of the gut and its microbial flora and their potential link to the associated systemic inflammation...
  8. pmc Role of urea in intestinal barrier dysfunction and disruption of epithelial tight junction in chronic kidney disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, CA 92868, USA
    Am J Nephrol 37:1-6. 2013
    ..This study tested the hypothesis that intestinal barrier dysfunction in uremia may be due to diffusion of urea into the gut and its conversion to ammonia by microbial urease...
  9. doi request reprint Chronic kidney disease alters intestinal microbial flora
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, UC Irvine Medical Center, Irvine, California 92868, USA
    Kidney Int 83:308-15. 2013
    ..Thus, uremia profoundly alters the composition of the gut microbiome. The biological impact of this phenomenon is unknown and awaits further investigation...
  10. pmc Reasons for the lack of salutary effects of cholesterol-lowering interventions in end-stage renal disease populations
    Nosratola D Vaziri
    Departments of Medicine, Physiology and Biophysics, Division of Nephrology and Hypertension, University of California, Irvine, CA 92868, USA
    Blood Purif 35:31-6. 2013
    ....
  11. pmc Dysregulation of hepatic fatty acid metabolism in chronic kidney disease
    Kyubok Jin
    Division of Nephrology and Hypertension, University of California, Irvine, Irvine, CA, USA
    Nephrol Dial Transplant 28:313-20. 2013
    ..However, data on the effect of CKD on fatty acid metabolism in the liver is limited and was investigated here...
  12. pmc Uremic plasma impairs barrier function and depletes the tight junction protein constituents of intestinal epithelium
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, USA
    Am J Nephrol 36:438-43. 2012
    ..This study determined whether CKD-associated disruption of TJ is mediated by retained uremic toxins/metabolites and, if so, whether they are removed by hemodialysis...
  13. pmc Disintegration of colonic epithelial tight junction in uremia: a likely cause of CKD-associated inflammation
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 27:2686-93. 2012
    ..This study was designed to test the hypothesis that impaired intestinal barrier function in uremia must be due to disruption of the intestinal tight junction complex...
  14. pmc Lipoprotein lipase deficiency in chronic kidney disease is accompanied by down-regulation of endothelial GPIHBP1 expression
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Irvine, CA, USA
    Clin Exp Nephrol 16:238-43. 2012
    ..Given its central role in regulation of LPL activity and triglyceride metabolism, we explored the effect of chronic kidney disease (CKD) on GPIHBP1 expression...
  15. doi request reprint Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease
    Mohammad A Aminzadeh
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 27:498-504. 2012
    ..However, the effect of CKD on expression of H(2)S-producing enzymes in the diseased kidney and other tissues is unknown and was studied here...
  16. pmc Effect of uremia on structure and function of immune system
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Orange, California, USA
    J Ren Nutr 22:149-56. 2012
    ..This is coupled with immune deficiency that is caused by depletion of dendritic cells, naïve and central memory T cells and B cells, and impaired phagocytic function of polymorphonuclear leukocytes and monocytes...
  17. ncbi request reprint Downregulation of hepatic acyl-CoA:diglycerol acyltransferase in chronic renal failure
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, CA 92868, USA
    Am J Physiol Renal Physiol 287:F90-4. 2004
    ..Given the critical role of DGAT in triglyceride biosynthesis, the present study points to diminished, not increased, hepatic triglyceride synthetic capacity in CRF rats...
  18. ncbi request reprint Effects of aging and AT-1 receptor blockade on NO synthase expression and renal function in SHR
    N D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, UCI Medical Center, University of Irvine, 101 The City Drive, Bldg 53, Rm 125, Rt 81, Orange, CA 92868, USA
    Biochim Biophys Acta 1592:153-61. 2002
    ..Hypertension control with AT-1 receptor blockade initiated early in the course of the disease prevents target organ damage and preserves renal and vascular NOS...
  19. ncbi request reprint Interplay of reactive oxygen species and nitric oxide in the pathogenesis of experimental lead-induced hypertension
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Clin Exp Pharmacol Physiol 34:920-5. 2007
    ..In recent years, increasing evidence has emerged pointing to the role of oxidative stress as a major mediator of lead-induced hypertension. 3. The present article provides an overview of the published studies on this subject...
  20. doi request reprint Anemia and anemia correction: surrogate markers or causes of morbidity in chronic kidney disease?
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nat Clin Pract Nephrol 4:436-45. 2008
    ..I have focused on data from basic and translational studies, which are often overlooked in the design and interpretation of clinical studies and in the formulation of clinical guidelines...
  21. pmc Mechanisms of lead-induced hypertension and cardiovascular disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, UCI Medical Center, 101 The City Dr, Bldg 53, Rm 125, Rt 81, Orange, CA 92868, USA
    Am J Physiol Heart Circ Physiol 295:H454-65. 2008
    ..More importantly, these studies have elucidated the cellular and molecular mechanisms of lead's action on cardiovascular/renal systems, a task that is impossible to accomplish using clinical and epidemiological investigations alone...
  22. ncbi request reprint Cardiovascular effects of lead exposure
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, California 92697, USA
    Indian J Med Res 128:426-35. 2008
    ..This review is intended to provide an overview of the epidemiology and the underlying mechanisms of lead-associated HTN and cardiovascular disease...
  23. ncbi request reprint NAD(P)H oxidase, superoxide dismutase, catalase, glutathione peroxidase and nitric oxide synthase expression in subacute spinal cord injury
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California at Irvine Medical Center, 101 The City Drive, Building 53, Room 125, Rt 81, Orange, CA 92868, USA
    Brain Res 995:76-83. 2004
    ..Thus, concurrent upregulations of NAD(P)H oxidase, eNOS and iNOS (but not nNOS), work in concert to maintain oxidative and nitrosative stress in the injured cord tissue...
  24. ncbi request reprint Superoxide dismutase, catalase, glutathione peroxidase and NADPH oxidase in lead-induced hypertension
    Nosratola D Vaziri
    Departments of Medicine, Physiology and Biophysics University of California, Irvine, Irvine, California, USA
    Kidney Int 63:186-94. 2003
    ....
  25. ncbi request reprint Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency
    Nosratola D Vaziri
    Department of Medicine, Physiology and Biophysics, College of Medicine, University of California, Irvine, USA
    Kidney Int 63:179-85. 2003
    ..We hypothesized that CRF-induced oxidative stress may be due to increased production and/or decreased dismutation of superoxide...
  26. ncbi request reprint Causal link between oxidative stress, inflammation, and hypertension
    Nosratola D Vaziri
    Department of Medicine, University of California, Irvine, California, USA
    Iran J Kidney Dis 2:1-10. 2008
    ..Finally, evidence for participation of tissue angiotensin system in the vicious cycle of oxidative stress, inflammation, and HTN will be presented, and the approach to treatment of HTN-associated oxidative stress will be discussed...
  27. ncbi request reprint Intra-renal angiotensin II/AT1 receptor, oxidative stress, inflammation, and progressive injury in renal mass reduction
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    J Pharmacol Exp Ther 323:85-93. 2007
    ..Thus, the study demonstrated a link between up-regulation of Ang II/AT1r system and oxidative stress, inflammation, hypertension, and progression of renal disease in rats with renal mass reduction...
  28. ncbi request reprint Roles of oxidative stress and antioxidant therapy in chronic kidney disease and hypertension
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California 92868, USA
    Curr Opin Nephrol Hypertens 13:93-9. 2004
    ..This article is intended to provide an overview of oxidative stress in hypertension and chronic renal failure...
  29. ncbi request reprint Up-regulation of hepatic Acyl CoA: Diacylglycerol acyltransferase-1 (DGAT-1) expression in nephrotic syndrome
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Kidney Int 66:262-7. 2004
    ..The present study tested the hypothesis that the reported increase in hepatic triglyceride secretion in nephrotic syndrome may be caused by up-regulation of DGAT...
  30. ncbi request reprint Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences
    N D Vaziri
    Division of Nephrology and Hypertension, UCI Medical Center, Orange, CA 92868, USA
    Am J Physiol Renal Physiol 290:F262-72. 2006
    ..Together, these abnormalities may contribute to the risk of arteriosclerotic cardiovascular disease and may adversely affect progression of renal disease and energy metabolism in CRF...
  31. ncbi request reprint Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells
    N D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    J Pharmacol Exp Ther 313:121-6. 2005
    ..The observed modulations of eNOS expression are mediated by NO and represent an adaptive physiologic response...
  32. ncbi request reprint Mechanisms of dyslipidemia of chronic renal failure
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California 92868, USA
    Hemodial Int 10:1-7. 2006
    ..This review is intended to provide an overview of the molecular basis of lipid disorders in chronic renal failure and explore their potential impact on cardiovascular disease and energy metabolism...
  33. ncbi request reprint Effects of HMG-CoA reductase inhibition on hepatic expression of key cholesterol-regulatory enzymes and receptors in nephrotic syndrome
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, Calif 92868, USA
    Am J Nephrol 24:606-13. 2004
    ..This study was carried out to discern the effect of inhibition of HMG-CoA reductase on expression of the key enzymes and receptors involved in cholesterol metabolism in the liver...
  34. ncbi request reprint Mechanisms of disease: oxidative stress and inflammation in the pathogenesis of hypertension
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, at the University of California Irvine, Irvine, CA, USA
    Nat Clin Pract Nephrol 2:582-93. 2006
    ..Although the initiating factor might vary between hypertensive disorders, according to the proposed model, the three components of the cycle eventually coalesce in all forms of hypertension...
  35. ncbi request reprint Oxidative stress in uremia: nature, mechanisms, and potential consequences
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, Physiology, and Hypertension, University of California Irvine, Irvine, CA, USA
    Semin Nephrol 24:469-73. 2004
    ..The problem is compounded by limited intake of fresh fruits and vegetables (K(+) restriction), which contain numerous natural phytochemicals and antioxidant vitamins...
  36. ncbi request reprint ACAT inhibition reverses LCAT deficiency and improves plasma HDL in chronic renal failure
    N D Vaziri
    Irvine Medical Center, Division of Nephrology and Hypertension, University of California, 101 The City Drive, Bldg 53, Rm 125, Rt 81, Orange, CA 92868, USA
    Am J Physiol Renal Physiol 287:F1038-43. 2004
    ..In conclusion, inhibition of ACAT reversed LCAT deficiency and improved plasma HDL level in CRF rats. Future studies are needed to explore the efficacy of ACAT inhibition in humans with CRF...
  37. ncbi request reprint Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome
    N D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, USA
    Circulation 110:419-25. 2004
    ..Because hepatic ACAT-2 is markedly upregulated in NS, we tested the hypothesis that inhibition of ACAT may improve cholesterol metabolism in NS...
  38. ncbi request reprint Lead-induced hypertension: role of oxidative stress
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, UCI Medical Center, 101 The City Drive, Building 53, Room 125, Route 81, Orange, CA 92868, USA
    Curr Hypertens Rep 6:314-20. 2004
    ..In this article, we present an overview of the epidemiology and proposed underlying mechanisms of lead-induced hypertension...
  39. ncbi request reprint Role of AT-1 receptor in regulation of vascular MCP-1, IL-6, PAI-1, MAP kinase, and matrix expressions in obesity
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California at Irvine, Irvine, CA 92868, USA
    Kidney Int 68:2787-93. 2005
    ..In an attempt to explore the molecular sources of vascular inflammation and possible involvement of renin-angiotensin system, we studied obese Zucker rats, which exhibit all features of metabolic syndrome...
  40. pmc Potential risks of nitric oxide inhibition in spinal cord injury
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California Irvine Medical Center, Orange, CA 92868, USA
    J Spinal Cord Med 30:3-4. 2007
  41. ncbi request reprint Expression of NOX-I, gp91phox, p47phox and P67phox in the aorta segments above and below coarctation
    N D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA 92868, United States
    Biochim Biophys Acta 1723:321-7. 2005
    ..These observations suggest that HTN control may represent a specific form of antioxidant therapy for hypertensive disorders...
  42. ncbi request reprint Nitric oxide in microgravity-induced orthostatic intolerance: relevance to spinal cord injury
    N D Vaziri
    Division of Nephrology and Hypertension, University of California Irvine, Irvine, California, USA
    J Spinal Cord Med 26:5-11. 2003
    ..The possible relevance of the new findings to orthostatic intolerance in patients with acute SCI and its potential therapeutic implications will be discussed...
  43. ncbi request reprint Cardiovascular effects of erythropoietin and anemia correction
    N D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine, University of California, Irvine, California, USA
    Curr Opin Nephrol Hypertens 10:633-7. 2001
    ..However, data on the risks and benefits of complete correction of anemia in this population are limited and inconclusive, and await future investigation...
  44. ncbi request reprint Erythropoietin and transferrin metabolism in nephrotic syndrome
    N D Vaziri
    Department of Medicine, Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Am J Kidney Dis 38:1-8. 2001
    ..However, correction or amelioration of the underlying proteinuria, when possible, is the ideal approach to reversal of these complications...
  45. pmc Causes of dysregulation of lipid metabolism in chronic renal failure
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine, Physiology and Biophysics, University of California, Irvine, California, USA
    Semin Dial 22:644-51. 2009
    ....
  46. doi request reprint HDL metabolism and activity in chronic kidney disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, School of Medicine, The City Drive, City Tower, Suite 400, Orange, CA 92868 3217, USA
    Nat Rev Nephrol 6:287-96. 2010
    ..This Review aims to provide an overview of the mechanisms and consequences of CKD-induced HDL deficiency and dysfunction...
  47. doi request reprint Nephrotic syndrome causes upregulation of HDL endocytic receptor and PDZK-1-dependent downregulation of HDL docking receptor
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, CA 92868, USA
    Nephrol Dial Transplant 26:3118-23. 2011
    ..This study explored the effect of NS on hepatic expression of these important molecules...
  48. ncbi request reprint Effect of chronic renal failure on nitric oxide metabolism
    N D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine, Physiology and Biophysics, University of California, Irvine, CA, USA
    Am J Kidney Dis 38:S74-9. 2001
    ....
  49. pmc Amelioration of nephropathy with apoA-1 mimetic peptide in apoE-deficient mice
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 25:3525-34. 2010
    ..Given the central role of oxidative stress and inflammation in progression of renal disease, we hypothesized that apoA-1 mimetic peptide, D-4F, may attenuate renal lesions in apoE(-/-) mice...
  50. ncbi request reprint Effect of lead on nitric oxide synthase expression in coronary endothelial cells: role of superoxide
    N D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, USA
    Hypertension 37:223-6. 2001
    ....
  51. ncbi request reprint Enhanced nitric oxide inactivation and protein nitration by reactive oxygen species in renal insufficiency
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA 92868, USA
    Hypertension 39:135-41. 2002
    ..Amelioration of oxidative stress by high-dose vitamin E enhances NO availability, improves hypertension, lowers protein nitration products, and increases NOS expression and vascular NO production in CRF animals...
  52. ncbi request reprint The effect of pregnancy on renal clearance of boron in rats given boric acid orally
    N D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California 92697, USA
    Toxicol Sci 60:257-63. 2001
    ..In conclusion, pregnancy did not appear to significantly alter the renal clearance or the plasma half-life of boron in Sprague-Dawley rats under the conditions of this study...
  53. ncbi request reprint Pathogenesis of lead-induced hypertension: role of oxidative stress
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Departments of Medicine, Physiology and Biophysics, University of California, Irvine, USA
    J Hypertens Suppl 20:S15-20. 2002
    ..This paper provides an overview of the epidemiology of lead-induced hypertension followed by a review of the available data on the above-mentioned topics...
  54. pmc Salutary effects of hemodialysis on low-density lipoprotein proinflammatory and high-density lipoprotein anti-inflammatory properties in patient with end-stage renal disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine Medical Center, 101 The City Dr, 4th Floor City Tower, Orange, CA 92868, USA
    J Natl Med Assoc 103:524-33. 2011
    ..Hemodialysis partially improves LDL and HDL inflammatory activities. The salutary effects of hemodialysis are in part mediated by heparin, which is known to possess lipolytic and antioxidant properties...
  55. doi request reprint Lipid disorders and their relevance to outcomes in chronic kidney disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Irvine Medical Center, University of California Irvine, Orange, CA 92868, USA
    Blood Purif 31:189-96. 2011
    ....
  56. pmc In vitro stimulation of HDL anti-inflammatory activity and inhibition of LDL pro-inflammatory activity in the plasma of patients with end-stage renal disease by an apoA-1 mimetic peptide
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, California, USA
    Kidney Int 76:437-44. 2009
    ..Whether 4F or other apolipoproteinA-1 mimetic peptides will have any therapeutic benefit in end-stage renal disease will have to be examined directly in clinical studies...
  57. ncbi request reprint Down-regulation of hepatic lecithin:cholesterol acyltransferase gene expression in chronic renal failure
    N D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    Kidney Int 59:2192-6. 2001
    ..This study was conducted to determine whether impaired LCAT activity can be confirmed in CRF animals and if so whether it is due to down-regulation of hepatic LCAT expression...
  58. doi request reprint Lipotoxicity and impaired high density lipoprotein-mediated reverse cholesterol transport in chronic kidney disease
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    J Ren Nutr 20:S35-43. 2010
    ..This article is intended to provide a brief review of the effects of CKD on HDL structure and function and pathways of lipid influx, efflux, synthesis, and catabolism in the artery wall and the diseased kidney...
  59. ncbi request reprint Up-regulation of acyl-coenzyme A:cholesterol acyltransferase (ACAT) in nephrotic syndrome
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Irvine, California, USA
    Kidney Int 61:1769-75. 2002
    ..Therefore, we hypothesized that NS may result in up-regulation of hepatic ACAT...
  60. ncbi request reprint Compensatory up-regulation of nitric-oxide synthase isoforms in lead-induced hypertension; reversal by a superoxide dismutase-mimetic drug
    N D Vaziri
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Irvine, California 92868, USA
    J Pharmacol Exp Ther 298:679-85. 2001
    ..Thus, the study supports the presence of increased O2* activity and its role in the pathogenesis of HTN and altered NO metabolism in lead-exposed animals...
  61. ncbi request reprint Expression of catalase and glutathione peroxidase in renal insufficiency
    Ram K Sindhu
    Division of Nephrology and Hypertension, Department of Medicine, College of Medicine, University of California at Irvine, Irvine, CA 92697 4066, USA
    Biochim Biophys Acta 1743:86-92. 2005
    ..These events point to the role of impaired antioxidant defense system in the pathogenesis of oxidative stress in CRF...
  62. ncbi request reprint Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria
    Zhenmin Ni
    Division of Nephrology and Hypertension, Departments of Medicine, Physiology and Biophysics, University of California, Irvine, CA 92868, USA
    Biochim Biophys Acta 1638:129-37. 2003
    ....
  63. ncbi request reprint Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, CA 90095, USA
    Metabolism 55:928-34. 2006
    ....
  64. doi request reprint Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure
    Hyun Ju Kim
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Am J Physiol Renal Physiol 298:F662-71. 2010
    ..Thus oxidative stress and inflammation in the remnant kidney are compounded by conspicuous impairment of Nrf2 activation and consequent downregulation of the antioxidant enzymes...
  65. ncbi request reprint Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1606, USA
    J Appl Physiol (1985) 100:1657-65. 2006
    ..Nine of 15 were no longer positive for metabolic syndrome postintervention. Intensive lifestyle modification may ameliorate novel coronary artery disease risk factors in men with metabolic syndrome factors before reversal of obesity...
  66. doi request reprint ApoA-1 mimetic peptide reverses uremia-induced upregulation of pro-atherogenic pathways in the aorta
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, Calif, USA ndvaziri uci edu
    Am J Nephrol 32:201-11. 2010
    ..We hypothesized that long-term administration of ApoA-1 mimetic peptide, L4F, may ameliorate inflammation and oxidative stress in the conduit arteries in experimental CKD...
  67. ncbi request reprint Superoxide dismutase, catalase and glutathione peroxidase in the spontaneously hypertensive rat kidney: effect of antioxidant-rich diet
    Chang De Zhan
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    J Hypertens 22:2025-33. 2004
    ..e. superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX)] in the kidney of SHR fed a regular or an antioxidant-rich diet...
  68. ncbi request reprint A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles 90095, USA
    J Appl Physiol (1985) 94:941-6. 2003
    ..Thus chronic consumption of an HFS diet results in hypertension and salt sensitivity, which may be in part due to a combination of ROS-mediated NO inactivation and depressed renal nNOS protein expression...
  69. ncbi request reprint HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles, California, USA
    Kidney Int 66:1503-11. 2004
    ..While plasma lipid abnormalities in syndrome X have been well characterized, their molecular basis remains unclear. This study explored potential mechanisms of hypercholesterolemia in diet-induced syndrome X...
  70. ncbi request reprint Effects of nerve graft on nitric oxide synthase, NAD(P)H oxidase, and antioxidant enzymes in chronic spinal cord injury
    Yu Shang Lee
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697 4066, USA
    Free Radic Biol Med 36:330-9. 2004
    ..We conclude that the combination of nerve graft and aFGF enhances the local antioxidant defense system after spinal cord transection in rats...
  71. ncbi request reprint Upregulation of hepatic LDL receptor-related protein in nephrotic syndrome: response to statin therapy
    Sara Kim
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Am J Physiol Endocrinol Metab 288:E813-7. 2005
    ..These findings exclude depressed hepatic LRP expression as the primary cause of elevated plasma lipoprotein remnants in N-S...
  72. pmc Air pollution exposures and circulating biomarkers of effect in a susceptible population: clues to potential causal component mixtures and mechanisms
    Ralph J Delfino
    Department of Epidemiology, School of Medicine, University of California, Irvine, Irvine, California 92617, USA
    Environ Health Perspect 117:1232-8. 2009
    ..Experimental evidence suggests that organic components and ultrafine particles (UFP) are important...
  73. doi request reprint Niacin improves renal lipid metabolism and slows progression in chronic kidney disease
    Kyu hyang Cho
    Division of Nephrology and Hypertension, University of California, Irvine, Irvine, CA, USA
    Biochim Biophys Acta 1800:6-15. 2010
    ..Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF...
  74. ncbi request reprint Effects of aortic coarctation on aortic antioxidant enzymes and NADPH oxidase protein expression
    Ram K Sindhu
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, Irvine, CA, 92697, USA
    Life Sci 76:945-53. 2005
    ....
  75. pmc High-calorie diet with moderate protein restriction prevents cachexia and ameliorates oxidative stress, inflammation and proteinuria in experimental chronic kidney disease
    Hyun Ju Kim
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, CA, USA
    Clin Exp Nephrol 14:536-47. 2010
    ..This study was conducted to explore the mechanism of the salutary effect of HFED in association with moderate protein restriction in this model...
  76. ncbi request reprint Antioxidant therapy does not ameliorate oxidative stress and inflammation in patients with end-stage renal disease
    Mohammad Kamgar
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    J Natl Med Assoc 101:336-44. 2009
    ..Thus, high doses of vitamins beyond the routinely prescribed vitamin supplements do not appear to be indicated in this population...
  77. doi request reprint Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure
    Kyu hyang Cho
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Am J Physiol Renal Physiol 297:F106-13. 2009
    ..Thus niacin supplementation helps to attenuate histological injury and mitigate upregulation of oxidative and inflammatory systems in the remnant kidney...
  78. ncbi request reprint Up-regulation of kidney NAD(P)H oxidase and calcineurin in SHR: reversal by lifelong antioxidant supplementation
    Chang De Zhan
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    Kidney Int 65:219-27. 2004
    ..The study further sought to explore the effect of diet modification on renal tissue NAD(P)H oxidase and calcineurin abundance...
  79. ncbi request reprint Dysregulation of hepatic superoxide dismutase, catalase and glutathione peroxidase in diabetes: response to insulin and antioxidant therapies
    Ram K Sindhu
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California 92697 4066, USA
    Clin Exp Hypertens 26:43-53. 2004
    ..Thus diabetes-associated reductions in antioxidant enzymes can be ameliorated by insulin and/or antioxidant therapy...
  80. ncbi request reprint Effect of renal injury-induced neurogenic hypertension on NO synthase, caveolin-1, AKt, calmodulin and soluble guanylate cyclase expressions in the kidney
    Y Bai
    Division of Nephrology and Hypertension, University of California, Irvine, CA 92868, USA
    Am J Physiol Renal Physiol 292:F974-80. 2007
    ....
  81. ncbi request reprint Antioxidant therapy potentiates antihypertensive action of insulin in diabetic rats
    Ja Ryong Koo
    Department of Medicine, University of California Irvine, 92697, USA
    Clin Exp Hypertens 24:333-44. 2002
    ..Therefore, we hypothesized that antioxidant therapy may enhance the BP-lowering effect of glycemia control with insulin replacement in diabetes...
  82. ncbi request reprint Lead exposure raises superoxide and hydrogen peroxide in human endothelial and vascular smooth muscle cells
    Zhenmin Ni
    Division of Nephrology and Hypertension, University of California, Irvine, Irvine, California, USA
    Kidney Int 66:2329-36. 2004
    ....
  83. ncbi request reprint Enhanced nitric oxide inactivation in aortic coarctation-induced hypertension
    C H Barton
    Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine, California, USA
    Kidney Int 60:1083-7. 2001
    ..The normality of nitrotyrosine abundance in the abdominal aorta wherein blood pressure is not elevated points to the role of baromechanical factors as opposed to circulating humoral factors that were necessarily similar in both segments...
  84. ncbi request reprint Involvement of endothelium and endothelin-1 in lead-induced smooth muscle cell dysfunction in rats
    L Molero
    Cardiovascular Research Unit, Hospital Clinico San Carlos, Madrid, Spain, and Department of Medicine, University of California, Irvine, USA
    Kidney Int 69:685-90. 2006
    ..As conclusion, the endothelium through the activation of ETA-type receptors mediates the downregulation of sGC expression by lead in the vascular wall...
  85. ncbi request reprint HMG-CoA reductase inhibition reverses LCAT and LDL receptor deficiencies and improves HDL in rats with chronic renal failure
    K Liang
    Div of Nephrology and Hypertension, Univ of California, Irvine Medical Ctr, Bldg 53, Rm 125, 101 The City Dr, Rt 81, Orange, CA 92868, USA
    Am J Physiol Renal Physiol 288:F539-44. 2005
    ..Thus administration of rosuvastatin reversed LCAT and LDL receptor deficiencies and promoted a shift in plasma cholesterol from ApoB-containing lipoproteins to HDL in CRF rats...
  86. ncbi request reprint Molecular mechanisms of altered cholesterol metabolism in rats with spontaneous focal glomerulosclerosis
    Nosratola D Vaziri
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Kidney Int 63:1756-63. 2003
    ..In this study, we investigated key factors involved in cholesterol metabolism...
  87. pmc Reverse cholesterol transport pathway in experimental chronic renal failure
    Hamid Moradi
    Division of Nephrology and Hypertension, University of California, Irvine, Calif, USA
    Am J Nephrol 30:147-54. 2009
    ..In the liver, lipid-rich HDL unloads its lipid contents via reversible binding to SR-BI while lipid-poor HDL is degraded by the holo-receptor (ATP synthase beta-chain)...
  88. ncbi request reprint Effects of diabetes, insulin and antioxidants on NO synthase abundance and NO interaction with reactive oxygen species
    Ja Ryong Koo
    Department of Medicine University of California, Irvine, Irvine, California, USA
    Kidney Int 63:195-201. 2003
    ..This study was intended to explore the effect of type I diabetes and its treatment with insulin alone or insulin plus antioxidant-fortified diet on expression of NOS isoforms and ROS interactions with lipids, glucose and NO...
  89. ncbi request reprint Effects of dietary salt on intrarenal angiotensin system, NAD(P)H oxidase, COX-2, MCP-1 and PAI-1 expressions and NF-kappaB activity in salt-sensitive and -resistant rat kidneys
    G Chandramohan
    Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
    Am J Nephrol 28:158-67. 2008
    ....
  90. pmc Effect of exercise on cardiac tissue oxidative and inflammatory mediators in chronic kidney disease
    Y Bai
    Division of Nephrology and Hypertension, University of California Irvine, Irvine, CA 92868, USA
    Am J Nephrol 29:213-21. 2009
    ..This study was designed to explore the effect of exercise on oxidative and inflammatory mediators in the left ventricle (LV) of CRF rats...
  91. ncbi request reprint Effect of diet and exercise intervention on blood pressure, insulin, oxidative stress, and nitric oxide availability
    Christian K Roberts
    Department of Physiological Science, University of California, Los Angeles 90095 1527, USA
    Circulation 106:2530-2. 2002
    ..Diet and exercise can affect blood pressure and atherosclerotic risk...
  92. doi request reprint Impaired antioxidant activity of high-density lipoprotein in chronic kidney disease
    Hamid Moradi
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, CA 92868, USA
    Transl Res 153:77-85. 2009
    ..Thus, in addition to diminished plasma HDL concentration, the composition and antioxidant activity of HDL are altered in CKD; these events can contribute to a heightened risk of atherosclerosis...
  93. ncbi request reprint HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia
    Kaihui Liang
    Division of Nephrology and Hypertension, University of California, Irvine, California, USA
    Kidney Int 64:192-8. 2003
    ..The present study was undertaken to explore the effect of hereditary analbuminemia on protein expression of the key factors involved in cholesterol metabolism...
  94. ncbi request reprint Regional expression of NO synthase, NAD(P)H oxidase and superoxide dismutase in the rat brain
    Vito M Campese
    Division of Nephrology, Department of Medicine, Keck School of Medicine, University of Southern California, 1200 North State Street, Los Angeles, CA 90033, USA
    Brain Res 1134:27-32. 2007
    ....
  95. ncbi request reprint Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemia
    Christian K Roberts
    Department of Physiological Science, UCLA, University of California, PO Box 951606, Los Angeles, CA 90095 1606, USA
    Atherosclerosis 161:133-41. 2002
    ..Conversion to a LFCC diet can ameliorate the dyslipidemia and tissue changes induced by long-term HFS diet consumption...
  96. ncbi request reprint Blood pressure response to hypoxia: role of nitric oxide synthase
    Cyril H Barton
    Division of Nephrology and Hypertension, University of California, Irvine, Orange, California 92868, USA
    Am J Hypertens 16:1043-8. 2003
    ..In view of the latter observations, we hypothesized that hypoxia-induced hypertension may be associated with downregulation of NO synthase (NOS)...
  97. ncbi request reprint Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, and LDL receptor in hereditary analbuminemia
    Youngshin Shin
    Division of Nephrology and Hypertension, UCI Medical Center, University of California Irvine, 101 The City Drive, Rt 81, Orange, CA 92868, USA
    Am J Physiol Endocrinol Metab 289:E993-8. 2005
    ..Thus the greater severity of hypercholesterolemia in the female NAR appears to be due, in part, to a combination of the constrained compensatory upregulation of cholesterol 7alpha-hydroxylase and LDL receptor deficiency...
  98. doi request reprint Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney
    Won Suk An
    Div of Nephrology and Hypertension, UCI Medical Center, 101 The City Drive, Bldg 53, Rm 125, Rt 81, Orange, CA 92868, USA
    Am J Physiol Renal Physiol 297:F895-903. 2009
    ..Thus, long-term O-3FA supplementation can reduce or reverse upregulation of prooxidant, proinflammatory, and profibrotic pathways and attenuate tubulointerstitial fibrosis in the remnant kidney...
  99. doi request reprint Effect of nephrotic syndrome on homocysteine metabolism
    Mohammad A Aminzadeh
    Division of Nephrology and Hypertension, University of California, Irvine, CA, USA
    Nephrol Dial Transplant 26:1244-7. 2011
    ....
  100. ncbi request reprint Acquired lecithin-cholesterol acyltransferase deficiency in nephrotic syndrome
    N D Vaziri
    Division of Nephrology, Department of Medicine, University of California-Irvine, Irvine, CA 92697, USA
    Am J Physiol Renal Physiol 280:F823-8. 2001
    ..Therefore, proteinuria, not hypoalbuminemia, causes LCAT deficiency and a depressed HDL-to-total cholesterol ratio in NS...